A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19
NCT05386472
Recruiting
The purpose of this clinical trial is to learn about how study medicine (Paxlovid, which contains nirmatrelvir and ritonavir) is changed and eliminated from the body, as well as its safety, and the extent to which side effects can be tolerated for treatment of pregnant women with mild or moderate COVID-19 compared to non-pregnant women with mild or moderate COVID-19. This study is seeking participants who: are expecting a healthy baby and are in their second or third trimester pregnancy and ha... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Locations: St. David's Medical Center, Austin, Texas +25 locations
Conditions: COVID-19
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Study of Obeldesivir in Nonhospitalized Participants With COVID-19
NCT05715528
Recruiting
The goal of this clinical study is to test if obeldesivir (formerly GS-5245) is safe and effective for the treatment of coronavirus disease 2019 (COVID-19) in participants who have a standard risk of developing severe illness. This study will also measure how much obeldesivir gets into the blood and how long it takes for the body to get rid of it.
Gender:
All
Ages:
Between 12 years and 64 years
Locations: Central Texas Clinical Research, Austin, Texas +142 locations
Conditions: COVID-19
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A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals
NCT05472038
Recruiting
The purpose of this clinical trial is to learn about the safety, tolerability and immunogenicity of BNT162b, RNA-based SARS-CoV-2 vaccine candidates given as a booster dose in adults to prevent COVID-19. For all cohorts (groups of participants), this study is seeking participants who are healthy (who may have preexisting disease if it is stable); All participants will receive a single dose of the study vaccine at the first study clinic and will return to the study clinic at least 4 more times.... Read More
Gender:
All
Ages:
12 years and above
Locations: Benchmark Research, Austin, Texas +32 locations
Conditions: SARS-CoV-2 Infection, COVID-19
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A Study of mRNA-1283.222 Injection Compared With mRNA-1273.222 Injection in Participants ≥12 Years of Age to Prevent COVID-19
NCT05815498
Recruiting
The purpose of this study is to evaluate the safety, reactogenicity, and relative vaccine efficacy (rVE) of the mRNA-1283.222 vaccine as well as its immunogenicity in comparison to the mRNA-1273.222 vaccine.
Gender:
All
Ages:
12 years and above
Locations: Benchmark Research, Austin, Texas +215 locations
Conditions: COVID-19
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Relative Bioavailability, Safety, and Tolerability of Single-dose Sotrovimab Injection in Adults (COSMIC)
NCT05280717
Recruiting
This clinical pharmacology study will evaluate the relative bioavailability, safety, and tolerability of two different concentrations of sotrovimab injections administered at different injection sites in male or female healthy participants aged 18 to 65 years. The study will be conducted in three parts (Part A, an optional Part B and Part C).
Gender:
All
Ages:
Between 18 years and 65 years
Locations: Investigative Site, Austin, Texas +9 locations
Conditions: Covid19
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Natural History of COVID-19-Related Atrial Fibrillation
NCT04830774
Recruiting
The unCOVer-AF prospective, multicenter registry aims at determining the natural history of atrial fibrillation (AF) via continuous cardiac rhythm monitoring in patients with a first arrhythmic episode during COVID-19 hospitalization.
Gender:
All
Ages:
18 years and above
Locations: Texas Cardiac Arrhythmia Institute, Austin, Texas +11 locations
Conditions: COVID-19, Atrial Fibrillation New Onset
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Genetic Mechanisms Underlying SARS-CoV-2 Infection and the Impact of COVID-19 on Cognitive Function
NCT04506229
Recruiting
There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of in... Read More
Gender:
All
Ages:
18 years and above
Locations: Texas Cardiac Arrhythmia Institute, Austin, Texas
Conditions: Covid19
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Comparison of the Efficacy of Rapid Tests to Identify COVID-19 Infection (CATCh COVID-19)
NCT04372004
Recruiting
This study is designed to compare the efficacy of detection of COVID-19 infection using the serology test in blood sample and the PCR-based test in the nasopharyngeal (NP) and sputum sample. Furthermore, it aims to evaluate the temporal trend of appearance of IgM and IgG in blood.
Gender:
All
Ages:
Between 18 years and 85 years
Locations: Texas Cardiac Arrhythmia Institute, Austin, Texas
Conditions: COVID-19
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ANTIBODY BASED TESTS FOR SARSCoV-2 COVID-19) - Evaluation of Patients and Healthcare Providers in the Confines of Healthcare Settings
NCT04352764
Recruiting
This study will be conducted as a registry to identify asymptomatic or symptomatic persons to determine whether they carry SARS-CoV-2 antibodies.
Gender:
All
Ages:
All
Locations: St. David's Medical Center, Austin, Texas
Conditions: Covid19
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