Safety and Effects of an Investigational COVID-19 Vaccine as a Booster in Healthy People
NCT05541861
Recruiting
This is an exploratory Phase I, randomized, observer-blind, active-controlled, dose escalation trial to evaluate three dose levels (DLs) of BNT162b4 given in combination with BNT162b2 Bivalent to select a safe and tolerable dose. There will be three observer-blind cohorts (1, 2, 3a, and 3b). The trial will use a staggered dosing process schema, i.e., enrollment into the next higher dose level is done sequentially and subject to safety data from the previous dose levels, with sentinel participant... Read More
Gender:
All
Ages:
18 years and above
Locations: DM Clinical Research, Tomball, Texas +16 locations
Conditions: SARS-CoV-2 Infection, COVID-19
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A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals
NCT05472038
Recruiting
The purpose of this clinical trial is to learn about the safety, tolerability and immunogenicity of BNT162b, RNA-based SARS-CoV-2 vaccine candidates given as a booster dose in adults to prevent COVID-19. For all cohorts (groups of participants), this study is seeking participants who are healthy (who may have preexisting disease if it is stable); All participants will receive a single dose of the study vaccine at the first study clinic and will return to the study clinic at least 4 more times.... Read More
Gender:
All
Ages:
12 years and above
Locations: DM Clinical Research, Tomball, Texas +32 locations
Conditions: SARS-CoV-2 Infection, COVID-19
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A Study of mRNA-1283.222 Injection Compared With mRNA-1273.222 Injection in Participants ≥12 Years of Age to Prevent COVID-19
NCT05815498
Recruiting
The purpose of this study is to evaluate the safety, reactogenicity, and relative vaccine efficacy (rVE) of the mRNA-1283.222 vaccine as well as its immunogenicity in comparison to the mRNA-1273.222 vaccine.
Gender:
All
Ages:
12 years and above
Locations: DM Clinical Research, Tomball, Texas +215 locations
Conditions: COVID-19
Register for Updates