Systemic Lupus Erythematosus Clinical Trials

A listing of 48 Systemic Lupus Erythematosus clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 48 active clinical trials seeking participants for Systemic Lupus Erythematosus research studies. The states with the highest number of trials for Systemic Lupus Erythematosus participants are California, Florida, Texas and New York.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Trial

Chronic Cough Study

Recruiting

Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Allergic Asthma

Learn More

Featured Trial

Studying an Investigational Virus Vaccine

Recruiting

The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.

Conditions:

Healthy

Interested in vaccine studies

All Conditions

Preventative Trials

Learn More

Featured Trial

Type 2 Diabetes Clinical Trial

Recruiting

Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.

Conditions:

Type 2 Diabetes

Diabetes Mellitus Type 2 in Obese

Diabetes Type Two

Type 2 Diabetes Mellitus

Diabete Type 2

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CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy, in Patients With Refractory Systemic Lupus Erythematosus (GALLOP)

NCT06752876

Recruiting

This is a Phase 1 study to evaluate the safety and efficacy of a single infusion of CB-010 in patients with refractory Systemic Lupus Erythematosus (SLE) with cohorts for lupus nephritis (LN) and extrarenal lupus (ERL).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/14/2025

Locations: Oncology Hematology Care, Cincinnati, Ohio

Conditions: Systemic Lupus Erythematosus, Lupus, Lupus Erythematosus, Lupus Nephritis

Learn More ›

Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users

NCT06659029

Recruiting

PRIMULA Preg (Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users) is a prospective, observational cohort study designed to evaluate the association between anifrolumab exposure during pregnancy and subsequent adverse maternal, fetal, and infant outcomes. This study will fulfil an FDA post-marketing requirement.

Gender:

FEMALE

Ages:

All

Trial Updated:

04/17/2025

Locations: Research Site, Las Vegas, Nevada

Conditions: Systemic Lupus Erythematosus

Learn More ›

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

NCT05440422

Recruiting

Background: People with systemic lupus erythematosus (SLE) are at risk of developing complications in their blood vessels. This can increase the risk of heart attacks or stroke. No medications have been effective at reducing this risk in people with lupus. Objective: To test whether a drug (anifrolumab) can improve blood vessel function and reduce blood vessel inflammation in people with SLE. Eligibility: People aged 18 to 80 years with SLE. Design: Participants will undergo screening. Th... Read More

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

04/17/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Systemic Lupus Erythematosus, Cardiovascular Disease, Premature Atherosclerosis

Learn More ›

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

NCT06617325

Recruiting

The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinically relevant long term improvement of moderate to severe disease activity.

Gender:

ALL

Ages:

16 years and above

Trial Updated:

04/17/2025

Locations: Sl0044 50058, Avondale, Arizona +127 locations

Sl0044 50058, Avondale, Arizona

Sl0044 50550, Chandler, Arizona

Sl0044 50052, Phoenix, Arizona

Sl0044 50670, Searcy, Arkansas

Sl0044 50275, La Palma, California

Sl0044 50258, Los Angeles, California

Sl0044 50340, Orange, California

Sl0044 50316, San Leandro, California

Sl0044 50630, Clearwater, Florida

Sl0044 50681, Miami, Florida

Sl0044 50698, Tampa, Florida

Sl0044 50566, Gainesville, Georgia

Sl0044 50659, Marietta, Georgia

Sl0044 50699, Chicago, Illinois

Sl0044 50285, Lake Charles, Louisiana

Sl0044 50660, New Orleans, Louisiana

Sl0044 50219, Detroit, Michigan

Sl0044 50010, Brooklyn, New York

Sl0044 50264, Manhasset, New York

Sl0044 50077, New York, New York

Sl0044 50238, Charlotte, North Carolina

Sl0044 50001, Jackson, Tennessee

Sl0044 50693, Murfreesboro, Tennessee

Sl0044 50562, Allen, Texas

Sl0044 50688, Houston, Texas

Sl0044 50696, Houston, Texas

Sl0044 50036, Mesquite, Texas

Sl0044 50061, Spokane, Washington

Sl0044 60004, C.a.b.a, Not set

Sl0044 60002, Capital Federal, Not set

Sl0044 60029, Mendoza, Not set

Sl0044 60003, Quilmes, Not set

Sl0044 60011, San Juan, Not set

Sl0044 60014, Tucuman, Not set

Sl0044 40002, Leuven, Not set

Sl0044 20293, Baotou, Not set

Sl0044 20128, Beijing, Not set

Sl0044 20157, Beijing, Not set

Sl0044 20173, Beijing, Not set

Sl0044 20201, Bengbu, Not set

Sl0044 20186, Chang ZHOU, Not set

Sl0044 20291, Changchun, Not set

Sl0044 20295, Changsha, Not set

Sl0044 20019, Guangzhou, Not set

Sl0044 20290, Guilin, Not set

Sl0044 20271, Haikou, Not set

Sl0044 20296, Hangzhou, Not set

Sl0044 20185, Jinan, Not set

Sl0044 20192, Nanchang, Not set

Sl0044 20024, Nanjing, Not set

Sl0044 20272, Pingxiang, Not set

Sl0044 20020, Shanghai, Not set

Sl0044 20172, Shanghai, Not set

Sl0044 20204, Suzhou, Not set

Sl0044 20136, Tianjin, Not set

Sl0044 20275, Urumuqi, Not set

Sl0044 20025, Wenzhou, Not set

Sl0044 20180, Wuhan, Not set

Sl0044 20270, Wuhan, Not set

Sl0044 20274, Xi'an, Not set

Sl0044 20273, Yangzhou, Not set

Sl0044 20132, Zhengzhou, Not set

Sl0044 40513, Copenhagen, Not set

Sl0044 40386, Cologne, Not set

Sl0044 40322, DESSAU-ROßLAU, Not set

Sl0044 40356, Dresden, Not set

Sl0044 40072, Freiburg, Not set

Sl0044 40027, Herne, Not set

Sl0044 40139, Jena, Not set

Sl0044 40716, Köln, Not set

Sl0044 40078, Leipzig, Not set

Sl0044 40715, Vogelsang-gommern, Not set

Sl0044 40376, Athens, Not set

Sl0044 40501, Athens, Not set

Sl0044 40377, Heraklion, Not set

Sl0044 40507, Larissa, Not set

Sl0044 40514, Genova, Not set

Sl0044 40291, Milano, Not set

Sl0044 40471, Milano, Not set

Sl0044 40148, Roma, Not set

Sl0044 20035, Bunkyo-ku, Not set

Sl0044 20196, Bunkyo-ku, Not set

Sl0044 20279, Bunkyo-ku, Not set

Sl0044 20030, Chuo-ku, Not set

Sl0044 20281, Fukuoka, Not set

Sl0044 20282, Fukuoka, Not set

Sl0044 20039, Kawagoe, Not set

Sl0044 20045, Kita-gun, Not set

Sl0044 20065, Kitakyushu, Not set

Sl0044 20069, Meguro-ku, Not set

Sl0044 20071, Nagasaki, Not set

Sl0044 20287, Nagoya, Not set

Sl0044 20283, Sagamihara, Not set

Sl0044 20084, Saga, Not set

Sl0044 20031, Sapporo, Not set

Sl0044 20042, Sasebo, Not set

Sl0044 20171, Sendai-shi, Not set

Sl0044 20076, Shinjuku-ku, Not set

Sl0044 20285, Shinjuku-ku, Not set

Sl0044 20032, Suita, Not set

Sl0044 20277, Suita, Not set

Sl0044 20278, TSU, Not set

Sl0044 20276, Yoshida-gun, Not set

Sl0044 20141, Busan, Not set

Sl0044 20104, Seoul, Not set

Sl0044 20092, Suwon-si, Not set

Sl0044 40838, Amsterdam, Not set

Sl0044 40398, Katowice, Not set

Sl0044 40502, Krakow, Not set

Sl0044 40044, Poznan, Not set

Sl0044 40821, Poznan, Not set

Sl0044 40097, Warszawa, Not set

Sl0044 40098, Warszawa, Not set

Sl0044 40481, Wroclaw, Not set

Sl0044 50671, Caguas, Not set

Sl0044 50683, San Juan, Not set

Sl0044 40466, Kragujevac, Not set

Sl0044 40392, Novi Sad, Not set

Sl0044 40045, A Coruna, Not set

Sl0044 40826, Badajoz, Not set

Sl0044 40160, Barcelona, Not set

Sl0044 40341, Málaga, Not set

Sl0044 40101, Sabadell, Not set

Sl0044 40103, Sevilla, Not set

Sl0044 20142, Taichung City, Not set

Sl0044 20080, Taichung, Not set

Sl0044 20086, Taipei City, Not set

Sl0044 20099, Taipei City, Not set

Conditions: Systemic Lupus Erythematosus

Learn More ›

Efficacy and Safety of Frexalimab (SAR441344) in the Treatment of Systemic Lupus Erythematosus

NCT05039840

Recruiting

This is a multinational, randomized, placebo-controlled, parallel treatment, Phase 2, double-blind, 2 arm study evaluating the efficacy and safety of SAR441344 in comparison with placebo in the treatment of participants aged 18 to 70 years with active Systemic Lupus Erythematosus (SLE). Study details include: * Study duration: 36 weeks * Treatment duration: 24 weeks * Visit frequency: every 2 weeks

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

04/15/2025

Locations: Accel Research Sites Network - Birmingham- Site Number : 8400003, Birmingham, Alabama +70 locations

Accel Research Sites Network - Birmingham- Site Number : 8400003, Birmingham, Alabama

AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler- Site Number : 8400026, Chandler, Arizona

Arizona Arthritis & Rheumatology Associates - South Vineyard Avenue- Site Number : 8400022, Mesa, Arizona

Arizona Arthritis & Rheumatology Research - Sun City- Site Number : 8400027, Sun City, Arizona

AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast- Site Number : 8400023, Tucson, Arizona

Saint John's Physician Partners- Site Number : 8400015, Santa Monica, California

Millennium Clinical Trials - Simi Valley- Site Number : 8400004, Simi Valley, California

Omega Research Consultants - Debary - North Charles Richard Beall Boulevard- Site Number : 8400002, DeBary, Florida

Integral Rheumatology and Immunology Specialists- Site Number : 8400014, Plantation, Florida

Infigo Clinical Research- Site Number : 8400016, Sanford, Florida

Sahni Rheumatology & Therapy- Site Number : 8400021, West Long Branch, New Jersey

Inspire Santa Fe Medical Group- Site Number : 8400019, Santa Fe, New Mexico

Columbia University Medical Center - New York- Site Number : 8400009, New York, New York

RAO - Rheumatology Associates of Oklahoma- Site Number : 8400013, Oklahoma City, Oklahoma

Private Practice - Dr. Ramesh C. Gupta I- Site Number : 8400008, Memphis, Tennessee

Tekton Research - West Gate- Site Number : 8400001, Austin, Texas

Precision Comprehensive Clinical Research Solutions - Colleyville- Site Number : 8400017, Colleyville, Texas

Lone Start Arthritis & Rheumatology Associates- Site Number : 8400025, Fort Worth, Texas

Prolato Clinical Research Center- Site Number : 8400005, Houston, Texas

AARA Clinical Research - Lone Star Arthritis & Rheumatology Associates - Irving- Site Number : 8400024, Irving, Texas

West Texas Clinical Research- Site Number : 8400018, Lubbock, Texas

Investigational Site Number : 0320008, Berazategui, Buenos Aires

Investigational Site Number : 0320003, San Miguel de Tucumán, Tucumán

Investigational Site Number : 0320006, Buenos Aires, Not set

Investigational Site Number : 0320001, Buenos Aires, Not set

Investigational Site Number : 0320004, Buenos Aires, Not set

Investigational Site Number : 0320002, Buenos Aires, Not set

Centro de Estudos em Terapias Inovadoras- Site Number : 0760002, Curitiba, Paraná

LMK Servicos Medicos- Site Number : 0760001, Porto Alegre, Rio Grande Do Sul

Fundação Faculdade Regional de Medicina de São José do Rio Preto- Site Number : 0760006, São José Do Rio Preto, São Paulo

Núcleo de Pesquisa Clínica da Rede São Camilo- Site Number : 0760007, São Paulo, Not set

Centro Paulista de Investigaçăo Clínica - CEPIC- Site Number : 0760004, São Paulo, Not set

Investigational Site Number : 1520002, Osorno, Los Lagos

Investigational Site Number : 1520003, Talca, Maule

Investigational Site Number : 1520004, Santiago, Reg Metropolitana De Santiago

Investigational Site Number : 1520001, Santiago, Reg Metropolitana De Santiago

Investigational Site Number : 2680004, Tbilisi, Not set

Investigational Site Number : 2680001, Tbilisi, Not set

Investigational Site Number : 2680003, Tbilisi, Not set

Investigational Site Number : 2680002, Tbilisi, Not set

Investigational Site Number : 3000004, Athens, Not set

Investigational Site Number : 3000001, Athens, Not set

Investigational Site Number : 3000003, Heraklion, Not set

Investigational Site Number : 3000005, Larissa, Not set

Investigational Site Number : 3000002, Thessaloniki, Not set

Investigational Site Number : 3480002, Gyula, Not set

Investigational Site Number : 3480003, Székesfehérvár, Not set

IRCCS Ospedale San Raffaele-Site Number : 3800001, Milan, Milano

AOU Luigi Vanvitelli-Site Number : 3800004, Caserta, Not set

Fondazione Policlinico Universitario Agostino Gemelli-Site Number : 3800002, Roma, Not set

Investigational Site Number : 4800001, Vacoas-phoenix, Not set

Investigational Site Number : 4840009, Mexico City, Ciudad De Mexico

Investigational Site Number : 4840004, Mexico City, Ciudad De Mexico

Investigational Site Number : 4840001, Monterrey, Nuevo León

Investigational Site Number : 4840005, Mérida, Yucatán

Investigational Site Number : 4840006, Chihuahua, Not set

Investigational Site Number : 4840011, Chihuahua, Not set

Investigational Site Number : 4840007, Mexico City, Not set

Investigational Site Number : 4840008, Veracruz, Not set

GCM Medical Group - San Juan - Calle Jose Marti- Site Number : 8400011, San Juan, Not set

Investigational Site Number : 6430002, Moscow, Not set

Investigational Site Number : 7240002, Sabadell, Castilla Y León

Investigational Site Number : 7240001, Madrid, Not set

Investigational Site Number : 7240005, Valencia, Not set

Investigational Site Number : 7240004, Valladolid, Not set

Investigational Site Number : 7560001, St. Gallen, Not set

Investigational Site Number : 7920003, Ankara, Not set

Investigational Site Number : 7920002, Denizli, Not set

Investigational Site Number : 8040006, Kyiv, Not set

Investigational Site Number : 8040001, Kyiv, Not set

Investigational Site Number : 8040005, Poltava, Not set

Conditions: Systemic Lupus Erythematosus

Learn More ›

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

NCT05843643

Recruiting

Systemic Lupus Erythematosus (SLE) is an immune-mediated disease associated with inflammation of multiple organ systems. This study will assess how safe and effective upadacitinib is in treating adult participants with moderately to severely active SLE. Adverse events and change in the disease activity will be assessed. Upadacitinib is an approved drug for rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of SLE. This study is "double... Read More

Gender:

ALL

Ages:

Between 18 years and 63 years

Trial Updated:

04/15/2025

Locations: AZ Arthritis and Rheumatology /ID# 261848, Chandler, Arizona +324 locations

AZ Arthritis and Rheumatology /ID# 261848, Chandler, Arizona

AZ Arthritis and Rheumotology Research, PLLC - Flagstaff /ID# 254767, Flagstaff, Arizona

Arizona Arthritis & Rheumatology Research, PLLC /ID# 252820, Gilbert, Arizona

Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 252824, Glendale, Arizona

Arizona Arthritis & Rheumatology Research, PLLC /ID# 261845, Mesa, Arizona

Arizona Arthritis & Rheumatology Research /ID# 273555, Peoria, Arizona

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 252831, Phoenix, Arizona

Arizona Arthritis & Rheumatology Research, PLLC /ID# 252825, Phoenix, Arizona

HonorHealth Rheumatology /ID# 261953, Scottsdale, Arizona

Arizona Arthritis & Rheumatology Associates - Tucson /ID# 252828, Tucson, Arizona

Arthritis and Rheumatism Associates /ID# 253033, Jonesboro, Arkansas

Kaiser Permanente Lakeview Medical Offices /ID# 253906, Anaheim, California

David S. Hallegua MD, A Professional Corporation /ID# 253902, Beverly Hills, California

Wallace Rheumatic Studies Center, LLC /ID# 252806, Beverly Hills, California

Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 272870, Chula Vista, California

Providence - St. Jude Medical Center /ID# 252822, Fullerton, California

Private Practice - Dr. Chandrakant V. Mehta /ID# 275100, Hemet, California

Newport Huntington Medical Group /ID# 252827, Huntington Beach, California

Moores Cancer Center at UC San Diego /ID# 253903, La Jolla, California

Arthritis & Osteo Medical Ctr /ID# 252812, La Palma, California

Providence St. John's Health Center /ID# 253905, Santa Monica, California

Millennium Clinical Trials /ID# 252817, Thousand Oaks, California

Cohen Medical Centers /ID# 268524, Thousand Oaks, California

Upland Rheumatology Center /ID# 268623, Upland, California

University of Colorado Hospital /ID# 253184, Aurora, Colorado

Denver Arthritis Clinic /ID# 253189, Denver, Colorado

Yale University School of Medicine /ID# 254567, New Haven, Connecticut

Arthritis and Rheumatic Disease Specialties /ID# 253624, Aventura, Florida

HARAC Research Corp. /ID# 254922, Avon Park, Florida

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253623, Boca Raton, Florida

Bay Area Arthritis and Osteo /ID# 253597, Brandon, Florida

Believe Clinical Trials /ID# 255427, Coral Springs, Florida

International Medical Research /ID# 253617, Daytona Beach, Florida

Omega Research Debary, LLC /ID# 254939, DeBary, Florida

University of Florida /ID# 261984, Gainesville, Florida

Finlay Medical Research - Greenacres /ID# 274902, Greenacres City, Florida

Evolution Research Center /ID# 272991, Hialeah, Florida

Neoclinical Research /ID# 253614, Hialeah, Florida

South Florida Rheumatology /ID# 268525, Hollywood, Florida

Encore Research Group-Jacksonville Center for Clinical Research /ID# 257272, Jacksonville, Florida

UF Health Rheumatology /ID# 255351, Jacksonville, Florida

Life Clinical Trials /ID# 253615, Margate, Florida

Lakes Research, LLC /ID# 253621, Miami, Florida

University of Miami, Division of Rheumatology /ID# 261594, Miami, Florida

HMD Research LLC /ID# 253595, Orlando, Florida

University of Central Florida /ID# 261112, Orlando, Florida

Millennium Research /ID# 253600, Ormond Beach, Florida

Vitalia Research /ID# 272642, Palm Beach Gardens, Florida

IRIS Research and Development, LLC /ID# 253618, Plantation, Florida

BayCare Medical Group /ID# 253593, Saint Petersburg, Florida

Clinical Research of West Florida - Tampa /ID# 253602, Tampa, Florida

Clinical Research of West Florida, Inc /ID# 253899, Tampa, Florida

BayCare Medical Group, Inc. /ID# 255135, Tampa, Florida

Winship Cancer Institute of Emory University /ID# 261529, Atlanta, Georgia

Trinity Research Centers /ID# 262039, Kennesaw, Georgia

Atlanta Research Center for Rheumatology /ID# 253610, Marietta, Georgia

University of Illinois at Chicago /ID# 263014, Chicago, Illinois

Next Innovative Clinical Research - Chicago /ID# 268739, Chicago, Illinois

Deerbrook Medical Associates /ID# 253029, Libertyville, Illinois

Advanced Quality Medical Research /ID# 254983, Orland Park, Illinois

OrthoIllinois /ID# 253188, Rockford, Illinois

Greater Chicago Specialty Physicians /ID# 253021, Schaumburg, Illinois

Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 253020, Skokie, Illinois

NorthShore University HealthSystem - Skokie /ID# 254568, Skokie, Illinois

Willow Rheumatology and Wellness, PLLC /ID# 253018, Willowbrook, Illinois

Western KY Rheumatology /ID# 254937, Hopkinsville, Kentucky

Accurate Clinical Research /ID# 272647, Lake Charles, Louisiana

Willis Knighton /ID# 256343, Shreveport, Louisiana

University of Maryland, Baltimore /ID# 262556, Baltimore, Maryland

UMass Memorial Medical Center /ID# 262742, Worcester, Massachusetts

AA Medical Research Center - Grand Blanc /ID# 253028, Grand Blanc, Michigan

June DO, PC /ID# 253030, Lansing, Michigan

Kansas City Physician Partners /ID# 254786, Kansas City, Missouri

Logan Health Research /ID# 252808, Kalispell, Montana

Dartmouth-Hitchcock Medical Center - 1 Medical Center Drive /ID# 254923, Lebanon, New Hampshire

Arthritis and Osteoporosis Associates of New Mexico /ID# 252818, Las Cruces, New Mexico

Joseph S. and Diane H. Steinberg Ambulatory Care Center /ID# 253592, Brooklyn, New York

NYU Langone Orthopedic Center /ID# 253613, New York, New York

St. Lawrence Health System /ID# 253598, Potsdam, New York

Joint And Muscle Research Institute /ID# 272845, Charlotte, North Carolina

DJL Clinical Research, PLLC /ID# 253620, Charlotte, North Carolina

Raleigh Medical Group /ID# 256328, Raleigh, North Carolina

Accellacare - Salisbury /ID# 253608, Salisbury, North Carolina

Atrium Health Wake Forest Baptist Medical Center /ID# 254125, Winston-Salem, North Carolina

University of Cincinnati Medical Center /ID# 259174, Cincinnati, Ohio

Paramount Medical Research and Consulting /ID# 253016, Middleburg Heights, Ohio

Clinical Research Source, Inc. /ID# 253027, Perrysburg, Ohio

Oklahoma Medical Research Foundation /ID# 263509, Oklahoma City, Oklahoma

Clinical Research of Philadelphia, LLC /ID# 254156, Philadelphia, Pennsylvania

Albert Einstein Medical Center /ID# 256661, Philadelphia, Pennsylvania

West Tennessee Research Institute /ID# 252807, Jackson, Tennessee

Shelby Research /ID# 256937, Memphis, Tennessee

Arthritis and Rheumatology Research Institute, PLLC /ID# 253014, Allen, Texas

Arthritis Care of Texas /ID# 261719, Corpus Christi, Texas

JPS Rheumatology Clinic /ID# 253185, Fort Worth, Texas

Arthiritis and Rheumatology Specialists PA /ID# 255950, Fort Worth, Texas

Integrative Rheumatology of South Texas /ID# 261977, Harlingen, Texas

R & H Clinical Research - 777 Katy /ID# 254126, Katy, Texas

Biopharma Informatic /ID# 273651, Katy, Texas

Valley Arthritis Center /ID# 253022, McAllen, Texas

Trinity Universal Research Associates, Inc /ID# 253013, Plano, Texas

Sun Research Institute /ID# 255832, San Antonio, Texas

Clinical Trials of Texas, Inc /ID# 254949, San Antonio, Texas

DM Clinical Research - Tomball /ID# 255134, Tomball, Texas

Carilion Clinic /ID# 253374, Roanoke, Virginia

Wisconsin Medical Center /ID# 256660, Milwaukee, Wisconsin

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 254278, Ciudad Autonoma Buenos Aires, Buenos Aires

Organizacion Medica de Investigacion (OMI) /ID# 254281, Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires

Fundacion CIDEA /ID# 254279, Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires

Instituto Medico Especializado /ID# 255281, Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires

Aprillus Asistencia e Investigacion /ID# 254276, Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires

Instituto CAICI S.R.L /ID# 254280, Rosario, Santa Fe

Centro de Investigaciones Medicas Tucuman /ID# 254274, San Miguel de Tucuman, Tucuman

Emeritus Research Sydney /ID# 256249, Botany, New South Wales

Concord Repatriation General Hospital /ID# 257945, Concord, New South Wales

Momentum Clinical Research /ID# 253542, Darlinghurst, New South Wales

Royal Darwin Hospital /ID# 263160, Tiwi, Northern Territory

The Queen Elizabeth Hospital /ID# 253826, Woodville, South Australia

Emeritus Research /ID# 256800, Camberwell, Victoria

Monash Health - Monash Medical Centre /ID# 255678, Clayton, Victoria

Colin Bayliss Research and Teaching Unit /ID# 261077, Victoria Park, Western Australia

ZAS Palfijn /ID# 252802, Merksem, Antwerpen

Universite Libre de Bruxelles - Hopital Erasme /ID# 261997, Anderlecht, Bruxelles-Capitale

Universitair Ziekenhuis Brussel /ID# 269065, Jette, Bruxelles-Capitale

Institute of Physical Medicine,Rehab. and Orthopedic Surgery Dr.Miroslav Zotovic /ID# 262588, Banja Luka, Republika Srpska

Klinicki centar Banja Luka /ID# 253581, Banja Luka, Republika Srpska

Klinicki centar Banja Luka /ID# 253582, Banja Luka, Republika Srpska

Clinical Center University of Sarajevo /ID# 253583, Sarajevo, Not set

Polyclinic Srce Sarajeva /ID# 255475, Sarajevo, Not set

SER - Servicos Especializados em Reumatologia da Bahia /ID# 253354, Salvador, Bahia

CEDOES - Centro de Diagnóstico e Pesquisa da Osteoporose do Espírito Santo /ID# 254588, Vitoria, Espirito Santo

CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 253346, Juiz de Fora, Minas Gerais

EDUMED Educacao em Saude S/S LTDA /ID# 253274, Curitiba, Parana

Hospital de Clinicas de Porto Alegre /ID# 253357, Porto Alegre, Rio Grande Do Sul

LMK Sevicos Medicos S/S /ID# 253353, Porto Alegre, Rio Grande Do Sul

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 261024, Sao Jose Do Rio Preto, Sao Paulo

Hospital do Rim /ID# 253983, Sao Paulo, Not set

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 254316, Sao Paulo, Not set

Mc Excelsior /ID# 272499, Sofiya, Sofia

Medical Center Academy /ID# 253322, Sofiya, Sofia

Umbal Kaspela /ID# 252645, Plovdiv, Not set

Medical Center Artmed Ltd /Id# 254572, Plovdiv, Not set

Medical center Unimed /ID# 253324, Plovdiv, Not set

Medical center Teodora /ID# 252646, Ruse, Not set

Military Medical Academy Multiprofile Hospital /ID# 252644, Sofia, Not set

Diagnostic consultative center Focus-5 /ID# 252642, Sofiya, Not set

Diagnostic consultative center Focus-5 /ID# 252643, Sofiya, Not set

University of Calgary /ID# 259515, Calgary, Alberta

University of Manitoba /ID# 259517, Winnipeg, Manitoba

CIUSSS de l'Estrie - CHUS /ID# 254716, Sherbrooke, Quebec

Servicio de Salud Araucanía Norte Hospital Victoria /ID# 255179, Victoria, Araucania

Hospital Guillermo Grant Benavente de Concepción /ID# 254841, Concepción, Bio-Bio

Inmunocel /Id# 256390, Las Condes, Region Metropolitana De Santiago

Centro Internacional de Estudios Clinicos - CIEC /ID# 254838, Santiago, Region Metropolitana Santiago

Investigaciones Medicas Limitada /Id# 254842, Providencia, Not set

The first affiliated hospital of bengbu medical college /ID# 252853, Bengbu, Anhui

China-Japan Friendship Hospital /ID# 253048, Beijing, Beijing

Peking University Third Hospital /ID# 253138, Beijing, Beijing

Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 253045, Beijing, Beijing

The First Affiliated Hospital of Xiamen University /ID# 252630, Xiamen, Fujian

Guangdong Provincial People's Hospital /ID# 252920, Guangzhou, Guangdong

The First Affiliated Hospital, Sun Yat-sen University /ID# 252921, Guangzhou, Guangdong

Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 253137, Guangzhou, Guangdong

The First Affiliated Hospital of Guangzhou Medical University /ID# 252927, Guangzhou, Guangdong

The Third Affiliated Hospital, Sun Yat-Sen University /ID# 252923, Guangzhou, Guangdong

The First Affiliated Hospital of Shantou University Medical College /ID# 253426, Shantou, Guangdong

Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 252963, Wuhan, Hubei

Tongji Hospital Tongji Medical College of HUST /ID# 252632, Wuhan, Hubei

Zhuzhou Central Hospital /ID# 252962, Zhuzhou, Hunan

The Affiliated Hospital of Inner Mongolia Medical University /ID# 252629, Huhehaote, Inner Mongolia

The First People's Hospital of Changzhou /ID# 252992, Changzhou, Jiangsu

Nanjing Drum Tower Hospital /ID# 253042, Nanjing, Jiangsu

Affiliated hospital of nantong university /ID# 252991, Nantong, Jiangsu

Wuxi People's Hospital /ID# 253858, Wuxi, Jiangsu

Xuzhou Central Hospital /ID# 252922, Xuzhou, Jiangsu

Yancheng First People's Hospital /ID# 254599, Yancheng, Jiangsu

Northern Jiangsu People's Hospital /ID# 252945, Yangzhou, Jiangsu

The First People's Hospital of Jiujiang /ID# 252989, Jiujiang, Jiangxi

Jiangxi Provincial People's Hospital /ID# 252940, Nanchang, Jiangxi

Jiangxi Pingxiang People's Hospital /ID# 252919, Pingxiang, Jiangxi

The First Hospital of Jilin University /ID# 252771, Changchun, Jilin

Second Affiliated Hospital of Xian Jiaotong University /ID# 252861, Xi'an, Shaanxi

Jining No.1 People's Hospital /ID# 252897, Jining, Shandong

Linyi People's Hospital /ID# 252898, Linyi, Shandong

Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 263435, Shanghai, Shanghai

West China Hospital, Sichuan University /ID# 252854, Chengdu, Sichuan

Tianjin Medical University General Hospital /ID# 252868, Tianjin, Tianjin

People's Hospital of Xinjiang Uygur Autonomous Region /ID# 266897, Urumqi, Xinjiang

First Affiliated Hospital of Kunming Medical University /ID# 252925, Kunming, Yunnan

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 252633, Hangzhou, Zhejiang

Zhejiang Provincial People's Hospital /ID# 253860, Hangzhou, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University /ID# 253649, Wenzhou, Zhejiang

IPS Suramericana SAS - IPS Sura San Diego /ID# 261536, Medellín, Antioquia

Hospital Pablo Tobón Uribe /ID# 254101, Medellín, Antioquia

Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 254097, Bogotá, Cundinamarca

Healthy Medical Center S.A.S /ID# 254098, Zipaquirá, Cundinamarca

Fundacion Oftalmologica de Santander - FOSCAL /ID# 254100, Bucaramanga, Santander

Clinica de la Costa S.A.S /ID# 260727, Barranquilla, Not set

Poliklinika Bonifarm /ID# 252846, Zagreb, Grad Zagreb

Poliklinika Solmed /ID# 252965, Zagreb, Grad Zagreb

Klinicki bolnicki centar Osijek /ID# 252847, Osijek, Osjecko-baranjska Zupanija

Klinicki bolnicki centar Rijeka /ID# 252848, Rijeka, Primorsko-goranska Zupanija

Klinicki Bolnicki Centar (KBC) Split /ID# 252849, Split, Splitsko-dalmatinska Zupanija

Opća Bolnica Zadar /ID# 272415, Zadar, Not set

Innomedica /ID# 253722, Tallinn, Harjumaa

East Tallinn Central Hospital - Magdaleena Unit /ID# 253721, Tallinn, Harjumaa

North Estonia Medical Centre Foundation /ID# 253723, Tallinn, Harjumaa

MediTrials /ID# 253720, Tartu, Tartumaa

CHU Toulouse - Hopital Rangueil /ID# 254148, Toulouse, Haute-Garonne

Hopital Pitie Salpetriere /ID# 253009, Paris Cedex 13, Ile-de-France

HCL - Hopital de la Croix-Rousse /ID# 254147, Lyon, Rhone

Krankenhaus Porz am Rhein /ID# 254373, Cologne, Nordrhein-Westfalen

Universitaetsmedizin Mainz /ID# 260735, Mainz, Rheinland-Pfalz

Universitaetsklinikum Carl Gustav Carus Dresden /ID# 270832, Dresden, Sachsen

Immanuel Krankenhaus Berlin /ID# 253389, Berlin-buch, Not set

Fraunhofer Institute for Translational Medicine & Pharmacology ITMP /ID# 253734, Frankfurt am Main, Not set

General Hospital of Athens Laiko /ID# 252952, Athens, Attiki

University General Hospital Attikon /ID# 253209, Athens, Attiki

University General Hospital of Heraklion PA.G.N.I /ID# 252951, Heraklion, Kriti

Clinica Medica Especializada en Medicina Interna y Reumatologia /ID# 261156, Guatemala, Not set

Clinica Medica Reumatologica /ID# 255009, Guatemala, Not set

Clinica Especializada en Medicina Interna /ID# 255006, Guatemala, Not set

Clínica Médica Especializada en Medicina Interna y Reumatologia /ID# 257248, Guatemala, Not set

Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 254552, Pecs, Baranya

Debreceni Egyetem-Klinikai Kozpont /ID# 252877, Debrecen, Hajdu-Bihar

Vita Verum Medical Bt. /ID# 273579, Székesfehérvár, Szekesfehervar

Vital Medicina Kft /ID# 252876, Veszprém, Veszprem

Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz /ID# 252886, Gyula, Not set

The Lady Davis Carmel Medical Center /ID# 253303, Haifa, H_efa

Meir Medical Center /ID# 254187, Kfar Saba, HaMerkaz

Galilee Medical Center /ID# 252859, Nahariya, HaTsafon

The Chaim Sheba Medical Center /ID# 252857, Ramat Gan, Tel-Aviv

Tel Aviv Sourasky Medical Center /ID# 252858, Tel Aviv, Tel-Aviv

Hadassah Medical Center-Hebrew University /ID# 252654, Jerusalem, Yerushalayim

Azienda Ospedaliera San Camillo Forlanini /ID# 253680, Rome, Roma

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 254288, Rome, Roma

Azienda Ospedaliero Universitaria delle Marche /ID# 254138, Ancona, Not set

Azienda Ospedale-Universita Padova /ID# 253704, Padova, Not set

Azienda Ospedaliero Universitaria Pisana /ID# 254289, Pisa, Not set

Hospital of the University of Occupational and Environmental Health, Japan /ID# 253269, Kitakyushu-shi, Fukuoka

Hokkaido University Hospital /ID# 253306, Sapporo-shi, Hokkaido

Tohoku University Hospital /ID# 253267, Sendai-shi, Miyagi

University of Miyazaki Hospital /ID# 253416, Miyazaki-shi, Miyazaki

Okayama University Hospital /ID# 253821, Okayama-shi, Okayama

Shinkenko Clinic /ID# 253271, Naha-shi, Okinawa

Saitama Medical Center /ID# 253263, Kawagoe-shi, Saitama

Institute of Science Tokyo Hospital /ID# 254430, Bunkyo-ku, Tokyo

University of Yamanashi Hospital /ID# 253264, Chuo-shi, Yamanashi

National Hospital Organization Chibahigashibyoin /ID# 253268, Chiba, Not set

SoonChunHyang University Hospital Cheonan /ID# 254777, Cheonan-si, Chungcheongnamdo

Chonnam National University Bitgoeul Hospital /ID# 254675, Gwangju, Gwangju Gwang Yeogsi

Hanyang University Seoul Hospital /ID# 252955, Seoul, Seoul Teugbyeolsi

Asan Medical Center /ID# 254022, Seoul, Seoul Teugbyeolsi

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 252958, Seoul, Seoul Teugbyeolsi

Riga East Clinical University Hospital /ID# 253751, Rīga, Riga

M & M Centrs LTD /ID# 253752, Adazi, Not set

Daugavpils Regional Hospital /ID# 253754, Daugavpils, Not set

Dr. Saulites-Kandevicas PP in Cardiology and Rheumatology /ID# 273246, Liepaja, Not set

Pauls Stradins Clinical University Hospital /ID# 253750, Riga, Not set

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 253755, Kaunas, Not set

Republic Klaipeda Hospital /ID# 253759, Klaipeda, Not set

Klaipeda University Hospital, Klaipeda Hospital /ID# 253757, Klaipeda, Not set

Inlita - Santara KTC /ID# 253758, Vilnius, Not set

Vilnius University Hospital Santaros Klinikos /ID# 253756, Vilnius, Not set

Aotearoa Clinical Trials /ID# 253555, Papatoetoe, Auckland

North Shore Hospital /ID# 253554, Takapuna, Auckland

MICS Centrum Medyczne Bydgoszcz /ID# 253281, Bydgoszcz, Kujawsko-pomorskie

Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 253233, Bydgoszcz, Kujawsko-pomorskie

MICS Centrum Medyczne Warszawa /ID# 253273, Warsaw, Mazowieckie

ETYKA-Osrodek Badan Klinicznych /ID# 252967, Olsztyn, Warminsko-mazurskie

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 252964, Poznan, Wielkopolskie

Centro Hospitalar do Tamega e Sousa - Hospital Padre Americo /ID# 252911, Guilhufe, Porto

Hospital Garcia de Orta /ID# 252903, Almada, Setubal

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 252902, Ponte de Lima, Viana Do Castelo

Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 252899, Porto, Not set

Clinical Research Investigator Group, LLC /ID# 259170, Bayamon, Not set

Clinical Research Puerto Rico /ID# 256352, San Juan, Not set

GCM Medical Group PSC /ID# 253039, San Juan, Not set

Caribbean Medical Research Center /ID# 254882, San Juan, Not set

Mindful Medical Research /ID# 253040, San Juan, Not set

Spitalul Clinic Judetean de Urgenta Cluj -Napoca /ID# 252904, Cluj-Napoca, Cluj

Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 253207, Brasov, Not set

Spitalul Clinic Sf. Maria /ID# 252905, Bucuresti, Not set

Institute for Rheumatology /ID# 253172, Belgrade, Beograd

Institute for Rheumatology /ID# 253173, Belgrade, Beograd

Institute for Rheumatology /ID# 253174, Belgrade, Beograd

Institute for Rheumatology /ID# 253175, Belgrade, Beograd

Military Medical Academy /ID# 264235, Belgrade, Beograd

Clin Hosp Ctr Bezanijska Kosa /ID# 253179, Belgrade, Beograd

General Hospital Djordje Joanovic /ID# 253177, Zrenjanin, Vojvodina

University Clinical Center Vojvodina /ID# 253176, Novi Sad, Not set

ARTROMAC n.o. /ID# 253056, Kosice, Kosicky Kraj

Narodny Ustav Reumatickych Chorob Piestany /ID# 273341, Piešťany, Trnavsky Kraj

MEDMAN s.r.o. /ID# 252950, Martin, Zilinsky Kraj

ZAZABIE s. r .o. /ID# 255793, Košice II, Not set

Thermium s.r.o. /ID# 260839, Piestany, Not set

Wits Clinical Research /ID# 252931, Johannesburg, Gauteng

University of Pretoria /ID# 252932, Pretoria, Gauteng

Dr Elsa van Duuren /ID# 254218, Pretoria, Gauteng

Dr Asokan Naidoo /ID# 253351, Umhlanga, Kwazulu-Natal

Winelands Medical Research - Somerset West /ID# 254614, Cape Town, Western Cape

Arthritis Clinical Research Trials /ID# 253349, Cape Town, Western Cape

Winelands Medical Research Centre /ID# 252934, Stellenbosch, Western Cape

Complejo Hospitalario Universitario A Coruña /ID# 253123, A Coruña, A Coruna

Hospital Meixoeiro (CHUVI) /ID# 253124, Vigo, Pontevedra

Hospital Universitario Virgen de Valme /ID# 253121, Sevilla, Not set

Universitätsspital Basel /ID# 252907, Basel Town, Basel-Stadt

Kantonsspital St. Gallen /ID# 252906, St. Gallen, Sankt Gallen

Inselspital, Universitaetsspital Bern /ID# 252909, Bern, Not set

National Taiwan University Hospital /ID# 252937, Taipei City, Taipei

Chang Gung Mem Hosp Keelung /ID# 253636, Keelung, Not set

China Medical University Hospital /ID# 252936, Taichung, Not set

Hacettepe Universitesi Tip Fak /ID# 253266, Sihhiye, Ankara

Gazi Universitesi Tip Fakultes /ID# 252843, Yenimahalle, Ankara

Sanko Universitesi Hastanesi /ID# 252841, Şehitkamil, Gaziantep

Akdeniz Universitesi Tip Fakul /ID# 252839, Antalya, Not set

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 252844, Istanbul, Not set

Necmettin Erbakan Universitesi /ID# 252837, Meram Konya, Not set

Karadeniz Technical University Farabi Hospital /ID# 252845, Trabzon, Not set

North West Anglia NHS Foundation Trust /ID# 254590, Bretton, Cambridgeshire

University Hospital Southampton NHS Foundation Trust /ID# 252982, Southampton, Hampshire

Northampton General Hospital NHS Trust /ID# 254813, Northampton, Northamptonshire

Western Health and Social Care Trust /ID# 254592, Londonderry, Northern Ireland

Luton and Dunstable Hospital NHS Foundation Trust /ID# 255323, Luton, Not set

Portsmouth Hospitals University NHS Trust /ID# 252986, Portsmouth, Not set

Conditions: Systemic Lupus Erythematosus

Learn More ›

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

NCT05869955

Recruiting

The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory autoimmune diseases (Breakfree-1).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/15/2025

Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado +53 locations

University of Colorado Anschutz Medical Campus, Aurora, Colorado

Colorado Blood Cancer Institute, Denver, Colorado

Local Institution - 0048, New Haven, Connecticut

Mayo Clinic in Florida, Jacksonville, Florida

University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida

Local Institution - 0053, Chicago, Illinois

Local Institution - 0030, Baltimore, Maryland

Local Institution - 0038, Boston, Massachusetts

Local Institution - 0046, Boston, Massachusetts

University of Massachusetts Chan Medical School, Worcester, Massachusetts

University of Michigan, Ann Arbor, Michigan

Local Institution - 0037, Detroit, Michigan

Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota

Washington University School of Medicine, Saint Louis, Missouri

University Of Nebraska Medical Center, Omaha, Nebraska

Atlantic Health System Overlook Medical Center, Summit, New Jersey

NYU Langone Health, New York, New York

Local Institution - 0054, New York, New York

Icahn School of Medicine at Mount Sinai, New York, New York

Columbia University Irving Medical Center, New York, New York

Local Institution - 0055, New York, New York

The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Cleveland Clinic, Cleveland, Ohio

Local Institution - 0027, Columbus, Ohio

UT Southwestern Medical Center, Dallas, Texas

The University of Texas Health Science Center at Houston, Houston, Texas

University of Texas MD Anderson Cancer Center, Houston, Texas

Swedish Medical Center, Seattle, Washington

Local Institution - 0057, Seattle, Washington

Fred Hutchinson Cancer Center, Seattle, Washington

UZ Leuven, Leuven, Vlaams-Brabant

Local Institution - 0043, Strasbourg, Alsace

CHU Bordeaux Haut-Leveque, Pessac, Aquitaine

CHU Montpellier Lapeyronie Hospital, Montpellier, Hérault

Hopital Claude Huriez - CHU de Lille, Lille, Not set

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Not set

Hôpital Saint-Louis, Paris, Not set

Local Institution - 0052, Paris, Not set

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes, Not set

Universitaetsklinikum Wuerzburg, Wuerzburg, Bayern

Universitaetsklinikum Koeln, Köln, Nordrhein-Westfalen

Local Institution - 0045, Magdeburg, Sachsen-Anhalt

Universitätsklinikum Leipzig, Leipzig, Sachsen

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin, Not set

Universitaetsklinikum Duesseldorf, Düsseldorf, Not set

Universitaetsklinikum Erlangen, Erlangen, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Lazio

Humanitas, Rozzano, Milano

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria

Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña]

Hospital Universitario Reina Sofia, Cordoba, Not set

H.R.U Málaga - Hospital General, Málaga, Not set

Conditions: Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis

Learn More ›

Efficacy And Safety Of MK-6194 In Adult Participants With Systemic Lupus Erythematosus (MK-6194-006)

NCT06161116

Recruiting

The purpose of this study is to evaluate the efficacy and safety of MK-6194 in adult participants with Systemic Lupus Erythematosus. The primary hypothesis is that at least 1 of the MK-6194 arms is superior to placebo in the primary endpoint of percentage of participants with systemic lupus erythematosus responder index (SRI-4) response at Week 28.

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

04/15/2025

Locations: Medvin Clinical Research - Metyas ( Site 0128), Covina, California +118 locations

Medvin Clinical Research - Metyas ( Site 0128), Covina, California

Arthritis & Osteoporosis Medical Center - La Palma ( Site 0108), La Palma, California

Medvin Clinical Research - Tujunga ( Site 0127), Tujunga, California

Denver Arthritis Clinic ( Site 0102), Denver, Colorado

Clinical Research of West Florida, Inc. (Clearwater) ( Site 0111), Clearwater, Florida

IRIS Research and Development, LLC-Research ( Site 0117), Plantation, Florida

Clinical Research of West Florida, Inc ( Site 0124), Tampa, Florida

Accurate Clinical Research, Inc ( Site 0135), Lake Charles, Louisiana

AA Medical Research Center ( Site 0136), Grand Blanc, Michigan

Javara - Tryon Medical Partners ( Site 0121), Charlotte, North Carolina

DJL Clinical Research, PLLC ( Site 0103), Charlotte, North Carolina

University of Oklahoma Health Science Center ( Site 0130), Oklahoma City, Oklahoma

Shelby Research, LLC ( Site 0142), Memphis, Tennessee

Accurate Clinical Management, LLC. ( Site 0134), Baytown, Texas

Epic Medical Research ( Site 0113), DeSoto, Texas

Accurate Clinical Research, Inc. ( Site 0133), Houston, Texas

SouthWest Rheumatology Research, LLC ( Site 0115), Mesquite, Texas

Centro de Investigaciones Médicas Mar del Plata ( Site 0210), Mar del Plata, Buenos Aires

Sanatorio Parque ( Site 0205), Rosario, Santa Fe

Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0206), Santa Fe., Santa Fe

Centro de Investigaciones Médicas Tucuman ( Site 0203), SAN M. DE Tucuman, Tucuman

Instituto de Reumatología ( Site 0201), Mendoza, Not set

Núcleo de Pesquisa Clínica do Rio Grande do Sul ( Site 0309), Porto Alegre, Rio Grande Do Sul

LMK Serviços Médicos S/S-Reumacenter ( Site 0303), Porto Alegre, Rio Grande Do Sul

Centro Multidisciplinar de Estudos Clinicos ( Site 0302), Sao Bernardo do Campo, Sao Paulo

Hospital de Base de São José do Rio Preto-CIP - Centro Integrado de Pesquisas ( Site 0311), São José do Rio Preto, Sao Paulo

Diex Recherche Sherbrooke ( Site 0003), Sherbrooke, Quebec

James Lind Centro de Investigacion del Cancer ( Site 0407), Temuco, Araucania

IC La Serena Research ( Site 0414), La Serena., Coquimbo

Centro Internacional de Estudios Clinicos (CIEC) ( Site 0410), Santiago., Region M. De Santiago

Complejo Asistencial Dr. Sotero del Rio ( Site 0402), Santiago, Region M. De Santiago

CECIM ( Site 0405), Santiago, Region M. De Santiago

The First Afflilated Hospital of Bengbu Medical College-Urology Surgery ( Site 2019), Bengbu, Anhui

Anhui Provincial Hospital ( Site 2043), Hefei, Anhui

Beijing Peking Union Medical College Hospital-Department of Rheumatology and Immunology ( Site 2001), Beijing, Beijing

Gansu Provincial Hospital ( Site 2065), Lanzhou, Gansu

Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 2036), Guangzhou, Guangdong

Southern Medical University Nanfang Hospital ( Site 2037), Guangzhou, Guangdong

The Affiliated Hospital of Guizhou Medical University ( Site 2051), Guiyang, Guizhou

The Second Afilliated Hospital of Hebei Medical University-Immunology And Rheumatology ( Site 2064), Shijiazhuang, Hebei

The First Affiliated Hospital of Henan University of Science &Technology ( Site 2041), Luoyang, Henan

Tongji Hospital Tongji Medical,Science & Technology ( Site 2042), Wuhan, Hubei

The First Affiliated Hospital of Nanhua University ( Site 2061), Hengyang, Hunan

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Te, Baotou, Inner Mongolia

Affiliated Hospital of Nantong University ( Site 2027), Nantong, Jiangsu

Pingxiang People's Hospital ( Site 2005), Pingxiang, Jiangxi

Jilin Province People's Hospital ( Site 2033), Chang chun, Jilin

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 2056), Xi'an, Shaanxi

Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 2053), Shanghai, Shanghai

Shanxi Bethune Hospital ( Site 2029), Taiyuan, Shanxi

The First Affiliated Hospital Of Chengdu Medical College ( Site 2052), Chengdu, Sichuan

Tianjin Medical University General Hospital-Rheumatism and Immunology ( Site 2011), Tianjin, Tianjin

Salud SURA Industriales ( Site 0508), Medellín, Antioquia

Centro Integral de Reumatología del Caribe ( Site 0501), Barranquilla, Atlantico

Clinica de la Costa S.A.S. ( Site 0502), Barranquilla, Atlantico

Preventive Care ( Site 0507), Chía, Cundinamarca

Healthy Medical Center S.A.S ( Site 0505), Zipaquira, Cundinamarca

Fundación Valle del Lili ( Site 0506), Cali, Valle Del Cauca

Centro de Estudios de Reumatología y Dermatología SAS ( Site 0512), Cali, Valle Del Cauca

CHU Bordeaux Haut-Leveque ( Site 1007), Pessac, Aquitaine

CHU Rangueil ( Site 1008), Toulouse, Haute-Garonne

CHU Montpellier Lapeyronie Hospital-Rhumatologie ( Site 1006), Montpellier, Herault

Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord ( Site 1009), Saint Priest En Jarez, Loire

Hopital Claude Huriez - CHU de Lille ( Site 1005), Lille, Nord

Centre Hospitalier Saint Joseph - Saint Luc ( Site 1003), Lyon, Rhone-Alpes

Clinica Medica Especializada en Medicina Interna y Reumatología ( Site 0601), Ciudad de Guatemala, Not set

Clínica Médica Especializada en Pediatría e Infectología Pediátrica - Dr. Mario Melgar ( Site 0602), Guatemala, Not set

CELAN,S.A ( Site 0603), Guatemala, Not set

Istituto Clinico Humanitas Research Hospital ( Site 1310), Rozzano, Milano

Fondazione Policlinico Universitario Campus Bio-Medico ( Site 1307), Rome, Roma

Azienda Ospedaliero Universitaria Senese-Medicina Interna e Specialistica ( Site 1306), Siena, Toscana

Azienda Ospedaliera Universitaria dell'Università "Luigi Van-UNITA'OPERATIVA DI REUMATOLOGIA, DIPAR, Napoli, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -UOC Reumatologia ( Site 1304), Roma, Not set

Japan Community Healthcare Organization Chukyo Hospital ( Site 2107), Nagoya, Aichi

St. Marianna University Hospital ( Site 2121), Kawasaki, Kanagawa

Tohoku University Hospital ( Site 2116), Sendai-shi, Miyagi

Yuuai Medical Center ( Site 2122), Tomigusuku, Okinawa

Shimane University Hospital ( Site 2119), Izumo, Shimane

Dokkyo Medical University Hospital ( Site 2118), Shimotsuga, Tochigi

Nihon University Itabashi Hospital ( Site 2105), Itabashiku, Tokyo

Showa Medical University East Hospital ( Site 2123), Shinagawa, Tokyo

Chiba University Hospital ( Site 2120), Chiba, Not set

NHO Chiba Medical Center Chibahigashi National Hospital ( Site 2112), Chiba, Not set

Okayama University Hospital ( Site 2106), Okayama, Not set

Osaka Keisatsu Hospital ( Site 2117), Osaka, Not set

University Malaya Medical Centre-Clinical Investigation Centre (CIC) ( Site 2222), Lembah Pantai, Kuala Lumpur

Hospital Tengku Ampuan Afzan-Medical Outpatient Department ( Site 2224), Kuantan, Pahang

Hospital Taiping ( Site 2221), Taiping, Perak

RM Pharma Specialists ( Site 0711), Mexico City, Distrito Federal

Morales Vargas Centro de Investigacion ( Site 0710), León, Guanajuato

Centro Integral en Reumatologia ( Site 0701), Guadalajara, Jalisco

Centro de Atención en Enfermedades Inflamatorias CATEI ( Site 0707), Guadalajara, Jalisco

Clinica de Investigacion en Reumatologia y Obesidad S. C. ( Site 0705), Guadalajara, Jalisco

Centro de Estudios de Investigacion Basica y Clinica ( Site 0708), Guadalajara, Jalisco

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Rheumatology ( Site 0706), Monterrey, Nuevo Leon

Centro Potosino de Investigación Médica ( Site 0703), San Luis Potosí, San Luis Potosi

Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan (, Merida, Yucatan

ICARO Investigaciones en Medicina ( Site 0702), Chihuahua, Not set

Clinstile, S.A. de C.V. ( Site 0709), Distrito Federal, Not set

Mary Mediatrix Medical Center ( Site 2303), Lipa City, Batangas

ST. LUKE'S MEDICAL CENTER ( Site 2304), Quezon City, National Capital Region

Iloilo Doctors' Hospital ( Site 2301), Iloilo, Not set

MICS Centrum Medyczne Bydgoszcz ( Site 1410), Bydgoszcz, Kujawsko-pomorskie

Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 1408), Lublin, Lubelskie

Centrum Medyczne Plejady ( Site 1407), Krakow, Malopolskie

MICS Centrum Medyczne Warszawa ( Site 1411), Warszawa, Mazowieckie

Nova Reuma Społka Partnerska ( Site 1405), Bialystok, Podlaskie

NZOZ BIF-MED ( Site 1409), Bytom, Slaskie

Medyczne Centrum Hetmańska ( Site 1406), Poznan, Wielkopolskie

Prywatna Praktyka Lekarska Prof. UM dr hab. med. Pawel Hrycaj ( Site 1402), Poznan, Wielkopolskie

CHUAC-Complejo Hospitalario Universitario A Coruña-Reumatologia ( Site 1604), A Coruña, La Coruna

HOSPITAL CLINICO DE VALENCIA ( Site 1608), Valencia, Valenciana, Comunitat

Hospital Universitari Vall d'Hebron-Rheumatology ( Site 1601), Barcelona, Not set

Hospital Quiron Infanta Luisa-Unidad de investigacion de Reumatologia ( Site 1602), Sevilla, Not set

Hospital Universitario Rio Hortega ( Site 1606), Valladolid, Not set

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 1709), Kadikoy, Istanbul

ANKARA UNIVERSITY IBNI SINA HOSPITAL-Rheumatology Department ( Site 1703), Ankara, Not set

Ankara Bilkent Şehir Hastanesi-Rheumatology ( Site 1702), Ankara, Not set

Sakarya Training and Research Hospital-Rheumatology ( Site 1708), Sakarya, Not set

Conditions: Systemic Lupus Erythematosus

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A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus

NCT05620407

Recruiting

The purpose of this study is to evaluate the effectiveness and safety of deucravacitinib compared with placebo in an active moderate to severe Systemic Lupus Erythematosus (SLE) population.

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

04/11/2025

Locations: UCSD - Altman Clinical and Translational Research Institute (ACTRI), La Jolla, California +198 locations

UCSD - Altman Clinical and Translational Research Institute (ACTRI), La Jolla, California

East Bay Rheumatology Medical Group, Inc, San Leandro, California

Providence Saint John's Medical Foundation, Santa Monica, California

Clinical Research of West Florida, Inc. (Clearwater), Clearwater, Florida

Clinical Research Center of Pompano, Delray Beach, Florida

UF Health Deerwood Park, Jacksonville, Florida

Life Clinical Trials, Margate, Florida

Emory University School of Medicine- Grady Campus, Atlanta, Georgia

Atlanta Research Center for Rheumatology, Marietta, Georgia

Greater Chicago Specialty Physicians - Orland Park, Orland Park, Illinois

Local Institution - 0041, Skokie, Illinois

Local Institution - 0231, New Orleans, Louisiana

Massachusetts General Hospital, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

University of Massachusetts Chan Medical School, Worcester, Massachusetts

AA Medical Research Center-Grand Blanc, Grand Blanc, Michigan

Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota

Local Institution - 0200, Las Vegas, Nevada

Local Institution - 0216, Las Vegas, Nevada

The Valley Hospital, Inc., Paramus, New Jersey

Joseph S. and Diane H. Steinberg Ambulatory Care Center, Brooklyn, New York

Irving Goldman Family Care Center, Great Neck, New York

Hospital for Special Surgery, New York, New York

Columbia University Medical Center, New York, New York

SUNY Upstate Medical University, Syracuse, New York

Local Institution - 0178, Charlotte, North Carolina

University of Cincinnati Medical Center, Cincinnati, Ohio

University Hospitals Cleveland Medical Center, Cleveland, Ohio

Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

Temple University Hospital, Philadelphia, Pennsylvania

West Penn Allegheny Health, Pittsburgh, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Hope Health, Florence, South Carolina

Local Institution - 0228, Florence, South Carolina

West Tennessee Research Institute, Jackson, Tennessee

Austin Regional Clinic, Austin, Texas

Local Institution - 0001, Colleyville, Texas

Texas Arthritis Center, El Paso, Texas

Biopharma Informatic, LLC, Katy, Texas

Baylor Scott & White Medical Center - Temple, Temple, Texas

Spectrum Medical, Inc., Danville, Virginia

Sanatorio Guemes, Ciudad de Buenos Aires, Buenos Aires

Hospital El Cruce, Florencio Varela, Buenos Aires

Hospital Italiano de La Plata, La Plata, Buenos Aires

Centro de Investigacion Pergamino S.A., Pergamino, Buenos Aires

Hospital Universitario Austral, Pilar, Buenos Aires

Centro Dermatológico Schejtman, San Miguel, Buenos Aires

CER medical Institute, Quilmes, Ciudad Autónoma De Buenos Aires

Centro de Investigaciones Médicas Tucuman, SAN M. DE Tucuman, Tucumán

Centro Integral de Reumatologia, San Miguel de Tucumán, Tucumán

Local Institution - 0141, Río Cuarto, Not set

Liverpool Hospital, Liverpool, New South Wales

BJC Health, Paramatta, New South Wales

Rheumatology Research Unit, Maroochydore, Queensland

Austin Health - Repatriation Hospital, Ivanhoe, Victoria

RK Will Pty Ltd, Victoria Park, Western Australia

CEDOES, Vitória, Espírito Santo

Local Institution - 0232, Recife, Pernambuco

Hospital Bruno Born, Lajeado, Rio Grande Do Sul

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Hospital Moinhos de Vento, Porto Alegre, Rio Grande Do Sul

Local Institution - 0230, Porto Velho, Rondônia

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, São Paulo

Local Institution - 0095, Santo André, São Paulo

Centro Multidisciplinar de Estudos Clinicos, Sao Bernardo do Campo, São Paulo

Local Institution - 0033, Curitiba, Not set

Hospital São Lucas de Copacabana, Rio de Janeiro, Not set

Hospital Alemao Oswaldo Cruz, São Paulo, Not set

Hospital 9 De Julho, São Paulo, Not set

CEPIC - Centro Paulista de Investigação Clínica, São Paulo, Not set

Diagnostic Consultative Centre (DCC) - Foкus 5, Sofia, Sofia (stolitsa)

University Hospital Kaspela Clinic of Rheumatology, Plovdiv, Not set

Diagnostic Consultative Centre 1 Ruse, Ruse, Not set

Local Institution - 0214, Sofia, Not set

IC La Serena Research, La Serena, Coquimbo

Local Institution - 0099, Valdivia, Los Ríos

Estudios Clinicos CTR, Santiago, Región Metropolitana De Santiago

Biomedica Research Group, Santiago, Región Metropolitana De Santiago

Estudios Clinicos Limitada, Santiago, Región Metropolitana De Santiago

Local Institution - 0044, Santiago, Región Metropolitana De Santiago

Local Institution - 0098, Santiago, Región Metropolitana De Santiago

Pontificia Universidad Catolica de Chile, Santiago, Región Metropolitana De Santiago

Clínica Ensenada, Santiago, Región Metropolitana De Santiago

Local Institution - 0153, Santiago, Not set

INREA s.r.o., Ostrava, Ostrava Město

Revmatologicky ustav, Praha 2, Not set

General Hospital of Athens Hippokratio, Athens, Attikí (Region)

General Hospital of Athens "Laiko", Athens, Attikí

University General Hospital of Larissa, Larissa, Thessalía

Pécsi Tudományegyetem Klinikai Központ, Pécs, Baranya

Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház, Gyula, Békés

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged, Csongrád

Vital Medical Center, Veszprem, Veszprém City

Local Institution - 0197, New Delhi, Delhi

Local Institution - 0209, Ahmedabad, Gujarat

Local Institution - 0233, Ahmedabad, Gujarat

Sushruta Multispeciality Hospital & Research Centre, Hubli, Karnataka

JSS Hospital, Mysore, Karnataka

Local Institution - 0229, Nagpur, Maharashtra

Christian Medical College Vellore, Vellore, Tamil Nadu

Local Institution - 0204, Vellore, Tamil Nadu

Krishna Institute of Medical Science, Secundarabad, Telangana

Koujunkai Daido Clinic, Nagoya, Aichi

Nagoya University Hospital, Nagoya, Aichi

Fujita Health University, Toyoake, Aichi

Local Institution - 0086, Eiheiji-cho,Yoshida-gun, Fukui

University of Occupational and Enviromental Health, Kitakyushu, Fukuoka

National Hospital Organization Asahikawa Medical Center, Asahikawa, Hokkaido

Hokkaido University Hospital, Sapporo, Hokkaido

Kagawa University Hospital, Kita, Kagawa

Kitasato University Hospital, Sagamihara, Kanagawa

Yokohama City University Hospital, Yokohama, Kanagawa

Tohoku University Hospital, Sendai-shi, Miyagi

Sasebo Chuo Hospital, Sasebo, Nagasaki

Saitama Medical Center, Kawagoe, Saitama

Dokkyo Medical University Hospital, Shimotsuga, Tochigi

Juntendo University Hospital, Bunkyo-ku, Tokyo

Tokyo Medical and Dental University Hospital, Bunkyo-ku, Tokyo

Toho University Ohashi Medical Center, Meguro-ku, Tokyo

Center Hospital of the National Center for Global Health and Medicine, Shinjyuku-ku, Tokyo

Toyama University Hospital, Toyoma, Toyama

National Hospital Organization Chibahigashi National Hospital, Chiba, Not set

Kyushu University Hospital, Fukuoka, Not set

Fukushima Medical University, Fukushima, Not set

Gifu University Hospital, Gifu, Not set

Nagasaki University Hospital, Nagasaki, Not set

Niigata University Medical & Dental Hospital, Niigata, Not set

Okayama University Hospital, Okayama, Not set

Osaka Metropolitan University Hospital, Osaka, Not set

St. Luke's International Hospital, Tokyo, Not set

Keio university hospital, Tokyo, Not set

Wakayama Medical University Hospital, Wakayama, Not set

CIMAB SA de CV, Torreón, Coahuila

Local Institution - 0015, Cdmx, Distrito Federal

RM Pharma Specialists, Mexico city, Distrito Federal

CAIMED Investigacion en Salud, Mexico City, Distrito Federal

Centro de Investigacion Farmacologica del Bajio SC, Leon, Guanajuato

Boca Clinical Trials Mexico S.C., Guadajalara, Jalisco

Investigacion Biomedica para el Desarrollo de Fármacos S.A. de C.V., Zapopan, Jalisco

Local Institution - 0010, Cuernavaca, Morelos

Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo LEON

Local Institution - 0096, Chihuahua, Not set

IMACEN S.A de C.V., Chihuahua, Not set

Oaxaca Site Management Organization, Oaxaca, Not set

Local Institution - 0100, Lima, Not set

Instituto Peruano del Hueso y la Articulación, Lima, Not set

ACQ Medic SAC - Centro de Investigación Clinica Inmunoreumatología, Lima, Not set

Local Institution - 0093, Lima, Not set

Clinica San Juan Bautista, Lima, Not set

Clinica Medica Cayetano Heredia, Lima, Not set

Local Institution - 0218, Wroclaw, Dolnośląskie

Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda, Lublin, Lubelskie

Centrum Medyczne Reuma Park, Warszawa, Mazowieckie

Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warszawa, Mazowieckie

Futuremeds Targowek, Warszawa, Mazowieckie

Pratia MCM Krakow, Kraków, Małopolskie

Local Institution - 0016, Elbląg, Warmińsko-mazurskie

Ortopedyczno-Rehabilitacyjny Szpital Kliniczny UM w Poznaniu, Poznan, Wielkopolskie

Centrum Wsparcia Badań Klinicznych Pomorskiego Uniwersytetu Medycznego w Szczecinie, Szczecin, Not set

MICS Centrum Medyczne Warszawa, Warszawa, Not set

Local Institution - 0031, Wroclaw, Not set

SOMED CR, Lodz, Łódzkie

M2M Med, Chorzów, Śląskie

Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon, Lisboa

Centro Hospitalar de Vila Nova de Gaia/Espinho - Unidade I, Bila Nova De Gaia, Not set

Instituto Portugues de Reumatologia, Lisbon, Not set

Hospital Professor Doutor Fernando Fonseca, Lisbon, Not set

Latin Clinical Trial Center, San Juan, Not set

Singapore General Hospital, Singapore, Not set

Local Institution - 0127, Singapore, Not set

Hospital de Mérida, Mérida, Badajoz

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria

Hospital Universitario Reina Sofia, Cordoba, Madrid

Osi Bilbao-Basurto, Bilbo, País Vasco

Local Institution - 0055, Vitoria-Gasteiz, País Vasco

Hospital Quironsalud Infanta Luisa, Sevilla, Not set

Hospital Universitario Rio Hortega, Valladolid, Not set

Hospital Universitari i Politecnic La Fe, València, Not set

Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Kaohsiung

Chung Shan Medical University Hospital, Taichung City, Taichung

China Medical University Hospital, Taichung, Not set

Taichung Veterans General Hospital, Taichung, Not set

Chi Mei Medical Center, Tainan City, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Local Institution - 0207, Bangkok, Krung Thep Maha Nakhon

Ramathibodi Hospital, Bangkok, Krung Thep Maha Nakhon

Faculty of Medicine Siriraj Hospital, Bangkok, Krung Thep Maha Nakhon

Hacettepe Universite Hastaneleri, Ankara, Not set

Akdeniz Universitesi Hastanesi, Antalya, Not set

NCR International Hospital, Gaziantep, Not set

Local Institution - 0170, Istanbul, Not set

Royal Free Hospital, London, England

King's College Hospital, London, Greater London

Guy's & St Thomas' NHS Foundation Trust, London, London, City Of

James Cook University Hospital, Central Middlesbrough, Middlesbrough

Local Institution - 0092, Bradford, Not set

Oxford University Hospitals - Nuffield Orthopaedic Centre, Oxford, Not set

Conditions: Systemic Lupus Erythematosus

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Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM)

NCT06294236

Recruiting

SC291-102 is a Phase 1 study to evaluate SC291 safety and tolerability, preliminary clinical response, cellular kinetics and exploratory assessments for subjects with severe autoimmune diseases.

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

04/10/2025

Locations: University of Colorado, Aurora, Colorado +4 locations

Conditions: Lupus Erythematosus, Systemic Lupus Erythematosus, SLE (Systemic Lupus), Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Granulomatous Polyangiitis, Microscopic Polyangiitis

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Study of Systemic Lupus Erythematosus

NCT00001372

Recruiting

This protocol will evaluate patients with systemic lupus erythematosus (SLE) and their relatives to learn more about how the disease develops and changes over time. It will also study genetic factors that make a person susceptible to SLE. Patients 3 years of age and older with known or suspected SLE and their relatives may be eligible for this study. Patients will be evaluated with a medical history and physical examination, blood and urine tests. Other procedures may include: 1. Electrocardiogram 2. 24-hour urine collection 3. Imaging studies, such as chest and joint X-rays, magnetic resonance imaging (MRI) scans, bone scans, and bone densitometry. 4. Questionnaire about the degree of disease activity, and survey of risk factors for disease complications. 5. Apheresis-Collection of plasma (fluid portion of blood) or blood cells for analysis. Whole blood is collected through a needle in an arm vein. The blood circulates through a machine that separates it into its components. The required component (plasma or cells) is removed and the rest of the blood is returned to the body through the same needle or through a second needle in the other arm. 6. Skin biopsy-Removal of a small skin sample for microscopic analysis. An area of skin is numbed with an anesthetic and a small circular portion (about 1/4 inch in diameter) is removed, using a sharp cookie cutter-type instrument. 7. Kidney, bone marrow or other organ biopsy-Removal of a small sample of organ tissue. These biopsies are done only if they can provide information useful in better understanding the disease or making treatment decisions. 8. Genetic studies-Collection of a blood sample for gene testing. Patients will be followed at least once a year with a brief history and physical examination and routine blood and urine tests. Some patients may be seen more often. Treatment recommendations will be offered to patients' physicians, and patients who are eligible for other research treatment studies will be invited to enroll. Participating relatives of patients will fill out a brief medical history questionnaire and provide a DNA sample (either a blood sample or tissue swab from the inside of the cheek) for genetic testing. Read Less

Gender:

ALL

Ages:

Between 3 years and 120 years

Trial Updated:

04/10/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Systemic Lupus Erythematosus

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

NCT06121297

Recruiting

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

04/10/2025

Locations: University of California Irvine, Orange, California +21 locations

Conditions: Systemic Lupus Erythematosus, Lupus Nephritis

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