There are currently 1572 clinical trials in Dallas, Texas looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Texas Southwestern Medical Center, UT Southwestern Medical Center, UT Southwestern/Simmons Cancer Center-Dallas and GSK Investigational Site. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients
NCT03982160
Recruiting
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. A potential signal driving sympathetic nerve activity (SNA) involves accumulation of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). ADMA is elevated in CKD and is a strong, independent predictor of future ca... Read More
Gender:
All
Ages:
Between 35 years and 75 years
Trial Updated:
01/14/2024
Locations: UT Southwestern, Dallas, Texas
Conditions: Chronic Kidney Disease
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Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
NCT02089217
Recruiting
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical ma... Read More
Gender:
All
Ages:
Between 35 years and 100 years
Trial Updated:
01/12/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Carotid Stenosis
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Evaluation of Safety and Efficacy of Morpheus8 Applicator for the Treatment of Focal Hyperhidrosis of the Axillae Using Radio Frequency
NCT05860972
Recruiting
The InMode radio frequency Pro System with the Morpheus8 Applicator is a computerized system generating radio frequency energy, based on the underlying technology of Fractional RF. The Morpheus8 Applicator and 24 pin tip is used for the treatment of primary hyperhidrosis of the axillae
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: Dallas Plastic Surgery Institute, Dallas, Texas
Conditions: Hyperhidrosis Primary Focal Axilla
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Demographics, Characteristics and Outcomes of Male Breast Cancer Patients at Methodist Health System
NCT06133647
Recruiting
To determine the number of MBC cases as well as the demographics, characteristics, and outcomes of MBC patients at Methodist Health System (MHS).
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
01/11/2024
Locations: Clinical Research Institute at Methodist Health System, Dallas, Texas +1 locations
Conditions: Ductal Carcinoma in Situ, Invasive Lobular Breast Carcinoma
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Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)
NCT05752448
Recruiting
This study will enroll 120 women living with ovarian cancer following completion of initial treatment. Our objective is to test an intervention designed to provide support during the survivorship transition for this population, who live with a high degree of morbidity related to the illness and its treatment as well as a high risk of recurrence. Study participants will be randomly assigned to receive survivorship care using the POSTCare-O process or usual care. The primary outcome is quality of... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: UT Southwestern Parkland Health and Hospital System, Dallas, Texas
Conditions: Quality of Life, Depressive Symptoms, Ovarian Neoplasm
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Patients With and Without Phonotrauma
NCT05625191
Recruiting
There is a substantial need to identify objective measures associated with hyperadduction of the vocal folds to recognize those at higher risk of developing phonotrauma so that risk mitigation strategies can be implemented before phonotrauma develops. The overall objective of this proposed project is to investigate the sensitivity and direction of change in cepstral peak prominence (CPP) and the magnitude difference between the first two harmonics of the voice spectrum (H1-H2) in response to var... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/11/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Phonotrauma
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First-in-Human, Multiple Part Clinical Study of JNT-517 in Healthy Participants and in Participants With Phenylketonuria
NCT05781399
Recruiting
The goal of Parts A and B of this Phase 1, first-in-human, randomized study is to assess the safety, tolerability, and pharmacokinetics (PK) of single (SAD) and multiple (MAD) ascending doses of oral JNT-517 in healthy participants. In Part C, the goal is to evaluate the differences in bioavailability between a tablet and suspension formulation of JNT-517 and the food effect in healthy volunteers. All participants in Part C will receive JNT-517. The goal of Part D is to assess the safety, tolera... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/11/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Phenylketonuria
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First-in-Human Study of BBT-207 in Advanced Non-Small Cell Lung Cancer Harboring EGFR Mutation After Treatment With EGFR TKI
NCT05920135
Recruiting
This is an open label, multi-center, Phase 1/2 study evaluating the safety, tolerability, PK, PD, and preliminary efficacy (antitumor activity) of BBT-207. It will consist of 3 parts; dose escalation, recommended phase 2 dose selection, and dose expansion.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: Mary Crowley Cancer Research, Dallas, Texas
Conditions: EGFR Mutant Advanced Non-Small Cell Lung Cancer
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Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
NCT05678673
Recruiting
This is a multicenter, randomized (2:1), open-label, controlled Phase 3 trial of XL092 in combination with nivolumab versus sunitinib in subjects with unresectable, locally advanced or metastatic nccRCC who have not received prior systemic anticancer therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: Exelixis Clinical Site #31, Dallas, Texas
Conditions: Non-Clear Cell Renal Cell Carcinoma
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Decreasing On-Shift Stress With a Crisis Intervention Cart
NCT05944120
Recruiting
This Intervention study anticipates that 100 nurses, patient care technicians and unit secretaries in the acute care setting at four Methodist Health System facilities will provide surveys to participants who had interventions
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
01/11/2024
Locations: Methodist Dallas Medical Center, Dallas, Texas
Conditions: Decreasing On-Shift Stress With a Crisis Intervention Cart
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Vasopressor Outcomes in Spine Surgery
NCT06053398
Recruiting
This is a prospective, randomized control trial comparing norepinephrine versus phenylephrine for vasopressor support in patients undergoing elective spinal fusion surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: Clements University Hospital at Dallas, Dallas, Texas
Conditions: Hypotension
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Hearing Impairment, Strategies and Outcomes in VA Emergency Departments
NCT05028972
Recruiting
HearVA involves six VA facility emergency departments (ED) over a 3-year intervention period. The first part of this study will test whether providing personal amplifiers to Veteran ED patients who self-report hearing difficulty is acceptable to these patients, can improve their hearing, enhance understanding of discharge instructions, and can reduce the risk of coming back to the ED in a short period of time (3 days and 30 days). The second part of the study will then identify whether ED staff... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
01/10/2024
Locations: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas
Conditions: Hearing Loss, Emergency Service, Hospital Readmission
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