Depression Clinical Trials in Dallas, TX

A listing of Depression Clinical Trials in Dallas, TX actively recruiting patient volunteers.

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11 trials found

Behavioral Activation Plus Savoring for University Students


The current investigation aims to examine whether a brief, two-session, virtual behavioral activation plus savoring intervention will increase daily positive emotion in university students.

Conditions: Mood, Anhedonia, Depression
Phase: Not Applicable

The PATHway Study: Primary Care Based Depression Prevention in Adolescents


Prevention of depressive disorders has become a key priority for the NIMH, but the investigators have no widely available public health strategy to reduce morbidity and mortality. To address this need, the investigators developed and evaluated the primary care based-technology "behavioral vaccine," Competent Adulthood Transition with Cognitive-Behavioral Humanistic and Interpersonal Therapy (CATCH-IT). The investigators will engage N=4 health systems representative of the United States health ca ...

Conditions: Depression, Mental Disorder in Adolescence
Phase: Not Applicable

Affect Treatment for Depression and Anxiety


The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of anhedonia) in the context of depression or anxiety. Target enrollment is 100 male and female participants with low positive affect and depression or anxiety and impaired functioning, between the ages of 18 and 65 years, who will be randomized to either Positive Aff ...

Conditions: Depression, Anxiety
Phase: Not Applicable

Behavioral Activation Teletherapy to Increase Physical Activity


This is a pilot study of acceptability, feasibility, and preliminary efficacy of a brief, 10-session Behavioral Activation intervention delivered via teletherapy to increase physical activity and treat depressive symptoms.

Conditions: Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode
Phase: Not Applicable

A Study of the Change in Disease State and Safety of Oral Cariprazine Capsules in the Treatment of Depression in Pediatric Participants (10 to 17 Years of Age) With Bipolar I Disorder


Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate ...

Conditions: Depression, Bipolar I Disorder

Youth Depression and Suicide Research Network


The objective of this study is to build the Texas Youth Depression and Suicide Research Network to support the development of a Network Participant Registry and characterization of systems and interventions to examine statewide population health outcomes. All 12-13 sites represented in the Texas Child Mental Health Care Consortium ( have been invited to participate in the Texas Youth Depression and Suicide Research Network as "Nodes." 12 Nodes have been ...

Conditions: Depression, Suicide, Suicidal Ideation, Suicide, Attempted, Depressive Disorder, Depressive Symptoms, Depressive Episode, Depression and Suicide, Depression, Teen, Depression, Anxiety

Exploring the Effects of Corticosteroids on the Human Hippocampus


Chronic corticosteroid (CS) exposure is associated with changes in memory and the hippocampus in both humans and in animal models. The hippocampus has a high concentration of glucocorticoid receptors (GCRs), and the pre-clinical literature demonstrates shortening of apical dendrites in the CA3 region of the hippocampus and decreased neurogenesis in the dentate gyrus (DG) following CS administration. In humans, both stress and CS exposure are associated with a decline in declarative memory perfor ...

Conditions: Hydrocortisone, Depression, Healthy Volunteers

Resilience in Adolescent Development


The RAD study is a longitudinal study to prospectively characterize the biological mechanisms of resilience in adolescents and young adults at risk for developing depression. The study will capture biomarkers from the domains of socio-demographic and clinical data, cognitive and psychological assessments, fluid-based biomarkers, neuroimaging and EEG. Such biomarkers will compose a human biosignature of resilience and identify risk factors for depression, contributing to effective treatment selec ...

Conditions: Risk Assessment, Resilience, Psychological, Depression, Mood Disorders, Anxiety Disorders

Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression


This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression. Even with multiple medication trials, 30 - 40% of patients will experience a pharmacologically resistant form of illness. The ineffectiveness of current treatments for major depressive disorder (MDD) coupled with the economic burden associated with the disorder engenders a need for novel therapeutic interventions that can provide greater r ...

Conditions: Depression, Unipolar Depression, Treatment Resistant Depression
Phase: Not Applicable

Dallas 2K: A Natural History Study of Depression


The Dallas 2K is a 10-year natural history, longitudinal, prospective study of a cohort of 2,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological and neurobiological factors that contribute to anti-depressant treatment response: remission, recurrence, relapse and individual outcomes in depressive disorders. Hence, the expected duration of this study is 20 years in length. Since this is an observational study, investigators will explore a comprehensive ...

Conditions: Depression, Depression, Bipolar

UTSW Depression Cohort: A Longitudinal Study of Depression


This is a longitudinal observational study (via electronic records and biospecimens) designed to utilize health IT advances to collect information from patients undergoing routine care. This information will be stored in a database. Patients undergoing routine care from their providers will be invited to participate in the UTSW Depression Cohort. After obtaining informed consent, the CDRCC team will collect information from available sources and store it in a secure UT Southwestern network datab ...

Conditions: Depression, Other Diagnoses, Comorbidities, and Complications