There are currently 1572 clinical trials in Dallas, Texas looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Texas Southwestern Medical Center, UT Southwestern Medical Center, UT Southwestern/Simmons Cancer Center-Dallas and GSK Investigational Site. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma
NCT05664217
Recruiting
This study will evaluate the safety and efficacy of NKTR-255 following CD19-directed chimeric antigen (CAR)-T cell therapy in patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL). NKTR-255 is an investigational IL-15 receptor agonist designed to boost the immune system's natural ability to fight cancer. T cells are infection fighting blood cells that can kill tumor cells. Chimeric antigen (CAR)-T cell product consists of genetically engineered T-cells, modified to recognize C... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Non-Hodgkin Lymphoma, Relapsed/Refractory Diffuse Large B-cell Lymphoma
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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
NCT02915198
Recruiting
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in patients who have pre-diabetes and heart or blood vessel problems.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas
Conditions: Prediabetic State, Atherosclerosis, Metformin
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Tofacitinib in Recurrent GBM Patients
NCT05326464
Recruiting
The purpose of this study is to examine the effects of Tofacitinib in patients with recurrent Glioblastoma.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Glioblastoma
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UroLift System With SAbR for Prostate Cancer and BPH
NCT05311527
Recruiting
Confirming safety of combining UroLift System prior to SAbR for patients with newly diagnosed prostate cancer and a history of BPH, by measuring the acute complication rate of UroLift System implant in patients with BPH undergoing SAbR (within 90 days of treatment completion)
Gender:
Male
Ages:
45 years and above
Trial Updated:
01/05/2024
Locations: University of Texas Southwestern Medical Center - Dallas, Dallas, Texas
Conditions: Prostate Cancer
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4D-710 in Adult Patients With Cystic Fibrosis
NCT05248230
Recruiting
This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with CF who are ineligible for or unable to tolerate CFTR modulator therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: The University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Cystic Fibrosis Lung
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A Study to Evaluate EDP 938 Regimens in Children With RSV
NCT04816721
Recruiting
A 2-part study to evaluate the safety, pharmacokinetics and efficacy of EDP-938 in children with RSV infection.
Gender:
All
Ages:
Between 28 days and 36 months
Trial Updated:
01/04/2024
Locations: Children's Health Specialty Center Dallas Campus, Dallas, Texas
Conditions: Respiratory Syncytial Virus (RSV)
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Phase 1 Study to Assess Safety and Efficacy of ANG003
NCT06052293
Recruiting
Randomized, parallel, active-treatment Phase 1 study of a single dose of orally administered ANG003 with a test meal in adult subjects with cystic fibrosis-related exocrine pancreatic insufficiency. The study's overall objectives are to evaluate the safety, tolerability and effect of four dose levels of ANG003.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Exocrine Pancreatic Insufficiency
Register for Updates
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
NCT05878717
Recruiting
This study investigates the efficacy and safety of belimumab compared to placebo, in addition to standard therapy, for the treatment of participants with systemic sclerosis associated interstitial lung disease (SSc-ILD). The study will evaluate the effect of belimumab treatment on lung function as well as on extra-pulmonary disease manifestations, including skin thickening and general symptoms, such as fatigue, that impact quality of life (QoL).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/03/2024
Locations: GSK Investigational Site, Dallas, Texas
Conditions: Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic
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Polypill Strategy for Heart Failure With Reduced Ejection Fraction
NCT04633005
Recruiting
Heart failure with a reduced ejection fraction (HFrEF) represents a significant public health burden in the United States, with a growing prevalence particularly among African Americans and Hispanic Americans and individuals of low socioeconomic status (SES). Although effective therapies exist, gaps in their uptake contribute substantially to the excess burden of heart failure. The "polypill" is an inexpensive once daily pill containing three agents proven to improve morbidity and mortality in h... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Heart Failure
Register for Updates
Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis
NCT05403541
Recruiting
The purpose of this 4-period study is to confirm the efficacy and safety of batoclimab in participants with gMG. In Period 1, participants will be randomized 1:1:1 to receive batoclimab 680 milligrams (mg) subcutaneously (SC) once a week (QW) or 340 mg SC QW or placebo. The primary efficacy endpoint will be assessed by change in the myasthenia gravis activities of daily living (MG- ADL) score in acetylcholine receptor antibody seropositive (AChRAb+) participants. In Period 2, participants previo... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Site Number -1016, Dallas, Texas
Conditions: Generalized Myasthenia Gravis
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AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department
NCT04669288
Recruiting
AZ-SWED is a parallel group, double blind, placebo control efficacy clinical trial with two separate hypotheses. The trial will compare the 5-day outcome of preschool children presenting to an Emergency Department (ED) with an acute, severe wheezing episode and treated with either once daily oral Azithromycin (12 mg/kg/day for 5 days) or placebo. The AZ-SWED researchers will make separate comparisons in children in whom specific pathogenic bacteria are isolated from nasopharyngeal swabs, and in... Read More
Gender:
All
Ages:
Between 18 months and 60 months
Trial Updated:
01/02/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Asthma, Wheezing
Register for Updates
The Use of a Non-Incised Minimally Invasive Flap Procedure in Conjunction With Emdogain® MI Compared to Traditional SRCP
NCT05964699
Recruiting
This study is designed to evaluate the use of Emdogain® MI in a procedure where a significant portion of the lining of the sulcus is removed by curettage (similar to the traditional clinical procedure described as "gingival curettage") to the point of tissue mobility. This will be designated as a "non-incised minimally invasive flap access procedure". A videoscope will be utilized to assist with the requirement to adequately visualize and debride the root surface. This research project will defi... Read More
Gender:
All
Ages:
Between 30 years and 75 years
Trial Updated:
01/02/2024
Locations: Texas A&M School of Dentistry, Dallas, Texas
Conditions: Periodontitis, Attachment Loss, Periodontal
Register for Updates