Oral Nadolol for the Treatment of Adults With Mild Asthma
NCT00670267
Completed
The purpose of this study is to confirm previous observations in asthmatics that chronic nadolol treatment reduces asthmatic airway hyper-responsiveness.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/06/2016
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Asthma
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HOP-3 Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone
NCT00839319
Completed
The purpose of this investigational study is to determine how much male hormone, testosterone, is necessary to maintain sperm production in the testis. This knowledge will be used to help in the development of a safe male hormonal contraception.
Gender:
MALE
Ages:
Between 18 years and 50 years
Trial Updated:
12/09/2015
Locations: University of Washington, Seattle, Washington
Conditions: Healthy Males
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Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers
NCT02217930
Completed
The study designed to determine the effect induced by WCK 2349 on the QT interval. The study will be conducted in two parts: 1) to determine the supratherapeutic dose; and 2) to assess the safety of high doses of single-dose administration of WCK 2349 on the QT interval.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/28/2015
Locations: Phase 1 unit : Spaulding Clinical Research, LLC, West Bend, Wisconsin
Conditions: Qt Interval, Variation in
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Pharmacokinetics of WCK 2349 In Patients With Hepatic Impairment
NCT02244827
Completed
This study is aimed to compare the pharmacokinetics of levonadifloxacin and its sulfate metabolite after a single dose of oral WCK 2349 1000 mg in patients with hepatic impairment and healthy volunteers.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/28/2015
Locations: University of Miami,Division of Clinical Pharmacology, Miami, Florida
Conditions: Hepatic Impairment
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Study to Determine and Compare Plasma and Intrapulmonary Pharmacokinetics of WCK 2349 in Healthy Adult Human Subjects
NCT02253342
Completed
This study to determine and compare plasma, epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations of levonadifloxacin after administration of WCK 2349 in healthy adult subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/28/2015
Locations: Pulmonary Associates, 1112 E. McDowell Rd., Phoenix, Arizona
Conditions: Intrapulmonary Pharmacokinetics of WCK 2349
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Muscle-Sparing Effect Of Human Chorionic Gonadotropin (hCG) During a Very Low Calorie Diet (VLCD)
NCT02427529
Completed
Subjects are female patients, randomized to HCG group or placebo group, during a prospective trial, in order to determine the significance, if any, of HCG on maintaining muscle mass during a very low calorie diet in order to demonstrate the potential significance of HCG administration on preserving lean body mass while losing weight.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
04/27/2015
Locations: Dr. Emma's Corporation, Colts Neck, New Jersey
Conditions: HCG
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Estrogen Sensitivity and Ovulatory Dysfunction in Obesity
NCT01381016
Completed
The sole purpose of this study is to evaluate pathophysiology of disease. The disease state that is being evaluated is the obesity-related alterations in reproductive hormones * The obesity epidemic in the United States is advancing at an accelerated pace. It is estimated that by 2015, 41% of U.S. adults will be obese as defined by a body mass index (BMI) of greater than 30 kg/m2. The U.S. government's 2010 Dietary Guidelines regard obesity as the single greatest health hazard in this century.... Read More
Gender:
FEMALE
Ages:
Between 18 years and 42 years
Trial Updated:
04/02/2015
Locations: University of Colorado, Anschutz Medical Campus, Aurora, Colorado
Conditions: Obesity, Infertility
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Leuprolide in Determining the Cause of Gonadotropin Deficiency
NCT00004426
Completed
RATIONALE: The body's response to one injection of leuprolide may provide more information than the standard test for gonadotropin deficiency in determining whether the cause of gonadotropin deficiency is related to the hypothalamus or the pituitary gland. PURPOSE: Randomized double-blinded clinical trial to study the effectiveness of leuprolide in determining the cause of gonadotropin deficiency.
Gender:
ALL
Ages:
Between 9 years and 18 years
Trial Updated:
03/25/2015
Locations: University of Chicago Children's Hospital, Chicago, Illinois
Conditions: Hypogonadism
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A Study to Compare Subject Comfort During and After Injections With the Study Products and the Safety of the Non-FDA Approved Product for the Correction of Nasolabial Folds (NLFs)
NCT00417469
Completed
The purpose of this research study is to compare subject comfort during and after injection with NADGL and Captique® Injectable Gel, in the nasolabial folds. Captique® is an FDA-approved product without lidocaine and is manufactured by Genzyme Biosurgery (Ridgefield, NJ). NADGL is a new product (not FDA approved) with lidocaine and is also manufactured by Genzyme Biosurgery. We do not know which of these treatments results in less pain during and after injection. The safety of NADGL is also bein... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2015
Locations: Not set, Birmingham, Alabama
Conditions: Facial Wrinkles
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Topical Treatment of Under Eye Dark Circles and Swelling
NCT01172522
Completed
This study examines topical treatment of under eye circles and swelling.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/16/2015
Locations: TKL Research, Paramus, New Jersey
Conditions: Edema
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Investigating the Regulation of Reproductive Hormones in Adult Men
NCT00392457
Completed
The purpose of the research study is to learn more about the regulation of reproductive hormones in adult men. We would like to understand what role testosterone and estradiol play in controlling the release of LH (lutenizing hormone) and FSH (follicle stimulating hormone). Testosterone and estradiol come from the testes, and LH and FSH are released from a gland in the head called the pituitary. Men involved in the study will have detailed evaluations that involve overnight stays in the hospita... Read More
Gender:
MALE
Ages:
Between 18 years and 50 years
Trial Updated:
02/12/2015
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Kallmann Syndrome, Hypogonadism, Gonadal Disorder
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Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation
NCT01044862
Completed
The objective of this application is to identify a pharmacologic agent which helps couples in whom the female partner ovulates regularly successfully obtain their goal of delivering a healthy child, whose use will result in low rates of multiple gestations. The central hypothesis is that, in infertile ovulatory women undergoing ovarian stimulation (OS) and intrauterine insemination (IUI), the use of aromatase inhibitors (AI) will stimulate the ovaries sufficiently to produce no reduction in the... Read More
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
01/22/2015
Locations: University of Alabama Birmingham, Birmingham, Alabama +13 locations
Conditions: Pregnancy, Unexplained Infertility
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