High-Dose Melphalan and a Second Stem Cell Transplant or Low-Dose Cyclophosphamide in Treating Patients With Relapsed Multiple Myeloma After Chemotherapy
NCT00747877
Unknown
RATIONALE: Giving chemotherapy and bortezomib before a peripheral stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-form... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/09/2013
Locations: Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, England +52 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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Evaluating the Side Effects and How Well Anticancer Drugs Work in Very Young Patients With Cancer
NCT00897871
Unknown
RATIONALE: Studying samples of blood in the laboratory from young patients with cancer may help doctors learn how carboplatin, cyclophosphamide, and etoposide affect the body and how patients will respond to treatment. PURPOSE: This laboratory study is evaluating the side effects and how well anticancer drugs work in very young patients with cancer.
Gender:
ALL
Ages:
2 years and below
Trial Updated:
08/09/2013
Locations: Our Lady's Hospital for Sick Children Crumlin, Dublin, Not set +20 locations
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
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Chemotherapy or Letrozole Before Surgery in Treating Postmenopausal Women With Breast Cancer That Can Be Removed By Surgery
NCT00963729
Completed
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by reducing the production of estrogen. It is not yet known whether giving more than one drug (combination chemotherapy) or giving letrozole before surgery is more effective in treating women with breast cancer. PURPOSE: This... Read More
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
08/09/2013
Locations: Asan Medical Center - University of Ulsan College of Medicine, Seoul, Not set +4 locations
Conditions: Breast Cancer
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Combination Chemotherapy in Treating Older Patients With Intermediate- or High-Grade Non-Hodgkin's Lymphoma
NCT00002576
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy consisting of cyclophosphamide, vincristine, and prednisolone, with either mitoxantrone or doxorubicin in treating patients with intermediate- or high-grade non-Hodgkin's lymphoma.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/06/2013
Locations: Nottingham City Hospital NHS Trust, Nottingham, England
Conditions: Lymphoma
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Combination Chemotherapy in Treating Women With Breast Cancer Who Have Undergone Surgery
NCT00039546
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which chemotherapy regimen is more effective in treating women after surgery for breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of paclitaxel, epirubicin, and cyclophosphamide with or without gemcitabine in treating women who have undergone surgery for breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/06/2013
Locations: Queen Elizabeth Hospital at University of Birmingham, Birmingham, England +45 locations
Conditions: Breast Cancer
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Neoadjuvant Epirubicin, Cyclophosphamide, and Paclitaxel With or Without Gemcitabine in Treating Women Who Are Undergoing Surgery for Early Breast Cancer
NCT00070278
Unknown
RATIONALE: Drugs used in chemotherapy, such as epirubicin, cyclophosphamide, paclitaxel, and gemcitabine use different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy before surgery may shrink the tumor so that it can be removed during surgery. It is not yet known which combination chemotherapy regimen is more effective in treating early breast cancer. PURPOSE: This randomized phase III trial is studying different regimens of combination chemo... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
08/06/2013
Locations: Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust, Cambridge, England
Conditions: Breast Cancer
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Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer
NCT00427245
Completed
RATIONALE: Goserelin may help prevent early menopause in patients undergoing chemotherapy for breast cancer. It is not yet known whether goserelin is effective in preventing early menopause in women undergoing chemotherapy for breast cancer. PURPOSE: This randomized phase III trial is studying goserelin to see how well it works compared with no goserelin in preventing early menopause in premenopausal women undergoing chemotherapy for stage I, stage II, or stage III breast cancer.
Gender:
FEMALE
Ages:
All
Trial Updated:
08/06/2013
Locations: Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke, England +65 locations
Conditions: Breast Cancer, Infertility, Menopausal Symptoms
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Doxorubicin or Epirubicin and Cyclophosphamide in Treating Older Women With Invasive Breast Cancer
NCT00516425
Unknown
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, epirubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy after surgery may kill any tumor cells that remain after surgery. Sometimes, after surgery, the tumor may not need more treatment until it progresses. In this case, observation may be sufficient. It is not yet known whether giving doxorubicin or epirubi... Read More
Gender:
FEMALE
Ages:
70 years and above
Trial Updated:
08/06/2013
Locations: Charing Cross Hospital, London, England +1 locations
Conditions: Breast Cancer
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Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer
NCT00002582
Completed
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen. Combination chemotherapy uses different ways to stop tumor cells from dividing so they stop growing or die. Combining hormone therapy with chemotherapy may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of tamoxifen with or without chemotherapy and/or ovarian ablation in treating women with stage... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
08/01/2013
Locations: Cancer Research Campaign Trials Unit-Birmingham (CRCTU), Birmingham, England +1 locations
Conditions: Breast Cancer
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Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors
NCT00025077
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug before surgery or radiation therapy may shrink the tumor so that it can be removed during surgery or radiation therapy. Peripheral stem cell transplant may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy and allow doctors to give higher doses of chemotherapy. PURPOSE: This phase II trial is studying how well c... Read More
Gender:
ALL
Ages:
20 years and below
Trial Updated:
08/01/2013
Locations: Our Lady's Hospital for Sick Children Crumlin, Dublin, Not set +20 locations
Conditions: Brain and Central Nervous System Tumors
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Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney
NCT00025103
Unknown
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: This phase II trial is studying how well chemotherapy followed by surgery and radiation therapy with or without stem cell transplant work in treating patients with relapsed or refractory Wilms' tumor or clear cell sarco... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
08/01/2013
Locations: Our Lady's Hospital for Sick Children Crumlin, Dublin, Not set +20 locations
Conditions: Kidney Cancer
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Combination Chemotherapy With or Without Rituximab in Treating Patients With Previously Treated Chronic Lymphocytic Leukemia
NCT00337246
Completed
RATIONALE: Drugs used in chemotherapy, such as fludarabine, cyclophosphamide, and mitoxantrone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving combination chemotherapy together with ritu... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/01/2013
Locations: Birmingham Heartlands Hospital, Birmingham, England +15 locations
Conditions: Leukemia
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