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Cyclophosphamide Treatment Options in United Kingdom
A collection of 244 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the United Kingdom . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.
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Clinical Trial Phase
Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma
Terminated
RATIONALE: Drugs used in chemotherapy, such as prednisolone and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known whether prednisolone is more effective than dexamethasone when given together with combination chemotherapy in treating lymphoblastic lymphoma.
PURPOSE: This phase III randomized clinical trial is... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
07/09/2013
Locations: Kinderklinik, Giessen, Not set +21 locations
Conditions: Lymphoma
Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of combination chemotherapy is most effective for non-Hodgkin's lymphoma.
PURPOSE: This randomized phase III trial is studying two regimens of combination chemotherapy and comparing how well they work in treating patients with aggressive non-Hodgkin's lymphoma.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
06/25/2013
Locations: Stoke Mandeville Hospital, Aylesbury-Buckinghamshire, England +45 locations
Conditions: Lymphoma
IMA910 Plus GM-CSF With Low-dose Cyclophosphamide Pre-treatment in Advanced Colorectal Carcinoma Patients Following a Successful 12 Week First-line Treatment With Oxaliplatin-based Chemotherapy (IMA910-101)
Completed
This study is being conducted in order determine whether IMA910 as single agent with GM-CSF as adjuvant following pre-treatment with low-dose cyclophosphamide is safe and shows sufficient anti-tumour effectiveness in patients with advanced CRC to warrant further development. Secondary objectives of this study are investigation of immunological parameters and additional effectiveness endpoints. Furthermore, safety, immunological parameters and effectiveness of IMA910 as single agent with GM-CSF i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2013
Locations: Medische Oncologie, Imeldaziekenhuis, Bonheiden, Not set +40 locations
Conditions: Colorectal Carcinoma
Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating older patients who have non-Hodgkin's lymphoma.
Gender:
ALL
Ages:
70 years and above
Trial Updated:
09/20/2012
Locations: Ziekenhuis Network Antwerpen Middelheim, Antwerp, Not set +16 locations
Conditions: Lymphoma
Chemotherapy Plus Interferon Alfa Alone or With Radiation Therapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma
Terminated
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and radiation therapy and kill more cancer cells.
PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy follo... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/29/2012
Locations: Academisch Ziekenhuis Utrecht, Utrecht, Not set +1 locations
Conditions: Lymphoma
Treatment of Mature B-cell Lymphoma/Leukaemia
Completed
This is an international trial conducted by three cooperative groups: SFOP (France, Belgium, Netherlands), CCG (USA, Canada, Australia), and UKCCSG (UK and Ireland). Children with mature B-cell lymphoma/leukaemia are stratified into three different risk groups (A, B, C) and receive treatment of progressive intensity. Randomized trials in the 2 biggest groups (B and C) test whether "reduced" therapy is equivalent to standard intensive therapy (LMB-89 B and C) in terms of event free survival. The... Read More
Gender:
ALL
Ages:
Between 6 months and 20 years
Trial Updated:
03/27/2012
Locations: Morgan Stanley Childrens Hospital of New York Presbyterian, New York, New York +2 locations
Conditions: B-Cell Lymphoma
Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating Patients With Cancer
Terminated
RATIONALE: Placing a gene into T cells may improve the body's ability to recognize cancer cells and build an immune response to fight cancer. Drugs used in chemotherapy, such as cyclophosphamide and fludarabine phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Biological therapies, such as aldesleukin, may stimulate the immune system in different ways and stop cancer cells from growing. Giving specially treated T c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2012
Locations: Christie Hospital, Manchester, England
Conditions: Breast Cancer, Colorectal Cancer, Gastric Cancer, Lung Cancer, Ovarian Cancer, Pancreatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
BIG 02/98 Docetaxel - Breast Cancer
Completed
Primary objectives:
* To compare Disease-Free Survival (DFS) of an adjuvant treatment with docetaxel given either sequentially or in combination with doxorubicin and followed by CMF to doxorubicin alone or in combination with cyclophosphamide and followed by CMF in operable breast cancer patients with positive axillary lymph nodes.
Secondary objectives:
* To compare DFS of an adjuvant treatment with doxorubicin followed by docetaxel followed by CMF to doxorubicin followed by CMF in operable b... Read More
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
11/09/2011
Locations: Sanofi-Aventis, Macquarie Park, Not set +20 locations
Conditions: Breast Neoplasms
A Study of Mycophenolate Mofetil (CellCept) in Management of Patients With Lupus Nephritis.
Completed
This 2 arm study assessed the efficacy of Mycophenolate Mofetil (MMF; CellCept) compared to cyclophosphamide in inducing a response in patients with lupus nephritis, and the long term efficacy of MMF compared to azathioprine in maintaining remission and renal function. Patients were randomized to receive either MMF (1.5 g twice daily \[bid\]) or cyclophosphamide (0.5-1.0 g/m\^2 in monthly pulses) in the induction phase. Those patients meeting criteria for response were re-randomized for entry in... Read More
Gender:
ALL
Ages:
Between 12 years and 75 years
Trial Updated:
10/31/2011
Locations: Not set, Huntsville, Alabama +107 locations
Conditions: Lupus Nephritis
Docetaxel in Node Positive Adjuvant Breast Cancer
Completed
The purpose of this study was to compare disease-free survival after treatment with docetaxel in combination with doxorubicin and cyclophosphamide to 5-fluorouracil in combination with doxorubicin and cyclophosphamide in operable breast cancer patients with positive axillary lymph nodes.
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
02/14/2011
Locations: Sanofi-Aventis Administrative Office, Bridgewater, New Jersey +19 locations
Conditions: Breast Cancer
Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Nonmetastatic Breast Cancer
Unknown
RATIONALE: Drugs used in chemotherapy, such as docetaxel, fluorouracil, epirubicin hydrochloride, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help ki... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2010
Locations: Addenbrooke's Hospital, Cambridge, England
Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma
Unknown
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving rituximab together with one of five different combination chemotherapy regimens may kill more cancer... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2009
Locations: Leeds Cancer Centre at St. James's University Hospital, Leeds, England +7 locations
Conditions: Lymphoma
229 - 240 of 244