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Cyclophosphamide Treatment Options in United Kingdom
A collection of 244 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the United Kingdom . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.
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RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
Recruiting
RESET-Myositis: Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects with Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
RESET-Myositis: Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects with Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy Read Less
Gender:
ALL
Ages:
Between 6 years and 75 years
Trial Updated:
07/14/2025
Locations: University of California Irvine - Accepting Adult Patients, Orange, California +16 locations
University of California Irvine - Accepting Adult Patients, Orange, California
University of California, San Francisco Benioff Children's Hospital - Accepting Young Adult and Juvenile Patients, San Francisco, California
Mayo Clinic Florida - Accepting Adult Patients, Jacksonville, Florida
Emory University - Accepting Adult Patients, Atlanta, Georgia
Northwestern Memorial Hospital - Accepting Adult Patients, Chicago, Illinois
The University of Chicago Medical Center - Accepting Adult and Juvenile Patients, Chicago, Illinois
University of Kansas Medical Center - Accepting Adult Patients, Kansas City, Kansas
Mayo Clinic - Accepting Adult Patients, Rochester, Minnesota
Oregon Health & Science University - Accepting Adult Patients, Portland, Oregon
Children's Hospital of Philadelphia - Accepting Young Adult and Juvenile Patients, Philadelphia, Pennsylvania
Vanderbilt University Medical Center - Accepting Adult Patients, Nashville, Tennessee
Houston Methodist Hospital - Accepting Adult Patients, Houston, Texas
University of Texas MD Anderson Cancer Center - Accepting Adult Patients, Houston, Texas
Kings College Hospital NHS Foundation Trust - Accepting Adult Patients, London, Not set
University College London Hospitals NHS Foundation Trust - Accepting Adult Patients, London, Not set
Manchester Royal Infirmary - Accepting Adult Patients, Manchester, Not set
Salford Royal Hospital - Accepting Adult Patients, Salford, Not set
Conditions: Idiopathic Inflammatory Myopathy, Dermatomyositis, Anti-Synthetase Syndrome, Immune-Mediated Necrotizing Myopathy, Juvenile Dermatomyositis, Juvenile Polymyositis, Juvenile Idiopathic Inflammatory Myopathy (JIIM), Juvenile Myositis
A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma
Recruiting
The purpose of this study is to assess the efficacy and safety of golcadomide in combination with rituximab in participants with newly diagnosed advanced stage Follicular Lymphoma (FL).
The purpose of this study is to assess the efficacy and safety of golcadomide in combination with rituximab in participants with newly diagnosed advanced stage Follicular Lymphoma (FL). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Local Institution - 0152, Birmingham, Alabama +67 locations
Local Institution - 0152, Birmingham, Alabama
Alaska Oncology and Hematology, Anchorage, Alaska
Mayo Clinic in Arizona - Phoenix, Phoenix, Arizona
Arizona Oncology Associates, PC - HOPE, Tucson, Arizona
UCSF Helen Diller Medical Center at Parnassus Heights, San Francisco, California
Georgetown University Medical Center, Washington, District of Columbia
Florida Cancer Specialists - South, Fort Myers, Florida
Mayo Clinic in Florida, Jacksonville, Florida
Florida Cancer Specialists - North, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Florida Cancer Specialists - East, West Palm Beach, Florida
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
Local Institution - 0173, Jefferson, Louisiana
Local Institution - 0033, Baltimore, Maryland
Local Institution - 0001, Boston, Massachusetts
Local Institution - 0004, Boston, Massachusetts
Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota
Comprehensive Cancer Centers Of Nevada, Henderson, Nevada
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Local Institution - 0020, New Brunswick, New Jersey
Local Institution - 0036, New York, New York
Utah Cancer Specialists, Salt Lake City, Utah
Local Institution - 0200, Norfolk, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Local Institution - 0166, Seattle, Washington
Fred Hutchinson Cancer Center, Seattle, Washington
Liverpool Hospital, Liverpool, New South Wales
Mater Misercordiae Hospital, South Brisbane, Queensland
Latrobe Regional Health, Traralgon, Victoria
Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec
Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago
Clínica Inmunocel, Santiago, Región Metropolitana De Santiago
Institut Curie - site Saint-Cloud, Saint-Cloud, Hauts-de-Seine
Hopital Claude Huriez - CHU de Lille, Lille, Nord
Centre Hospitalier Universitaire de Poitiers, Poitiers, Vienne
Hôpital Saint-Louis, Paris, Not set
Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Bayern
Klinikum Chemnitz - Flemmingstraße, Chemnitz, Sachsen
Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden, Not set
Fondazione Policlinico Tor Vergata, Rome, Lazio
Istituto Clinico Humanitas, Rozzano, Milano
Local Institution - 0096, Bari, Puglia
Local Institution - 0098, Bari, Puglia
Local Institution - 0097, Bari, Not set
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set
Local Institution - 0104, Hwasun Gun, Jeonranamdo
Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi
Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0186, Bydgoszcz, Kujawsko-pomorskie
Local Institution - 0185, Warszawa, Mazowieckie
Local Institution - 0187, Skórzewo, Wielkopolskie
Hospital Universitari Son Espases, Palma, Balears [Baleares]
Hospital Universitario Doctor Peset, Valencia, Valenciana, Comunitat
Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung, Not set
National Taiwan University Hospital, Taipei, Not set
Southampton General Hospital, Southampton, Hampshire
Kent and Canterbury Hospital, Canterbury, Kent
Western General Hospital, Edinburgh, Midlothian
City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, Not set
Conditions: Lymphoma, Follicular
A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer
Completed
This randomized, double-blind, placebo-controlled, two-arm study will assess the safety and efficacy of pertuzumab in addition to chemotherapy plus trastuzumab as adjuvant therapy in participants with operable HER2-positive primary breast cancer. This study will be carried out in collaboration with the Breast International Group (BIG).
This randomized, double-blind, placebo-controlled, two-arm study will assess the safety and efficacy of pertuzumab in addition to chemotherapy plus trastuzumab as adjuvant therapy in participants with operable HER2-positive primary breast cancer. This study will be carried out in collaboration with the Breast International Group (BIG). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2025
Locations: HonorHealth Research Institute ? Bisgrove, Scottsdale, Arizona +545 locations
HonorHealth Research Institute ? Bisgrove, Scottsdale, Arizona
Providence Regional Medical Center, Everett, California
Marin Cancer Care Inc, Greenbrae, California
Kaiser Permanente - Hayward, Hayward, California
UCSD Moores Cancer Center, La Jolla, California
Cedars-Sinai Medical Center, Los Angeles, California
Kaiser Permanente - Oakland, Oakland, California
Kaiser Permanente - Roseville, Roseville, California
Sutter Cancer Center, Sacramento, California
Kaiser Permanente Sacramento Medical Center, Sacramento, California
Southern California Kaiser Permanente, San Diego, California
K. Permanente - San Fransisco, San Francisco, California
K. Permanente - San Jose, San Jose, California
K. Permanente - Santa Clara, Santa Clara, California
K. Permanente - S. San Fran, South San Francisco, California
Kaiser Permanente, Vallejo, California
K. Permanente - Walnut Creek, Walnut Creek, California
Rocky Mountain Cancer Center - Denver, Denver, Colorado
Lutheran Hematology &Oncology, Wheat Ridge, Colorado
Eastern Ct Hema/Onco Assoc, Norwich, Connecticut
Washington Cancer Institute at MedStar Washington Hospital Center., Washington, District of Columbia
Georgetown U, Washington, District of Columbia
Florida Cancer Specialists, Fort Myers, Florida
Memorial Cancer Institute, Hollywood, Florida
Mayo Clinic-Jacksonville, Jacksonville, Florida
Cancer Specialists, Jacksonville, Florida
Ocala Oncology Center, Ocala, Florida
Memorial Breast Cancer Center, Pembroke Pines, Florida
Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie, Florida
Florida Cancer Specialists, Saint Petersburg, Florida
Florida Cancer Specialists, Research Department, West Palm Beach, Florida
Phoebe Putney Memorial Hospital, Albany, Georgia
Georgia Cancer Specialists, Atlanta, Georgia
Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia
Kootenai Cancer Center, Post Falls, Idaho
Rush University Medical Center, Chicago, Illinois
Uni of Chicago, Chicago, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
Loyola University Med Center, Maywood, Illinois
Edward Cancer Center Naperville, Naperville, Illinois
Illinois Cancer Care, Peoria, Illinois
Edward Cancer Center Plainfield, Plainfield, Illinois
Quincy Medical Group, Quincy, Illinois
Carle Foundation, Urbana, Illinois
University of Iowa, Iowa City, Iowa
Cancer Center of Kansas, Wichita, Kansas
Cancer Center of Acadiana at Lafayette General, Lafayette, Louisiana
Cancer Care of Maine, Bangor, Maine
New England Cancer Specialists, Scarborough, Maine
Mercy Medical Center, Baltimore, Maryland
Weinberg CA Inst Franklin Sq, Baltimore, Maryland
Maryland Oncology & Hematology, PA, Bethesda, Maryland
Massachusetts General Hospital., Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
Beth Israel Deac Med Ctr, Boston, Massachusetts
Dana Farber Can Ins, Boston, Massachusetts
Berkshire Hematology, Oncology Pc, Pittsfield, Massachusetts
Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Southdale Cancer Clinic, Edina, Minnesota
Coborn Cancer Center, Saint Cloud, Minnesota
Metro-Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota
Jackson Oncology Associates, PLLC, Jackson, Mississippi
Washington University School of Medicine, Saint Louis, Missouri
Heartland CCOP/Missouri Baptist Medical Center, Saint Louis, Missouri
Cancer Alliance of Nebraska, Lincoln, Nebraska
Cancer Alliance of Nebraska, Omaha, Nebraska
Dartmouth Hitchcock Med Center, Lebanon, New Hampshire
Saint Barnabas Medical Center, Livingston, New Jersey
New York Oncology Hematology, P.C., Albany, New York
Montefiore Medical Center, Bronx, New York
Roswell Park Cancer Inst., Buffalo, New York
Mount Sinai Beth Israel Medical Center, New York, New York
Mount Sinai Beth Israel Comprehensive Cancer Center, New York, New York
Mount Sinai West, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
SUNY Upstate Medical University, Syracuse, New York
University of North Carolina-Chapel Hill, Chapel Hill, North Carolina
Carolina Oncology Specialists, PA - Hickory, Hickory, North Carolina
Oncology Hematology Care Inc, Cincinnati, Ohio
The Mark H. Zangmeister Ctr, Columbus, Ohio
Dayton Clinical Oncology Prog, Dayton, Ohio
Toledo Clinic Cancer Center, Toledo, Ohio
Northwest Cancer Specialists - Portland (NE Hoyt St), Portland, Oregon
Abramson Cancer Center, Philadelphia, Pennsylvania
Albert Einstein Healthcare Network, Philadelphia, Pennsylvania
Magee Womens Hospital, Pittsburgh, Pennsylvania
Charleston Oncology, P .A, Charleston, South Carolina
Roper Bon Secours St. Francis Cancer Center, Charleston, South Carolina
South Carolina Oncology Associates - SCRI, Columbia, South Carolina
University of Missouri-Columbia, Columbia, South Carolina
Cancer Centers of the Carolina, Greenville, South Carolina
Sanford USD School of Medicine, Sioux Falls, South Dakota
Tennessee Oncology , PLLC - Chattanooga, Chattanooga, Tennessee
Tennessee Oncology - Nashville, Nashville, Tennessee
Vanderbilt Breast Center at One Hundred Oaks, Nashville, Tennessee
Texas Oncology-Medical City Dallas, Dallas, Texas
Texas Oncology - DFW at Dallas Presbyterian Hospital, Dallas, Texas
Texas Oncology - DFW, Dallas, Texas
Texas Oncology-El Paso Cancer Treatment Center Grandview, El Paso, Texas
Texas Oncology - DFW Fort Worth, Fort Worth, Texas
The Center for Cancer and Blood Disorders - Fort Worth, Fort Worth, Texas
Texas Oncology, P.A. - Garland, Garland, Texas
Texas Oncology - Houston (Gessner), Houston, Texas
Cancer Care Centers of South Texas-HOAST - San Antonio, New Braunfels, Texas
Texas Oncology - DFW Plano, Plano, Texas
Texas Oncology-Tyler, Tyler, Texas
Community Cancer Trials of Utah, Ogden, Utah
Wellmonth Physician Services, Bristol, Virginia
Virginia Cancer Institute, Richmond, Virginia
Providence St. Mary Regional Cancer Center, Walla Walla, Washington
West Virginia University Hospitals Inc, Morgantown, West Virginia
Green Bay Oncology/St. Mary?s Hospital, Green Bay, Wisconsin
Marshfield Clinic, Marshfield, Wisconsin
Centro Medico San Roque, San Miguel de Tucuman, Not set
Lismore Base Hospital, Lismore, New South Wales
Mater Misericordiae Hospital, Sydney, New South Wales
Newcastle Mater Misericordiae Hospital, Waratah, New South Wales
Westmead Hospital, Westmead, New South Wales
Wesley Medical Centre, Auchenflower, Queensland
Mater Hospital, Brisbane, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Royal Hobart Hospital, Hobart, Tasmania
Monash Medical Centre, EAST Bentleigh, Victoria
Geelong Hospital, Geelong, Victoria
Austin Hospital, Heidelberg, Victoria
Peter Maccallum Cancer Institute, Melbourne, Victoria
Sir Charles Gairdner Hospital, Perth, Western Australia
Lkh-Univ. Klinikum Graz, Graz, Not set
Tiroler Landeskrankenanstalten Ges.M.B.H., Innsbruck, Not set
Ordensklinikum Linz Barmherzige Schwestern, Linz, Not set
Lhk Feldkirch, Rankweil, Not set
Lkh Salzburg - Univ. Klinikum Salzburg, Salzburg, Not set
A. Ö. Krankenhaus Der Barmherzigen Brüder, St Veit An Der Glan, Not set
Lkh Vöcklabruck, Vöcklabruck, Not set
Klinikum Kreuzschwestern Wels, Wels, Not set
Medizinische Universität Wien; Klinik für Frauenheilkunde, Wien, Not set
Medizinische Universität Wien; Klinik für Innere Medizin; Abteilung für Onkologie, Wien, Not set
Krankenhaus Der Stadt Wien-Hietzing, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
GHdC Site Les Viviers, Charleroi, Not set
UZ Antwerpen, Edegem, Not set
Jessa Zkh (Campus Virga Jesse), Hasselt, Not set
AZ Groeninge, Kortrijk, Not set
UZ Leuven Gasthuisberg, Leuven, Not set
CHU de Liège (Sart Tilman), Liege, Not set
Clinique Ste-Elisabeth, Namur, Not set
Sint Augustinus Wilrijk, Wilrijk, Not set
UMHAT Tsaritsa Yoanna - ISUL, Sofia, Not set
SHATO - Sofia, Sofia, Not set
SHATOD Dr. Marko Antonov Markov-Varna, EOOD, Varna, Not set
Arthur J.E. Child Comprehensive Cancer Center, Calgary, Alberta
Cross Can Inst, Edmonton, Alberta
BC Cancer Agency, CSI, Kelowna, British Columbia
BC Cancer ? Surrey, Surrey, British Columbia
BCCA-Vancouver Cancer Centre, Vancouver, British Columbia
Bcca - Vancouver Island Cancer Centre, Victoria, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia
Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton, Ontario
Cancer Centre of Southeastern Ontario, Kingston, Ontario
London Health Sciences Centre, London, Ontario
Credit Valley Hospital/Carlo Fidani Peel Regional Cancer Centre, Mississauga, Ontario
Southlake Regional Health Center, Newmarket, Ontario
Ottawa Regional Cancer Centre, Ottawa, Ontario
Niagara Health Systems - St. Catherines General Site, St. Catharines, Ontario
Northeastern Ontario, Sudbury, Ontario
Sunnybrook Odette Cancer Centre, Toronto, Ontario
Mount Sinai Hospital, Toronto, Ontario
Princess Margaret Cancer Center, Toronto, Ontario
Hopital Maisonneuve- Rosemont, Montreal, Quebec
Hopital Sacre-Coeur Research Centre, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Hopital du Saint Sacrement, Quebec, Not set
INTOP, Providencia, Not set
Fundacion Arturo Lopez Perez, Santiago, Not set
Cancer Hospital Chinese Academy of Medical Sciences., Beijing, Not set
The Affiliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese PLA), Beijing, Not set
Hu Nan Provincial Cancer Hospital, Chang Sha, Not set
Jilin Cancer Hospital, Changchun, Not set
the First Hospital of Jilin University, Changchun, Not set
Sichuan Provincial People's Hospital, Chengdu, Not set
Fujian Medical University Union Hospital, Fujian, Not set
The 900th Hospital of PLA joint service support force, Fuzhou, Not set
Sun Yet-sen University Cancer Center, Guangzhou, Not set
Guangdong General Hospital, Guangzhou, Not set
The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Not set
Harbin Medical University Cancer Hospital; Dept. of Breast Surgery, Harbin, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
The 1st Affiliated Hospital of Nanchang Unversity, Nanchang, Not set
Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital), Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Shanghai First People's Hospital, Shanghai, Not set
Changhai Hospital of Shanghai, Shanghai, Not set
Hebei Medical University Fourth Hospital, Shijiazhuang, Not set
Xiehe Hospital, Tongji Medical College Huazhong University of Science & Technology, Wuhan, Not set
Tongji Hosp, Tongji Med. Col, Huazhong Univ. of Sci. & Tech, Wuhan, Not set
Hubei Cancer Hospital, Wuhan, Not set
Fundacion Cardioinfantil, Bogota, Not set
Inst. Nacional de Cancerologia, Bogota, Not set
Hospital Pablo Tobon Uribe, Medellin-Antioquia, Not set
Oncomedica S.A., Monteria, Not set
Uni Hospital Split, Split, Not set
General Hospital Varazdin, Varazdin, Not set
Clinical Hospital Centre Zagreb, Zagreb, Not set
Masarykuv onkologicky ustav, Brno, Not set
Fakultni Nemocnice Hradec Kralove, Hradec Kralove, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
MULTISCAN, s.r.o., Radiologicke centrum Pardubice, Pardubice, Not set
Aalborg Universitetshospital, Aalborg, Not set
Sydvestjysk Sygehus Esbjerg, Esbjerg, Not set
Herlev Hospital, Herlev, Not set
Nordsjællands Hospital, Hillerød, Onkologisk Afdeling, Hillerod, Not set
Rigshospitalet, København, Not set
Sjællands Universitetshospital, Næstved, Naestved, Not set
Odense Universitetshospital, Onkologisk Afdeling R, Odense C, Not set
Sygehus Syd Roskilde, Roskilde, Not set
Vejle Sygehus, Vejle, Not set
Hospital Oncologia, El Salvador, Not set
Clinique De L Europe, Amiens, Not set
ICO Paul Papin, Angers, Not set
HOP Prive Arras Les Bonnettes, Arras, Not set
Institut Sainte Catherine, Avignon, Not set
ICONE, Bezannes, Not set
Institut Bergonie, Bordeaux, Not set
Polyclinique Bordeaux Nord, Bordeaux, Not set
Hopital Augustin Morvan, Brest, Not set
Centre Francois Baclesse, Caen, Not set
Centre Jean Perrin, Clermont-ferrand, Not set
Centre Leonard De Vinci, Dechy, Not set
Centre Georges-François Lecler, Dijon, Not set
Institut Daniel Hollard, Grenoble, Not set
Centre Hospitalier Departemental Les Oudairies, La Roche Sur Yon, Not set
Clinique des Ormeaux, Le Havre, Not set
Centre Oscar Lambret, Lille, Not set
Hopital Dupuytren, Limoges, Not set
Centre Leon Berard, Lyon, Not set
Institut Paoli Calmettes, Marseille, Not set
Institut régional du Cancer Montpellier, Montpellier, Not set
Polyclinique De Gentilly, Nancy, Not set
Centre Antoine Lacassagne, Nice, Not set
Institut de cancerologie du Gard, Nimes, Not set
Institut Curie, Paris, Not set
Ch Pitie Salpetriere, Paris, Not set
Polyclinique Francheville, Perigueux, Not set
Clinique Armoricaine Radiologie, Plerin, Not set
Chu De Poitiers, Poitiers, Not set
Institut Jean Godinot, Reims, Not set
Centre Eugene Marquis, Rennes, Not set
Centre Henri Becquerel, Rouen, Not set
ICL, Saint Prient En Jarez, Not set
Centre Rene Huguenin, St Cloud, Not set
Ico Rene Gauducheau, St Herblain, Not set
Institut d'oncologie de l'Orangerie, Strasbourg, Not set
Hopital Hautepierre, Strasbourg, Not set
Institut Claudius Regaud, Toulouse, Not set
Clinique Pasteur, Toulouse, Not set
Centre Alexis Vautrin, Vandoeuvre Les Nancy, Not set
Institut Gustave Roussy, Villejuif, Not set
Gesundheitszentrum St. Marien GmbH, Amberg, Not set
Hochwaldkrankenhaus, Bad Nauheim, Not set
Praxisklinik Krebsheilkunde für Frauen / Brustzentrum (Dres. Kittel/Klare), Berlin-Lichtenberg, Not set
Praxis Dr. Schoenegg, Berlin, Not set
HELIOS Klinikum Berlin-Buch, Berlin, Not set
Frauenarzt-Zentrum Zehlendorf an der Teltower Eiche, Berlin, Not set
Onkologische Schwerpunktpraxis Bielefeld, Bielefeld, Not set
Universitätsklinikum Bonn, Bonn, Not set
Praxis Dr. Ralf Lorenz, Braunschweig, Not set
Hämato-Onkologie im Medicum/Home, Bremen, Not set
Klinikum Sindelfingen-Böblingen, Böblingen, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
DONAU ISAR Klinikum Deggendorf, Deggendorf, Not set
St. Johannes-Hospital, Dortmund, Not set
Universitätsklinikum "Carl Gustav Carus", Dresden, Not set
Universitätsklinikum Düsseldorf, Düsseldorf, Not set
Luisenkrankenhaus GmbH & Co. KG., Brustzentrum, Düsseldorf, Not set
Praxis für Hamatologie und Onkologie, Erfurt, Not set
Universitätsklinikum Erlangen, Erlangen, Not set
Klinikum Esslingen, Esslingen, Not set
Hämatologisch-Onkologische Gemeinschaftspraxis am Bethanien-Krankenhaus, Frankfurt am Main, Not set
Klinik Johann Wolfgang von Goethe Uni, Frankfurt, Not set
Städtische Kliniken Frankfurt am Main Höchst, Frankfurt, Not set
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR, Freiburg, Not set
Dres.Jochen Wilke und Harald Wagner, Fürth, Not set
Universitätsklinikum Greifswald, Greifswald, Not set
Universitätsklinikum Halle (Saale), Halle, Not set
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
SANA Klinikum Hameln-Pyrmont, Hameln, Not set
Diakovere Henriettenstift, Frauenklinik, Hannover, Not set
MVZ Onko Medical GmbH Hannover, Ralf Lohse (Geschäftsführer), Hannover, Not set
Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg, Not set
Praxisgemeinschaft, Hildesheim, Not set
Universitätsklinikum des Saarlandes, Homburg/Saar, Not set
ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG, Karlsruhe, Not set
Elisabeth-Krankenhaus Brustzentrum, Kassel, Not set
Klinikum Kassel GmbH, Kassel, Not set
UNI-Klinikum Campus Kiel Klinik für Gynäkologie und Geburtshilfe, Kiel, Not set
St. Elisabeth Krankenhaus Köln GmbH, Koeln, Not set
Uniklinik Köln, Klinik und Poliklinik und Geburtshilfe, Köln, Not set
Klinikum Landshut Frauenklinik, Landshut, Not set
Sankt Elisabeth Krankenhaus, Leipzig, Not set
Evangelisches Krankenhaus, Ludwigsfelde, Not set
Universitätsklinikum Schleswig-Holstein / Campus Lübeck, Lübeck, Not set
Universitätsmedizin Mainz, Mainz, Not set
Rotkreuzklinikum München, Muenchen, Not set
Brustzentrum Rhein-Ruhr Servicegesellschaft mbH, Mönchengladbach, Not set
Klinikum der Universität München, München, Not set
Klinikum rechts der Isar der TU München, München, Not set
Universitätsklinikum Münster, Münster, Not set
Sana Klinikum Offenbach GmbH, Offenbach, Not set
Medizinisches Versorgungszentrum am Klinikum Oldenburg GmbH, Oldenburg, Not set
Hämatologisch/Onkologische Praxis Prof. Dr. Decker, Studienzentrum, Ravensburg, Not set
Oncologianova GmbH, Recklinghausen, Not set
RoMed Klinikum Rosenheim, Rosenheim, Not set
Universitätsfrauen- und Poliklinik am Klinikum Suedstadt, Rostock, Not set
MVZ für Hämatologie, Onkologie, Strahlentherapie und Palliativmedizin -, Stade, Not set
Klinikum Mutterhaus der Borromaeerinnen gGmbH, Trier, Not set
Universitätsklinik Tübingen, Tübingen, Not set
Universitätsklinikum Ulm Am Michelsberg, Ulm, Not set
Dres. Arnd Nusch Naser Ali-Mohammad Kalhori und Werner Langer, Velbert, Not set
Schwarzwald-Baar Klinikum Klinik für Frauenheilkunde und Geburtshilfe, Villingen-Schwenningen, Not set
St. Josefs-Hospital Wiesbaden, Wiesbaden, Not set
Marien-Hospital Witten, Witten, Not set
Hämatologisch-Onkologische Schwerpunktpraxis Dres. Schlag & Schöttker, Würzburg, Not set
Grupo Angeles, Guatemala City, Not set
Queen Mary Hospital; Dept. of Clinical Oncology, Hong Kong, Not set
Queen Mary Hospital; Surgery, Hong Kong, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Not set
Debreceni Egyetem, Klinikai Kozpont, Onkologiai Klinika, Debrecen, Not set
Petz Aladar Megyei Oktato Korhaz, Gyor, Not set
Békés Megyei Pándy Kálmán Kórház, Gyula, Not set
Bács-Kiskun Vármegyei Oktatókórház, Kecskemet, Not set
Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika, Szeged, Not set
Cork Uni Hospital, Cork, Not set
Mater Misericordiae Uni Hospital, Dublin, Not set
St. James Hospital, Dublin, Not set
Beaumont Hospital, Dublin, Not set
St Vincent'S Uni Hospital, Dublin, Not set
Galway University Hospital, Galway, Not set
University Hospital Limerick - Oncology, Limerick, Not set
Rambam Medical Center, Haifa, Not set
Rabin MC, Petach Tikva, Not set
Chaim Sheba Medical Center, Ramat-Gan, Not set
Kaplan Medical Center, Rehovot, Not set
Sourasky / Ichilov Hospital, Tel Aviv, Not set
Campus Universitario S.Venuta, Catanzaro, Calabria
AORN'S.G.Moscati, Avellino, Campania
IRCCS Istituto Nazionale Tumori Fondazione Pascale, Napoli, Campania
Ist. Uni Federico Ii, Napoli, Campania
Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, Bologna, Emilia-Romagna
Ospedale Ramazzini, Carpi, Emilia-Romagna
Arcispedale Santa Maria Nuova, Reggio Emilia, Emilia-Romagna
Irccs Centro Di Riferimento Oncologico (CRO), Aviano, Friuli-Venezia Giulia
Divisione Onc Med dell'Azienda, Udine, Friuli-Venezia Giulia
Ospedale Belcolle Di Viterbo, Viterbo, Lazio
Ente Ospedaliero Ospedali Galliera, Genova, Liguria
Az. Osp. Uni Ria San Martino, Genova, Liguria
IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST), Genova, Liguria
Asst Degli Spedali Civili Di Brescia, Brescia, Lombardia
Asst Di Lecco, Lecco, Lombardia
Ospedale Mater Salutis, Legnago, Lombardia
Irccs Istituto Europeo Di Oncologia (IEO), Milano, Lombardia
Policlinico di Monza, Monza, Lombardia
IRCCS Fondazione Maugeri, Pavia, Lombardia
IRCCS Istituto Clinico Humanitas, Rozzano, Lombardia
Az. Osp. Di Busto P.O. Di Saronno, Saronno, Lombardia
Ospedale S. Croce Di Fano, Fano, Marche
Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo, Candiolo, Piemonte
Ospedale Antonio Perrino, Brindisi, Puglia
Nuovo Ospedale di Prato S. Stefano - Azienda USL Toscana Centro, Prato, Toscana
Ospedale Di Bolzano, Bolzano, Trentino-Alto Adige
Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia, Perugia, Umbria
Azienda Ospedaliera S. Maria - Terni, Terni, Umbria
Aichi Cancer Center Hospital, Breast Oncology, Aichi, Not set
Chiba Cancer Center, Chiba, Not set
National Cancer Center Hospital East, Chiba, Not set
Natl Hosp Org Shikoku, Ehime, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Gunma University Hospital, Gunma, Not set
Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Not set
Iwate Med Univ School of Med, Iwate, Not set
Sagara Hospital, Kagoshima, Not set
St. Marianna University School of Medicine Hospital, Breast and Endocrine Surgery, Kanagawa, Not set
Tokai University Hospital, Breast Surgery, Kanagawa, Not set
Kumamoto Shinto General Hospital, Kumamoto, Not set
Kyoto University Hospital, Kyoto, Not set
Niigata Cancer Ctr Hospital, Niigata, Not set
National Hospital Organization Osaka National Hospital, Osaka, Not set
Osaka International Cancer Institute, Osaka, Not set
Saitama Medical University International Medical Center, Saitama, Not set
Saitama Cancer Center, Breast Oncology, Saitama, Not set
Shizuoka Cancer Center, Shizuoka, Not set
Shizuoka General Hospital, Shizuoka, Not set
Jichi Medical School, Tochigi, Not set
National Cancer Center Hospital, Tokyo, Not set
Tokyo Metropolitan, Tokyo, Not set
The Cancer Inst. Hosp. of JFCR, Tokyo, Not set
Tokyo Medical Uni. Hospital, Tokyo, Not set
Seoul National University Bundang Hospital, Gyeonggi-do, Not set
Seoul National Uni Hospital, Seoul, Not set
Yonsei University Severance Hospital, Seoul, Not set
Kyunghee University Hospital, Seoul, Not set
Samsung Medical Centre, Seoul, Not set
Korea University Anam Hospital, Seoul, Not set
Centro Estatal de Oncología de Campeche, Campehe, Campeche
Fundacion Rodolfo Padilla Padilla A.C., León, Guanajuato
Núcleo de Especialidades Oncológicas, Guadalajara, Jalisco
Hospital Angeles Metropolitano, Mexico City, Mexico CITY (federal District)
Hospital General de México, Mexico DF, Mexico CITY (federal District)
Centro Universitario Contra El Cancer, Monterrey, Nuevo LEON
Centro de Diagnóstico y Tratamiento Integral de Mama, Hospital San José Tec de Monterrey, Montrrey, Nuevo LEON
Oaxaca Site Management Organization, Oaxaca de Juárez, Oaxaca
Médicos Especialistas en Cáncer SC, Aguascalientes, Not set
Centro Estatal De Cancerologia De Durango, Durango, Not set
Cancerologia de Queretaro, Queretaro, Not set
Medisch Centrum Alkmaar, Alkmaar, Not set
Amphia ziekenhuis, locatie langendijk, Breda, Not set
Reinier de Graaf Gasthuis, Delft, Not set
Academish Ziekenhuis Maastricht (Azm), Maastricht, Not set
Isala Klinieken, Zwolle, Not set
Waikato Hospital, Hamilton, Not set
Palmerston North Hospital, Palmerston North, Not set
The Panama Clinic, Panama City, Not set
Centro Oncologico America, Panama, Not set
Instituto Nacional de Enfermedades Neoplasicas, Lima, Not set
Clinica Anglo Americana - Centro de Investigacion Oncologia CAA, Lima, Not set
Clinica El Golf, San Isidro, Not set
Clinica Peruana Americana, Trujillo, Not set
University Of Santo Tomas, Manila, Not set
Rizal Medical Center, Pasig City, Not set
Veterans Memorial Medical Ctr, Quezon City, Luzon, Not set
Bialostockie Ctr Onkologii, Bialystok, Not set
Centrum Onkologii, Bydgoszcz, Not set
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gda?sk, Not set
Opolskie Centrum Onkologii, Opole, Not set
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad, Warszawa, Not set
NZOZ Mazowiecki Szpital Onkologiczny Uczelni Warszawskiej im. M. Sk?odowskiej-Curie, Wieliszew, Not set
Emergency University Bucharest Hospital, Bucharest, Not set
Prof. Dr. I. Chiricuta Institute of Oncology, Cluj Napoca, Not set
Oncology Inst. Cluj-Napoca, Cluj-napoca, Not set
Euroclinic Center of Oncology SRL, Iasi, Not set
S.I. Russian Oncological Research Center n.a. N.N. Blokhin, Moscow, Moskovskaja Oblast
State Budget Institution of Healthcare of Stavropol region Pyatigorsk Oncology Dispensary, Pyatigorsk, Stavropol
Clinical Oncology Dispensary of Ministry of Health of Tatarstan, Kazan, Tatarstan
SBI of Healthcare Samara Regional Clinical Oncology Dispensary, Samara, Not set
SBI of Healthcare of Stavropol region Stavropol Regional Clinical Oncology Dispensary, Stavropol, Not set
Tula Regional Oncology Dispensary, Tula, Not set
Institute of Oncology Ljubljana, Ljubljana, Not set
National Hospital, Bloemfontein, Not set
Wits Donald Gordon Clinical Trial Centre, Johannesburg, Not set
Steve Biko Academic Hospital, Pretoria, Not set
Hospital General Universitario de Elche, Elche, Alicante
Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona, Barcelona
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
Hospital Universitario Reina Sofia, Córdoba, Cordoba
IInstituto Oncologico de San Sebastian, Oncologikoa, San Sebastian, Guipuzcoa
Hospital de Donostia, San Sebastian, Guipuzcoa
Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares
Hospital Son Llatzer, Palma de Mallorca, Islas Baleares
Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología, La Coruña, LA Coruna
Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, LA Coruna
Hospital Universitari Arnau de Vilanova de Lleida, Lleida, Lerida
Hospital Clinico Universitario Virgen de la Victoria, Málaga, Malaga
Hospital Universitario de Canarias, La Laguna, Tenerife
Hospital del Mar, Barcelona, Not set
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set
Hospital Clínic i Provincial, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Duran i Reynals, Barcelona, Not set
Hospital Universitari Germans Trias i Pujol, Barcelona, Not set
Hospital Provincial de Castellon, Castellon, Not set
Hospital Juan Ramon Jimenez, Huelva, Not set
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico, Jaen, Not set
Centro Oncológico Gallego José Antonio Quiroga y Piñeiro, Servicio de Oncologia, La Coruna, Not set
Centro Oncologico MD Anderson Internacional, Madrid, Not set
Hospital Ramon y Cajal, Madrid, Not set
Hospital Universitario Clínico San Carlos, Madrid, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Centro Integral Oncologico Clara Campal (CIOCC), Madrid, Not set
Hospital General Universitario J.M Morales Meseguer, Murcia, Not set
Hospital Clinico Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Univ. Nuestra Señora de Valme, Sevilla, Not set
Complejo Hospitalario de Toledo- H. Virgen de la Salud, Toledo, Not set
Instituto Valenciano Oncologia, Valencia, Not set
Hospital Clinico Universitario de Valencia, Valencia, Not set
Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia, Valencia, Not set
Hospital Universitario la Fe, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Sahlgrenska Universitetssjukhuset, Goteborg, Not set
Uni Hospital Linkoeping, Linkoeping, Not set
Karolinska University Hospital, Stockholm, Not set
Norrlands Universitetssjukhus, Umeå, Cancercentrum, Umea, Not set
Akademiska sjukhuset, Onkologkliniken, Uppsala, Not set
Universitaetsspital Basel, Basel, Not set
Hôpitaux Universit. de Genève Gynécologique - Oncologie, Genève 14, Not set
Luzerner Kantonsspital, Luzern, Not set
Kantonsspital St. Gallen, St. Gallen, Not set
Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich, Zürich, Not set
Changhua Christian Hospital, Changhua, Not set
Kaohsiung Medical Uni Chung-Ho Hospital, Kaohsiung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung Uni Hospital, Tainan, Not set
Veterans General Hospital, Taipei, Not set
National Taiwan Uni Hospital, Taipei, Not set
Tri-Service General Hospital, Division of General Surgery, Taipei, Not set
Chiang Rai Prachanukraw Hospital, Chiang Rai, Not set
Lopburi Cancer Hospital, Lopburi, Not set
Buddhachinaraj Phitsanulok Hospital, Phitsanulok, Not set
Songklanagarind Hospital, Songkla, Not set
Surat Thani Hospital, Surat Thani, Not set
Cherkassy Regional Oncological Hospital, Cherkassy, Not set
State Medical Academy, Dnipropetrovsk, Not set
Ivano-Frankivsk Regional Oncology Center, Ivano-Frankivsk, Not set
Kyiv City Clinical Oncological Center, Day Hospital Department for Oncological patients, Kiev, Not set
Volyn Regional Oncology Dispensary, Lutsk, Not set
Lvov State Regional Oncology Medical & Diagnostic Center, Lvov, Not set
Ternopil State Medical Academy, Ternopil, Not set
Royal Berkshire Hospital, Berkshire, Not set
Velindre Cancer Centre, Cardiff, Not set
Cheltenham General Hospital, Cheltenham, Not set
Colchester General Hospital, Colchester, Essex, Not set
University Hospital coventry, Coventry, Not set
Western General Hospital, Edinburgh, Not set
Royal Devon & Exeter Hospital, Exeter, Not set
Ipswich Hospital, Ipswich, Not set
St James Uni Hospital, Leeds, Not set
St. Bartholomew'S Hospital, London, Not set
UCL Hospital NHS Trust, London, Not set
Royal Marsden Hospital, London, Not set
Christie Hospital, Manchester, Not set
Mount Vernon Hospital, Northwood, Not set
Nottingham City Hospital, Nottingham, Not set
Churchill Hospital, Oxford, Not set
Peterborough City Hospital, Edith Cavell Campus, Peterborough, Not set
Queen Alexandra Hospital, Portsmouth, Not set
Royal Preston Hosp, Preston, Not set
Weston Park Hospital, Sheffield, Not set
Uni Hospital of North Staffordshire, Stoke-on-Trent, Not set
Royal Marsden Hosp NHS Fnd, Sutton, Not set
Royal Cornwall Hospital, Truro, Not set
The Clatterbridge Cancer Ctr For Oncolgy, Wirral, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Breast Cancer
Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors
Active Not Recruiting
This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumors.
This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumors. Read Less
Gender:
ALL
Ages:
10 years and above
Trial Updated:
07/10/2025
Locations: City of Hope National Medical Center, Duarte, California +37 locations
City of Hope National Medical Center, Duarte, California
Stanford Hospital and Clinics, Stanford, California
Sarah Cannon Research Institute, Denver, Colorado
Mayo Clinic Jacksonville, Jacksonville, Florida
University of Chicago, Chicago, Illinois
University of Iowa College of Medicine, Iowa City, Iowa
Dana Farber Cancer Institute, Boston, Massachusetts
Massachusetts General Hospital, Boston, Massachusetts
University of Michigan Medical Center, Ann Arbor, Michigan
Minnesota Oncology Hematology, Minneapolis, Minnesota
Mayo Clinic Rochester, Rochester, Minnesota
Washington University, Saint Louis, Missouri
Memorial Sloan Kettering cancer center, New York, New York
Duke University Medical Center, Durham, North Carolina
Ohio State University-Columbus, Columbus, Ohio
Oregon Health and Science University, Portland, Oregon
University of Pittsburgh, Hillman Cancer Centre, Pittsburgh, Pennsylvania
Sarah Cannon Research Institute, Nashville, Tennessee
University Of Texas Southwestern Medical Center, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
University of Utah, Salt Lake City, Utah
Virginia Commonwealth University, Richmond, Virginia
Fred Hutchinson Cancer Research, Seattle, Washington
Froedtert Hospital, Milwaukee, Wisconsin
Princess Margaret Cancer Centre, Toronto, Ontario
CIUSSS de L'Est-De-Lile-De-Montreal, Montreal, Quebec
Centre Léon Bérard, Lyon cedex 08, Not set
CHU de Bordeaux GH Sud Hôpital Haut Lévêque, Pessac cedex, Not set
Fondazione IRCCS Instituto Nazionale Dei Tumori, Milano, Lombardia
Ircss Istituto Clinico Humanitas, Rozzano (MI), Lombardia
The Netherlands Cancer Institute, Amsterdam, Not set
Hospital Santa Creu Y Sant Pau, Barcelona, Not set
Ico Duran y Reynals l'Hospitalet de Llobrega, Hospitalet de Llobregat, Barcelona, Not set
Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Hospital Virgen Del Rocio, Sevilla, Not set
Royal Marsden Hospital, London, Not set
University College Hospital-London, London, Not set
Christie Hospital NHS Foundation Trust, Manchester, Not set
Conditions: Neoplasms
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
Active Not Recruiting
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in the treatment of adults who have high-risk early-stage estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer.
The primary study hypotheses are: 1) pembrolizumab is superior to placebo, both in combination with the protocol-specified neo... Read More
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in the treatment of adults who have high-risk early-stage estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer.
The primary study hypotheses are: 1) pembrolizumab is superior to placebo, both in combination with the protocol-specified neoadjuvant anticancer therapy, as assessed by pathological Complete Response (pCR) rate defined by the local pathologist, and 2) pembrolizumab is superior to placebo (both in combination with the protocol-specified neoadjuvant and adjuvant anticancer therapies) as assessed by Event-Free Survival (EFS) as determined by the investigator. The study is considered to have met its primary objective if pembrolizumab is superior to placebo with respect to either pCR (ypT0/Tis ypN0) or EFS. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2025
Locations: Southern Cancer Center, PC ( Site 8003), Daphne, Alabama +243 locations
Southern Cancer Center, PC ( Site 8003), Daphne, Alabama
Cancer Treatment Centers of America at Western Regional Medical Center ( Site 0001), Goodyear, Arizona
Arizona Oncology Associates PC- HOPE ( Site 8008), Tucson, Arizona
Cedars Sinai Medical Center Samuel Oschin Comp. Cancer Institute ( Site 0079), Los Angeles, California
El Camino Hospital Cancer Center ( Site 0004), Mountain View, California
Stanford Cancer Center ( Site 0072), Palo Alto, California
UC Davis Comprehensive Cancer Center ( Site 0073), Sacramento, California
University of Colorado, Anschutz Cancer Pavilion ( Site 0008), Aurora, Colorado
Baptist MD Anderson Cancer Center ( Site 0014), Jacksonville, Florida
Southeastern Regional Medical Center, Inc. ( Site 0075), Newnan, Georgia
The University of Chicago Medical Center ( Site 0080), Chicago, Illinois
Orchard Healthcare Research Inc. ( Site 0020), Skokie, Illinois
Midwestern Regional Medical Center, Inc. ( Site 0077), Zion, Illinois
Goshen Center for Cancer Care ( Site 0021), Goshen, Indiana
MercyOne Waterloo Cancer Center ( Site 0016), Waterloo, Iowa
James Graham Brown Cancer Center ( Site 0022), Louisville, Kentucky
Maryland Oncology Hematology, P.A. ( Site 8007), Bethesda, Maryland
Massachusetts General Hospital ( Site 0024), Boston, Massachusetts
MGH - North Shore Cancer Center ( Site 0081), Danvers, Massachusetts
MGH Newton-Wellesley Hospital's Vernon Cancer Center ( Site 0082), Newton, Massachusetts
Henry Ford Health System ( Site 0028), Detroit, Michigan
Mayo Clinic and Medical School (Rochester) ( Site 0029), Rochester, Minnesota
St. Vincent Frontier Cancer Center ( Site 0033), Billings, Montana
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0039), Omaha, Nebraska
Holy Name Medical Center ( Site 0041), Teaneck, New Jersey
Weill Cornell Medical College ( Site 0043), New York, New York
CTCA Southwestern ( Site 0074), Tulsa, Oklahoma
OHSU Knight Cancer Institute ( Site 0051), Portland, Oregon
Northwest Cancer Specialists, P.C. ( Site 8000), Tigard, Oregon
Geisinger Medical Center ( Site 0052), Danville, Pennsylvania
Fox Chase Cancer Center ( Site 0078), Philadelphia, Pennsylvania
Cancer Treatment Centers of America-Eastern Regional Medical Center ( Site 0076), Philadelphia, Pennsylvania
Medical University of South Carolina ( Site 0053), Charleston, South Carolina
Tennessee Oncology, PLLC/The Sarah Cannon Research Institute ( Site 7000), Nashville, Tennessee
Texas Oncology-Austin Central ( Site 8004), Austin, Texas
Texas Oncology-Dallas Presbyterian Hospital ( Site 8002), Dallas, Texas
Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 8009), Dallas, Texas
Texas Oncology-Memorial City ( Site 8012), Houston, Texas
University of Texas-MD Anderson Cancer Center ( Site 0083), Houston, Texas
Texas Oncology- Plano East ( Site 8010), Plano, Texas
Texas Oncology - Northeast Texas ( Site 8006), Tyler, Texas
Bon Secours St. Francis Medical Center Oncology Research ( Site 0064), Midlothian, Virginia
Virginia Oncology Associates ( Site 8001), Norfolk, Virginia
Kadlec Clinic Hematology and Oncology ( Site 0070), Kennewick, Washington
Medical Oncology Associates (Summit Cancer Centers) ( Site 0066), Spokane, Washington
Chris OBrien Lifehouse ( Site 2107), Camperdown, New South Wales
Royal North Shore Hospital ( Site 2100), Sydney, New South Wales
Westmead Hospital ( Site 2101), Sydney, New South Wales
Mater Misericordiae Ltd ( Site 2106), South Brisbane, Queensland
Frankston Hospital ( Site 2103), Frankston, Victoria
Peter MacCallum Cancer Centre ( Site 2102), Melbourne, Victoria
Imelda Ziekenhuis Bonheiden ( Site 0703), Bonheiden, Antwerpen
UZ Antwerpen - Medical Oncology ( Site 0709), Edegem, Antwerpen
Institut Jules Bordet ( Site 0710), Anderlecht, Bruxelles-Capitale, Region De
Cliniques Universitaires Saint-Luc ( Site 0701), Brussels, Bruxelles-Capitale, Region De
CHC MontLegia ( Site 0707), Liège, Liege
Jessa Ziekenhuis Campus Virga Jesse ( Site 0704), Hasselt, Limburg
CHU UCL Namur Site de Godinne ( Site 0706), Yvoir, Namur
AZ Maria Middelares Gent ( Site 0700), Gent, Oost-Vlaanderen
UZ Leuven ( Site 0702), Leuven, Vlaams-Brabant
AZ Groeninge ( Site 0705), Kortrijk, West-Vlaanderen
Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 0205), Goiania, Goias
ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 0206), Ijui, Rio Grande Do Sul
Associacao Hospitalar Moinhos de Vento ( Site 0201), Porto Alegre, Rio Grande Do Sul
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0202), Porto Alegre, Rio Grande Do Sul
CEPON - Centro de Pesquisas Oncologicas ( Site 0208), Florianopolis, Santa Catarina
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0207), Itajai, Santa Catarina
Instituto Nacional de Câncer - INCA-Pesquisa Clinica HC3 ( Site 0200), Rio de Janeiro, Not set
Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 0204), Sao Paulo, Not set
Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 0210), Sao Paulo, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0209), Sao Paulo, Not set
Cross Cancer Institute ( Site 0115), Edmonton, Alberta
BC Cancer-Vancouver Center ( Site 0116), Vancouver, British Columbia
Princess Margaret Cancer Centre ( Site 0112), Toronto, Ontario
CISSS de la Monteregie-Centre ( Site 0108), Greenfield Park, Quebec
Hopital Maisonneuve-Rosemont CIUSSS de l Est de L Ile de Montreal ( Site 0111), Montreal, Quebec
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0114), Montreal, Quebec
Jewish General Hospital ( Site 0103), Montreal, Quebec
Centre Hospitalier Regional de Trois-Rivieres ( Site 0106), Trois-Rivières, Quebec
CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0101), Quebec, Not set
Anhui Provincial Hospital ( Site 3224), Heifei, Anhui
Ruijin Hosp,Shanghai Jiao Tong University School of Medicine ( Site 3215), Shanghai, Anhui
Cancer Hospital Chinese Academy of Medical Sciences ( Site 3208), Beijing, Beijing
Fujian Medical University Union Hospital-1 Bingfanglou-Oncology ( Site 3207), Fuzhou Fujian, Fujian
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ( Site 3213), Guangzhou, Guangdong
Fourth Hospital Of Hebei Medical University ( Site 3216), Shijia Zhuang, Hebei
Harbin Medical University Cancer Hospital ( Site 3200), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 3212), Zhengzhou, Henan
Hubei Cancer Hospital ( Site 3211), Wuhan, Hubei
Hunan Cancer Hospital ( Site 3214), Changsha, Hunan
The First Affiliated Hospital of Zhejiang University ( Site 3203), Hangzhou, Jiangsu
The First Hospital of Jilin University ( Site 3201), Changchun, Jilin
Fudan University Shanghai Cancer Center ( Site 3205), Shanghai, Shanghai
The First Affiliated Hospital of Xi an Jiaotong University ( Site 3220), XI An, Shanxi
Tianjin Medical University Cancer Institute & Hospital ( Site 3209), Tianjin, Tianjin
The Affiliated Cancer Hospital of Xinjiang Medical ( Site 3219), Urumqi, Xinjiang
Zhejiang Provincial People's Hospital ( Site 3225), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 3210), Hangzhou, Zhejiang
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0405), Medellin, Antioquia
Rodrigo Botero SAS ( Site 0407), Medellin, Antioquia
Clinica de la Costa S.A.S. ( Site 0400), Barranquilla, Atlantico
IMAT S.A.S ( Site 0401), Monteria, Cordoba
Centro de Investigacion Clinica del Country ( Site 0402), Bogota, Distrito Capital De Bogota
Fundacion Universitaria Sanitas ( Site 0403), Bogota, Distrito Capital De Bogota
Clínica Imbanaco S.A.S ( Site 0406), Cali, Valle Del Cauca
Hospital Metropolitano - Sede Lindora ( Site 4203), Santa Ana, San Jose
Centre Francois Baclesse ( Site 0927), Caen, Calvados
Centre Georges Francois Leclerc ( Site 0920), Dijon, Cote-d Or
Institut Claudius Regaud IUCT Oncopole ( Site 0903), Toulouse, Haute-Garonne
Institut Curie - Centre Rene Huguenin ( Site 0917), Saint-Cloud, Hauts-de-Seine
Centre de Cancerologie du Grand Montpellier ( Site 0925), Montpellier, Herault
CHR-METZ-THIONVILLE - Hopital de Mercy ( Site 0919), Metz, Moselle
Centre Oscar Lambret ( Site 0911), Lille, Nord-Pas-de-Calais
Institut Sainte Catherine ( Site 0916), Avignon, Provence-Alpes-Cote-d Azur
Centre Jean Perrin ( Site 0909), Clermont Ferrand Cedex, Puy-de-Dome
Clinique Victor Hugo Le Mans ( Site 0906), Le Mans, Sarthe
Institut Gustave Roussy ( Site 0926), Villejuif, Val-de-Marne
Institut Curie ( Site 0900), Paris, Not set
Hopital Saint-Louis ( Site 0908), Paris, Not set
Hopital Tenon ( Site 0914), Paris, Not set
Medizinische Management GmbH ( Site 1012), Friedrichshafen, Baden-Wurttemberg
Universitaetsklinikum Erlangen ( Site 1001), Erlangen, Bayern
Klinikum der Universitaet Muenchen - Grosshadern ( Site 1000), Muenchen, Bayern
Sana Klinikum Offenbach GmbH ( Site 1002), Offenbach, Hessen
HELIOS Dr. Horst Schmidt Kliniken Wiesbaden ( Site 1004), Wiesbaden, Hessen
MVZ Onko Medical GmbH Hannover ( Site 1013), Hannover, Niedersachsen
Gynaekologisches Zentrum ( Site 1003), Bonn, Nordrhein-Westfalen
Kliniken Essen Mitte Gmbh Evang. Huyssens Stiftung ( Site 1006), Essen, Nordrhein-Westfalen
Frauenklinik St. Louise ( Site 1014), Paderborn., Nordrhein-Westfalen
Caritas Klinikum Saarbruecken St. Theresia ( Site 1009), Saarbruecken, Saarland
Universitaetsklinikum Carl Gustav Carus ( Site 1008), Dresden, Sachsen
MVZ Nordhausen gGmbH - Praxis Dr. Grafe ( Site 1005), Nordhausen, Thuringen
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 2913), Kecskemét, Bacs-Kiskun
Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 2905), Pecs, Baranya
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi OktatoKorhaz ( Site 2904), Miskolc, Borsod-Abauj-Zemplen
Budapesti Szent Margit Korhaz ( Site 2901), Budapest, Not set
Orszagos Onkologiai Intezet ( Site 2908), Budapest, Not set
Budapesti Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 2902), Budapest, Not set
Debreceni Egyetem Klinikai Kozpont ( Site 2907), Debrecen, Not set
Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 2915), Kaposvar, Not set
Bon Secours Hospital ( Site 1554), Cork, Not set
St. James s Hospital ( Site 1553), Dublin, Not set
HaEmek Medical Center ( Site 1712), Afula, Not set
Assuta Ashdod Public ( Site 1704), Ashdod, Not set
Soroka Medical Center ( Site 1701), Beer Sheva, Not set
Rambam Health Care Campus-Oncology Division ( Site 1705), Haifa, Not set
Shaare Zedek Medical Center ( Site 1708), Jerusalem, Not set
Hadassah Ein Karem - Sharett Institute of Oncology ( Site 1700), Jerusalem, Not set
Meir Medical Center ( Site 1710), Kfar-Saba, Not set
Holy Family Hospital ( Site 1711), Nazareth, Not set
Rabin Medical Center ( Site 1702), Petah Tikva, Not set
Chaim Sheba Medical Center. ( Site 1707), Ramat Gan, Not set
Kaplan Medical Center ( Site 1703), Rehovot, Not set
Sourasky Medical Center ( Site 1706), Tel Aviv, Not set
Assuta Medical Center ( Site 1709), Tel Aviv, Not set
Aichi Cancer Center ( Site 2601), Nagoya, Aichi
National Cancer Center Hospital East ( Site 2613), Kashiwa, Chiba
National Hospital Organization Hokkaido Cancer Center ( Site 2607), Sapporo, Hokkaido
Hyogo Medical University Hospital ( Site 2600), Nishinomiya, Hyogo
Kitasato University Hospital ( Site 2616), Sagamihara, Kanagawa
Kumamoto University Hospital ( Site 2602), Kumamoto-shi, Kumamoto
Saitama Medical University International Medical Center ( Site 2606), Hidaka, Saitama
Saitama Prefectural Cancer Center ( Site 2612), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 2611), Suntogun, Shizuoka
Chiba Cancer Center ( Site 2605), Chiba, Not set
Fukushima Medical University Hospital ( Site 2610), Fukushima, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 2603), Hiroshima, Not set
National Hospital Organization Osaka National Hospital ( Site 2614), Osaka, Not set
Toranomon Hospital ( Site 2608), Tokyo, Not set
Cancer Institute Hospital of JFCR ( Site 2604), Tokyo, Not set
Showa Medical University Hospital ( Site 2615), Tokyo, Not set
National Cancer Center ( Site 2204), Goyang-si, Kyonggi-do
Seoul National University Hospital ( Site 2200), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 2201), Seoul, Not set
Asan Medical Center ( Site 2202), Seoul, Not set
Samsung Medical Center ( Site 2203), Seoul, Not set
Tauranga Hospital ( Site 2302), Tauranga, Bay Of Plenty
Canterbury Regional Cancer & Blood Services ( Site 2303), Christchurch, Canterbury
Capital & Coast District Health Board - Wellington Hospital ( Site 2301), Wellington, Not set
Dolnoslaskie Centrum Onkologii. ( Site 1820), Wrocław, Dolnoslaskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1800), Bydgoszcz, Kujawsko-pomorskie
Instytut Centrum Zdrowia Matki Polki ( Site 1821), Lodz, Lodzkie
Mazowiecki Szpital Specjalistyczny im. dr Jozefa Psarskiego ( Site 1814), Ostroleka, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 1899), Warszawa, Mazowieckie
Mazowiecki Szpital Onkologiczny ( Site 1803), Wieliszew, Mazowieckie
Bialostockie Centrum Onkologii ( Site 1819), Bialystok, Podlaskie
Wojewodzkie Centrum Onkologii Copernicus ( Site 1817), Gdansk, Pomorskie
Szpitale Pomorskie Sp. z o.o. ( Site 1818), Gdynia, Pomorskie
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1810), Bielsko-Biala, Slaskie
Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu ( Site 1807), Bytom, Slaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1801), Gliwice, Slaskie
Fundacao Champalimaud ( Site 2500), Lisboa, Aveiro
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2501), Lisboa, Not set
Unidade Local de Saude de Santo António - Hospital Santo António ( Site 2503), Porto, Not set
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 2502), Porto, Not set
UPR Comprehensive Cancer Center ( Site 6200), San Juan, Not set
Arkhangelsk Clinical Oncological Dispensary ( Site 1901), Arkhangelsk, Arkhangel Skaya Oblast
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1909), Ufa, Baskortostan, Respublika
N.N. Blokhin NMRCO ( Site 1908), Moscow, Moskva
Central Clinical Hospital with outpatient Clinic ( Site 1907), Moscow, Moskva
Medical Rehabilitation Center ( Site 1912), Moscow, Moskva
Ryazan Regional Clinical Oncology Dispensary ( Site 1910), Ryazan, Ryazanskaya Oblast
Railway Hospital of OJSC ( Site 1913), Saint Petersburg, Sankt-Peterburg
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1900), Saint Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 1903), Kazan, Tatarstan, Respublika
Tomsk Scientific Research Institute of Oncology ( Site 1905), Tomsk, Tomskaya Oblast
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 1363), Hospitalet de Llobregat, Barcelona
Hospital Teresa Herrera - Chuac ( Site 1358), A Coruna, La Coruna
Hospital General Universitario Gregorio Maranon ( Site 1367), Madrid, Madrid, Comunidad De
Hospital Quiron de Madrid ( Site 1351), Pozuelo de Alarcon, Madrid
Hospital Clinico Universitario de Valencia ( Site 1355), Valencia, Valenciana, Comunitat
Instituto Oncologico Baselga.Hospital Quiron. ( Site 1352), Barcelona, Not set
Hospital Vall D Hebron ( Site 1357), Barcelona, Not set
Hospital Clinic I Provincial de Barcelona ( Site 1353), Barcelona, Not set
Complejo Hospitalario de Jaen ( Site 1364), Jaen, Not set
Hospital Beata María Ana-oncology ( Site 1370), Madrid, Not set
Hospital Clinico San Carlos ( Site 1354), Madrid, Not set
Hospital Universitario 12 de Octubre ( Site 1356), Madrid, Not set
Hospital Universitario Virgen del Rocio ( Site 1360), Sevilla, Not set
Hospital General Arnau de Vilanova de Valencia ( Site 1369), Valencia, Not set
China Medical University Hospital ( Site 2401), Taichung, Not set
National Cheng Kung University Hospital ( Site 2400), Tainan, Not set
National Taiwan University Hospital ( Site 2404), Taipei, Not set
Koo Foundation Sun Yat-Sen Cancer Center ( Site 2403), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 2402), Taoyuan, Not set
MNPE City Clinical Hospital #4 of Dnipro Regional Council ( Site 2702), Dnipro, Dnipropetrovska Oblast
MI Kryviy Rih Center of Dnipropetrovsk Regional Council ( Site 2700), Kryviy Rih, Dnipropetrovska Oblast
MI Precarpathian Clinical Oncology Center ( Site 2707), Ivano-Frankivsk, Ivano-Frankivska Oblast
Communal non profit enterprise Regional Clinical Oncology Center ( Site 2721), Kharkiv, Kharkivska Oblast
Communal nonprofit enterprise "Kherson Regional Oncology Dispensary" of Kherson Regional Council ( Site 2713), Antonivka Village, Khersonska Oblast
Khmelnitskiy Regional Onkology Dispensary ( Site 2704), Khmelnitskiy, Khmelnytska Oblast
SNPE National Cancer Institute ( Site 2719), Kyiv, Kyivska Oblast
MI Odesa Regional Clinical Hospital ( Site 2701), Odesa, Odeska Oblast
MI Odessa Regional Oncological Centre ( Site 2714), Odesa, Odeska Oblast
Medical center of the Limited Liability Company Yulis ( Site 2720), Zaporizhzhia, Zaporizka Oblast
Kyiv City Clinical Oncology Centre ( Site 2716), Kyiv, Not set
University Hospitals Bristol NHS Foundation Trust ( Site 1503), Bristol, Bristol, City Of
Nottingham University Hospitals NHS Trust ( Site 1504), Nottingham, England
Colchester General Hospital ( Site 1508), Colchester, Essex
Barts Health NHS Trust ( Site 1500), London, London, City Of
Guy's Hospital ( Site 1501), London, London, City Of
St. Georges University Hospital NHS Foundation Trust ( Site 1505), London, London, City Of
Birmingham & Solihull Heartlands Hospital NHS ( Site 1506), Solihull, Not set
Royal Cornwall Hospital ( Site 1502), Truro, Not set
Conditions: Breast Cancer
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
Recruiting
This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma.
This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
21 years and below
Trial Updated:
06/25/2025
Locations: Sydney children Hospital, Sydney, Randwick +141 locations
Sydney children Hospital, Sydney, Randwick
Children's Cancer Centre, Monash Children's Hospital, Clayton, Not set
Oncology/Haematology Department, Perth Children's Hospital, Nedlands, Not set
Children's Cancer & Haematology Services, John Hunter Children's Hospital, New Lambton Heights, Not set
Australian and New Zealand Children's Hematology/oncology Group, Sydney, Not set
sydney children Hospital, Sydney, Not set
Cancer Centre for Children, The Children's Hospital, Westmead, Not set
Medical University Graz, Graz, Not set
Landeskrankenhaus-Universitätsklinikum Innsbruck, Innsbruck, Not set
Kepler Universitatsklinikum Linz, Linz, Not set
Universitastsklinikum Salzburg, Salzburg, Not set
St Anna'S Children Hospital, Vienna, Not set
Hôpital Universitaire des Enfants Reine Fabiola (ULB), Brussels, Not set
Cliniques Universitaires Saint-Luc (UCL), Brussel, Not set
University Hospital Gent, Gent, Not set
University Hospitals Leuven, Leuven, Not set
CHR Citadelle, Liège, Not set
University Hospital Motol, Prague,, Prague
Klinika dětské onkologie FN Brno, Brno, Not set
Aarhus University Hospital, Aarhus, Not set
Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Not set
The Hans Christian Andersen Children's Hospital, University of Southern Denmark, Odense, Not set
New Children's Hospital, Helsinki University Hospital, Helsinki and Uusimaa Hospital District, Helsinki, Not set
Kuopio University Hospital, Kuopio, Not set
Oulu University Hospital, Oulu, Not set
Tampere University Hospital, Tampere, Not set
Turku University Hospital, Turku, Not set
Gustave Roussy, Villejuif, Val De Marne
CHU d'AMIENS, Amiens, Not set
CHU angers, Angers, Not set
CHU-Pôle Médico-Chirurgical de l'Enfant et l'Adolescant, Besançon, Not set
CHU Bordeaux, Bordeaux, Not set
Groupe Hospitalier Pellegrin - Chu - Bordeaux, Bordeaux, Not set
CHU Brest, Brest, Not set
CHU Brest - Hôpital du Morvan, Brest, Not set
Centre François Baclesse, Caen, Not set
CHU de Caen, Caen, Not set
CHU Estaing, Clermont-Ferrand, Not set
Centre Georges-François Leclerc, Dijon, Not set
Hopital d'enfants Marechal de lattre, Dijon, Not set
Hôpital Couple-Enfant CHU de Grenoble, Grenoble, Not set
Chu de La Reunion - St Denis, La Réunion, Not set
centre Oscar lambert, Lille, Not set
Hôpital de la Mère et de l'Enfant - CHU Limoges, Limoges, Not set
Centre Léon Berard, Lyon, Not set
hopital la Timone, Marseille, Not set
CHRU Nancy-Hôpital Brabois Enfant, Nancy, Not set
Institut de cancérologie de Loraine, Nancy, Not set
Centre Antoine Lacassagne, Nice, Not set
CHU Nice-Hôpital d'Archet, Nice, Not set
Hôpital Armand Trousseau, Paris, Not set
institut Curie, Paris, Not set
CHU Poitiers, Poitiers, Not set
Hôpital Américain -CHU Reims, Reims, Not set
Centre Eugène Marquis, Rennes, Not set
CHU Rennes, Rennes, Not set
Hôpital des Enfants - CHU Rouen, Rouen, Not set
Institut de cancérologie de l'Ouest - Sité René Gauducheau, Saint-Herblain, Not set
CHU Saint Etienne, Saint-Étienne, Not set
CHU Haute Pierre, Strasbourg, Not set
Institut de Cancérologie Strasbourg, Strasbourg, Not set
Hopital des enfants-CHU Toulouse, Toulouse, Not set
IUCT Oncopole, Toulouse, Not set
CHU Tours Hôpital Clocheville, Tours, Not set
charite universitatsmedizin Berlin, Berlin, Not set
Uniklinik Köln, Klinik und Poliklinik für Kinder und Jugendmedizin, Köln, Not set
Children's General Hospital "I AGHIA SOFIA", Athens, Not set
Children's General Hospital "P. & A. KYRIAKOU", Athens, Not set
"MITERA" Private, General, Obstetrics - Gynaecology, Paediatric Clinic S.A., Athens, Not set
Children's General Hospital "AGHIA SOFIA", Athens, Not set
University General Hospital of Heraklion (UnGHH), Heraklion, Not set
University General Hospital of Thessaloniki "AHEPA", Thessaloniki, Not set
General Hospital of Thessaloniki "IPPOKRATIO", Thessaloniki, Not set
RAMBAM Medical Center, Haifa, Not set
A.O.U Policlinico di Bari, Bari, Not set
Spedali civili Ospedale Dei Bambini Oncoematologia pediatrica e TMO, Brescia, Not set
policlinico rodolico San marco, Catania, Not set
Azienda ospedaliero universtaria Anna Meyer, Firenze, Not set
instituto Giannina Gaslini genova, Genova, Not set
IRCCS "Istituto Giannina Gaslini", Genova, Not set
Azienda Policlinico di Modena, Modena, Not set
Azienda ospedaliero universitaria di Parma, Parma, Not set
Policlino San matteo di Pavia, Pavia, Not set
U.O Pediatria, SS Oncoematologia pediatrica, Rimini, Not set
IRCCS Burlo Garoflo oncoematologia, Trieste, Not set
U.O.C oncoematologia pediatrica ospedale Donna Bambino, Verona, Not set
Vilnius University Hospital Santaros Klinikos, Vilnius, Not set
National Cancer Institute, Vilnius, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Princess Maxima center, Utrecht, Not set
Haukeland University Hospital, Haukeland, Not set
Oslo University Hospital, Oslo, Not set
University Hospital Northern Norway, Tromsoe, Tromsø, Not set
St Olavs Hospital,, Trondheim, Not set
Children's University Hospital Banská Bystrica, Banská Bystrica, Not set
NÚDCH- National Institute of Children's Diseases,, Bratislava, Not set
Children's University Hospital Košice, Košice, Not set
University medical center Ljubljana, University Children's Hospital Ljubljana, Slovenia, Ljubljana, Not set
Hospital Universitario Son Espases, Balea, Not set
Hospital Universitario Vall D´Hebron, Barcelona, Not set
Hospital Universitario Cruces, Cruces, Not set
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Not set
Hospital Universitario Infantil Niño Jesús, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Regional Universitario de Málaga, Málaga, Not set
Hospital Universitario Donostia, San Sebastián, Not set
Hospital Clínico Universitario de Santiago, Santiago De Compostela, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Hospital Universitario Politécnico de La FE, Valence, Not set
Sahlgrenska University Hospital, Gothenburg, Not set
Linköping University Hospital, Linköping, Not set
Skåne University Hospital, Lund, Not set
Karolinska University Hospital, Stockholm, Stockholm, Not set
Norrland University Hospital, Umeå, Not set
Uppsala University Hospital, Uppsala, Not set
Kantonsspital Aarau AG Klinik für Kinder und Jugendliche, Aarau, Not set
Universitäts-Kinderspital beider Basel (UKBB), Basel, Not set
Ospedale San Giovanni Pediatria, Emato-oncologia pediatrica, Bellinzona, Not set
Inselspital, Universitätsklinik für Kinderheilkunde, Bern, Not set
HUG Hôpitaux Universitaires de Genève Unité d'Hémato-Oncologie Pédiatrique, Geneva, Not set
CHUV - Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Luzerner Kantonsspital, Kinderspital pädiatrische Hämatologie/Onkologie, Lucerne, Not set
Ostschweizer Kinderspital Hämatologie/Onkologie Claudiusstrasse 6, Saint Gallen, Not set
Division of Pediatric Oncology Universitäts-Kinderspital Zürich, Zürich, Not set
Royal Aberdeen Children's Hospital, Aberdeen, Not set
Royal Belfast Hospital for Sick Children, Belfast, Not set
Birmingham children's Hospital, Birmingham, Not set
University Hospitals Birmingham Queen Elisabeth Hospital(UHB), Birmingham, Not set
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Not set
Addenbrookes Hospital, Cambridge, Cambridge, Not set
Noah's Ark Children's Hospital for Wales - Cardiff, Cardiff, Not set
Royal Hospital for Sick Children - Edinburgh, Edinburgh, Not set
Royal Hospital for Children Glasgow, Glasgow, Not set
Leeds General Infirmary, Leeds, Not set
Alder Hey Children's Hospital - Liverpool, Liverpool, Not set
Great Ormond Street Hospital - London, London, Not set
Royal Manchester Children's Hospital, Manchester, Not set
Royal Victoria Infirmary, Newcastle, Newcastle, Not set
Nottingham Children's Hospital, Nottingham, Not set
Sheffield Children's Hospital, Sheffield, Not set
Southampton General Hospital, Southampton, Not set
Royal Marsden Hospital, Sutton, Not set
Conditions: High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma
Active Not Recruiting
This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plus R-CHP versus R-CHOP in participants with previously untreated diffuse large B-cell lymphoma (DLBCL).
This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plus R-CHP versus R-CHOP in participants with previously untreated diffuse large B-cell lymphoma (DLBCL). Read Less
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/24/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +215 locations
University of Alabama at Birmingham, Birmingham, Alabama
Southern Cancer Center, Daphne, Alabama
City of Hope, Duarte, California
Ronald Reagan UCLA Medical Center, Los Angeles, California
Rocky Mountain Cancer Centers, LLP, Aurora, Colorado
Georgetown University Medical Center, Washington, District of Columbia
Florida Cancer Specialists - Fort Myers (New Hampshire Ct), Fort Myers, Florida
Florida Cancer Specialists & Research Institute, Saint Petersburg, Florida
Florida Cancer Specialists, West Palm Beach, Florida
Emory University, Atlanta, Georgia
Illinois Cancer Specialists, Arlington Heights, Illinois
University of Louisville Hospital, Louisville, Kentucky
Ochsner Medical Center, New Orleans, Louisiana
University of Maryland, Baltimore, Maryland
Johns Hopkins University, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Dana Farber Cancer Institute, Boston, Massachusetts
University of Michigan Health System, Ann Arbor, Michigan
Karmanos Cancer Center, Detroit, Michigan
Washington University, Saint Louis, Missouri
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Cancer Center - Commack, Commack, New York
Memorial Sloan Kettering Cancer Center at Westchester, Harrison, New York
New York University Cancer Cen, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester Medical Center, Rochester, New York
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Levine Cancer Institute - Clincal Trials Administration, Charlotte, North Carolina
Oncology/Hematology Care Clinical Trials LLC, Cincinnati, Ohio
University Hospitals Case Medical Center, Cleveland, Ohio
Ohio State University, Columbus, Ohio
Oncology Associates of Oregon, P.C, Eugene, Oregon
Northwest Cancer Specialists - Portland (SW Barnes Rd), Portland, Oregon
Oregon HSU, Portland, Oregon
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania
Medical University of South Carolina Hospital, Charleston, South Carolina
Prisma Health ? Upstate, Greenville, South Carolina
Greco-Hainesworth Centers for Research, Chattanooga, Tennessee
Tennessee Oncology - Nashville, Nashville, Tennessee
Texas Oncology-Austin Midtown, Austin, Texas
Texas Oncology San Antonio Medical Center, San Antonio, Texas
Texas Oncology-Tyler, Tyler, Texas
University of Utah, Salt Lake City, Utah
Oncology Associates of Southwest Virginia, Inc., Blacksburg, Virginia
Virginia Cancer Specialists, PC, Fairfax, Virginia
Seattle Cancer Care Alliance, Seattle, Washington
West Virginia Uni Med. Center - Robert Byrd Health Science, Morgantown, West Virginia
Concord Repatriation General Hospital, Concord, New South Wales
St George Hospital, Kigarah, New South Wales
Prince of Wales Hospital, Randwick, New South Wales
Calvary Mater Newcastle, Waratah, New South Wales
Westmead Hospital, Westmead, New South Wales
Princess Alexandra Hospital Woolloongabba, Woolloongabba, Queensland
Ashford Cancer Center Research, Kurralta Park, South Australia
The University of Adelaide - The Queen Elizabeth Hospital (TQEH), Woodville South, South Australia
Monash Medical Centre, Clayton, Victoria
Austin Hospital, Heidelberg, Victoria
Paracelsus Medizinischen Privatuniversitaet-Salzburger Landeskliniken (SALK), Salzburg, Not set
Medizinische Universität Wien, Wien, Not set
Wiener Gesundheitsverbund ? Klinik Ottakring, Wien, Not set
UZ Gent, Gent, Not set
CH Jolimont - Lobbes (Jolimont), Haine-Saint-Paul, Not set
CHU UCL Mont-Godinne, Mont-godinne, Not set
Hospital Erasto Gaertner, Curitiba, Paraná
Hospital das Clinicas - UFRGS, Porto Alegre, Rio Grande Do Sul
Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP, Campinas, São Paulo
Hospital das Clinicas - FMUSP, Sao Paulo, São Paulo
University of Alberta Hospital, Edmonton, Alberta
BC Cancer ? Vancouver, Vancouver, British Columbia
CancerCare Manitoba (CCMB), Winnipeg, Manitoba
The Ottawa Hospital, Ottawa, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont, Montreal, Quebec
CHU de Quebec-Universite Laval, Quebec, Not set
Beijing Cancer Hospital, Beijing, Not set
The First Hospital of Jilin University, Changchun City, Not set
Fujian Provincial Cancer Hospital, Fuzhou City, Not set
Sun Yet-sen University Cancer Center, Guangzhou, Not set
The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Not set
Jiangsu Cancer Hospital, Nanjing, Not set
Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai City, Not set
Shanghai East Hospital, Tongji University, Shanghai City, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences, Tianjin City, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjing, Not set
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan City, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Fakultni Nemocnice Hradec Kralove (FNHK), Hradec Kralove, Not set
Fakultni nemocnice Olomouc, Olomouc, Not set
Fakultni nemocnice Ostrava, Ostrava - Poruba, Not set
Fakultni Nemocnice Kralovske Vinohrady (FNKV), Prague, Not set
Univerzita Karlova v Praze 1. Lekarska Fakulta, Prague, Not set
CHU Amiens - Hopital Sud, Amiens, Not set
CHU Angers, Angers, Not set
Centre Hospitalier de La Cote Basque, Bayonne, Not set
Hopital Jean Minjoz, Besancon, Not set
Institut Bergonie, Bordeaux, Not set
Institut d'Hématologie de Basse Normandie, Caen, Not set
CH Metropole de Savoie, CHAMBERY Cedex, Not set
Hopital Henri Mondor, Creteil, Not set
CHU de Dijon - Hopital le Bocage, Dijon, Not set
L'Union Mutualiste de la Gestion des Eaux Claires - Institut Daniel Hollard, Grenoble, Not set
CHD Vendée, La Roche Sur Yon, Not set
Hôpital Albert Michallon, La Tronche, Not set
Clinique Victor Hugo - Centre Jean Bernard, Le Mans Cedex 02, Not set
Hôpital Saint Vincent de Paul, Lille, Not set
Hopital Claude Huriez, Lille, Not set
Hopital Uni Ire Dupuytren, Limoges, Not set
Centre Leon Berard, Lyon, Not set
CHU Montpellier - Saint ELOI, Montpellier, Not set
CHU de Nantes - Hotel Dieu, Nantes, Not set
Centre Antoine Lacassagne, Nice, Not set
CHU de Nîmes - Hôpital Carémeau, Nimes, Not set
Hôpital Saint-Louis, Paris, Not set
Gh Necker Enfants Malades, Paris, Not set
Hopital Saint Jean, Perpignan, Not set
Hopital Haut-Leveque - Centre Francois Magendie, Pessac, Not set
CHU Lyon Sud - Service Hématologie, Pierre Benite, Not set
CHU de Poitiers, Poitiers, Not set
Centre Hospitalier de Quimper Cornouaille (CHIC), Quimper Cedex, Not set
Hopital Pontchaillou, Rennes, Not set
Centre Henri Becquerel, Rouen, Not set
Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll, St Brieuc, Not set
Pôle de Cancérologie ? CHU de Saint?Etienne', St Priest en Jarez, Not set
Chru de Strasbourg, Strasbourg, Not set
Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O), Toulouse, Not set
CHU Bretonneau, Tours, Not set
CHU de Brabois, Vandoeuvre Les Nancy, Not set
CH Bretagne Atlantique, Vannes Cedex, Not set
Institut Gustave Roussy, Villejuif, Not set
Vivantes Klinikum Am Urban, Berlin, Not set
Städtisches Klinikum Dessau, Dessau-Roßlau, Not set
Universitätsklinikum Essen, Essen, Not set
Universitaetsklinikum Halle (Saale), Halle, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
InVO - Institut für Versorgungsforschung in der Onkologie GbR, Koblenz, Not set
Universitatsklinikum Munster, Münster, Not set
Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Abruzzo
Universita degli Studi Di Brescia - Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Abruzzo
Universita degli Studi di Roma ''La Sapienza" - Clinica Ematologica, Rome, Abruzzo
AUSL di Reggio Emilia, IRCCS, P.O. Arcispedale Santa Maria Nuova, Reggio Emilia, Emilia-Romagna
IRCCS AOU San Martino - IST, Genova, Liguria
Istituto Nazionale dei Tumori, Monza, Lombardia
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara, Novara, Piemonte
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino, Torino, Piemonte
Aichi Cancer Center, Aichi, Not set
Chiba Cancer Center, Chiba, Not set
National Cancer Center Hospital East, Chiba, Not set
Chiba University Hospital, Chuo-ku, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Hiroshima University Hospital, Hiroshima, Not set
Hokkaido University Hospital, Hokkaido, Not set
Kobe City Medical Center General Hospital, Hyogo, Not set
Tokai University Hospital, Isehara-shi, Not set
Kumamoto University Hospital, Kumamoto, Not set
University Hospital Kyoto Prefectural University of Medicine, Kyoto, Not set
Tohoku University Hospital, Miyagi, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
The University of Osaka Hospital, Osaka, Not set
Kindai University Hospital, Osaka, Not set
Jichi Medical University Hospital, Tochigi, Not set
National Cancer Center Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Pusan National University Hospital, Busan, Not set
National Cancer Center, Gyeonggi-do, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Pusan National University Yangsan Hospital, Yangsan, Not set
Auckland City Hospital, Cancer and Blood Research, Auckland, Not set
Canterbury Health Laboratories, Christchurch, Not set
Waikato Hospital, Hamilton, Not set
Wojewódzki Szpital Specjalistyczny im. M. Kopernika, ?ód?, Not set
Samodzielny Publiczny Zak?ad Opieki Zdrowotnej Zespó? Szpitali Miejskich w Chorzowie, Chorzów, Not set
PRATIA MCM Kraków, Kraków, Not set
SPZOZ Ministerstwa Spraw Wewn?trznych i Administracji w Poznaniu, Pozna?, Not set
Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy, Warszawa, Not set
Leningrad Regional Clinical Hospital, St Petersburg, Sankt Petersburg
Complejo Hospitalario de Navarra, Pamplona, Navarra
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Institut Catala d Oncologia Hospitalet, Barcelona, Not set
Hospital San Pedro de Alcantara, Caceres, Not set
Hospital Universitari Dr. Josep Trueta, Girona, Not set
Hospital Universitario La Paz, Madrid, Not set
Fundación Jimenez Díaz, Madrid, Not set
Hospital Quiron Madrid, Madrid, Not set
Hospital Universitario Virgen de la Victoria, Malaga, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Universitätsspital Basel Gynäkologie - Onkologie, Basel, Not set
Kaohsiung Medical University Hospital, Cancer Center, Kaohsiung, Not set
China Medical University Hospital, Taichung, Not set
Chi-Mei Hospital, Liouying, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Ankara University Faculty of Medicine Cebeci Hospital, Ankara, Not set
Ege Üniversitesi Tip Fakültesi, Lzmir, Not set
Dokuz Eylul Universitesi Tip Fakultesi, Lzmir, Not set
Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council, Cherkassy, Chernihiv Governorate
MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care, Lviv, Chernihiv Governorate
Khmelnytskyi Regional Hospital, Khmelnytskyi, Kharkiv Governorate
Feofaniya Center of Haematology and Chemotherapy of Haemoblastosis, Kyiv, Volhynian Governorate
Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital, Cambridge, Not set
East Kent Hospitals University NHS Foundation Trust, Canterbury, Not set
University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary, Leicester, Not set
Barts Health NHS Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Newcastle upon Tyne Hospitals NHS Foundation Trust. Freeman Hospital, Newcastle upon Tyne, Not set
Nottingham City Hospital, Nottingham, Not set
Oxford University Hospitals NHS Foundation Trust, Oxford, Not set
Conditions: Diffuse Large B-Cell Lymphoma
Rescue of Nephrons With ALE.F02 (RENAL-F02)
Recruiting
The goal of this clinical trial is to learn if a new drug that might help protect and preserve kidney function in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). AAV is a type of autoimmune disease where the body's own immune system attacks itself, and in the case of AAV the body attacks its own small blood vessels. There are many small blood vessels in the kidneys meaning the kidneys are commonly affected in AAV.
The main questions it aims to answer are:
* Is the new d... Read More
The goal of this clinical trial is to learn if a new drug that might help protect and preserve kidney function in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). AAV is a type of autoimmune disease where the body's own immune system attacks itself, and in the case of AAV the body attacks its own small blood vessels. There are many small blood vessels in the kidneys meaning the kidneys are commonly affected in AAV.
The main questions it aims to answer are:
* Is the new drug well tolerated and safe?
* Can the new drug protect and preserve kidney functions when is added to standard therapy?
Researchers will compare the following groups to see how the new drug is tolerated and what effect to preserve kidney tissue has:
* Group A: Standard treatment + ALE.F02 low dose infusions
* Group B: Standard treatment + ALE.F02 high dose infusions
* Group C: Standard treatment + ALE.F02 maximum dose infusions
* Group D: Standard treatment + placebo infusions (inactive substance)
The Treatment period will consist of 24 weeks beginning on Day 1, during which time participants will receive 13 infusions of the study medicine, along with standard therapy for kidney inflammation due to AAV. During the treatment period, participants will have the following assessments:
* A brief physical examination focusing on their skin any pre-existing medical conditions that you have.
* Collection of blood and urine samples for routine safety tests and to assess renal function.
* Collection of blood samples:
* To measure the amount of study medicine in their blood. This is called pharmacokinetics (PK) and it is tested to see how study medicine enters, moves through, and exits the body.
* To test for antidrug antibodies (ADA). To check if their body create antibodies against the study medicine, as this could reduce its effect.
* To measure biomarkers. Biomarkers are specific compounds in the body (can be protein, hormones, or genetic molecules) that indicate normal or abnormal processes taking place in your body and may be a sign of an underlying condition or disease (for example glucose levels are used as biomarker in managing diabetes). They are used to see how well the body responds to a treatment for a disease or condition.
* Collection of urine to measure urine markers of vasculitis/inflammation called biomarkers.
* Urine pregnancy test. A urine pregnancy test is a quick medical test that can tell if a woman is pregnant or not by checking for a hormone which is produced during pregnancy, usually in the urine.
* Chest High Resolution Computed Tomography (HRCT) scan to check whether they have vasculitis affecting their lungs. A CT scan uses special x-ray equipment to take detailed pictures of body tissues and organs to diagnose and monitor conditions in various parts of the body. For the CT scan, they will need to lie still on a table. At Week 24 a second lung CT scan will be performed for participants whose initial scan showed lung vasculitis to see whether your lung vasculitis is getting better or ongoing/worse. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: Vseobecna fakultni nemocnice v Praze, Prague, Not set +47 locations
Vseobecna fakultni nemocnice v Praze, Prague, Not set
Institut klinicke a experimentalni mediciny, Praha 4, Not set
Aalborg University Hospital, Aalborg, Not set
Aarhus University Hospital, Aarhus, Not set
Rigshospitalet, København, Not set
Odense University Hospital, Odense, Not set
Centre Hospitalier Boulogne sur Mer, Boulogne-sur-Mer, Cedex
CHU Bordeaux - Hopital Pellegrin, Bordeaux, Not set
CHRU de Brest - Hopital de la Cavale Blanche, Brest, Not set
CHU Grenoble-Alpes - Hopital Michallon, La Tronche, Not set
CHU de Nantes - Hotel-Dieu, Nantes, Not set
CHU de Nimes, Nîmes, Not set
AP-HP Hopital Pitie-Salpetriere, Paris, Not set
AP-HP Hopital Cochin, Paris, Not set
CHU de Toulouse - Hopital Rangueil, Toulouse, Not set
Centre Hospitalier de Valenciennes, Valenciennes, Not set
Charite Universitaetsmedizin Berlin, Berlin, Not set
Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Not set
Universitaetsklinikum Essen, Essen, Not set
Medizinische Hochschule Hannover (MHH), Hanover, Not set
Universitaetsklinikum Koeln (AoeR), Koeln, Not set
Universitaetsklinikum Leipzig, Leipzig, Not set
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck, Luebeck, Not set
Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Not set
Azienda Ospedaliero-Universitaria Careggi, Firenze, Not set
IRCCS Ospedale San Raffaele, Milano, Not set
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Rome, Not set
APSS Ospedale Santa Chiara di Trento, Trento, Not set
Fundacio Puigvert, Barcelona, Not set
Hospital Universitari de Bellvitge, Barcelona, Not set
Hospital Universitari Arnau de Vilanova, Lleida, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Regional Universitario de Malaga, Malaga, Not set
Linkoping University Hospital, Linköping, Not set
University Hospital of Umea, Umeå, Not set
Kantonsspital Baden AG, Baden, Not set
Inselspital, Universitaetsspital Bern, Bern, Not set
Kantonsspital St. Gallen, Saint Gallen, Not set
Hôpital Fribourgeois-Freiburger Spital, Villars-sur-Glâne, Not set
Ankara Etlik City Hospital, Ankara, Keçiören
Marmara University Medical Faculty Hospital, Istanbul, Not set
Kocaeli University Medical School - Internal Medicine - Nephrology, Kocaeli, Not set
Erciyes University Faculty of Medicine, Melikgazi, Not set
Queen Elizabeth Hospital Birmingham, Birmingham, Not set
Cambridge University - Addenbrooke's Hospital, Cambridge, Not set
Royal Liverpool University Hospital, Liverpool, Not set
Imperial College Healthcare NHS Trust, London, Not set
Royal Preston Hospital, Preston, Not set
Conditions: Glomerulonephritis Rapidly Progressive
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
Active Not Recruiting
This study will evaluate the efficacy and safety of multiple biomarker-selected treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. Enrollment will take place in two phases: a preliminary phase followed by a potential expansion phase.
This study will evaluate the efficacy and safety of multiple biomarker-selected treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. Enrollment will take place in two phases: a preliminary phase followed by a potential expansion phase. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: UCSF Helen Diller Family CCC, San Francisco, California +38 locations
UCSF Helen Diller Family CCC, San Francisco, California
Washington University School of Medicine, Saint Louis, Missouri
Levine Cancer Institute, Charlotte, North Carolina
Ohio State University, Columbus, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Texas Oncology - Gulf Coast, The Woodlands, Texas
Virginia Oncology Associates, Norfolk, Virginia
University of Washington - Seattle Cancer Care Alliance, Seattle, Washington
Cabrini Hospital, Malvern, Victoria
Princess Margaret Cancer Center, Toronto, Ontario
McGill University Health Centre - Glen Site, Montreal, Quebec
Gynekologicko-porodnicka klinika, Prague, Not set
CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, Not set
Centre Francois Baclesse, Caen, Not set
Centre Leon Berard, Lyon, Not set
Groupe Hospitalier Diaconesses, Paris, Not set
Centre Eugène Marquis, Rennes, Not set
Institut Claudius Regaud, Toulouse, Not set
Gustave Roussy, Villejuif CEDEX, Not set
Kliniken Essen-Mitte Evang. Huyssens-Stiftung, Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Not set
Universitätsklinikum Mannheim, Mannheim, Not set
Istituto Tumori Napoli, Napoli, Campania
Policlinico Universitario Agostino Gemelli, Roma, Lazio
IRCCS S. Raffaele, Milano, Lombardia
A.O. U. Consorziale Policlinico di Bari, Bari, Puglia
Samsung Medical Center, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Institutio Catalan De Oncologia, Barcelona, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Clinico Universitario Virgen de la Victoria, Malaga, Not set
Hôpitaux Universitaires de Genève, Genève, Not set
Adana Baskent University Medical Faculty; Oncology, Adana, Not set
Baskent Universitesi Ankara Hastanesi; Tıbbi Onkoloji Bölümü, Ankara, Not set
Koc University Medical Faculty; Department of Gynecology & Obstetrics, Istanbul, Not set
Western General Hospital, Edinburgh, Not set
University College London Hospitals NHS Foundation Trust - University College Hospital, London, Not set
Conditions: Ovarian Cancer
NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922)
Active Not Recruiting
Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in combination with chemotherapy in patients with relapsed/refractory neuroblastoma. The dose escalation phase of this study (Cohort A1) uses a traditional Phase I 3+3 design. Once a recommended phase 2 pediatric dose is identified, an expansion cohort of 6 patients (Cohort B1), within which ALKi naïve p... Read More
Lorlatinib is a novel inhibitor across ALK variants, including those resistant to crizotinib. In this first pediatric phase 1 trial of lorlatinib, the drug will be utilized as a single agent and in combination with chemotherapy in patients with relapsed/refractory neuroblastoma. The dose escalation phase of this study (Cohort A1) uses a traditional Phase I 3+3 design. Once a recommended phase 2 pediatric dose is identified, an expansion cohort of 6 patients (Cohort B1), within which ALKi naïve patients will be prioritized, will be initiated. Parallel cohorts will be initiated in adults or patients with large BSA (Cohort A2) and in combination with chemotherapy upon establishing RP2D (Cohort B2). Read Less
Gender:
ALL
Ages:
Between 1 year and 99 years
Trial Updated:
05/30/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +12 locations
Children's Hospital Los Angeles, Los Angeles, California
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California
Children Hospital of Colorado, Aurora, Colorado
Children's Healthcare of Atlanta, Atlanta, Georgia
University of Chicago, Comer Children's Hospital, Chicago, Illinois
Childrens Hospital Boston, Dana-Farber Cancer Institute., Boston, Massachusetts
C.S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Cook Children's Healthcare System, Fort Worth, Texas
Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington
Hospital for Sick Children, Toronto, Ontario
Institut Curie, Paris, Cedex
Royal Marsden Hospital, Sutton, Surrey
Conditions: Neuroblastoma
A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma
Recruiting
The purpose of this study is to compare the efficacy of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in newly diagnosed multiple myeloma patients.
The purpose of this study is to compare the efficacy of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in newly diagnosed multiple myeloma patients. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/26/2025
Locations: University of Arkansas, Little Rock, Arkansas +108 locations
University of Arkansas, Little Rock, Arkansas
City of Hope, Duarte, California
UC San Diego Health Moores Cancer Center, San Diego, California
University of California San Francisco (UCSF), San Francisco, California
Stanford University, Stanford, California
Moffitt Cancer Center, Tampa, Florida
Emory University Hospital, Atlanta, Georgia
University of Chicago, Chicago, Illinois
University of Iowa, Iowa City, Iowa
University Of Maryland Medical Center, Baltimore, Maryland
Massachusetts General Hospital, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Karmanos Cancer Center, Detroit, Michigan
Mayo Clinic Hospital - Rochester, Rochester, Minnesota
Montefiore M-E Center, Bronx, New York
Mount Sinai Medical Venter, New York, New York
Memorial Sloan-Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Cleveland Clinic, Cleveland, Ohio
The Ohio State University, Columbus, Ohio
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
University of Texas Southwestern Medical Center, Dallas, Texas
University of Virginia, Charlottesville, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Medical College Wisconsin, Milwaukee, Wisconsin
Princess Alexandra Hospital, Brisbane, Not set
Royal Prince Alfred Hospital, Camperdown, Not set
Royal Brisbane and Womens Hospital, Herston, Not set
Alfred Health, Melbourne, Not set
Austin Hospital, Melbourne, Not set
Peter MacCallum Cancer Centre, Melbourne, Not set
Fiona Stanley Hospital, Murdoch, Not set
Calvary Mater Newcastle Hospital, Waratah, Not set
Westmead Hospital, Westmead, Not set
Jules Bordet Instituut, Anderlecht, Not set
UZA, Antwerpen, Not set
UZ Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Cross Cancer Institute, Edmonton, Not set
McMaster University, Hamilton, Not set
Hopital Maisonneuve-Rosemont, Montréal, Not set
Mcgill University Health Centre, Montréal, Not set
Ottawa Hospital Research Institute, Ottawa, Not set
(CHU) Centre Hospitalier Universitaire de Quebec Laval, Québec, Not set
Princess Margaret Cancer Centre, Toronto, Not set
Vancouver General Hospital, Vancouver, Not set
Fakultni nemocnice Brno, Brno, Not set
Fakultni nemocnice Hradec Kralove, Králová, Not set
Fakutni nemocnice Ostrava, Ostrava, Not set
Fakultni nemocnice Plzen, Plzen, Not set
Vseobecna fakultni nemocnice v Prague, Prague, Not set
CHRU de Lille - Hopital Claude Huriez, Lille, Not set
Hospices Civils De Lyon, Lyon, Not set
CHU De Nantes - Hématologie Clinique, Nantes, Not set
CHU Poitiers - Pôle régional de Cancérologie, Poitiers, Not set
Hopital Saint Louis - Aphp Hôpitaux Universitaires Saint-Louis, Saint-Louis, Not set
CHU de Toulouse, Toulouse, Not set
University Hospital of Cologne, Cologne, Not set
Universitätsklinikum Hamburg - Eppendorf, Hamburg, Not set
University Hospital of Leipzig, Leipzig, Not set
Tübingen, Tübingen, Not set
University Hospital of Würzburg, Würzburg, Not set
Attikon University General Hospital of Attica, Athens, Not set
'G. Papanikolaou' Hospital of Thessaloniki, Thessaloníki, Not set
Hadassah Medical Center, Jerusalem, Not set
Sheba medical center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
Juntendo University Hospital, Bunkyō-Ku, Not set
Kyushu University Hospital - Hematology/Oncology, Fukuoka, Not set
Hokkaido University Hospital-Department of Hematology, Hokkaido, Not set
Hyogo College of Medicine, Hyōgo, Not set
Kanazawa University Hospital, Kanazawa, Not set
Nagoya City University Hospital - Department of Hematology & Oncology, Nagoya, Not set
Okayama University Hospital - Hematology/Oncology, Okayama, Not set
Osaka metropolitan university hospital, Osaka, Not set
Japanese Red Cross Medical Center - Hematology, Shibuya, Not set
Keio University Hospital - Hematology, Shinjuku-Ku, Not set
Tohoku University Hospital - Hematology, Tōhoku, Not set
VU Medisch Centrum, Amsterdam, Not set
University Medical Center Groningen, Groningen, Not set
Radboud UMC, Nijmegen, Not set
Erasmus MC, Rotterdam, Not set
UMC Utrecht, Utrecht, Not set
Oslo University Hospital Ullevål - Oncology, Oslo, Not set
Hospital Universitario Germans Trias i Pujol, Badalona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Instituto Catalán de Oncología, Barcelona, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
CLINICA UNIV. DE NAVARRA, Pamplona, Pamplona, Not set
Hospital Universitario de Salamanca, Salamanca, Not set
Hospital de Santiago de Compostela, Santiago De Compostela, Not set
Hospital Universitario Virgen del Rocío, Sevilla, Not set
Hospital Universitario la Fe, Valencia, Valencia, Not set
Sahlgrenska Universitetssjukhuset, Göteborg, Not set
Landstinget i Ostergotland-Universitetssjukhuset i Linkoping, Linköping, Not set
Skånes University Hospital Lund, Lund, Not set
Akademiska Sjukhuset, Uppsala, Not set
Universitaetsspital Basel - Zentrum fur Hamato-Onkologie, Basel, Not set
Universitaetsspital Bern, Inselspital, Bern, Not set
Centre Hospitalier Universitaire Vaudois (CHUV)Département d'oncologie, Lausanne, Not set
Universitaetsspital Zuerich -Universitaeren Herzzentrum Zuerich, Zürich, Not set
Queen Elizabeth Medical Centre, Birmingham, Not set
University Hospital of Wales, Cardiff, Not set
Conditions: Multiple Myeloma
Study of KITE-363 or KITE-753 in Participants With Relapsed and/or Refractory B-cell Lymphoma
Recruiting
The goal of this clinical study is to learn more about the safety and dosing of the study drugs, KITE-363 and KITE-753, in participants with relapsed and/or refractory B-cell lymphoma.
The goal of this clinical study is to learn more about the safety and dosing of the study drugs, KITE-363 and KITE-753, in participants with relapsed and/or refractory B-cell lymphoma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +13 locations
Banner MD Anderson Cancer Center, Gilbert, Arizona
Stanford Cancer Institute, Stanford, California
Northside Hospital, Atlanta, Georgia
University of MD, Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Hackensack University Medical Center, Hackensack, New Jersey
Columbia University Irving Medical Center, New York, New York
University of Rochester Medical Center, Rochester, New York
The Ohio State University Wexner Medical Center - James Cancer Hospital, Columbus, Ohio
The University of Texas, MD Anderson Cancer Center, Houston, Texas
Virginia Oncology Associates, Norfolk, Virginia
Royal North Shore Hospital, St Leonards, New South Wales
Universitatsklinikum Wurzburg, Wuerzburg, Not set
Academisch Medisch Centrum, Amsterdam, Not set
King's College Hospital, London, Not set
Conditions: Relapsed and/or Refractory B-cell Lymphoma
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