There are currently 334 clinical trials in Norfolk, Virginia looking for participants to engage in research studies. Trials are conducted at various facilities, including Children's Hospital of The King's Daughters, Sentara Norfolk General Hospital, Virginia Oncology Associates and Eastern Virginia Medical School. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
All
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Digestive & Liver Disease Specialists, Norfolk, Virginia
Conditions: NASH - Nonalcoholic Steatohepatitis
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Decellularized Femoral Artery Allograft (Nexeon AVX) Prospective Registry
NCT05880537
Recruiting
Post market registry to assess the safety and efficacy of a novel decellularized human femoral artery allograft (Nexeon AVX Decellularized Femoral Artery,
Gender:
All
Ages:
18 years and above
Trial Updated:
01/23/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: End-Stage Renal Disease
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Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
NCT06100952
Recruiting
A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
Gender:
All
Ages:
Between 8 years and 45 years
Trial Updated:
01/23/2024
Locations: Virginia Eye Consultants, Norfolk, Virginia
Conditions: Keratoconus
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Cephea Early Feasibility Study
NCT05061004
Recruiting
The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral stenosis and mixed mitral valve disease) in whom transcatheter therapy is deemed more appropriate than open heart surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Mitral Regurgitation
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Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation
NCT04203316
Recruiting
This trial studies the side effects of enasidenib and to see how well it works in treating patients with acute myeloid leukemia that has come back after treatment (relapsed) or has been difficult to treat with chemotherapy (refractory). Patients must also have a specific genetic change, also called a mutation, in a protein called IDH2. Enasidenib may stop the growth of cancer cells by blocking the mutated IDH2 protein, which is needed for cell growth.
Gender:
All
Ages:
Between 24 months and 21 years
Trial Updated:
01/19/2024
Locations: Children's Hospital of The King's Daughters, Norfolk, Virginia
Conditions: Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
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Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms
NCT03728985
Recruiting
Prospective, non-randomized, , multicenter study with two independent arms: Primary Study Arm - TAAA and Pararenal aneurysms requiring only TAMBE System. Hypothesis-driven analysis. Up to 65 additional subjects may be implanted in Continued Access Phase under the Primary Study Arm only Secondary Study Arm - TAAA requiring TAMBE System and CTAG Device(s). Non hypothesis-driven analysis. Minimum: 122 implanted subjects. Maximum: 202 implanted subjects with up to 65 additional subjects implanted... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
01/18/2024
Locations: Sentara Medical Group, Norfolk, Virginia
Conditions: Thoracoabdominal Aortic Aneurysm
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A Study Assessing Corneal Endothelial Cells in Patients With Neovascular Age-related Macular Degeneration Treated With the Port Delivery System With Ranibizumab (PDS)
NCT04853251
Recruiting
This study will assess corneal endothelial cells in patients with neovascular age-related macular degeneration (nAMD) treated with Port Delivery System with ranibizumab (PDS) refilled every 24 weeks (Q24W)
Gender:
All
Ages:
50 years and above
Trial Updated:
01/16/2024
Locations: Wagner Kapoor Institute, Norfolk, Virginia
Conditions: Neovascular Age-related Macular Degeneration
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TRISCEND II Pivotal Trial
NCT04482062
Recruiting
Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid valve replacement system
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
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Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
NCT05102019
Recruiting
To demonstrate the safety and effectiveness of the Reducer system for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myocardial ischemia in the distribution of the left coronary artery and who are deemed unsuitable for revascularization. A non-randomized single-arm will further assess the safety and effectiveness of the Neovasc Reducer System in selected subjects with rever... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Refractory Angina
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MitraClip REPAIR MR Study
NCT04198870
Recruiting
The objective of this randomized controlled trial (RCT) is to compare the clinical outcome of MitraClip™ device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/14/2023
Locations: Sentara Norfolk General Hospital, Norfolk, Virginia
Conditions: Mitral Valve Regurgitation
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Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert
NCT06087913
Recruiting
MATRIX-001 will examine the safety, PK, modeled PD, and acceptability of inserts containing the combination of TAF and EVG applied vaginally, daily for 3 days, then every other day for 14 days. The inserts are ultimately intended to be the basis of an event-driven, on-demand method for prevention of HIV and HSV sexual infection.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
12/12/2023
Locations: Eastern Virginia Medical School Clinical Research Clinic (EVMS CRC), Norfolk, Virginia
Conditions: Safety Issues
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Use of Harmonic Scalpel to Decrease Lymphatic and Chest Tube Drainage After Lymph Node Dissection With Lobectomy.
NCT00591552
Recruiting
In an effort to elucidate whether the Harmonic Scalpel will improve sealing lymphatics and decrease lymphatic drainage thereby decreasing the length of time that chest tubes are required and minimizing length of stay; the Harmonic Scalpel will be compared to a control group which uses electrocautery. This study will assess these two different methods to determine if there is a notable decrease in the amount of drainage with one versus the other.
Gender:
All
Ages:
Between 20 years and 75 years
Trial Updated:
11/20/2023
Locations: Sentara Norfolk General Hospital/Sentara Heart Hospital, Norfolk, Virginia
Conditions: Lung Cancer
Register for Updates