There are currently 543 clinical trials in Madison, Wisconsin looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Wisconsin, University of Wisconsin Hospital and Clinics, University of Wisconsin-Madison and University of Wisconsin Carbone Cancer Center - University Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Ribociclib and Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer
NCT05467891
Recruiting
This is an open label, multicenter, single arm phase II study to evaluate the efficacy and safety of ribociclib and ET in patients with locoregional recurrence of HR-positive, HER2-negative breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Locoregional Recurrence, Hormone Receptor-positive Breast Cancer, HER2-negative Breast Cancer
Register for Updates
SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma
NCT05568680
Recruiting
This first-in-human (FIH) trial is designed to assess the safety, feasibility, and potential activity of a single intravenous (IV) dose of SynKIR-110 administered to subjects with mesothelin-expressing advanced ovarian cancer, mesothelioma, and cholangiocarcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Ovarian Cancer, Cholangiocarcinoma Recurrent, Mesothelioma, Malignant
Register for Updates
Neuroplasticity Biomarkers in Aphasia
NCT06471127
Recruiting
Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate... Read More
Gender:
ALL
Ages:
Between 40 years and 90 years
Trial Updated:
03/19/2025
Locations: UW School of Medicine and Public Health, Madison, Wisconsin
Conditions: Aphasia, Language, Stroke
Register for Updates
Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain
NCT06848348
Recruiting
A randomized study to determine safety and efficacy of single subcutaneous (SC) administration of HAL treatment in patients with CINP.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: SSM Health Dean Medical Group, Madison, Wisconsin
Conditions: Chemotherapy Induced Neuropathic Pain
Register for Updates
PET/CT Characterization of Treatment Resistance
NCT05647564
Recruiting
This study will use different types of medical imaging to assess how lesions from advanced prostate cancer become resistant to second-generation AR-targeted therapy, and how the different types of imaging compare in that assessment. Participants in this study have advanced prostate cancer and are either scheduled to start a second-generation androgen receptor (AR) targeted therapy (such as enzalutamide, abiraterone, or apalutamide) or are already being treated with one. Participants can expect t... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/18/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Prostate Cancer
Register for Updates
OTC Hearing Aid and MCI
NCT06112860
Recruiting
The goal of this study is to better understand if, in patients with mild to moderate hearing loss who are also experiencing mild cognitive impairment (MCI) or Alzheimer's disease and related dementias (ADRD), Over-the-Counter (OTC) hearing aids: 1. improve communication 2. Whether the magnitude of benefit depends on the patient's level of cognitive disability, 3. Whether alternative remediation (such as targeted communication strategies) offer similar benefits. Participants and a communication... Read More
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
03/18/2025
Locations: UW Madison, Madison, Wisconsin
Conditions: Hearing Loss, Mild Cognitive Impairment, Alzheimer Disease and Related Dementias (ADRD)
Register for Updates
GRoup A StrePtococcus
NCT01558804
Recruiting
The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.
Gender:
ALL
Ages:
Between 5 years and 15 years
Trial Updated:
03/17/2025
Locations: UW Health Pediatric Clinics, Madison, Wisconsin
Conditions: Streptococcal Pharyngitis
Register for Updates
Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation
NCT05917522
Recruiting
800 adult first time kidney transplant recipients will be enrolled in the Observational Study and followed to evaluate their Human Leukocyte Antigen (HLA)-DR/DQ molecular mismatch (mMM) score as a risk-stratifying prognostic biomarker. Six months after transplant the study will identify those who meet the eligibility criteria for the Nested Randomized Control Trial (RCT). 300 eligible subjects will be randomized 2:1 to abatacept or Standard of care (SOC) in the randomization and followed for 18... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/17/2025
Locations: University of Wisconsin School of Medicine and Public Health: Transplantation, Madison, Wisconsin
Conditions: Kidney Transplant
Register for Updates
Rapalog Pharmacology (RAP PAC) Study
NCT05949658
Recruiting
The objective of RAP PAC is to identify safe and effective weekly dose(s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging. Participants who are 55-89 years old that are free of overt chronic diseases will be assigned to either 6 weeks of sirolimus or everolimus (5 mg, 10 mg, or 15 mg once per week). The investigators will complete the everolimus arm first and then subsequently complete the sirolimus arm of the study. Total time on st... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
03/17/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Aging
Register for Updates
Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty
NCT06733597
Recruiting
The purpose of this study is to examine femur bone mineral density (BMD) change before and after surgery in patients receiving cemented or cementless total knee arthroplasty (TKA). performed with manual or robotic methods. 100 participants will be enrolled and can expect to be on study for up to 14 months.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
03/17/2025
Locations: UW School of Medicine and Public Health, Madison, Wisconsin
Conditions: Knee Arthropathy
Register for Updates
Study of DF1001 in Patients with Advanced Solid Tumors
NCT04143711
Recruiting
DF1001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express human epidermal growth factor receptor 2 (HER2). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eli... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Solid Tumor, Adult
Register for Updates
US Imaging for the Assessment of LUTS
NCT06323109
Recruiting
The purpose of this research is to develop an ultrasound (US) based urodynamics (UDS) evaluation of voiding based on successful magnetic resonance imaging (MRI)-UDS evaluation. Both US and MRI are non-invasive imaging techniques, but US is a more cost-effective and widely available technology. 80 participants will be enrolled and will be on study for up to 2.5 hours (1.5 hour MRI and 1 hour US).
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
03/12/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Lower Urinary Tract Symptoms, BPH
Register for Updates