GLP-1 Medications for Weight Loss Now Available!

There are currently 31 active clinical trials seeking participants for Weight Loss research studies. The states with the highest number of trials for Weight Loss participants are California, Texas, Florida and North Carolina.
VK2735 for Weight Management Phase 3
NCT07104500
Recruiting
This is a phase 3, multicenter, 78-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the weight loss efficacy as well as safety, tolerability, pharmacodynamic effects, and pharmacokinetics of VK2735 in adults who are obese (BMI ≥30 kg/m2) or overweight (BMI ≥27 kg/m2) with one or more weight related comorbid condition without Type 2 Diabetes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: Viking Clinical Site #1037, Birmingham, Alabama +120 locations
Conditions: Weight Loss
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VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)
NCT07104383
Recruiting
This is a phase 3, multicenter, 78-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the weight loss efficacy as well as safety, tolerability, pharmacodynamic effects, and pharmacokinetics of VK2735 in adults with Type 2 Diabetes who are obese or overweight
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: Viking Clinical Site #2037, Birmingham, Alabama +111 locations
Conditions: Weight Loss
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Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
NCT00739362
Recruiting
This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person eats and weight loss over 4 weeks. It will also compare weight changes in people who attend weight loss counseling sessions and those who do not over this period of time. Obese, non-diabetic people between 18 and 60 years of age who are in good health and who live in the... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/09/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Electric Stimulation Therapy, Obesity, Weight Loss, Eating
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Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
NCT06138821
Recruiting
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectrum, bariatric surgery has shown promise in the treatment of MASLD/metabolic dysfunction-associated steatohepatitis (MASH) due to its efficacy in inducing weight loss. Nevertheless, its adoption has been... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obesity, Liver Diseases, Liver Fibrosis, Liver Fat, Weight Loss, Insulin Resistance, Insulin Sensitivity, Insulin Sensitivity/Resistance, Diabetes, Diabetes Mellitus, Type 2, NASH With Fibrosis, Non-Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver, Non-alcoholic Steatohepatitis, Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, MASLD, MASH, Metabolic Disease
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Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions
NCT06463249
Recruiting
The objective of the HELPLINE Weight Loss Program is to determine the comparative effectiveness of two active multi-component, augmented interventions for cancer survivors with overweight or obesity who do not achieve early weight loss goal in the initial intervention period (termed, early non-responders). The core study design is randomized controlled trial with adaptive intervention. 1. CORE Helpline in all participants (first 2 months) 2. Extended Helpline in early responders (additional 6 m... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Johns Hopkins ProHealth, Baltimore, Maryland
Conditions: Weight Loss
Register for Updates
A Novel Intervention for Weight Loss in Young Adults
NCT06230744
Recruiting
Obesity and cardiometabolic risks are significant public health issues, with about two-thirds of U.S. adults overweight or obese. Weight loss can prevent these health problems, but current lifestyle interventions have limited success. New, effective strategies are needed to address this rising issue at the population level. The goal of this clinical trial is to investigate how a behavioral intervention combined with technology impacts weight loss in young adults. The main questions it aims to an... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
07/14/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Weight Loss
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WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)
NCT06861790
Recruiting
The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improves brain function and thinking. The study does NOT cover any costs associated with bariatric surgery.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
07/11/2025
Locations: University of Florida - College of Public Health and Health Professions, Gainesville, Florida
Conditions: Diabetes, Weight Loss
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Feasibility of Immersive Virtual Reality Dietician Program in Metabolic-dysfunction Associated Steatotic Liver Disease
NCT06215131
Recruiting
Metabolic-dysfunction associated steatotic liver disease, often referred to as "fatty liver disease", is a leading cause of liver failure. Dietary weight loss is a cornerstone of treating fatty liver disease, but access to traditional in-person nutritional education is often limited by cost, availability, and transportation. Immersive virtual reality (iVR) has the potential to not only overcome these barriers, but also provide an interactive learning experience, such as measuring and preparing f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Penn State College of Medicine, Hershey, Pennsylvania
Conditions: Fatty Liver, Nonalcoholic, Weight Loss, Virtual Reality, Implementation Science
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Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
NCT05114798
Recruiting
Approximately 42% of American adults are obese, and this condition is strongly related to the development of colorectal cancer. Innovative lifestyle strategies to treat obesity and reduce colorectal cancer risk are critically needed. This research will demonstrate that time-restricted eating, a type of intermittent fasting, is an effective therapy to help obese individuals reduce and control their body weight and prevent the development of colorectal cancer.
Gender:
ALL
Ages:
Between 45 years and 70 years
Trial Updated:
07/01/2025
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Time Restricted Eating, Obesity, Weight Loss, Colorectal Cancer
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Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
NCT06967389
Recruiting
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3). The main questions it aims to answer are: * How do the rate of weight loss, body mass index (BMI), body composition, heart structure and function, and exercise ability interact with one another in the study population at enrollment? * How do risk markers of disease change over the study in the study participant... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
07/01/2025
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss, Cardiovascular Disease Risk Factor
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Exercise Effects on Adipose Tissue Structure and Function
NCT04812314
Recruiting
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the wei... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/25/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain
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A Trial to Assess Gastrointestinal Responses to Dietary Fibers in Adults Using Weight Loss Medications
NCT07012317
Recruiting
The objective of this study is to assess self-reported gastrointestinal (GI) responses to three snack bars containing fiber/fiber blends vs. a control snack bar for 7 days each in adults using GLP-1 agonists.
Gender:
ALL
Ages:
Between 25 years and 64 years
Trial Updated:
06/06/2025
Locations: Excellence Medical and Research, Miami Gardens, Florida +1 locations
Conditions: Gastrointestinal Symptoms, Weight Loss, GLP-1
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