Oregon is currently home to 1214 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Portland, Eugene, Medford and Clackamas. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis
NCT05521022
Recruiting
This is a multicenter, international, three-part, Phase 1 study designed to evaluate the safety, tolerability, and PK of rising single doses of AT-02 in healthy volunteers and in subjects with systemic amyloidosis and to assess the safety, tolerability, and PK of multiple doses of AT-02 in subjects with systemic amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2024
Locations: OHSU (Oregon Health & Science University), Portland, Oregon
Conditions: Amyloidosis; Systemic
Register for Updates
Impact of Two Dietary Interventions on Simple Carbohydrate Intolerance
NCT06057376
Recruiting
In this project we want to assess impact of dietary fructose as a simple sugar intolerance on abdominal pain and compare a low FODMAP diet versus an added sugar elimination diet effectiveness on symptoms but also impact on microbiome and its metabolome.
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
04/01/2024
Locations: Oregon Health and Science University, Springfield, Oregon
Conditions: Carbohydrate Intolerance
Register for Updates
Food and Circadian Timing
NCT04743271
Recruiting
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
04/01/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Diet, High-Fat, Circadian Rhythm
Register for Updates
Brown Adipose Tissue Activation by Spinal Cord Stimulation
NCT04326192
Recruiting
The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
04/01/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Pain, Back, Obesity, Morbid, Type 2 Diabetes
Register for Updates
Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)
NCT02342444
Recruiting
The risk of developing a blood clot occurs in up to 60% of all critical care patients. Many times enoxaparin (or Lovenox) is given to patients who are at a higher risk of developing clots in their legs or lungs. There are two standard doses of enoxaparin that are recommended by the drug companies. These two doses have never been directly compared in trauma, general, and vascular surgery patients. The purposes of this study are: 1. to compare the development of blood clots in patients receiving... Read More
Gender:
ALL
Ages:
Between 15 years and 100 years
Trial Updated:
04/01/2024
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Trauma, Surgery, Deep Vein Thrombosis (DVT), Thromboembolic Events
Register for Updates
Carrying for the Culture
NCT06148831
Recruiting
Suboptimal postpartum health outcomes in the US, including low rates of lactation and high rates of postpartum depression, contribute to high rates of perinatal mortality and morbidity as well as long-term and intergenerational health outcomes. Black birthing parents and infants are at the highest risk, with the lowest rates of lactation and the highest rates of postpartum depression. Yet most interventions to support lactation and postpartum mental health are based on models of care that are un... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: Nurturely, Eugene, Oregon
Conditions: Postpartum Depression, Breast Feeding
Register for Updates
Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrophy
NCT03813056
Recruiting
Recently, published literature has reported that performing a descemetorhexis in combination with topical Rho kinase (ROCK) inhibitor therapy was successful in clearing edematous corneas in patients with Fuchs Endothelial Corneal Dystrophy. Ripasudil hydrochloride hydrate( Glanatec ophthalmic solution 0.4%), a potent ROCK inhibitor, has been approved in Japan since 2014 for ocular use in the treatment of glaucoma. Ripasudil acts as an IOP-lowering drug by affecting aqueous outflow through the t... Read More
Gender:
ALL
Ages:
Between 30 years and 99 years
Trial Updated:
03/19/2024
Locations: Devers Eye Institute, Portland, Oregon
Conditions: Fuchs Endothelial Dystrophy
Register for Updates
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Eugene, Oregon
Conditions: Neoplasms
Register for Updates
Evaluation of the PrevisEA Device for Predicting Gastrointestinal Impairment
NCT04880473
Recruiting
PrevisEA is a noninvasive, disposable device that uses audio spectral analysis of sounds produced by the gastrointestinal tract to predict gastrointestinal impairment (GII). GII is most commonly associated with postoperative ileus (POI), but could be the result of other causes, such as early postoperative bowel obstruction. GII is defined as failure of successful early oral re-feeding in a subject undergoing major abdominal surgery. For subjects who are allowed to resume a diet during the first... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/11/2024
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Gastrointestinal Complication
Register for Updates
KEEP Connecting Kin
NCT06294392
Recruiting
The current study provides a unique opportunity to conduct a summative evaluation of the KEEP Connecting Kin (KEEP-CK) program by leveraging extant relationships with Oregon's Child Welfare System (CWS), Self-Sufficiency Program (SSP), and our community partners to address the needs of informal kinship families and the youth in their care. Specifically, a randomized "services-as-usual" (SAU) waitlist control design plus qualitative methods will be used to evaluate the immediate (post-interventio... Read More
Gender:
ALL
Ages:
Between 4 years and 18 years
Trial Updated:
02/27/2024
Locations: Oregon Center Learning Center, Eugene, Oregon
Conditions: Internalizing Behavior, Externalizing Behavior, Child Permanency, Parenting, Parent Stress, Service Utilization
Register for Updates
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Oregon Health and Science University, Portland, Oregon
Conditions: Huntington's Disease
Register for Updates
OCT in Diagnosis of Irregular Corneas
NCT03504800
Recruiting
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guid... Read More
Gender:
ALL
Ages:
Between 14 years and 85 years
Trial Updated:
02/20/2024
Locations: Humberto Martinez, Portland, Oregon
Conditions: Keratoconus, Corneal Opacity, Corneal Dystrophy
Register for Updates