There are currently 1011 clinical trials in Birmingham, Alabama looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Alabama at Birmingham, University of Alabama, University of Alabama at Birmingham Cancer Center and University of Alabama Birmingham. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors
NCT05511844
Recruiting
This is a Phase 1 first-in-human study of ORM-5029 in participants with HER2-expressing advanced solid tumors. The study consists of two parts: a Part 1 Dose Escalation and Part 2 Dose Expansion.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/28/2024
Locations: University of Alabama Birmingham, Birmingham, Alabama
Conditions: HER2-positive Breast Cancer, HER-2 Protein Overexpression, HER-2 Gene Amplification, HER2 Gene Mutation
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Trikafta in Cystic Fibrosis Patients
NCT03506061
Recruiting
This clinical study will enroll 42 participants without the F508del mutation, carrying partial function or N1303K mutations not approved for Trikafta, and who are not expected to be approved for CFTR modulator treatment in the immediate future. Each participant will be given Trikafta for approximately four weeks. The study researchers will monitor clinical endpoints that include forced expiratory volume (FEV1) and sweat chloride. Additionally, the researchers will obtain skin biopsy material and... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
03/28/2024
Locations: University of Alabama Cystic Fibrosis Research Center, Birmingham, Alabama
Conditions: Cystic Fibrosis
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Pulsed Lavage in Implant-Based Breast Reconstruction
NCT05585710
Recruiting
To determine if there is any benefit to using pulsed lavage to wash out the mastectomy pocket during breast reconstruction. Primary outcomes will include post-op complications including surgical site infection (SSI), hematoma, seroma, and implant failure.
Gender:
Female
Ages:
Between 18 years and 75 years
Trial Updated:
03/27/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Breast Reconstruction
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Cold Agglutinin Disease Real World Evidence Registry
NCT05791708
Recruiting
This is a multinational, multi-center, observational, prospective, longitudinal disease registry designed to collect data on participants with cold agglutinin disease (CAD) or cold agglutinin syndrome (CAS). Among them, a minimum of 30 patients with CAD treated with sutimlimab are expected to take part in the sutimlimab cohort study. Patients with CAD who have been enrolled in previous sutimlimab clinical trials (e.g., BIVV009-01/LTS16214 [NCT02502903,CAD patients], BIVV009-03/EFC16215 [NCT03347... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: University of Alabama at Birmingham Site Number : 1230, Birmingham, Alabama
Conditions: Cold Agglutinin Disease (CAD), Cold Agglutinin Syndrome (CAS)
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GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
NCT05216042
Recruiting
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have ~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have ~20%... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure, Glucose Metabolism, Exercise, Obesity
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Effect of Sublingually Generated S-nitroso-N-acetylcysteine on Systemic Blood Pressure.
NCT05798481
Recruiting
The purpose of the study is to increase the in vivo levels of nitric oxide by generating nitric oxide donor compound S-nitrosoacetylcysteine (SNOAC) using the mixture of sodium nitrite and N-acetylcysteine crystals in the sublingual space. The generated SNOAC rapidly diffuses into blood circulation thereby decrease the systemic blood pressure. This compound can be an alternative to organic nitrate NO donor drugs without developing tolerance in patients.
Gender:
All
Ages:
Between 21 years and 80 years
Trial Updated:
03/27/2024
Locations: Anesthesiology and Perioperative Medicine, Birmingham, Alabama
Conditions: Hypertension, Cardiovascular Diseases
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NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
NCT04055428
Recruiting
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the metabolic health of an individual. Low circulating level of NPs is an important contributor to increased risk for diabetes. The NP levels are relatively lower among Black individuals thus affecting their... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease, Natriuretic Peptides, Metabolism, Energy Expenditure
Register for Updates
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
NCT04331769
Recruiting
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction (HFrEF).
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Grandview Medical Group Research, LLC, Birmingham, Alabama +1 locations
Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
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PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
NCT04971720
Recruiting
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death. Natriuretic Peptides (NPs) are hormones produced by the heart which directly regulate BP by causing dilation of blood vessels and by removing sodium and water from the body. NPs have a 24-hour day-night rhythm and this controls the day-night rhythm of BP as well. The NP-BP rhythm relationship is b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Obesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood Pressure, Natriuretic Peptides, Renin-Angiotensin-Aldosterone System
Register for Updates
Anemia Studies in CKD: Erythropoiesis Via a Novel PHI Daprodustat - Pediatric (ASCEND-P)
NCT05682326
Recruiting
This is an international, multicenter trial, evaluating pharmacokinetics (PK) (4 weeks), safety (52 weeks), and hemoglobin (Hgb) response (52 weeks) to daprodustat in children and adolescent participants with anemia associated with chronic kidney disease (CKD) incorporating 2 independent sub-trials (Non dialysis [ND] and Dialysis [D]). This study will enroll participants with anemia associated with CKD, in 2 distinct sub-populations differing only by their CKD stage and dialysis requirement (ND:... Read More
Gender:
All
Ages:
Between 3 months and 17 years
Trial Updated:
03/26/2024
Locations: GSK Investigational Site, Birmingham, Alabama
Conditions: Anaemia
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Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study
NCT05006729
Recruiting
The University of Texas Health Science Center at San Antonio (UTHSCSA) will serve as the site for the RURAL Study Coordinating Center, led by PI Vasan Ramachandran, MD. The primary function of the Study Coordinating Center (SCC) is to serve as an administrative liaison between all of the RURAL study's cores. The SCC schedules, facilitates, and hosts, all RURAL meetings including preparation for Observational Study Monitoring Board (OSMB) meetings, and maintains direct communication with the stu... Read More
Gender:
All
Ages:
Between 25 years and 64 years
Trial Updated:
03/26/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Rural Health, Pulmonary Disease, Heart Diseases
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Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama
NCT05384145
Recruiting
The purpose of this study is to adapt and evaluate a combination intervention that includes: (1) a data-driven approach to directed community-based HIV testing to areas with high need, (2) Project Connect to expedite linkage to care at time of diagnosis, (3) and a Rapid ART (antiretroviral therapy)Start program, all in Mobile County Health Department (MCHD) jurisdictions in Alabama.
Gender:
All
Ages:
13 years and above
Trial Updated:
03/26/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: HIV, HIV Linkage to Care, HIV Testing, HIV Treatment
Register for Updates