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Carboplatin Treatment Options in Canada
A collection of 336 research studies where Carboplatin is the interventional treatment. These studies are located in the Canada . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Recruiting
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Clearview Cancer Institute, Huntsville, Alabama +427 locations
Clearview Cancer Institute, Huntsville, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
Banner University Medical Center Phoenix, Phoenix, Arizona
The University of Arizona Cancer Center - North Campus, Tucson, Arizona
Highlands Oncology Group, Springdale, Arkansas
Cedars-Sinai Medical Center, Los Angeles, California
Mercy Cancer Center, Merced, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
BASS Cancer Center, Walnut Creek, California
USO - Rocky Mountain Cancer Centers, Lone Tree, Colorado
Yale University School of Medicine, New Haven, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
Millennium Oncology Research Clinic, Hollywood, Florida
University of Florida - Jacksonville, Jacksonville, Florida
Miami Cancer Institute at Baptist Health, Inc., Miami, Florida
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala, Ocala, Florida
Comprehensive Hematology Oncology, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
University Cancer & Blood Center, LLC, Athens, Georgia
Emory University School of Medicine- Grady Campus, Atlanta, Georgia
Winship Cancer Institute, Emory University, Atlanta, Georgia
University of Illinois at Chicago, Chicago, Illinois
University of Chicago Hospital, Chicago, Illinois
Springfield Clinic Main Campus, Springfield, Illinois
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Franciscan Health, Indianapolis, Indiana
Community Cancer Center North, Indianapolis, Indiana
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
CHI Saint Joseph Cancer Center - East, Lexington, Kentucky
University of Kentucky Chandler Medical Center, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
USO - Maryland Oncology Hematology, Annapolis, Maryland
Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Boston Medical Center, Boston, Massachusetts
Lahey Hospital & Medical Center, Burlington, Massachusetts
University of Michigan, Ann Arbor, Michigan
Karmanos Cancer Institute, Detroit, Michigan
The Cancer & Hematology Centers, Grand Rapids, Michigan
Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota
HealthPartners Cancer Research Center, Saint Paul, Minnesota
North Mississippi Hematology and Oncology Associates, Tupelo, Mississippi
Oncology Hematology Associates, Springfield, Missouri
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
The Valley Hospital, Inc., Paramus, New Jersey
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Maimonides Cancer Center, Brooklyn, New York
Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York
Laura and Isaac Perlmutter Cancer Center, New York, New York
Manhattan Eye, Ear and Throat Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Clinical Research Alliance, Westbury, New York
University of North Carolina Medical Center, Chapel Hill, North Carolina
Duke Cancer Institute, Durham, North Carolina
UNC REX Cancer Center, Raleigh, North Carolina
USO - Oncology Hematology Care, Cincinnati, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio
USO - Oncology Associates of Oregon, Eugene, Oregon
Asante Rogue Regional Medical Center, Medford, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Kaiser Permanente Interstate Medical Office Central, Portland, Oregon
USO - Alliance Cancer Specialists, PC, Horsham, Pennsylvania
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Lifespan Cancer Institute, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute, Greenville, South Carolina
Lexington Medical Center, West Columbia, South Carolina
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Memorial Hospital-Memphis, Memphis, Tennessee
Tennessee Oncology, Nashville, Tennessee
USO - US Oncology Research Network, Nashville, Tennessee
USO - Texas Oncology, Austin, Texas
William Beaumont Army Medical Center, Fort Bliss, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
Houston Methodist Hospital, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
USO - Texas Oncology, Webster, Texas
The University of Vermont Medical Center Inc., Burlington, Vermont
University of Virginia Health System, Charlottesville, Virginia
USO - Virginia Cancer Specialists, Fairfax, Virginia
VCU Health Adult Outpatient Pavillion, Richmond, Virginia
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
Swedish Medical Center, Seattle, Washington
VA Puget Sound Health Care System, Seattle, Washington
USO - Northwest Cancer Specialists, Vancouver, Washington
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical, Madison, Wisconsin
Royal Adelaide Hospital, Adelaide, Not set
Icon Cancer Centre Wesley, Auchenflower, Not set
Ballarat Health Services, Ballarat Central, Not set
Sunshine Coast University Hospital, Birtinya, Not set
Gosford Hospital, Gosford, Not set
Mackay Base Hospital, Mackay, Not set
St Vincent's Hospital, Melbourne, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Goulburn Valley Health, Shepparton, Not set
Gold Coast University Hospital, Southport, Not set
The Townsville Hospital, Townsville, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Klinik Floridsdorf, Wien, Not set
ZNA Middelheim, Antwerp, Not set
CHIREC - site delta, Auderghem, Not set
AZ Sint-Jan Brugge-Oostende AV, Brugge, Not set
UZ Gent, Gent, Not set
AZ Groeninge Campus Kennedylaan, Kortrijk, Not set
UZ Leuven, Leuven, Not set
AZ Sint-Maarten, Mechelen, Not set
Clinique Saint Pierre, Ottignies, Not set
AZ Glorieux Ronse, Ronse, Not set
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, Not set
Oncocentro de Minas Gerais, Belo Horizonte, Not set
Hospital Tacchini, Bento Gonçalves, Not set
Hospital São Domingos, Bequimao, Not set
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul, Brasilia, Not set
Hospital Universitário Evangélico Mackenzie, Curitiba, Not set
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza, Not set
ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijui, Not set
Hospital Brasilia, Lago sul, Not set
Hospital de Cancer de Londrina, Londrina, Not set
Liga Norte Riograndense Contra o Câncer, Natal, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Oncominas, Pouso Alegre, Not set
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro, Not set
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro, Not set
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro, Not set
Clinica Amo - Rio Vermelho, Salvador, Not set
Faculdade de Medicina do ABC, Santo André, Not set
Hospital Sírio Libanês, Sao Paulo, Not set
Hospital BP, Sao Paulo, Not set
Hospital Paulistano, Sao Paulo, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
COE Ensino e Pesquisa, São José dos Campos, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set
Hospital Santa Catarina - Paulista, São Paulo, Not set
Centro Paulista de Oncologia Clínica, São Paulo, Not set
Núcleo de Pesquisa Clínica da Rede São Camilo, São Paulo, Not set
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T, São Paulo, Not set
CEDOES, Vitória, Not set
BC Cancer Abbotsford, Abbotsford, Not set
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Not set
BC Cancer Vancouver, Vancouver, Not set
Cancer Hospital Chinese Academy of Medical Science, Beijing, Not set
Beijing Cancer hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
The First People's Hospital of Changzhou, Changzhou, Not set
West China Hospital, Sichuan University, Cheng Du, Not set
The Third People's Hospital of Chengdu (CDTPH), Chengdu, Not set
Sichuan Cancer hospital, Chengdu, Not set
Fujian Cancer Hospital, Fuzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Hainan General Hospital, Haikou, Not set
The First Affiliated Hospital, Zhejiang University, Hangzhou, Not set
Sir Run Run Shaw Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jinan Central Hospital, Jinan, Not set
Shandong Cancer Hospital, Jinan, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
LinYi Cancer Hospital, Linyi, Not set
Liuzhou People's Hospital, Liuzhou, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Nanjing First Hospital, Nanjing, Not set
Nantong Tumor Hospital, Nantong, Not set
Hwa Mei Hospital University of Chinese Academy of Sciences, Ningbo, Not set
Shanghai Chest Hospital, Shanghai, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Not set
Xinjiang Medical University Cancer Hospital - Urumqi, Urumqi, Not set
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Not set
Wuhan Union Hospital, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Wannan Medical College Yijishan Hospital, Wuhu, Not set
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xiangyang, Not set
Yichang Central People's Hospital, Yichang, Not set
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Not set
ZhuZhou Central Hospital, Zhuzhou, Not set
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Not set
Fakultni nemocnice Bulovka, Prague, Not set
Roskilde University Hospital, Roskilde, Not set
Sainte Catherine Institut du Cancer Avignon Provence, Avignon, Not set
Hospices Civils de Lyon - Hopital Louis Pradel, Bron, Not set
CHU Lille - Institut Coeur Poumon, Lille Cedex, Not set
Centre Leon Berard, Lyon Cedex08, Not set
Centre Antoine-Lacassagne, Nice, Not set
Institut Curie, Paris, Not set
CHU Bordeaux Haut-Leveque, Pessac, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
Institut Jean Godinot, Reims, Not set
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
Nouvel Hôpital Civil (NHC), Strasbourg, Not set
Hôpital Foch, Suresnes, Not set
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon, Not set
CHU de Toulouse - Hopital Larrey, Toulouse, Not set
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Not set
Hôpital Robert Schuman, Vantoux, Not set
Gustave Roussy, Villejuif, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Charité Campus Virchow-Klinikum, Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
MV-Zentrum für Onkologie und Hämatologie, Cologne, Not set
Onkologiezentrum Donauwörth, Donauwörth, Not set
HELIOS Klinikum Erfurt, Erfurt, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
Asklepios Fachkliniken München-Gauting, Gauting, Not set
Franziskus-Hospital Harderberg, Georgsmarienhütte, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle-Dölau, Halle, Not set
Hämato-Onkologie Hamburg, Prof. Laack und Partner, Hamburg, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, Not set
Klinikum Nürnberg Nord, Nürnberg, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Agios Savvas Regional Cancer Hospital, Athens, Not set
Errikos Dunant Hospital Center, Athens, Not set
Sotiria Thoracic Diseases Hospital of Athens, Athens, Not set
Attikon General University Hospital, Chaidari, Not set
University General Hospital of Heraklion, Heraklion, Not set
University Hospital of Patras, Patras, Not set
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
G. Papanikolaou General Hospital, Thessaloniki, Not set
Országos Korányi Pulmonológiai Intézet, Budapest, Not set
Országos Onkológiai Intézet, Budapest, Not set
Budapesti Uzsoki Utcai Kórház, Budapest, Not set
Farkasgyepui Tudogyogyintezet, Farkasgyepu, Not set
Bacs-Kiskun Megyei Korhaz, Kecskemét, Not set
Hemato Oncology Clinic, Ahmedabad, Not set
KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi, Not set
SRV Hospitals, Bengaluru, Not set
All India Institute of Medical Sciences, Bhubaneswar, Not set
Ashwin Hospital, Coimbatore, Not set
Nizam's Institute of Medical Sciences, Hyderabad, Not set
Krishna Institute of Medical Sciences - Karad, Karad, Not set
Kolhapur Cancer Centre Private Limited, Kolhapur, Not set
Tata Memorial Hospital, Mumbai, Not set
HCG Manavata Cancer Centre, Nashik, Not set
Jawaharlal Institute Of Postgraduate Medical Education And Research, Puducherry, Not set
Grant Medical Foundation - Ruby Hall Clinic, Pune, Not set
Sahyadri Super Speciality Hospital, Pune, Not set
Lifepoint Multispeciality Hospital, Pune, Not set
Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram, Not set
Pacific Medical College & Hospital, Udaipur, Not set
Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi, Not set
Mahatma Gandhi Cancer Hospital and Research Institute, Visakhapatnam, Not set
Instituto Tumori Giovanni Paolo II, Bari, Not set
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Policlinico "G. Rodolico", Catania, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set
Istituto Oncologico Veneto IRCCS, Padova, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set
Istituto Nazionale Tumori Regina Elena, Rome, Not set
Ospedale di Circolo e Fondazione Macchi Varese, Varese, Not set
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set
National Hospital Organization Asahikawa Medical Center, Asahikawa, Not set
Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
Himeji Medical Center, Himeji, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kanazawa University Hospital, Kanazawa, Not set
Ibaraki Prefectural Central Hospital, Kasama, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Kobe City Medical Center General Hospital, Kobe, Not set
Japanese Foundation for Cancer Research, Koto, Not set
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Not set
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Not set
Nagasaki University Hospital, Nagasaki, Not set
Aichi Cancer Center Hospital, Nagoya, Not set
Miyagi Cancer Center, Natori, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
Okayama University Hospital, Okayama, Not set
Kindai University Hospital- Osakasayama Campus, Osakasayama, Not set
National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Not set
Hokkaido University Hospital, Sapporo, Not set
National Hospital Organization Yamaguchi Ube Medical Center, Ube, Not set
Tochigi Cancer Center, Utsunomiya, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Not set
Kanagawa cancer center, Yokohama, Not set
Tottori University Hospital, Yonago, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Keimyung University Dongsan Hospital, Daegu, Not set
Kyungpook National University Chilgok Hospital, Deagu, Not set
Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu, Not set
National Cancer Center, Goyang-si, Not set
Chonnam National University Hwasun Hospital, Hwasun, Not set
Korea University Anam Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Not set
Pusan National University Yangsan Hospital, Yangsan, Not set
Health Pharma Professional Research S.A. de C.V:, Ciudad de México, Not set
CIO - Centro de Inmuno-Oncología de Occidente, Guadalajara, Not set
PanAmerican Clinical Research - Guadalajara, Guadalajara, Not set
Actualidad Basada en la Investigación del Cáncer, Guadalajara, Not set
Renati Innovation, Guadalajara, Not set
Health Pharma Querétaro, Juriquilla, Not set
Preparaciones Oncológicas S.C., León, Not set
Centro Onco-Hematológico Roma (COHR), Mexico City, Not set
Higiea Oncologia, Mexico City, Not set
Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Not set
Avix Investigación Clinica, S.C., Monterrey, Not set
Centro de Investigacion Clinica de Oaxaca, Oaxaca, Not set
Clinica Integral Internacional de Oncología, Puebla, Not set
Oncare - Unidad Valle, San Pedro Garza García, Not set
Arké SMO S.A de C.V, Veracruz, Not set
Jeroen Bosch Hospital, Den Bosch, Not set
Medisch Spectrum Twente, Enschede, Not set
Ziekenhuis St. Jansdal, Harderwijk, Not set
Tergooiziekenhuizen, locatie Hilversum, Hilversum, Not set
Medische Centrum Leeuwarden, Leeuwarden, Not set
Leids Universitair Medisch Centrum, Leiden, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
ETZ Elisabeth, Tilburg, Not set
St. Antonius Ziekenhuis, locatie Utrecht, Utrecht, Not set
Haukeland Universitetssjukehus, Bergen, Not set
Drammen Sykehus, Vestre Viken HF, Drammen, Not set
Sykehuset Innlandet HF Gjøvik, Gjøvik, Not set
Akershus Universitetssykehus, Lørenskog, Not set
Oslo universitetssykehus, Radiumhospitalet, Oslo, Not set
Stavanger Universitetssykehus, Stavanger, Not set
St. Olavs Hospital, Trondheim, Not set
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce, Not set
One Day Med, Szczecin, Not set
MICS Centrum Medyczne Torun, Torun, Not set
Centro Hospitalar E Universitário De Coimbra, Coimbra, Not set
Hospital da Luz Lisboa, Lisboa, Not set
Champalimaud Foundation, Lisbon, Not set
Hospital Pulido Valente, Lisbon, Not set
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set
Hospital CUF Porto, Porto, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Lotus-Med, Bucharest, Not set
SC Memorial Healthcare International SRL, Bucharest, Not set
Gral Medical Diagnostic Center, București, Not set
Institutul Oncologic, Cluj, Not set
Centrul de Oncologie "Sfântul Nectarie", Craiova, Not set
Ovidius Clinical Hospital OCH, Ovidiu, Not set
S C Oncocenter Oncologie Clinica S R L, Timișoara, Not set
Cabinet Medical Oncomed, Timișoara, Not set
CHUAC-Hospital Teresa Herrera, A Coruña, Not set
Hospital Infanta Cristina, Badajoz, Not set
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, Not set
Parc de Salut Mar - Hospital del Mar, Barcelona, Not set
Hospital Universitari Dexeus, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet, Not set
Hospital Jerez de la Frontera, Jerez de la Frontera, Not set
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Complejo Asistencial Universitario de León - Hospital de León, León, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitari Son Espases, Palma, Not set
Complejo Hospitalario de Navarra, Pamplona, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Clinico de Valencia, Valencia, Not set
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set
Mälarsjukhuset, Eskilstuna, Not set
Västmanlands Sjukhus Västerås, Västerås, Not set
CHUV (centre hospitalier universitaire vaudois), Lausanne, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Changhua Christian Hospital, Changhua County, Not set
Buddhist Dalin Tzu Chi General Hospital, Chiayi, Not set
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu City, Not set
Hualien Tzu Chi Medical Center, Hualien City, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
New Taipei Municipal TuCheng Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung City, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Medical Center, Tainan City, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center (NTUCC), Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
National Taiwan University Hospital - Hsinchu branch, Zhu Bei City, Not set
Adana Medical Park Seyhan Hastanesi, Adana, Not set
Adana City Hospital, Adana, Not set
Ankara Etlik City Hospital, Ankara, Not set
Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital, Ankara, Not set
Ankara Bilkent Şehir Hastanesi, Ankara, Not set
Akdeniz Universitesi Hastanesi, Antalya, Not set
Memorial Antalya Hospital, Antalya, Not set
Uludag Universitesi, Bursa, Not set
Dicle Üniversitesi, Diyarbakir, Not set
Bezmialem Vakf Üniversitesi, Istanbul, Not set
İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul, Not set
Ege Universitesi Hastanesi, Izmir, Not set
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir, Not set
Kocaeli Üniversitesi, Kocaeli, Not set
Ondokuz Mayıs Universitesi, Samsun, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
Cheltenham General Hospital, Cheltenham, Not set
Ninewells Hospital and Medical School, Dundee, Not set
Huddersfield Royal Infirmary, Huddersfield, Not set
St James's University Hospital, Leeds, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Mount Vernon Hospital, Northwood, Not set
Weston Park Hospital, Sheffield, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
Active Not Recruiting
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/22/2025
Locations: Research Site, Boston, Massachusetts +67 locations
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, New York, New York
Research Site, Oklahoma City, Oklahoma
Research Site, Houston, Texas
Research Site, Heidelberg, Not set
Research Site, Melbourne, Not set
Research Site, Vancouver, British Columbia
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Harbin, Not set
Research Site, Jining, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Taiyuan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Brno, Not set
Research Site, Praha, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Milano, Not set
Research Site, Milan, Not set
Research Site, Modena, Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Roma, Not set
Research Site, Chuo-ku, Not set
Research Site, Koto-ku, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Bydgoszcz, Not set
Research Site, Gdańsk, Not set
Research Site, Gdynia, Not set
Research Site, Grzepnica, Not set
Research Site, Toruń, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Pozuelo de Alarcon, Not set
Research Site, Sevilla, Not set
Research Site, Chernivtsі, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kyiv, Not set
Research Site, Uzhgorod, Not set
Research Site, Cambridge, Not set
Research Site, Manchester, Not set
Research Site, Oxford, Not set
Research Site, Sutton, Not set
Conditions: Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer, Additional Indications Below for Module 4 and 5, Non-small Cell Lung Cancer, Colorectal Cancer, Bladder Cancer, Gastric Cancer, Biliary Cancer, Cervical Cancer, Endometrial Cancer, Small Cell Lung Cancer Only in Module 5
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Recruiting
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab bi... Read More
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
08/22/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +162 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
Recruiting
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs... Read More
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs that work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. The overall goal of this study is to see if selumetinib works just as well as the standard treatment of CV for patients with LGG. Another goal of this study is to compare the effects of selumetinib versus CV in subjects with LGG to find out which is better. Additionally, this trial will also examine if treatment with selumetinib improves the quality of life for subjects who take it. Read Less
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
08/22/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +131 locations
Children's Hospital of Alabama, Birmingham, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Morristown Medical Center, Morristown, New Jersey
Albany Medical Center, Albany, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
British Columbia Children's Hospital, Vancouver, British Columbia
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
Conditions: Low Grade Glioma, Low Grade Astrocytoma, Metastatic Low Grade Astrocytoma, Metastatic Low Grade Glioma
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer
Recruiting
The primary objective of this study is to compare the effect of zimberelimab (ZIM) and domvanalimab (DOM) in combination with chemotherapy relative to pembrolizumab (PEMBRO) in combination with chemotherapy on overall survival (OS) in patients with untreated metastatic non-small cell lung cancer with no actionable genomic alteration.
The primary objective of this study is to compare the effect of zimberelimab (ZIM) and domvanalimab (DOM) in combination with chemotherapy relative to pembrolizumab (PEMBRO) in combination with chemotherapy on overall survival (OS) in patients with untreated metastatic non-small cell lung cancer with no actionable genomic alteration. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Palo Verde Hematology Oncology Ltd, Glendale, Arizona +226 locations
Palo Verde Hematology Oncology Ltd, Glendale, Arizona
California Cancer Associates for Research and Excellence, San Marcos, California
Texas Oncology, Santa Barbara, California
Innovative Clinical Research Institute, Whittier, California
Eastern CT Hematology and Oncology Associates, Norwich, Connecticut
George Washington Medical Faculty Associates, Washington, District of Columbia
Lake City Cancer Care, Lake City, Florida
Florida Cancer Specialists, Sarasota, Florida
Moffitt Cancer Center, Tampa, Florida
Peachtree Hematology Oncology Consultants, Atlanta, Georgia
Illinois Cancer Care, Peoria, Illinois
Messino Cancer Centers, Asheville, North Carolina
Oncology Hematology Care, Inc., Cincinnati, Ohio
Hematology & Oncology Associates, Eugene, Oregon
AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
Arlington Cancer Center, Arlington, Texas
Texas Oncology - Austin, Austin, Texas
Texas Oncology, Dallas, Texas
Texas Oncology- Denison, Sherman, Texas
US Oncology Investigational Products Center (IPC), Arlington, Virginia
Oncology and Hematology Associates of Southwest Virginia, Inc, Blacksburg, Virginia
Northwest Cancer Specialists, PC, Vancouver, Washington
Investigaciones CORI S.R.L., Capital, Not set
Centro Médico Privado Centro de Especialidades Médicas Ambulatorias e Investigación Clínica, Cardoba, Not set
Centro Medico Barrio Parque, Ciudad Autanoma Buenos Aires, Not set
Sanatorio Allende, Cordoba, Not set
Sanatorio Britanico de Rosario, Rosario, Not set
Sanatorio Parque de Rosario, Rosario, Not set
Hospital Provincial del Centenario, Rosario, Not set
Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Not set
CAIPO - Centro para la Atención Integral del Paciente Oncológico, San Miguel de Tucumán, Not set
Clínica Viedma, Viedma, Not set
Klinikum Klagenfurt am Woerthersee, Klagenfurt Am Woerthersee, Not set
Ordensklinikum Linz GmbH, Elisabethinen, Linz, Not set
Klinikum Wels-Grieskirchen, Wels, Not set
Krankenhaus Nord - Klinik Floridsdorf, Wien, Not set
Algemeen Ziekenhuis Sint-Lucas, Aalst, Not set
Grand Hopital de Charleroi asbl (GHdC), Charleroi, Not set
AZ Sint-Maarten, Mechelen, Not set
CHU UCL Namur / Site Sainte Elisabeth, Namur, Not set
Cenantron Centro Avançado de Tratamento Oncologico Ltda, Belo Horizonte, Not set
Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro De Itapemirim, Not set
Fundacao Universidade De Caxias Do Sul - FUCS/RS, Caxias Do Sul, Not set
Instituto do Câncer do Ceará - ICC, Fortaleza, Not set
Oncosite - Centro de Pesquisa Clinica em Oncologia LTDA, Ijui, Not set
Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Hospital Ana Nery Santa Cruz do Sul, Santa Cruz Do Sul, Not set
Centro Des Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho, Sao Paolo, Not set
Instituto Brasiliero de Controle do Cancer IBCC, Sao Paulo, Not set
Centre Integre de sante et de services sociaux de la Monteregie Centre, Greenfield Park, Not set
Moncton Hospital, Moncton, Not set
CISSS des Laurentides, Quebec, Not set
Centre de santé et services sociaux de Rimouski-Neigette, Rimouski, Not set
BC Cancer - Victoria, Victoria, Not set
Clinica Alemana de Santiago, Las Condes, Not set
Orlandioncologia, Providencia, Not set
Oncovida- Santiago, Providencia, Not set
Clinica Puerto Montt, Puerto Montt, Not set
Biocinetic, Santiago, Not set
James Lind Centro de Investigacion del Cancer, Temuco, Not set
Oncocentro APYS, Vina del Mar, Not set
West China Hospital Sichuan University, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Deyang People's Hospital, Deyang, Not set
Fujian Cancer Hospital, Fuzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Guangzhou First People's Hospital, Guangzhou, Not set
Nanfang Hospital, Southern Medical University, Guangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Anhui Chest Hospital, Hefei, Not set
The Second Affiliated Hospital of Nanchang University, Jiangxi, Not set
Shandong Cancer Hospital, Jinan, Not set
Jiangxi Chest Hospital, Nanchang, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Guangxi Medical University Cancer Hospital, Nanning, Not set
Shanghai Chest Hospital, Shanghai, Not set
Shanghai East Hospital, Shanghai, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Cancer Hospital of Shantou University Medical College, Shantou, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Not set
Tongji Hospital Tongji Medical College of Hust, Wuhan, Not set
The First Affiliated Hospital of Xian Jiaotong University, Xi'an, Not set
The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Ambroise-Pare Hospital, Assistance Publique - Hopitaux de Paris, Boulogne-Billancourt, Not set
CHU de Caen, Caen, Not set
Clinique Victor Hugo, Centre de Cancerologie de la Sarthe, Le Mans, Not set
Hopital Nord, Marseille, Not set
Institut de Cancer de Montpellier (ICM) - Val d'Aurelle, Montpellier, Not set
Centre Antoine Lacassagne, Nice, Not set
Institut de cancerologie de l'ouest (ICO), Saint-Herblain, Not set
Hopital d'Instruction des Armees (HIA) Begin, Saint-Mandé, Not set
Centre Hospitalier de Saint-Quentin, Saint-Quentin, Not set
Institut de Cancerologie Strasbourg Europe (ICANS), Strasbourg, Not set
Hôpital Foch, Suresnes, Not set
CHI de Toulon la Seyne-sur-Mer Hopital Sainte Musse, Toulon cedex, Not set
Augusta-Kranken-Anstalt gGmbh Klinik für Hämatologie Onkologie und Palliativmedizin, Bochum, Not set
Klinikum Chemnitz gGmbH, Chemnitz, Not set
Universitatsklinikum Essen / Westdeutsches Tumorzentrum, Innere Klinik (Tumorforschung), Essen, Not set
Universitätsklinikum Freiburg, Klinik für Innere Medizin I Hämatologie, Onkologie und Stammzelltransplantation, Freiburg, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle Dölau, Halle, Not set
Asklepios Kliniken Hamburg, Hamburg, Not set
Katholisches Marienkrankenhaus gGmbH, Hamburg, Not set
Lungenklinik Hemer, Zentrum fur Pneumologie and Thoraxchirurgie, Hemer, Not set
Vincentius-Diakonissen-Kliniken gAG, St. Vincentius-Kliniken, Medizinische Klinik 2, Karlsruhe, Not set
Klinikum Kassel, Kassel, Not set
Kliniken der Stadt Köln ggmbh, Krankenhaus Koln-Merheim/Lungenklinik, Köln, Not set
Universitatsklinikum Schleswig-Holstein, Lubeck, Not set
Johannes Wesling Klinikum Minden, Minden, Not set
Munchen Klinik Bogenhausen, Klinik fur Pneumologie und Pneumologische Onkologie, Munchen, Not set
Sana Klinikum Offenbach GmbH, Medizinische Klinik IV, Hämatologie und Internistische Onkologie, Offenbach, Not set
Queen Elizabeth Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Prince of Wales Hospital, New Territories, Not set
Soroka University Medical Center, Itzchak Rager Blvd., Beer Seva, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Oncology Institute, Galilee Medical Center, Route 89 Nahariya-Cabri, Nahariya, Not set
Rabin Medical Center, Petah Tiqva, Not set
Kaplan Medical Center, Rehovot, Not set
Tel-Aviv Sourasky Medical Center, Tel Aviv, Not set
Azienda Ospedaliera San Giuseppe Moscati, Avellino, Not set
IRCCS Fondazoine del Piemonte per l'Oncologia, Candiolo, Not set
Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Not set
Ospedale Policlinico San Martino, Genova, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Ospedaliero Universitaria di Modena, Modena, Not set
AORN Cardarelli, Naples, Not set
Azienda Ospedaliera dei Colli, Napoli, Not set
IRCCS Policlinico S. Matteo, Dipartimento Oncologia Ematologia-Oncologia Medica, Pavia, Not set
Azienda Sanitaria Territoriale Pesaro e Urbino (AST), Pesaro, Not set
Ospedale Guglielmo da Saliceto AUSL di Piacenza, Piacenza, Not set
Centro di Riferimento Oncologico, Pordenone, Not set
Regina Elena Institute for Cancer Research, Rome, Not set
ASST Bergamo Ovest- ospedale di Treviglio, Treviglio, Not set
National Cancer Center Hospital East, Chiba, Not set
National Hospital Organization Shikoku Cancer Center, Ehime, Not set
Kyushu University Hospital, Fukuoka, Not set
Kurume University Hospital, Fukuoka, Not set
National Hospital Organization Himeji Medical Center, Hyogo, Not set
Hyogo Cancer Center, Hyogo, Not set
Kanazawa University Hospital, Ishikawa, Not set
Kanagawa Cancer Center, Kanagawa, Not set
Sendai Kousei Hospital, Miyagi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka Metropolitan University Hospital, Osaka, Not set
Osaka Medical and Pharmaceutical University Hospital, Osaka, Not set
Kindai University Hospital, Osaka, Not set
National Hospital Organization Kinki Chuo Chest Medical Center, Osaka, Not set
Saitama Medical University, Saitama, Not set
SMG - SNU Boramae Medical Center, Dongjak-Gu, Not set
Samsung Medical Center, Gangnam-Gu, Not set
National Cancer Center, Goyang, Not set
Chungbuk National University Hospital, Heungdeok-Gu, Not set
Inha University Hospital, Incheon, Not set
Gachon University Gil Medical Center, Inchon, Not set
Kosin University Gospel Hospital, Seo-gu, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Ajou University Hospital, Suwon-si, Not set
The Catholic University of Korea, Saint Vincent's Hospital, Suwon, Not set
Health Pharma Professional Research S.A. de C.V., Mexico, Not set
Hospital Universitario Dr. Jose Eleuterio Gonzalez, Mitras Centro, Not set
Oaxaca Site Management Organization, Oaxaca, Not set
Centro de Investigacion Clinica de Oaxaca, Oaxaca, Not set
Clinical Medical Research SC., Orizaba Centro, Not set
Clinica Integral Internacional de Oncologia S de RL de CV, Puebla, Not set
FAICIC Clínical Research, Veracruz, Not set
Amphia Ziekenhuis, Breda, Not set
Ziekenhuis Gelderse Vallei, Ede, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Ziekenhuis St Jansdal, Harderwijk, Not set
TweeSteden Ziekenhuis, Tilburg, Not set
Hospital Prof. Doutor Fernando Fonseca, Amadora, Not set
Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Not set
Fundacao Champalimaud, Lisboa, Not set
Centro Hospitalar Universitário Lisboa Norte - Hospital Pulido Valente, Lisboa, Not set
Hospital Beatriz Angelo. Hospital de Loures., Lisbon, Not set
Centro Hospitalar Universitario Sao Joao, EPE, Porto, Not set
Unidade Local de Saude de Matosinhos EPE - Hospital Pedro Hispano SA, Senhora da Hora, Not set
Raffles Hospital, Singapore, Not set
Tang Tock Seng Hospital, Singapore, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i de Sant Pau, Barcelona, Not set
Hospital Universitari Dexeus (USP Institut Universitari Dexeus/Hospital Universitari Quiron Dexeus), Barcelona, Not set
Hospital Universitari Vall D'Hebron, Barcelona, Not set
Hospital Parc Tauli, Barcelona, Not set
Hospital Universitario Reina Sofia, Cordoba, Not set
Hospital Doctor Josep Trueta, Girona, Not set
Hospital Universitario de Jaen, Jaen, Not set
Hospital Universitario de Canarias, Las Palmas de G.C., Not set
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set
Clinica Universidad de Navarra, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Not set
Hospital Sant Joan de Reus, Reus, Not set
Hospital Regional Universitario de Malaga, Rincon de la Victoria, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario Virgen del Rocio, Seville, Not set
Instituto Valenciano De Oncologia (IVO), Valencia, Not set
Hospital Universitari i Politecnic La Fe, Valencia, Not set
Hospital Vithas Valencia 9 de Octubre, Valencia, Not set
Changhua Christian Hospital, Changhua City, Not set
E-DA Hospital, Kaohsiung City, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Chang Gung Memorial Hospital Kaohsiung, Kaohsiung, Not set
National Cheng Kung University Hospital, Tainan, Not set
Chi Mei Hospital, Liouying, Tainan, Not set
National Taiwan University Hospital, Taipei City, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Memorial Hospital Linkou Branch of the Chang Gung Medical Foundation, Taoyuan City, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara, Not set
Trakya University Faculty of Medicine, Edirne, Not set
Istanbul University Cerrahpasa Medical Faculty Hospital, Fatih, Not set
Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi, Istanbul, Not set
Medipol Mega University Hospital, Istanbul, Not set
Acibadem Mehmet Ali Aydinlar Universitesi Atakent Hastanesi, Kaakaekmece, Not set
Turgut Ozal Medical Faculty, Malatya, Not set
Colchester General Hospital, Colchester, Not set
St Bartholomew's Hospital, Barts Health NHS Trust, London, Not set
The Christie NHS Foundation Trust, Department of Medical Oncology, Manchester, Not set
University Hospital Southampton Nhs Foundation Trust, Southampton, Not set
Conditions: Non-small Cell Lung Cancer
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Recruiting
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas +223 locations
UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060), Little Rock, Arkansas
Highlands Oncology Group-Research Department ( Site 0062), Springdale, Arkansas
Beverly Hills Cancer Center ( Site 0070), Beverly Hills, California
The Angeles Clinic and Research Institute ( Site 0040), Los Angeles, California
The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate ( Site 0079), Los Angeles, California
San Francisco Oncology Associates ( Site 0066), San Francisco, California
Stamford Hospital ( Site 0083), Stamford, Connecticut
Mount Sinai Cancer Center ( Site 0038), Miami Beach, Florida
Mid Florida Hematology and Oncology Center ( Site 0018), Orange City, Florida
Emory University School of Medicine-Phase I ( Site 0056), Atlanta, Georgia
Northside Hospital ( Site 0055), Atlanta, Georgia
Centricity Research Columbus Cancer Center ( Site 0005), Columbus, Georgia
Southeastern Regional Medical Center ( Site 0065), Newnan, Georgia
Lewis Cancer and Research Pavilion ( Site 0063), Savannah, Georgia
Archbold Cancer Center ( Site 0071), Thomasville, Georgia
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0017), Elmhurst, Illinois
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0078), Naperville, Illinois
Parkview Research Center at Parkview Regional Medical Center ( Site 0089), Fort Wayne, Indiana
Indiana University Health Arnett Cancer Center ( Site 0076), Lafayette, Indiana
Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0061), Edgewood, Kentucky
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0080), Baton Rouge, Louisiana
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027), Minneapolis, Minnesota
Mercy Research - David C. Pratt Cancer Center ( Site 0006), Saint Louis, Missouri
Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0037), Reno, Nevada
Atlantic Health Morristown Medical Center ( Site 0077), Morristown, New Jersey
Cayuga Medical Center ( Site 0086), Ithaca, New York
Stony Brook University-Cancer Center ( Site 0054), Stony Brook, New York
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0057), Fargo, North Dakota
Oregon Health and Science University ( Site 0052), Portland, Oregon
Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0068), Lancaster, Pennsylvania
Medical University of South Carolina-Hollings Cancer Center ( Site 0045), Charleston, South Carolina
Sanford Cancer Center ( Site 0053), Sioux Falls, South Dakota
Avera Cancer Institute- Research ( Site 0090), Sioux Falls, South Dakota
University of Tennessee Medical Center Knoxville ( Site 0082), Knoxville, Tennessee
Millennium Research & Clinical Development ( Site 0039), Houston, Texas
Huntsman Cancer Institute ( Site 0042), Salt Lake City, Utah
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0213), Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0207), Ciudad autónoma de Buenos Aires, Buenos Aires
Sanatorio Británico-Clinical Oncology Department ( Site 0206), Rosario, Santa Fe
Sanatorio Parque ( Site 0205), Rosario, Santa Fe
Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L ( Site 0217), San Miguel de Tucuman, Tucuman
Hospital Aleman-Oncology ( Site 0202), Buenos Aires, Not set
Hospital Privado Universitario de Córdoba-Hematology and Oncology ( Site 0204), Cordoba, Not set
Westmead Hospital ( Site 0701), Westmead, New South Wales
The Prince Charles Hospital ( Site 0700), Brisbane, Queensland
Fiona Stanley Hospital-Medical Oncology ( Site 0705), Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 1402), Linz, Oberosterreich
Medizinische Universitaet Innsbruck-Department for Internal Medicine V ( Site 1403), Innsbruck, Tirol
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1400), Wien, Not set
Antwerp University Hospital-Thoracic Oncology ( Site 1503), Edegem, Antwerpen
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 1502), Yvoir, Namur
VITAZ ( Site 1500), Sint-Niklaas, Oost-Vlaanderen
Liga Norte Riograndense Contra o Câncer ( Site 0301), Natal., Rio Grande Do Norte
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0303), Porto Alegre, Rio Grande Do Sul
Hospital Nossa Senhora da Conceição ( Site 0302), Porto Alegre, Rio Grande Do Sul
Instituto de Oncologia Saint Gallen ( Site 0319), Santa Cruz do Sul, Rio Grande Do Sul
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0304), Barretos, Sao Paulo
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0313), São José do Rio Preto, Sao Paulo
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0100), Greenfield Park, Quebec
St. Marys Hospital Center ( Site 0107), Montreal, Quebec
Centre Hospitalier de l'Université de Montréal ( Site 0104), Montréal, Quebec
FALP-UIDO ( Site 0401), Providencia, Region M. De Santiago
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0404), Santiago., Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0400), Santiago, Region M. De Santiago
ONCOCENTRO APYS-ACEREY ( Site 0410), Viña del Mar, Valparaiso
Beijing Cancer hospital-Thoracic Surgery department I ( Site 1301), Beijing, Beijing
Beijing Peking Union Medical College Hospital-Thoracic surgery department ( Site 1302), Beijing, Beijing
Peking University People's Hospital. ( Site 1300), Beijing, Beijing
Fujian Cancer Hospital-oncology department ( Site 1314), Fuzhou, Fujian
The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 1320), Guangzhou, Guangdong
Southern Medical University Nanfang Hospital-Thoracic surgery department ( Site 1313), Guangzhou, Guangdong
Henan Cancer Hospital-henan cancer hospital ( Site 1316), Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Thoracic Surgery ( Site 1306), Wuhan, Hubei
Hubei Cancer Hospital ( Site 1308), Wuhan, Hubei
Xiangya Hospital Central South University-Thoracic surgery ( Site 1311), Changsha, Hunan
Hunan Cancer Hospital ( Site 1312), Changsha, Hunan
Nanjing First Hospital ( Site 1310), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Thoracic Surgery Department ( Site 1318), Suzhou, Jiangsu
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 1330), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 1324), Changchun, Jilin
The Second Affiliated Hospital of Air Force Medical University ( Site 1332), Xian, Shaanxi
Shandong Cancer Hospital ( Site 1321), Jinan, Shandong
Zhongshan Hospital Fudan University ( Site 1325), Shangai, Shanghai
Shanghai Pulmonary Hospital-Thoracic Surgery department ( Site 1304), Shanghai, Shanghai
Sichuan Cancer hospital. ( Site 1327), Chengdu, Sichuan
The Second People's Hospital of Neijiang ( Site 1322), Neijiang, Sichuan
Yunnan Province Cancer Hospital ( Site 1315), Kunming, Yunnan
The first Affiliated Hospital, Zhejiang University School of-Thoracic Cardiovascular Surgery Ward ( Site 1303), Hangzhou, Zhejiang
Zhejiang Cancer Hospital ( Site 1309), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 1328), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 1329), Linhai, Zhejiang
Ningbo No. 2 Hospital ( Site 1305), Ningbo, Zhejiang
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 1600), Brno, Brno-mesto
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 1601), Ostrava, Ostrava Mesto
CHRU de Brest ( Site 1804), Brest, Finistere
CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 1801), Toulouse, Haute-Garonne
CHU Charles Nicolle ( Site 1803), Rouen, Haute-Normandie
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1805), Limoges, Haute-Vienne
Groupe hospitalier Paris saint Joseph. ( Site 1807), Paris, Ile-de-France
Clinique Teissier Groupe ( Site 1811), Valenciennes, Nord
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1810), Clermont-Ferrand, Puy-de-Dome
Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1809), Bron, Rhone
HIA Sainte Anne ( Site 1800), Toulon, Var
Hôpital Tenon ( Site 1802), Paris, Not set
Klinikum Esslingen-Klinik für Kardiologie und Pneumologie ( Site 1914), Esslingen, Baden-Wurttemberg
Katholisches Klinikum Koblenz ( Site 1911), Koblenz, Rheinland-Pfalz
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 1908), Halle, Sachsen-Anhalt
Universitätsklinikum Leipzig ( Site 1915), Leipzig, Sachsen
SRH Wald-Klinikum Gera-Lungenkrebszentrum ( Site 1900), Gera, Thuringen
Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 1912), Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf ( Site 1916), Berlin, Not set
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 2006), Patras, Achaia
251 Hellenic Air Force General Hospital ( Site 2003), Athens, Attiki
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 2000), Athens, Attiki
Athens Medical Center ( Site 2005), Athens, Attiki
Metaxa Cancer Hospital of Piraeus ( Site 2002), Piraeus, Attiki
University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 2001), Heraklion, Irakleio
University General Hospital of Larissa-Oncology Clinic ( Site 2004), Larissa, Thessalia
European Interbalkan Medical Center ( Site 2007), Thessaloniki, Not set
Queen Mary Hospital ( Site 3400), Hksar, Not set
Hong Kong United Oncology Centre ( Site 3403), Kowloon, Not set
Queen Elizabeth Hospital ( Site 3402), Yau Ma Tei, Not set
Rambam Health Care Campus-Oncology Division ( Site 2203), Haifa, Not set
Shaare Zedek Medical Center ( Site 2206), Jerusalem, Not set
Rabin Medical Center ( Site 2204), Petah Tikva, Not set
Sheba Medical Center ( Site 2200), Ramat Gan, Not set
Humanitas Istituto Clinico Catanese ( Site 2315), Misterbianco, Catania
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 2302), Meldola, Emilia-Romagna
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 2300), Milan, Lombardia
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2301), Monza, Lombardia
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 2309), Rome, Roma
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 2307), Firenze, Toscana
Humanitas Gavazzeni-ONCOLOGY ( Site 2310), Bergamo, Not set
Ospedale San Martino ( Site 2313), Genova, Not set
Ospedale San Raffaele-Oncologia Medica ( Site 2311), Milano, Not set
Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 2312), Parma, Not set
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 2303), Pavia, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 2306), Roma, Not set
APSS- Presidio Ospedaliero S. Chiara ( Site 2304), Trento, Not set
National Hospital Organization Shikoku Cancer Center ( Site 1216), Matsuyama, Ehime
Hospital of the University of Occupational and Environmental Health, Japan ( Site 1217), Kitakyushu, Fukuoka
Kobe City Medical Center General Hospital ( Site 1213), Kobe, Hyogo
St. Marianna University Hospital ( Site 1207), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 1206), Yokohama, Kanagawa
Kansai Medical University Hospital ( Site 1211), Hirakata, Osaka
Kindai University Hospital ( Site 1212), Osakasayama, Osaka
Saitama Prefectural Cancer Center ( Site 1201), Kitaadachi-gun, Saitama
Juntendo University Hospital ( Site 1204), Bunkyo-ku, Tokyo
Tokyo Medical University Hospital ( Site 1203), Shinjuku, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 1218), Fukuoka, Not set
Fukushima Medical University Hospital ( Site 1200), Fukushima, Not set
Hiroshima University Hospital ( Site 1215), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 1208), Niigata, Not set
Okayama University Hospital ( Site 1214), Okayama, Not set
Osaka International Cancer Institute ( Site 1210), Osaka, Not set
Nippon Medical School Hospital ( Site 1205), Tokyo, Not set
Chungbuk National University Hospital-Internal medicine ( Site 1000), Cheongju-si, Chungbuk
National Cancer Center-Lung Cancer Center ( Site 1002), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital-Medical Oncology ( Site 1003), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 1001), Suwon-si, Kyonggi-do
Keimyung University Dongsan Hospital CRC room 1 ( Site 1006), Daegu, Taegu-Kwangyokshi
Asan Medical Center-Lung Cancer Center ( Site 1005), Seoul, Not set
Samsung Medical Center-Division of Hematology/Oncology ( Site 1004), Seoul, Not set
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0506), Guadalajara, Jalisco
Centro de Investigacion Clinica de Oaxaca ( Site 0509), Oaxaca de Juarez, Oaxaca
Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 0504), Chihuahua, Not set
Mediadvance Clinical ( Site 0502), Chihuahua, Not set
Oaxaca Site Management Organization S.C. ( Site 0507), Oaxaca, Not set
Amphia Ziekenhuis, locatie Breda Molengracht-long oncologie ( Site 3453), Breda, Noord-Brabant
Isala, locatie Zwolle-Poli Longziekten ( Site 3454), Zwolle, Overijssel
Meander Medisch Centrum-Researchbureau Longgeneeskunde ( Site 3458), Amersfoort, Utrecht
Erasmus Medisch Centrum ( Site 3452), Rotterdam, Zuid-Holland
University Medical Center Groningen ( Site 3459), Groningen, Not set
Sint Antonius Ziekenhuis ( Site 3455), Utrecht, Not set
Auckland City Hospital ( Site 0800), Auckland, Not set
Akershus Universitetssykehus ( Site 2501), Lørenskog, Akershus
Drammen Sykehus, Vestre Viken HF ( Site 2502), Drammen, Buskerud
Sykehuset Innlandet HF Gjøvik ( Site 2503), Gjøvik, Oppland
Oslo universitetssykehus HF. Radiumhospitalet ( Site 2504), Oslo, Not set
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 0604), Lima, Not set
Oncosalud ( Site 0602), Lima, Not set
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 0600), Lima, Not set
Instituto Neuro Cardiovascular de las Americas ( Site 0607), Lima, Not set
Hospital Nacional Edgardo Rebagliati Martins-medical oncology ( Site 0603), Lima, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2600), Warszawa, Mazowieckie
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2601), Przemysl, Podkarpackie
Bialostockie Centrum Onkologii ( Site 2604), Bialystok, Podlaskie
Uniwersyteckie Centrum Kliniczne ( Site 2610), Gdansk, Pomorskie
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 2613), Prabuty, Pomorskie
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemioterapii ( Site 2606), Olsztyn, Warminsko-mazurskie
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 2602), Poznan, Wielkopolskie
UNIDADE LOCAL DE SAUDE DE MATOSINHOS-Serviço de Oncologia ( Site 2705), Matosinhos, Porto
Instituto Portugês de Oncologia de Coimbra Francisco Gentil-Oncologia Médica ( Site 2704), Coimbra, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2702), Porto, Not set
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L.. ( Site 2803), Bucharest, Bucuresti
Spitalul Universitar de Urgență Elias ( Site 2804), București, Bucuresti
Cardiomed SRL Cluj-Napoca-Medical Oncology ( Site 2801), Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2802), Florești, Cluj
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2805), Craiova, Dolj
Spitalul Clinic Municipal De Urgenta Timisoara ( Site 2806), Timişoara, Timis
SC ONCO CARD SRL ( Site 2808), Brasov, Not set
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2901), L Hospitalet, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2905), Santiago de Compostela, La Coruna
Hospital Insular de Gran Canaria-Oncology ( Site 2903), Las Palmas de Gran Canaria, Las Palmas
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2902), Pozuelo de Alarcon, Madrid
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2900), Barcelona, Not set
Hospital Clinico San Carlos-Oncology Department ( Site 2904), Madrid, Not set
Kantonsspital Graubünden-Medizin ( Site 3006), Chur, Grisons
Kantonsspital Münsterlingen - Spital Thurgau AG ( Site 3005), Munsterlingen, Thurgau
CHUV (centre hospitalier universitaire vaudois) ( Site 3003), Lausanne, Vaud
HFR Fribourg - Hôpital Cantonal ( Site 3004), Fribourg, Not set
National Taiwan University Cancer Center (NTUCC) ( Site 1105), Taipei City, Taipei
Tri-Service General Hospital ( Site 1100), Taipei City, Taipei
Taoyuan General Hospital ( Site 1106), Taoyuan City, Taoyuan
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 1103), Kaohsiung, Not set
Taichung Veterans General Hospital-Chest ( Site 1101), Taichung, Not set
National Cheng Kung University Hospital-Clinical Trial Center ( Site 1102), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 1104), Taipei, Not set
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 3106), Adana, Not set
Gulhane Egitim Arastirma Hastanesi-Onkoloji ( Site 3104), Ankara, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 3101), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 3110), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3103), Ankara, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3107), Istanbul, Not set
Conditions: Non Small Cell Lung Cancer
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Recruiting
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Local Institution - 0347, Birmingham, Alabama +328 locations
Local Institution - 0347, Birmingham, Alabama
Local Institution - 0581, Fullerton, California
Local Institution - 0202, Long Beach, California
Local Institution - 0643, Newport Beach, California
Local Institution - 0666, Orange, California
Local Institution - 0623, Santa Barbara, California
Local Institution - 0442, Denver, Colorado
Local Institution - 0651, Gainesville, Florida
Local Institution - 0621, Palm Bay, Florida
Local Institution - 0377, Tamarac, Florida
Local Institution - 0647, Tampa, Florida
Local Institution - 0392, Fort Eisenhower, Georgia
Local Institution - 0031, Marietta, Georgia
Local Institution - 0665, Arlington Heights, Illinois
Local Institution - 0423, Munster, Indiana
Local Institution - 0366, Edgewood, Kentucky
Local Institution - 0566, Louisville, Kentucky
Local Institution - 0644, Shreveport, Louisiana
Local Institution - 0385, Columbia, Maryland
Local Institution - 0019, Boston, Massachusetts
Local Institution - 0437, Worcester, Massachusetts
Local Institution - 0618, White Plains, New York
Local Institution - 0624, Asheville, North Carolina
Local Institution - 0672, Salisbury, North Carolina
Local Institution - 0620, Columbus, Ohio
Local Institution - 0657, York, Pennsylvania
Local Institution - 0658, Greenville, South Carolina
Local Institution - 0652, Laredo, Texas
Local Institution - 0622, San Antonio, Texas
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Buenos Aires
Local Institution - 0584, Pilar, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0571, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires
Sanatorio Plaza, Rosario, Santa Fe
Local Institution - 0126, Canberra, Australian Capital Territory
Tamworth Hospital, North Tamworth, New South Wales
Orange Hospital, Orange, New South Wales
Princess Alexandra Hospital, Brisbane, Queensland
Lyell McEwin Hospital, Elizabeth Vale, South Australia
Frankston Hospital, Frankston, Victoria
Northern Hospital, Melbourne, Victoria
Latrobe Regional Health, Traralgon, Victoria
Joondalup Health Campus, Joondalup, Western Australia
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Kepler Universitätsklinikum, Linz, Not set
Medizinische Universität Wien, Wien, Not set
Local Institution - 0673, Wien, Not set
UZ Brussel, Brussels, Bruxelles-Capitale, Région De
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De
Jessa Ziekenhuis, Hasselt, Limburg
AZ Maria Middelares, Gent, Oost-Vlaanderen
UZ Leuven, Leuven, Vlaams-Brabant
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set
Local Institution - 0257, Salvador, Bahia
Local Institution - 0242, Vitória, Espírito Santo
Local Institution - 0244, Belo Horizonte, Minas Gerais
Local Institution - 0235, Ijui, Rio Grande Do Sul
Local Institution - 0233, Porto Alegre, Rio Grande Do Sul
Local Institution - 0238, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0243, Porto Velho, Rondonia
Local Institution - 0237, Blumenau, Santa Catarina
Local Institution - 0245, Itajaí, Santa Catarina
Local Institution - 0240, Barretos, São Paulo
Local Institution - 0254, Sao Paulo, São Paulo
Local Institution - 0241, São Carlos, São Paulo
Local Institution - 0239, São José do Rio Preto, São Paulo
Local Institution - 0236, Rio de Janeiro, Not set
Local Institution - 0258, São Paulo, Not set
Local Institution - 0629, Panagyurishte, Pazardzhik
Local Institution - 0628, Sofia, Sofia (stolitsa)
Complex Oncology Center - Ruse EOOD, Ruse, Not set
Trakia Hospital, Stara Zagora, Not set
Local Institution - 0074, Halifax, Nova Scotia
Local Institution - 0559, Montreal, Quebec
Bradfordhill, Recoleta, Región Metropolitana De Santiago
FALP, Santiago, Región Metropolitana De Santiago
The First Afflilated Hospital of Bengbu Medical College, Bengbu, Anhui
Anhui Provincial Hospital, Hefei, Anhui
Beijing Cancer hospital, Beijing, Beijing
Local Institution - 0491, Beijing, Beijing
Local Institution - 0397, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Local Institution - 0362, Fuzhou Fujian, Fujian
The First Affiliated hospital of Xiamen University, Xiamen, Fujian
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Guangdong
ShenZhen People's Hospital, Shenzhen, Guangdong
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Nanyang City Center Hospital, Nanyang, Henan
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei
Local Institution - 0398, Changsha, Hunan
Local Institution - 0371, Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu
Northern Jiangsu People's Hospital, Yangzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
The First Hospital of Jilin University, Changchun, Jilin
The First Hospital of China Medical University, Shenyang, Liaoning
Shengjing Hospital of China Medical University, Shenyang, Liaoning
Local Institution - 0493, Shenyang, Liaoning
Shandong Cancer Hospital, Jinan, Shandong
LinYi Cancer Hospital, Linyi, Shandong
Local Institution - 0470, Shanghai, Shanghai
Local Institution - 0381, Shanghai, Shanghai
Shanxi Cancer Hospital, Taiyuan, Shanxi
West China Hospital, Sichuan University, Cheng Du, Sichuan
Sichuan Cancer hospital, Chengdu, Sichuan
Tianjin Medical University General Hospital, Tianjin, Tianjin
Local Institution - 0462, Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang
Shanghai East Hospital, Shanghai, Not set
Local Institution - 0580, Medellín, Antioquia
Local Institution - 0171, Rionegro, Antioquia
Local Institution - 0191, Puerto Colombia, Atlántico
Local Institution - 0253, Valledupar, Cesar
Local Institution - 0167, Montería, COR
Local Institution - 0671, Bogota, Cundinamarca
Local Institution - 0189, Bogotá, Distrito Capital De Bogotá
Local Institution - 0170, Floridablanca, Santander
Local Institution - 0173, Cali, Valle Del Cauca
Local Institution - 0619, Dubrovnik, Dubrovačko-neretvanska Županija
Local Institution - 0664, Rijeka, Primorsko-goranska Županija
Local Institution - 0639, Split, Splitsko-dalmatinska Županija
Local Institution - 0567, Osijek, Not set
Local Institution - 0585, Zagreb, Not set
Local Institution - 0159, Mulhouse, Alsace
Centre François Baclesse, Caen, Calvados
Centre Georges François Leclerc, Dijon, Côte-d'Or
CHRU de Brest, Brest, Finistère
Institut Régional du Cancer Montpellier, Montpellier, Hérault
Chu Grenoble Alpes, La Tronche, Isère
Local Institution - 0560, Angers, Maine-et-Loire
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Meurthe-et-Moselle
Local Institution - 0636, Marseille, Provence-Alpes-Côte-d'Azur
CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Somme
Gustave Roussy, Villejuif, Val-de-Marne
Hôpital Ambroise Paré, Boulogne-Billancourt, Not set
Chu Gabriel Montpied, Clermont-Ferrand, Not set
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges, Not set
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Local Institution - 0133, Paris, Not set
Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris, Not set
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain, Not set
Klinikum Esslingen, Esslingen, Baden-Württemberg
Local Institution - 0670, Ulm, Baden-Württemberg
Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bayern
Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen
Local Institution - 0535, Gießen, Hessen
Praxis Onkologie am Raschplatz, Hannover, Niedersachsen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Evangelisches Krankenhaus Herne - Eickel, Herne, Nordrhein-Westfalen
Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen
Local Institution - 0522, Halle, Sachsen-Anhalt
Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Schleswig-Holstein
Local Institution - 0524, Gera, Thüringen
Universitätsklinikum Jena, Jena, Thüringen
Vivantes Klinikum Neukölln, Berlin, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Local Institution - 0675, Halle, Not set
Local Institution - 0528, Hemer, Not set
Local Institution - 0517, Stuttgart, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Errikos Dunant Hospital Center, Athens, Attikí
Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí
University General Hospital of Larissa, Larissa, Thessalía
Queen Mary Hospital, Hksar, Not set
Queen Mary Hospital, Hksar, Not set
Local Institution - 0144, Gyöngyös, Heves
Local Institution - 0157, Tatabánya, Komárom-Esztergom
Local Institution - 0593, Kaposvár, Somogy
Local Institution - 0143, Farkasgyepu, Veszprém
Local Institution - 0151, Budapest, Not set
Local Institution - 0140, Budapest, Not set
Petz Aladar Egyetemi Oktato Korhaz, Győr, Not set
Local Institution - 0222, Visakhapatnam, Andhra Pradesh
Local Institution - 0312, New Delhi, Delhi
Local Institution - 0511, New Delhi, Delhi
Local Institution - 0135, New Delhi, Delhi
Local Institution - 0136, Ahmedabad, Gujarat
Local Institution - 0230, Ahmedabad, Gujarat
Local Institution - 0155, Thiruvananthapuram, Kerala
Local Institution - 0154, Mumbai, Maharashtra
Local Institution - 0226, Bhubaneswar, Odisha
Local Institution - 0224, Madurai, Tamil Nadu
Local Institution - 0663, Hyderabad, Telangana
Local Institution - 0153, Varanasi, Uttar Pradesh
Local Institution - 0161, Howrah, West Bengal
Local Institution - 0221, Kolkata, West Bengal
Local Institution - 0661, Hyderabad, Not set
Local Institution - 0102, Cork, Not set
Mater Private Hospital - Dublin, Dublin, Not set
St. James's Hospital, Dublin, Not set
Local Institution - 0100, Dublin, Not set
Beaumont Hospital, Dublin, Dublin, Not set
Rabin Medical Center, Petah Tikva, HaMerkaz
Sheba Medical Center, Ramat Gan, HaMerkaz
Yitzhak Shamir Medical Center, Zerifin, HaMerkaz
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0613, Haifa, Ḥeifā
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna
A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli
Local Institution - 0070, Orbassano, Piemonte
Local Institution - 0071, Bari, Puglia
Local Institution - 0068, Rome, Roma
Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana
Ospedale San Martino, Genova, Not set
Local Institution - 0073, Padova, Not set
Local Institution - 0156, Parma, Not set
Local Institution - 0543, Pavia, Not set
Local Institution - 0556, Varese, Not set
Local Institution - 0607, Nagoya, Aichi
Local Institution - 0305, Nagoya, Aichi
Local Institution - 0298, Sapporo, Hokkaido
Local Institution - 0304, Kanazawa, Ishikawa
Local Institution - 0302, Sagamihara, Kanagawa
Local Institution - 0369, Yokohama, Kanagawa
Local Institution - 0301, Sendai, Miyagi
Local Institution - 0306, Kashihara, Nara
Local Institution - 0368, Kurashiki, Okayama
Local Institution - 0642, Hirakata, Osaka
Local Institution - 0303, Hidaka, Saitama
Local Institution - 0300, Ina-machi, Saitama
Local Institution - 0606, Hamamatsu, Shizuoka
Local Institution - 0299, Shimotsuga, Tochigi
Local Institution - 0674, Bunkyo ku, Tokyo
Local Institution - 0343, Toyoma, Toyama
Local Institution - 0542, Iwakuni, Yamaguchi
Local Institution - 0307, Akashi, Not set
Local Institution - 0346, Aomori, Not set
Local Institution - 0310, Fukuoka, Not set
Local Institution - 0367, Fukushima, Not set
Local Institution - 0308, Kumamoto, Not set
Local Institution - 0297, Osaka, Not set
Local Institution - 0309, Osaka, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon]
Pusan National University Yangsan Hospital, Yangsan, Kyǒngsangnam-do
Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Korea University Guro Hospital, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0583, Saltillo, Coahuila
Local Institution - 0176, Mexico City, DIF
Local Institution - 0579, Pachuca, Hidalgo
Local Institution - 0178, Guadalajara, Jalisco
Local Institution - 0591, Monterrey, Nuevo León
Local Institution - 0175, Chihuahua, Not set
Local Institution - 0181, Puebla, Not set
Local Institution - 0638, Puebla, Not set
Local Institution - 0180, Veracruz, Not set
Local Institution - 0615, Maastricht, Limburg
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL), Amsterdam, Noord-Holland
Local Institution - 0205, Wrocław, Dolnośląskie
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin, Lubelskie
Szpital Specjalistyczny im. Henryka Klimontowicza, Gorlice, Małopolskie
Pratia MCM Krakow, Kraków, Małopolskie
Med-Polonia Sp. z o. o., Poznan, Wielkopolskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Local Institution - 0078, Katowice, Not set
Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Not set
Local Institution - 0509, Lisbon, Lisboa
Instituto Portugês de Oncologia de Coimbra Francisco Gentil, Coimbra, Not set
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
Cardiomed SRL Cluj-Napoca, Cluj-Napoca, Cluj
SC Radiotherapy Center Cluj SRL, Florești, Cluj
Ovidius Clinical Hospital OCH, Ovidiu, Constanța
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Spitalul Municipal Schuller Ploiești, Ploiești, Prahova
Cabinet Medical Oncomed, Timișoara, Timiș
Institutul Oncologic Cluj, Cluj, Not set
Institutul Oncologic Cluj, Cluj, Not set
Affidea Constanța, Constanța, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0614, Jeddah, Makkah Al Mukarramah
Local Institution - 0602, Riyadh, Not set
Local Institution - 0562, Riyadh, Not set
Local Institution - 0499, A Coruña, A Coruña [La Coruña]
Local Institution - 0506, Santiago de Compostela, A Coruña [La Coruña]
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]
Local Institution - 0497, Hospitalet, Barcelona [Barcelona]
Local Institution - 0505, Barcelona, Catalunya [Cataluña]
Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares]
Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad De
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Local Institution - 0669, Pontevedra, Pontevedra [Pontevedra]
Hospital Arnau de Vilanova, Valencia, València
Hospital Clinico San Carlos, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Local Institution - 0495, València, Not set
Kantonsspital Münsterlingen - Spital Thurgau AG, Münsterlingen, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Tainan
Tri-Service General Hospital, Taipei City, Taipei
Taipei Medical University Shuang Ho Hospital, New Taipei, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Local Institution - 0565, Muang, Khon Kaen
Local Institution - 0563, Bangkok, Krung Thep Maha Nakhon
Local Institution - 0564, Hatyai, Songkhla
Local Institution - 0548, Stanbul, İstanbul
Local Institution - 0199, Izmir, Karsiyaka, İzmir
Local Institution - 0197, Adana, Not set
Local Institution - 0201, Ankara, Not set
Local Institution - 0194, Ankara, Not set
Local Institution - 0198, Ankara, Not set
Local Institution - 0550, Istanbul, Not set
Local Institution - 0549, Istanbul, Not set
Local Institution - 0200, Izmir, Not set
University College London Hospital, London, London, City Of
Guy's & St Thomas' NHS Foundation Trust, London, London, City Of
Heartlands Hospital, Birmingham, Not set
Local Institution - 0545, Guildford, Not set
The Royal Surrey County Hospital, Guildford, Not set
Local Institution - 0093, Manchester, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Recruiting
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Southern Cancer Center, PC, Daphne, Alabama +190 locations
Southern Cancer Center, PC, Daphne, Alabama
Local Institution - 0283, Hot Springs, Arkansas
Florida Cancer Specialists - South, Fort Myers, Florida
Mid Florida Hematology and Oncology Center, Orange City, Florida
Florida Cancer Specialists - North, Saint Petersburg, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta, Georgia
Illinois Cancer Care, Peoria, Illinois
Local Institution - 0037, Minneapolis, Minnesota
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Duke Cancer Institute, Durham, North Carolina
Oncology Hematology Care, Cincinnati, Ohio
Local Institution - 0239, Cleveland, Ohio
Sanford Cancer Center, Sioux Falls, South Dakota
Local Institution - 0307, Knoxville, Tennessee
SCRI Oncology Partners, Nashville, Tennessee
Texas Oncology - Central/South Texas, Austin, Texas
Texas Oncology - Northeast Texas, Tyler, Texas
Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia
Swedish Cancer Institute - Edmonds, Edmonds, Washington
Swedish Medical Center, Seattle, Washington
Local Institution - 0007, Tacoma, Washington
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0100, Buenos Aires, Ciudad Autónoma De Buenos Aires
Clinica Adventista Belgrano, Caba, Ciudad Autónoma De Buenos Aires
Instituto Médico Río Cuarto, Río Cuarto, Córdoba
GenesisCare - Campbelltown, Campbelltown, New South Wales
Nepean Hospital, Penrith, New South Wales
Gallipoli Medical Research Ltd, Brisbane, Queensland
Grampians Health, Ballarat Central, Victoria
St. John of God Murdoch Hospital, Murdoch, Western Australia
Klinikum Wels-Grieskirchen GmbH, Wels, Oberösterreich
Medizinische Universität Graz, Graz, Steiermark
Kepler Universitätsklinikum, Linz, Not set
Landeskrankenhaus Rankweil, Rankweil, Not set
Local Institution - 0250, Wien, Not set
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région De
UZ Gent, Gent, Oost-Vlaanderen
VITAZ, Sint-Niklaas, Oost-Vlaanderen
Local Institution - 0180, Leuven, Vlaams-Brabant
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège, Not set
Local Institution - 0166, Fortaleza, Ceará
Local Institution - 0165, Porto Alegre, Rio Grande Do Sul
Local Institution - 0169, Porto Alegre, Rio Grande Do Sul
Local Institution - 0170, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0163, Itajaí, Santa Catarina
Local Institution - 0178, Barretos, São Paulo
Local Institution - 0111, Sao Paulo, São Paulo
Local Institution - 0289, Edmonton, Alberta
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski, Quebec
IUCPQ, Quebec, Not set
Orlandi Oncologia, Santiago, Región Metropolitana De Santiago
Fundacion Arturo Lopez Perez (FALP), Santiago, Región Metropolitana De Santiago
Pontificia Universidad Catolica de Chile, Santiago, Región Metropolitana De Santiago
Bradfordhill, Santiago, Región Metropolitana De Santiago
Oncocentro Apys, Viña del Mar, Valparaíso
Beijing Cancer hospital, Beijing, Beijing
Beijing Chest Hospital,Capital Medical University, Beijing, Beijing
Chongqing University Cancer Hospital, Chongqing, Chongqing
Fujian Cancer Hospital, Fuzhou, Fujian
Local Institution - 0212, Xiamen, Fujian
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong
Local Institution - 0227, Harbin, Heilongjiang
Local Institution - 0208, Wuhan, Hubei
Hubei Cancer Hospital, Wuhan, Hubei
Local Institution - 0216, Changsha, Hunan
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
Jilin Province Tumor Hospital, Changchun, Jilin
Local Institution - 0235, Shenyang, Liaoning
Xi'an International Medical Center Hospital, Xi'an, Shaanxi
Shandong Cancer Hospital, Jinan, Shandong
Local Institution - 0206, Shanghai, Shanghai
Zhongshan Hospital,Fudan University, Shanghai, Shanghai
Sichuan Cancer hospital, Chengdu, Sichuan
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang
Shanghai East Hospital, Shanghai, Not set
Masarykuv onkologicky ustav, Brno, Brno-město
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Ostrava Město
Fakultni Thomayerova nemocnice, Prague, Praha 4
Fakultni nemocnice Olomouc, Olomouc, Not set
Hôpital Arnaud de Villeneuve - CHU Montpellier, Montpellier, Hérault
Chu Grenoble Alpes, La Tronche, Isère
CHU Lille - Institut Coeur Poumon, Lille Cedex, Nord
L Hopital Nord Ouest, Gleize, Rhône
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Centre Hospitalier Intercommunal de Créteil, Créteil, Val-de-Marne
Gustave Roussy, Villejuif, Val-de-Marne
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille, Not set
Institut Curie, Paris, Not set
Centre Hospitalier de Cornouaille Quimper - Concarneau, Quimper, Not set
Krankenhaus Nordwest GmbH, Frankfurt, Hessen
Pius Hospital Oldenburg, Oldenburg, Niedersachsen
Klinikum Köln-Merheim, Köln, Nordrhein-Westfalen
Krankenhaus Martha-Maria Halle-Dölau, Halle, Sachsen-Anhalt
Zentralklinik Bad Berka, Bad Berka, Thüringen
Local Institution - 0263, Berlin, Not set
Asklepios Klinik Gauting GmbH, Gauting, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Robert Bosch Krankenhaus GmbH, Stuttgart, Not set
Errikos Dunant Hospital Center, Athens, Attikí
Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía
European Interbalkan Medical Center, Thessaloniki, Thessaloníki
University General Hospital of Larissa, Larissa, Thessalía
Local Institution - 0278, New Delhi, Delhi
Local Institution - 0274, Bengaluru, Karnataka
Local Institution - 0271, Madurai, Tamil Nadu
Local Institution - 0277, Varanasi, Uttar Pradesh
Local Institution - 0273, Kolkata, West Bengal
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia
Istituto Nazionale Tumori Regina Elena, Rome, Roma
AO Santa Maria della Misericordia, Perugia, Umbria
Casa di Cura Dott. Pederzoli, Peschiera del Garda, Verona
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Istituto Europeo di Oncologia IRCCS, Milano, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime
Kurume University Hospital, Kurume, Fukuoka
Hokkaido University Hospital, Sapporo, Hokkaido
Kobe City Medical Center General Hospital, Kobe-shi, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa
Sendai Kousei Hospital, Sendai, Miyagi
Nara Medical University Hospital, Kashihara city, Nara
Kurashiki Central Hospital, Kurashiki, Okayama
Kansai Medical University Hospital, Hirakata, Osaka
Kindai University Hospital- Osakasayama Campus, Osaka Sayama, Osaka
Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka
Saitama Medical University International Medical Center, Hidaka, Saitama
Saitama Prefectural Cancer Center, Ina-machi, Saitama
Hamamatsu University Hospital, Hamamatsu, Shizuoka
Nippon Medical School Hospital, Bunkyo-ku, Tokyo
The Cancer Institute Hospital of JFCR, Koto, Tokyo
Fukushima Medical University, Fukushima, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do
Ajou University Hospital, Suwon-si, Kyǒnggi-do
Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul]
Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]
Keimyung University Dongsan Hospital, Daegu, Taegu-Kwangyǒkshi
Local Institution - 0311, Kuching, Sarawak
Local Institution - 0310, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0312, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur
Local Institution - 0148, Pachuca, Hidalgo
Local Institution - 0146, Guadalajara, Jalisco
Local Institution - 0147, Monterrey, Nuevo León
Local Institution - 0145, Puebla, Not set
Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland
Ziekenhuis Rijnstate, Arnhem, Not set
University Medical Center Groningen, Groningen, Not set
Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Pomorskie
Przychodnia Lekarska KOMED, Konin, Wielkopolskie
Pratia Poznań, Poznań, Wielkopolskie
Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Not set
Instytut Centrum Zdrowia Matki Polki, Łódź, Łódzkie
SC Memorial Healthcare International SRL, Bucharest, București
Institutul Oncologic Bucuresti, Bucharest, București
SC Radiotherapy Center Cluj SRL, Florești, Cluj
Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj
Institutul Oncologic Cluj, Cluj, Not set
S.C. Centrul de Oncologie Euroclinic S.R.L., Iași, Not set
Institutul Regional de Oncologie, Iași, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña]
Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya [Cataluña]
Hospital Universitario de Jaen, Jaen, Jaén
Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De
Hospital General Universitario de Valencia, Valencia, Valenciana, Comunitat
Local Institution - 0299, Sevilla, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Kantonsspital Graubünden, Chur, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Local Institution - 0158, Cigli, İzmir
Local Institution - 0154, Adana, Not set
Local Institution - 0157, Ankara, Not set
Local Institution - 0177, Ankara, Not set
Local Institution - 0153, Istanbul, Not set
Local Institution - 0197, London, London, City Of
James Cook University Hospital, Central Middlesbrough, Middlesbrough
Aberdeen Royal Infirmary, Aberdeen, Not set
Local Institution - 0108, Leicester, Not set
The Christie NHS Foundation Trust, Manchester, Not set
The Clatterbridge Cancer Centre, Wirral, Not set
Conditions: Extensive-Stage Small Cell Lung Cancer
Prostate Cancer Biomarker Enrichment and Treatment Selection
Active Not Recruiting
The purpose of the pre-study screening is to test for DNA abnormalities or biomarkers.
The purpose of the pre-study screening is to test for DNA abnormalities or biomarkers. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Cross Cancer Institute, Edmonton, Alberta +10 locations
Cross Cancer Institute, Edmonton, Alberta
BCCA - Vancouver Cancer Centre, Vancouver, British Columbia
QEII Health Sciences Centre, Halifax, Nova Scotia
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
London Regional Cancer Program, London, Ontario
Ottawa Hospital Research Institute, Ottawa, Ontario
University Health Network, Toronto, Ontario
CHUM-Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
The Jewish General Hospital, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Conditions: Prostate Cancer
A Phase I/Ib Study of MEK162, a MEK Inhibitor, in Combination With Carboplatin and Pemetrexed in Patients With Non-squamous Carcinoma of the Lung
Completed
MEK162 has shown significant inhibition of tumor growth as a single agent in NSCLC xenograft models in mice and human cancer cells in vitro, which have KRAS and/or other mutations. These data suggest that MEK162 may provide a potential benefit in cancer indications harboring these mutations. MEK162 is currently being investigated in phase I clinical testing and has been well tolerated up to an MTD of 45mg BID in cancer patients.
There has been little change in survival benefit for patients with... Read More
MEK162 has shown significant inhibition of tumor growth as a single agent in NSCLC xenograft models in mice and human cancer cells in vitro, which have KRAS and/or other mutations. These data suggest that MEK162 may provide a potential benefit in cancer indications harboring these mutations. MEK162 is currently being investigated in phase I clinical testing and has been well tolerated up to an MTD of 45mg BID in cancer patients.
There has been little change in survival benefit for patients with non-small cell lung cancer in recent years. Emerging new treatment options relying on molecular and genetic markers are being studied extensively. Thus, there has been a shift to manage non-small cell lung cancer with molecular targeted therapies in combination with standard chemotherapy. This study will be targeting patients with KRAS mutations. Read Less
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/20/2025
Locations: Cross Cancer Institute, Edmonton, Alberta +3 locations
Cross Cancer Institute, Edmonton, Alberta
Juravinski Cancer Centre, Hamilton, Ontario
The Ottawa Hospital Regional Cancer Centre, Ottawa, Ontario
Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Lungcancer
AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
Recruiting
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted thoracic tumors. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted thoracic... Read More
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted thoracic tumors. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted thoracic tumors. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/20/2025
Locations: Comprehensive Blood and Cancer Center, Bakersfield, California +78 locations
Comprehensive Blood and Cancer Center, Bakersfield, California
City of Hope National Medical Center, Duarte, California
Translational Research in Oncology US Inc, Trio Central Pharmacy, Los Angeles, California
University of California Irvine, Orange, California
University of California Los Angeles, Santa Monica, California
Rocky Mountain Cancer Centers, Denver, Colorado
Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut
HealthPartners Institute, Saint Paul, Minnesota
Saint Lukes Hospital of Kansas City, Kansas City, Missouri
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Roswell Park Cancer Institute, Buffalo, New York
New York University Grossman School of Medicine, New York, New York
Perlmutter Cancer Center at New York University Langone Hospital----Long Island, New York, New York
Upstate University Hospital, Syracuse, New York
Hightower Clinical, Oklahoma City, Oklahoma
Fox Chase Cancer Center, Philadelphia, Pennsylvania
University of Tennessee Medical Center Knoxville, Knoxville, Tennessee
United States Oncology Regulatory Affairs Corporate Office, Nashville, Tennessee
Texas Oncology - Dallas Fort Worth, Dallas, Texas
US Oncology Research Investigational Products Center, Dallas, Texas
Oncology Consultants Cancer Center, Houston, Texas
Texas Oncology Northeast Texas, Tyler, Texas
Virginia Cancer Specialists PC, Fairfax, Virginia
Northwest Medical Specialties, PLLC, Tacoma, Washington
Instituto Argentino de Diagnóstico y Tratamiento, Ciudad Automona De Buenos Aires, Buenos Aires
Cemic, Ciudad Autonoma Buenos Aires, Not set
Orange Health Service, Orange, New South Wales
The Queen Elizabeth Hospital, Woodville South, South Australia
Medizinische Universitaet Graz, Graz, Not set
Medizinische Universitaet Innsbruck, Innsbruck, Not set
Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, Not set
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda, Ijui, Rio Grande Do Sul
Beneficencia Portuguesa de Sao Paulo - Bp, Sao Paulo, São Paulo
Fund Fac Reg Med Sao Jose Rio Preto, São José do Rio Preto, São Paulo
Instituto Cancer Sao Paulo Icesp, São Paulo, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Mengchao Hepatobiliary hospital of Fujian Medical University, Fuzhou, Fujian
Guangdong Provincial Peoples Hospital, Guangzhou, Guangdong
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei
Jilin Cancer Hospital, Changchun, Jilin
West China Hospital of Sichuan University, Chengdu, Sichuan
Beijing Cancer Hospital, Beijing, Not set
Institut Bergonie, Bordeaux, Not set
Hopital de la Timone, Marseille, Not set
Institut de Cancerologie de l Ouest Rene Gauducheau, Saint Herblain, Not set
Gustave Roussy, Villejuif, Not set
Universitaetsklinikum Essen, Essen, Not set
Thoraxklinik Heidelberg, Heidelberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
Alexandra Hospital, Athens, Not set
Saint Luke Hospital, Thessaloniki, Not set
General Hospital Of Thessaloniki Papageorgiou, Thessaloniki, Not set
Queen Mary Hospital, The University of Hong Kong, Hong Kong, Not set
Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Alessandria, Not set
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Not set
IRCCS Istituto Clinico Humanitas, Rozzano (MI), Not set
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona, Not set
Aichi Cancer Center, Nagoya-shi, Aichi
National Cancer Center Hospital East, Kashiwa-shi, Chiba
Shizuoka Cancer Center, Sunto-gun, Shizuoka
Wakayama Medical University Hospital, Wakayama-shi, Wakayama
Seoul National University Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Radboud Universitair Medisch Centrum, Nijmegen, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Narodowy Instytut Onkologii im Marii Slodowskiej Curie Panstwowy Instytut Badawczy, Gliwice, Not set
Futuremeds spolka z ograniczona odpowiedzialnoscia, Kraków, Not set
Instytut Centrum Zdrowia Matki Polki, Lodz, Not set
Centrum Medyczne Hope Clinic Sebastian Szklener, Lublin, Not set
Hospital Universitari Vall d Hebron, Barcelona, Cataluña
Hospital Clinic i Provincial de Barcelona, Barcelona, Cataluña
Hospital Universitario 12 de Octubre, Madrid, Not set
National Cheng Kung University Hospital, Tainan, Not set
Taipei Veterans General Hospital, Taipei, Not set
Adana Sehir Egitim ve Arastirma Hastanesi, Adana, Not set
Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara, Not set
Ankara Bilkent Sehir Hastanesi, Ankara, Not set
Conditions: Thoracic Tumors, Non-small Cell Lung Cancer
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Recruiting
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients... Read More
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT. Read Less
Gender:
ALL
Ages:
Between 3 years and 29 years
Trial Updated:
08/19/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +162 locations
Children's Hospital of Alabama, Birmingham, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
GenesisCare USA - Las Vegas, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Cancer Care Specialists - Reno, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Albany Medical Center, Albany, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Maimonides Medical Center, Brooklyn, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Christchurch Hospital, Christchurch, Not set
Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor, Embryonal Carcinoma, Immature Teratoma, Malignant Teratoma, Mixed Germ Cell Tumor, Pineal Region Germ Cell Tumor, Pineal Region Immature Teratoma, Pineal Region Yolk Sac Tumor, Choriocarcinoma, Suprasellar Germ Cell Tumor
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