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Carboplatin Treatment Options in Canada
A collection of 336 research studies where Carboplatin is the interventional treatment. These studies are located in the Canada . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)
Recruiting
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D will receive pembrolizumab + abiraterone + prednisone Cohort E will receive pembrolizumab+lenvatinib... Read More
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, Cohort C will receive pembrolizumab + enzalutamide, Cohort D will receive pembrolizumab + abiraterone + prednisone Cohort E will receive pembrolizumab+lenvatinib, Cohort F will receive pembrolizumab+lenvatinib, Cohort G will receive pembrolizumab/vibostolimab coformulation (MK-7684A), Cohort H will receive pembrolizumab/vibostolimab coformulation, Cohort I will receive pembrolizumab+carboplatin+etoposide in Arm 1 and carboplatin+etoposide in Arm 2 and Cohort J will receive belzutifan in Arm1 and Pembrolizumab+belzutifan in Arm 2. Outcome measures will be assessed individually for each cohort. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: Call for Information (Investigational Site 0005), Los Angeles, California +26 locations
Call for Information (Investigational Site 0005), Los Angeles, California
Call for Information (Investigational Site 2041), Aurora, Colorado
Call for Information (Investigational Site 2083), Baltimore, Maryland
Call for Information (Investigational Site 2091), Cleveland, Ohio
Call for Information (Investigational Site 2027), Portland, Oregon
Call for Information (Investigational Site 2094), Portland, Oregon
Call for Information (Investigational Site 0008), Pittsburgh, Pennsylvania
Call for Information (Investigational Site 2065), Charleston, South Carolina
Call for Information (Investigational Site 0019), Myrtle Beach, South Carolina
Call for Information (Investigational Site 0016), Seattle, Washington
MSD Australia, North Ryde, Not set
Merck Canada, Kirkland, Quebec
MSD Denmark, Glostrup, Not set
MSD Finland Oy, Espoo, Not set
MSD France, Paris, Not set
MSD Sharp & Dohme GmbH, München, Not set
MSD Ireland (Human Health) Ltd., Dublin, Not set
MSD Italia S.r.l., Rome, Not set
MSD Comercializadora, S. de R.L. de C.V., Mexico City, Not set
Merck Sharp & Dohme BV, Haarlem, Not set
Merck Sharp & Dohme (New Zealand) Ltd.,, Auckland, Not set
MSD Polska Sp. Z o.o., Warsaw, Not set
Merck Sharp and Dohme de Espana S.A., Madrid, Not set
MSD Sweden, Stockholm, Not set
Merck Sharp & Dohme (I.A.) Corp., Taipei, Not set
Merck Sharp & Dohme Ilaclari Ltd. Sti, Istanbul, Not set
Merck Sharp & Dohme Ltd., London, Not set
Conditions: Metastatic Castration-Resistant Prostate Cancer
Study of Inupadenant (EOS100850) With Chemotherapy as Second Line Treatment for Nonsquamous Non-small Cell Lung Cancer
Active Not Recruiting
The study will first determine the optimal dose of inupadenant to be given in combination with carboplatin and pemetrexed to patients that progressed after receiving first line anti-PD(L)1 treatment for locally advanced or metastatic non-small cell lung cancer. The efficacy and safety of the combination is then compared to standard of care carboplatin and pemetrexed in the same populations.
The study will first determine the optimal dose of inupadenant to be given in combination with carboplatin and pemetrexed to patients that progressed after receiving first line anti-PD(L)1 treatment for locally advanced or metastatic non-small cell lung cancer. The efficacy and safety of the combination is then compared to standard of care carboplatin and pemetrexed in the same populations. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Highlands Oncology Group, Fayetteville, Arkansas +20 locations
Highlands Oncology Group, Fayetteville, Arkansas
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Algemeen Ziekenhuis Sint-Lucas, Gent, Not set
Jessa Ziekenhuis, Hasselt, Not set
AZ Delta, Roeselare, Not set
William Osler Health System, Brampton, Ontario
Vseobecna Fakultni Nemocnice, Praha 3, Not set
CHU de Caen, Caen, Not set
Hopital de la Timone Centre d'Essais Précoces en Cancérologie de Marseille (CEPCM), Marseille, Not set
CHU Nantes, Nantes, Not set
Istituto Nazionale dei Tumori, Milano, Not set
Gruppo Humanitas - Istituto Clinico Humanitas, Rozzano, Not set
Hospital Universitari Son Espases, Palma De Mallorca, Illes Balears
Hospital Infanta Cristina (Hospital Universitario de Badajoz), Badajoz, Not set
Hospital Universitario Vall d'Hebron, Barcelona, Not set
Centro Oncologico de Galicia, Coruña, Not set
Althaia Hospital, Manresa, Not set
Complejo Hospitalario Universitario de Ourense, Ourense, Not set
Complejo Hospitalario de Navarra (CHN), Pamplona, Not set
Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Not set
Centre Hospitalier Universitaire Vaudois, Lausanne, Not set
Conditions: Metastatic NSCLC - Non-Small Cell Lung Cancer, Locally Advanced NSCLC - Non-Small Cell Lung Cancer
Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)
Active Not Recruiting
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, versus (vs) pembrolizumab plus maintenance pemetrexed for the treatment of non-squamous NSCLC. The study's 2 primary hypotheses are: 1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance pemetrexed with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent clinical review (BICR) and 2. Pembrolizu... Read More
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, versus (vs) pembrolizumab plus maintenance pemetrexed for the treatment of non-squamous NSCLC. The study's 2 primary hypotheses are: 1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance pemetrexed with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1) by blinded independent clinical review (BICR) and 2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance pemetrexed with respect to overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama +177 locations
Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama
Northwest Alabama Cancer Center, PC ( Site 0002), Muscle Shoals, Alabama
Disney Family Cancer Center ( Site 0005), Burbank, California
Boca Raton Regional Hospital ( Site 0018), Boca Raton, Florida
Mid-Florida Cancer Centers ( Site 0022), Orange City, Florida
Moffitt Cancer Center ( Site 0024), Tampa, Florida
Columbus Regional Research Institute ( Site 0098), Columbus, Georgia
Mount Sinai Hospital Medical Center ( Site 0032), Chicago, Illinois
Oncology of Northshore ( Site 0033), Rolling Meadows, Illinois
Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0036), Merrillville, Indiana
Medstar Good Samaritan Hospital ( Site 0040), Baltimore, Maryland
Barbara Ann Karmanos Cancer Institute ( Site 0041), Detroit, Michigan
Hattiesburg Clinic ( Site 0045), Hattiesburg, Mississippi
Frontier Oncology ( Site 0080), Billings, Montana
Bozeman Health Deaconness Cancer Center ( Site 0046), Bozeman, Montana
Waverly Hematology Oncology ( Site 0081), Cary, North Carolina
Thompson Cancer Survival Center ( Site 2812), Knoxville, Tennessee
University of Tennessee Medical Center Knoxville ( Site 0060), Knoxville, Tennessee
Renovatio Clinical ( Site 0062), The Woodlands, Texas
Cancer Care Northwest ( Site 0071), Spokane Valley, Washington
Hospital Italiano Regional del Sur ( Site 0509), Bahia Blanca, Buenos Aires
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0511), Ciudad Autonoma de Buenos Aires, Buenos Aires
Hospital Britanico de Buenos Aires ( Site 0500), Ciudad autónoma de Buenos Aires, Buenos Aires
Instituto Medico Rio Cuarto ( Site 0501), Rio Cuarto., Cordoba
Centro Oncológico de Rosario ( Site 0507), Rosario, Santa Fe
Centro Medico San Roque ( Site 0506), San Miguel de Tucuman, Tucuman
Clínica Universitaria Reina Fabiola ( Site 0505), Cordoba, Not set
Sanatorio Privado San Geronimo S.R.L ( Site 0510), Santa Fe, Not set
Liverpool Hospital ( Site 1201), Liverpool, New South Wales
Southern Medical Day Care Centre ( Site 1200), Wollongong, New South Wales
Townsville General Hospital ( Site 1202), Townsville, Queensland
Monash Cancer Centre ( Site 1205), Clayton, Victoria
Ordensklinikum Linz GmbH Elisabethinen ( Site 1307), Linz, Oberosterreich
Klinikum Wels-Grieskirchen ( Site 1304), Wels, Oberosterreich
Innsbruck LKH ( Site 1302), Innsbruck, Tirol
Social Medical Center - Otto Wagner Hospital ( Site 1301), Vienna, Wien
Krankenhaus Nord - Klinik Floridsdorf ( Site 1300), Wien, Not set
Hospital Sao Rafael ( Site 0212), Salvador, Bahia
Instituto do Cancer do Ceara ( Site 0201), Fortaleza, Ceara
Oncologica do Brasil ( Site 0210), Belem, Para
Hospital Tacchini ( Site 0208), Bento Goncalves, Rio Grande Do Sul
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0209), Porto Alegre, Rio Grande Do Sul
Saint Gallen Instituto de Oncologia ( Site 0206), Santa Cruz do Sul, Rio Grande Do Sul
YNOVA Pesquisa Clinica ( Site 0215), Florianopolis, Santa Catarina
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0202), Itajai, Santa Catarina
Centro de Hematologia e Oncologia ( Site 0205), Joinville, Santa Catarina
Hospital de Base de Sao Jose de Rio Preto ( Site 0204), Sao Jose Rio Preto, Sao Paulo
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0203), Rio de Janeiro, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0200), Sao Paulo, Not set
BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0214), Sao Paulo, Not set
Hospital Paulistano - Amil Clinical Research ( Site 0207), Sao Paulo, Not set
Lions Gate Hospital ( Site 0106), North Vancouver, British Columbia
BC Cancer - Victoria ( Site 0109), Victoria, British Columbia
Queen Elizabeth II Health Sciences Centre ( Site 0107), Halifax, Nova Scotia
Waterloo Regional Health Network (WRHN) ( Site 0117), Kitchener, Ontario
Stronach Regional Cancer Centre ( Site 0101), Newmarket, Ontario
Health Sciences North Research Institute ( Site 0115), Sudbury, Ontario
CISSS de la Monteregie-Centre ( Site 0114), Greenfield Park, Quebec
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0105), Montreal, Quebec
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110), Montreal, Quebec
Centre de Sante et des Services Sociaux de Rimouski-Neigette ( Site 0104), Rimouski, Quebec
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0103), Sherbrooke, Quebec
Fundacion Colombiana de Cancerologia Clinica Vida ( Site 0604), Medellin, Antioquia
Clinica de la Costa S.A.S. ( Site 0608), Barranquilla, Atlantico
Administradora Country S.A. ( Site 0603), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 0601), Bogotá, Distrito Capital De Bogota
Institut De Cancerologie De Lorraine ( Site 1409), Vandoeuvre les Nancy, Ain
Centre Hospitalier De Chauny ( Site 1411), Chauny, Aisne
CHU Caen ( Site 1406), Caen, Calvados
CHU Angers ( Site 1405), Angers, Maine-et-Loire
Hopital Robert Schuman ( Site 1402), Vantoux, Moselle
Centre Jean Perrin ( Site 1407), Clermont Ferrand, Puy-de-Dome
Centre Hospitalier de Pau ( Site 1412), Pau, Pyrenees-Atlantiques
CHU de Rouen ( Site 1403), Rouen, Seine-Maritime
Hopital d'Instruction des Armees Begin ( Site 1413), Saint-Mande, Val-de-Marne
Studienzentrum Aschaffenburg ( Site 1525), Aschaffenburg, Bayern
Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1523), Muenchen, Bayern
Klinikum der LMU ( Site 1500), Munich, Bayern
Universitaetsklinikum Regensburg ( Site 1512), Regensburg, Bayern
Klinikum Wuerzburg Mitte gGmbH ( Site 1509), Wuerzburg, Bayern
Universitaetsklinikum Frankfurt ( Site 1513), Frankfurt, Hessen
Pneumologische Lehrklinik Universitaet Goettingen ( Site 1501), Immenhausen, Hessen
Universitaetsmedizin Goettingen ( Site 1507), Goettingen, Niedersachsen
Universitaetsklinikum Bonn ( Site 1524), Bonn, Nordrhein-Westfalen
Kliniken Essen Mitte ( Site 1517), Essen, Nordrhein-Westfalen
InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1514), Koblenz, Rheinland-Pfalz
Helios Klinikum Erfurt GmbH ( Site 1502), Erfurt, Thuringen
Katholisches Marienkrankenhaus gGmbH ( Site 1522), Hamburg, Not set
National Hospital Organization Nagoya Medical Center ( Site 0806), Nagoya, Aichi
Aichi Cancer Center ( Site 0803), Nagoya, Aichi
National Cancer Center Hospital East ( Site 0801), Kashiwa, Chiba
Kanazawa University Hospital ( Site 0811), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0807), Yokohama, Kanagawa
Sendai Kousei Hospital ( Site 0812), Sendai, Miyagi
Kansai Medical University Hospital ( Site 0804), Hirakata, Osaka
National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813), Sakai, Osaka
Shizuoka Cancer Center ( Site 0802), Suntogun, Shizuoka
National Hospital Organization Kyushu Medical Center ( Site 0805), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 0808), Niigata, Not set
Okayama University Hospital ( Site 0810), Okayama, Not set
Osaka International Cancer Institute ( Site 0809), Osaka, Not set
Cancer Institute Hospital of JFCR ( Site 0800), Tokyo, Not set
Chungbuk National University Hospital ( Site 1002), Cheongju si, Chungbuk
National Cancer Center ( Site 1006), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 1003), Suwon, Kyonggi-do
Ajou University Hospital ( Site 1004), Suwon, Kyonggi-do
Gyeongsang National University Hospital ( Site 1005), Jinju, Kyongsangnam-do
Asan Medical Center ( Site 1007), Songpa-gu, Seoul
Seoul National University Hospital ( Site 1000), Seoul, Not set
Korea University Guro Hospital ( Site 1008), Seoul, Not set
MidCentral DHB Palmerston North Hospital ( Site 1102), Palmerston North, Manawatu-Wanganui
Capital & Coast District Health Board - Wellington Hospital ( Site 1101), Wellington, Not set
Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404), Zgorzelec, Dolnoslaskie
Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2418), Warszawa, Mazowieckie
Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402), Raciborz, Slaskie
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2417), Olsztyn, Warminsko-mazurskie
Przychodnia Lekarska Komed ( Site 2416), Konin, Wielkopolskie
MED-POLONIA Sp. z o.o. ( Site 2419), Poznan, Wielkopolskie
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 2502), Bucharest, Bucuresti
Cardiomed SRL Cluj-Napoca ( Site 2504), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 2507), Cluj-Napoca, Cluj
Ovidius Clinical Hospital OCH ( Site 2501), Ovidiu, Constanta
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508), Craiova, Dolj
Policlinica Oncomed SRL ( Site 2505), Timisoara, Timis
Spitalul PDR Medlife ( Site 2509), Brasov, Not set
Moscow Regional Oncological Dispensary ( Site 2028), Balashikha, Moskovskaya Oblast
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000), Moscow, Moskva
First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024), Moscow, Moskva
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009), Moscow, Moskva
FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006), Moscow, Moskva
Nizhniy Novgorod Region Oncology Dispensary ( Site 2026), Nizhniy Novgorod, Nizhegorodskaya Oblast
Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site 2010), Omsk, Omskaya Oblast
SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016), Samara, Samarskaya Oblast
SBHI Leningrad Regional Clinical Hospital ( Site 2002), Saint Petersburg, Sankt-Peterburg
SPb Central Clinical Railway Hospital ( Site 2003), Saint Petersburg, Sankt-Peterburg
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004), Saint Petersburg, Sankt-Peterburg
SPb SBHI City Clinical Oncological Dispensary ( Site 2001), Saint Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 2021), Kazan, Tatarstan, Respublika
Hospital Universitario Quiron Madrid ( Site 1701), Pozuelo de Alarcon, Madrid
Hospital Clinico Universitario de Valencia ( Site 1706), Valencia, Valenciana, Comunitat
Hospital del Mar ( Site 1702), Barcelona, Not set
Hospital Universitario Nuestra Senora de Valme ( Site 1703), Sevilla, Not set
Hospital Clinico Lozano Blesa ( Site 1700), Zaragoza, Not set
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907), Kaohsiung, Not set
China Medical University Hospital ( Site 0904), Taichung, Not set
National Cheng Kung University Hospital ( Site 0905), Tainan, Not set
National Taiwan University Hospital ( Site 0900), Taipei, Not set
Mackay Memorial Hospital ( Site 0902), Taipei, Not set
Chang Gung Medical Foundation.Linkou Branch ( Site 0903), Taoyuan, Not set
Namik Kemal Universitesi Tip Fakultesi ( Site 2100), Tekirdag, Tekirdas
Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101), Adana, Not set
Gazi Universitesi Tip Fakultesi ( Site 2104), Ankara, Not set
Ankara Bilkent Sehir Hastanesi ( Site 2105), Ankara, Not set
Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107), Istanbul, Not set
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103), Istanbul, Not set
Ege Universitesi Tip Fakultesi ( Site 2109), Izmir, Not set
Erciyes Universitesi Tip Fakultesi ( Site 2108), Kayseri, Not set
Ondokuz Mayıs Universitesi-Oncology department ( Site 2106), Samsun, Not set
Cherkasy Regional Oncology Dispensary ( Site 2211), Cherkasy, Cherkaska Oblast
Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 2201), Dnipro, Dnipropetrovska Oblast
MI Precarpathian Clinical Oncology Center ( Site 2204), Ivano-Frankivsk, Ivano-Frankivska Oblast
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2212), Kharkiv, Kharkivska Oblast
CNPE "Regional Center of Oncology"-Thoracic organs ( Site 2205), Kharkiv, Kharkivska Oblast
PP PPC Acinus Medical and Diagnostic Centre ( Site 2209), Kropyvnitskiy, Kirovohradska Oblast
Medical Center Asklepion LLC ( Site 2234), Khodosivka, Kyivska Oblast
Medical Center Verum ( Site 2230), Kyiv, Kyivska Oblast
Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2213), Kyiv, Kyivska Oblast
MI Odessa Regional Oncological Centre ( Site 2208), Odesa, Odeska Oblast
Central City Clinical Hospital ( Site 2207), Uzhgorod, Zakarpatska Oblast
Kyiv City Clinical Oncology Centre ( Site 2210), Kyiv, Not set
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923), London, London, City Of
Chelsea and Westminster Hospital ( Site 1901), London, London, City Of
West Suffolk Hospitals NHS Trust ( Site 1919), Bury Saint Edmunds, Suffolk
Singleton Hospital ( Site 1909), Swansea, Wales
Colchester General Hospital ( Site 1911), Colchester, Worcestershire
Birmingham Heartlands Hospital ( Site 1910), Birmingham, Not set
Western General Hospital, Edinburgh ( Site 1924), Edinburg, Not set
Conditions: Carcinoma, Nonsquamous Non-small-cell Lung
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
Active Not Recruiting
This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). Selumetinib is a drug that works by blocking some enzymes that low-grade glioma tumor cells need for their growth. This results in killing tumor cells. Chemotherapy drugs, such as carboplatin and v... Read More
This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). Selumetinib is a drug that works by blocking some enzymes that low-grade glioma tumor cells need for their growth. This results in killing tumor cells. Chemotherapy drugs, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine. Read Less
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
07/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +131 locations
Children's Hospital of Alabama, Birmingham, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Loma Linda University Medical Center, Loma Linda, California
Children's Hospital Los Angeles, Los Angeles, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Roswell Park Cancer Institute, Buffalo, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
British Columbia Children's Hospital, Vancouver, British Columbia
IWK Health Centre, Halifax, Nova Scotia
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
HIMA San Pablo Oncologic Hospital, Caguas, Not set
Conditions: Low Grade Glioma, Neurofibromatosis Type 1, Visual Pathway Glioma
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
Recruiting
The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1).
The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Research Site, Tucson, Arizona +290 locations
Research Site, Tucson, Arizona
Research Site, Springdale, Arkansas
Research Site, Beverly Hills, California
Research Site, Glendale, California
Research Site, Los Alamitos, California
Research Site, Redlands, California
Research Site, San Francisco, California
Research Site, Walnut Creek, California
Research Site, West Haven, Connecticut
Research Site, Newark, Delaware
Research Site, Bay Pines, Florida
Research Site, Fort Lauderdale, Florida
Research Site, Gainesville, Florida
Research Site, Gainesville, Florida
Research Site, Jacksonville, Florida
Research Site, Athens, Georgia
Research Site, Atlanta, Georgia
Research Site, Boise, Idaho
Research Site, Chicago, Illinois
Research Site, Decatur, Illinois
Research Site, Hinsdale, Illinois
Research Site, Quincy, Illinois
Research Site, Waterloo, Iowa
Research Site, Lexington, Kentucky
Research Site, Lexington, Kentucky
Research Site, Louisville, Kentucky
Research Site, Louisville, Kentucky
Research Site, Alexandria, Louisiana
Research Site, Baton Rouge, Louisiana
Research Site, Covington, Louisiana
Research Site, Shreveport, Louisiana
Research Site, Shreveport, Louisiana
Research Site, South Portland, Maine
Research Site, Baltimore, Maryland
Research Site, Bethesda, Maryland
Research Site, Detroit, Michigan
Research Site, Grand Rapids, Michigan
Research Site, Duluth, Minnesota
Research Site, Rochester, Minnesota
Research Site, Bridgeton, Missouri
Research Site, Columbia, Missouri
Research Site, Kansas City, Missouri
Research Site, Lincoln, Nebraska
Research Site, Camden, New Jersey
Research Site, Buffalo, New York
Research Site, East Syracuse, New York
Research Site, Westbury, New York
Research Site, Cincinnati, Ohio
Research Site, Bend, Oregon
Research Site, Medford, Oregon
Research Site, Salem, Oregon
Research Site, Hershey, Pennsylvania
Research Site, York, Pennsylvania
Research Site, Sioux Falls, South Dakota
Research Site, Chattanooga, Tennessee
Research Site, Nashville, Tennessee
Research Site, Fort Worth, Texas
Research Site, Houston, Texas
Research Site, Kingwood, Texas
Research Site, Lubbock, Texas
Research Site, Round Rock, Texas
Research Site, Fairfax, Virginia
Research Site, Fredericksburg, Virginia
Research Site, Olympia, Washington
Research Site, Seattle, Washington
Research Site, Silverdale, Washington
Research Site, Spokane, Washington
Research Site, Tacoma, Washington
Research Site, Wenatchee, Washington
Research Site, Buenos Aires, Not set
Research Site, Caba, Not set
Research Site, La Plata, Not set
Research Site, Pilar, Not set
Research Site, Rosario, Not set
Research Site, Darlinghurst, Not set
Research Site, Hyde Park, Not set
Research Site, Southport, Not set
Research Site, Wollongong, Not set
Research Site, Innsbruck, Not set
Research Site, Krems, Not set
Research Site, Rankweil, Not set
Research Site, Wien, Not set
Research Site, Wien, Not set
Research Site, Anderlecht, Not set
Research Site, Brussels, Not set
Research Site, Charleroi, Not set
Research Site, Kortrijk, Not set
Research Site, Ottignies, Not set
Research Site, Sint-Niklaas, Not set
Research Site, Barretos, Not set
Research Site, Florianópolis, Not set
Research Site, Ijuí, Not set
Research Site, Londrina, Not set
Research Site, Porto Alegre, Not set
Research Site, Salvador, Not set
Research Site, Sao Paulo, Not set
Research Site, São Paulo, Not set
Research Site, Taubaté, Not set
Research Site, Saint John, New Brunswick
Research Site, Sydney, Nova Scotia
Research Site, Hamilton, Ontario
Research Site, Sault Ste. Marie, Ontario
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changde, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Dalian, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Hangzhou, Not set
Research Site, Harbin, Not set
Research Site, Hefei, Not set
Research Site, Hefei, Not set
Research Site, Jinan, Not set
Research Site, Kunming, Not set
Research Site, Linhai, Not set
Research Site, Linyi, Not set
Research Site, Nanchang, Not set
Research Site, Ningbo, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Shenyang, Not set
Research Site, Shenzhen, Not set
Research Site, Taiyuan, Not set
Research Site, Tianjin, Not set
Research Site, Wenzhou, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Yangzhou, Not set
Research Site, Yueyang, Not set
Research Site, Zhengzhou, Not set
Research Site, Zhengzhou, Not set
Research Site, Avignon, Not set
Research Site, La Rochelle Cedex, Not set
Research Site, Lyon, Not set
Research Site, Nimes, Not set
Research Site, Rennes, Not set
Research Site, Strasbourg Cedex, Not set
Research Site, Suresnes, Not set
Research Site, Toulon Cedex 9, Not set
Research Site, Bad Berka, Not set
Research Site, Berlin, Not set
Research Site, Berlin, Not set
Research Site, Esslingen, Not set
Research Site, Frankfurt, Not set
Research Site, Gauting, Not set
Research Site, Gießen, Not set
Research Site, Großhansdorf, Not set
Research Site, Hamburg, Not set
Research Site, Hannover, Not set
Research Site, Hannover, Not set
Research Site, Heidelberg, Not set
Research Site, Hemer, Not set
Research Site, Homburg, Not set
Research Site, Kassel, Not set
Research Site, Kiel, Not set
Research Site, Krefeld, Not set
Research Site, Köln, Not set
Research Site, Minden, Not set
Research Site, Moers, Not set
Research Site, München, Not set
Research Site, Regensburg, Not set
Research Site, Würzburg, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Debrecen, Not set
Research Site, Gyöngyös, Not set
Research Site, Győr, Not set
Research Site, Pécs, Not set
Research Site, Székesfehérvár, Not set
Research Site, Törökbálint, Not set
Research Site, Calicut, Not set
Research Site, Delhi, Not set
Research Site, Kolkata, Not set
Research Site, Madurai, Not set
Research Site, Mumbai, Not set
Research Site, Nashik, Not set
Research Site, New Delhi, Not set
Research Site, Pondicherry, Not set
Research Site, Surat, Not set
Research Site, Varanasi, Not set
Research Site, Firenze, Not set
Research Site, Monza, Not set
Research Site, Orbassano, Not set
Research Site, Padova, Not set
Research Site, Peschiera Del Garda, Not set
Research Site, Roma, Not set
Research Site, Amagasaki-shi, Not set
Research Site, Bunkyo-ku, Not set
Research Site, Chuo-ku, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Fukuoka-shi, Not set
Research Site, Hiroshima-shi, Not set
Research Site, Kawagoe-shi, Not set
Research Site, Kitaadachi-gun, Not set
Research Site, Kitakyushu-shi, Not set
Research Site, Kobe-shi, Not set
Research Site, Koto-ku, Not set
Research Site, Kumamoto-shi, Not set
Research Site, Matsusaka-shi, Not set
Research Site, Osaka-shi, Not set
Research Site, Osakasayama, Not set
Research Site, Ota-shi, Not set
Research Site, Saitama-shi, Not set
Research Site, Sendai-shi, Not set
Research Site, Shinjuku-ku, Not set
Research Site, Yokohama-shi, Not set
Research Site, Yokohama-shi, Not set
Research Site, Cheongju-si, Not set
Research Site, Incheon, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Suwon-si, Not set
Research Site, Suwon-si, Not set
Research Site, George Town, Not set
Research Site, Johor Bahru, Not set
Research Site, Kuala Lumpur, Not set
Research Site, Alkmaar, Not set
Research Site, Ede, Not set
Research Site, Groningen, Not set
Research Site, Leidschendam, Not set
Research Site, Veldhoven, Not set
Research Site, Zwolle, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Lima, Not set
Research Site, Biała Podlaska, Not set
Research Site, Białystok, Not set
Research Site, Bydgoszcz, Not set
Research Site, Bystra, Not set
Research Site, Poznań, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, San Juan, Not set
Research Site, San Juan, Not set
Research Site, Barcelona, Not set
Research Site, Las Palmas de Gran Canaria, Not set
Research Site, Lérida, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Majadahonda, Not set
Research Site, Sevilla, Not set
Research Site, Kaohsiung, Not set
Research Site, Kaohsiung, Not set
Research Site, New Taipei, Not set
Research Site, New Taipei, Not set
Research Site, Taichung, Not set
Research Site, Taichung, Not set
Research Site, Tainan City, Not set
Research Site, Taoyuan, Not set
Research Site, Bangkok, Not set
Research Site, Chiang Mai, Not set
Research Site, Dusit, Not set
Research Site, Nakhon Ratchasima, Not set
Research Site, Songkla, Not set
Research Site, Antalya, Not set
Research Site, İstanbul, Not set
Research Site, Yenimahalle, Not set
Research Site, Aberdeen, Not set
Research Site, Cambridge, Not set
Research Site, Edinburgh, Not set
Research Site, Exeter, Not set
Research Site, Greater London, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Manchester, Not set
Research Site, Newcastle upon Tyne, Not set
Research Site, Preston, Not set
Research Site, Can Tho, Not set
Research Site, Hanoi, Not set
Research Site, Ho Chi Minh City, Not set
Research Site, Ho Chi Minh, Not set
Research Site, Vinh, Not set
Conditions: Non-small Cell Lung Cancer
Testing the Use of A Single Drug (Olaparib) or the Combination of Two Drugs (Cediranib and Olaparib) Compared to the Usual Chemotherapy for Women With Platinum Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Active Not Recruiting
This phase III trial studies olaparib or cediranib maleate and olaparib to see how well they work compared with standard platinum-based chemotherapy in treating patients with platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancer that has come back. Olaparib and cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cediranib maleate may stop the growth of ovarian, fallopian tube, or primary peritoneal cancer by blocking the... Read More
This phase III trial studies olaparib or cediranib maleate and olaparib to see how well they work compared with standard platinum-based chemotherapy in treating patients with platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancer that has come back. Olaparib and cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cediranib maleate may stop the growth of ovarian, fallopian tube, or primary peritoneal cancer by blocking the growth of new blood vessels necessary for tumor growth. Drugs used in chemotherapy, such as carboplatin, paclitaxel, gemcitabine hydrochloride, and pegylated liposomal doxorubicin hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether olaparib or cediranib maleate and olaparib is more effective than standard platinum-based chemotherapy in treating patients with platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancer. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +355 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
University of South Alabama Mitchell Cancer Institute, Mobile, Alabama
Alaska Women's Cancer Care, Anchorage, Alaska
Providence Alaska Medical Center, Anchorage, Alaska
Arizona Oncology Associates-West Orange Grove, Tucson, Arizona
Arizona Oncology Associates-Wilmot, Tucson, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
PCR Oncology, Arroyo Grande, California
Mercy San Juan Medical Center, Carmichael, California
Marin Cancer Care Inc, Greenbrae, California
UC San Diego Moores Cancer Center, La Jolla, California
Cedars Sinai Medical Center, Los Angeles, California
Palo Alto Medical Foundation-Camino Division, Mountain View, California
Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View, California
Kaiser Permanente-Oakland, Oakland, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Sutter Roseville Medical Center, Roseville, California
Mercy Cancer Center - Sacramento, Sacramento, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente Sacramento Medical Center, Sacramento, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
Kaiser Permanente-San Francisco, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California
Sutter Pacific Medical Foundation, Santa Rosa, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
Woodland Memorial Hospital, Woodland, California
Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado
UCHealth University of Colorado Hospital, Aurora, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
UCHealth Memorial Hospital Central, Colorado Springs, Colorado
Kaiser Permanente-Franklin, Denver, Colorado
Rocky Mountain Cancer Centers-Rose, Denver, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Kaiser Permanente-Rock Creek, Lafayette, Colorado
Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado
Kaiser Permanente-Lone Tree, Lone Tree, Colorado
Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado
Intermountain Health Lutheran Hospital, Wheat Ridge, Colorado
Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut
Hartford Hospital, Hartford, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut
Middlesex Hospital, Middletown, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
Yale University, New Haven, Connecticut
Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Helen F Graham Cancer Center, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
TidalHealth Nanticoke / Allen Cancer Center, Seaford, Delaware
Sibley Memorial Hospital, Washington, District of Columbia
University of Florida Health Science Center - Gainesville, Gainesville, Florida
University Cancer and Blood Center LLC, Athens, Georgia
Piedmont Hospital, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Emory Decatur Hospital, Decatur, Georgia
Atrium Health Navicent, Macon, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Queen's Medical Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Centralia Oncology Clinic, Centralia, Illinois
Northwestern University, Chicago, Illinois
John H Stroger Jr Hospital of Cook County, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital, Chicago, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Crossroads Cancer Center, Effingham, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Mercy Cancer Center-West Lakes, Clive, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Mercy Medical Center-West Lakes, West Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
Mercy Hospital Pittsburg, Pittsburg, Kansas
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas
Associates In Womens Health, Wichita, Kansas
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Hospital Pavilion and Medical Campus, Louisville, Kentucky
Norton Suburban Hospital and Medical Campus, Louisville, Kentucky
Norton Brownsboro Hospital and Medical Campus, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Woman's Hospital, Baton Rouge, Louisiana
Women's Cancer Care-Covington, Covington, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Lafayette Family Cancer Center-EMMC, Brewer, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
Greater Baltimore Medical Center, Baltimore, Maryland
MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
University of Maryland Shore Medical Center at Easton, Easton, Maryland
Tufts Medical Center, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Lahey Hospital and Medical Center, Burlington, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
OSF Saint Francis Hospital and Medical Group, Escanaba, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Green Bay Oncology-Manistique, Manistique, Michigan
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan
Henry Ford Health Providence Southfield Hospital, Southfield, Michigan
Munson Medical Center, Traverse City, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Fairview Ridges Hospital, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Mayo Clinic Health Systems-Mankato, Mankato, Minnesota
Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota
Saint John's Hospital - Healtheast, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
Saint Francis Regional Medical Center, Shakopee, Minnesota
Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota
Saint Dominic-Jackson Memorial Hospital, Jackson, Mississippi
University of Mississippi Medical Center, Jackson, Mississippi
Saint Francis Medical Center, Cape Girardeau, Missouri
Mercy Hospital Joplin, Joplin, Missouri
Barnes-Jewish Hospital, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Billings Clinic Cancer Center, Billings, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Logan Health Medical Center, Kalispell, Montana
Community Medical Center, Missoula, Montana
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska
CHI Health Good Samaritan, Kearney, Nebraska
Nebraska Methodist Hospital, Omaha, Nebraska
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska
Alegent Health Lakeside Hospital, Omaha, Nebraska
Women's Cancer Center of Nevada, Las Vegas, Nevada
Wentworth-Douglass Hospital, Dover, New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Dartmouth Cancer Center - Nashua, Nashua, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
Englewood Hospital and Medical Center, Englewood, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Southwest Gynecologic Oncology Associates Inc, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Memorial Medical Center-Las Cruces, Las Cruces, New Mexico
Montefiore Medical Center-Einstein Campus, Bronx, New York
State University of New York Downstate Medical Center, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Commack, Commack, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Dickstein Cancer Treatment Center, White Plains, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Duke University Medical Center, Durham, North Carolina
Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina
Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina
Duke Cancer Center Raleigh, Raleigh, North Carolina
Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Broadway Medical Center, Fargo, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Trinity Cancer Care Center, Minot, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio
TriHealth Cancer Institute-Westside, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Columbus Oncology and Hematology Associates Inc, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
The Mark H Zangmeister Center, Columbus, Ohio
Grandview Hospital, Dayton, Ohio
Orion Cancer Care, Findlay, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University Hospitals Sharon Health Center, Wadsworth, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Wright-Patterson Medical Center, Wright-Patterson Air Force Base, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa, Oklahoma
Saint Charles Health System, Bend, Oregon
Willamette Valley Cancer Center, Eugene, Oregon
Legacy Mount Hood Medical Center, Gresham, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Kaiser Permanente Northwest, Portland, Oregon
Legacy Meridian Park Hospital, Tualatin, Oregon
Jefferson Abington Hospital, Abington, Pennsylvania
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
Lancaster General Hospital, Lancaster, Pennsylvania
University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania
Geisinger Medical Oncology-Selinsgrove, Selinsgrove, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
UPMC Susquehanna, Williamsport, Pennsylvania
WellSpan Health-York Hospital, York, Pennsylvania
Women and Infants Hospital, Providence, Rhode Island
AnMed Health Cancer Center, Anderson, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Gibbs Cancer Center-Gaffney, Gaffney, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
South Carolina Cancer Specialists PC, Hilton Head Island, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
SMC Center for Hematology Oncology Union, Union, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Avera Cancer Institute, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Wellmont Medical Associates Oncology and Hematology-Johnson City, Johnson City, Tennessee
Ballad Health Cancer Care - Kingsport, Kingsport, Tennessee
Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee
Thompson Cancer Survival Center, Knoxville, Tennessee
Thompson Cancer Survival Center - West, Knoxville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Oncology - Central Austin Cancer Center, Austin, Texas
Texas Oncology - South Austin Cancer Center, Austin, Texas
Texas Oncology Bedford, Bedford, Texas
Parkland Memorial Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Texas Oncology - Fort Worth Cancer Center, Fort Worth, Texas
Houston Methodist Hospital, Houston, Texas
Methodist Willowbrook Hospital, Houston, Texas
Houston Methodist Sugar Land Hospital, Sugar Land, Texas
Texas Oncology-The Woodlands, The Woodlands, Texas
Intermountain Medical Center, Murray, Utah
Saint George Regional Medical Center, Saint George, Utah
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
Skagit Regional Health Cancer Care Center, Mount Vernon, Washington
Skagit Valley Hospital, Mount Vernon, Washington
Pacific Gynecology Specialists, Seattle, Washington
Fred Hutchinson Cancer Center, Seattle, Washington
Swedish Medical Center-First Hill, Seattle, Washington
University of Washington Medical Center - Northwest, Seattle, Washington
Women's Cancer Center of Seattle, Seattle, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
Wenatchee Valley Hospital and Clinics, Wenatchee, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Edwards Comprehensive Cancer Center, Huntington, West Virginia
Marshfield Clinic-Chippewa Center, Chippewa Falls, Wisconsin
Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Marshfield Medical Center - Ladysmith, Ladysmith, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Saint Vincent Hospital Cancer Center at Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Marshfield Clinic-Wausau Center, Wausau, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
London Regional Cancer Program, London, Ontario
Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario
Algoma District Cancer Program Sault Area Hospital, Sault Ste Marie, Ontario
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal, Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
Jewish General Hospital, Montreal, Quebec
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Iwate Medical University Hospital, Shiwa-gun, Iwate
Kagoshima City Hospital, Kagoshima City, Kagoshima
The Cancer Institute Hospital Of JFCR, Koto-ku, Tokyo
Saitama Medical University International Medical Center, Saitama, Not set
National Cancer Center Hospital, Tokyo, Not set
Seoul National University Hospital, Seoul, Not set
Conditions: Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Transitional Cell Carcinoma, Fallopian Tube Undifferentiated Carcinoma, Ovarian Clear Cell Adenocarcinoma, Ovarian Endometrioid Tumor, Ovarian Seromucinous Carcinoma, Ovarian Serous Tumor, Ovarian Transitional Cell Carcinoma, Ovarian Undifferentiated Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Ovarian Endometrioid Adenocarcinoma, Recurrent Primary Peritoneal Carcinoma
A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Recruiting
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations.
Advanced NSCLC is a group of lung cancers that have spread to nearby tissues or to other parts of the body or that are unlikely to be cured or controlled with currently available treatments. HER2 is a protein that helps cells to grow and divide. A damage (also called mutation) to the building... Read More
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations.
Advanced NSCLC is a group of lung cancers that have spread to nearby tissues or to other parts of the body or that are unlikely to be cured or controlled with currently available treatments. HER2 is a protein that helps cells to grow and divide. A damage (also called mutation) to the building plans (genes) for this protein in cancer cells leads to a production of abnormal HER2 and therefore abnormal cell growth and division.
The study treatment, BAY 2927088, is expected to block the mutated HER2 protein which may stop the spread of NSCLC.
The main purpose of this study is to learn how well BAY 2927088 works and how safe it is compared with standard treatment, in participants who have advanced NSCLC with specific genetic changes called HER2 mutations.
The study participants will receive one of the study treatments:
* BAY 2927088 twice every day as a tablet by mouth, or
* Standard treatment in cycles of 21 days via infusion ("drip") into the vein. The treatment will continue for as long as participants benefit from it without any severe side effects or until they or their doctor decide to stop the treatment.
During the study, the doctors and their study team will:
* take imaging scans, including CT, PET, MRI, and X-rays, of different parts of the body to study the spread of cancer
* check the overall health of the participants by performing tests such as blood and urine tests, and checking
* heart health using an electrocardiogram (ECG)
* perform pregnancy tests for women
* ask the participants questions about how they are feeling and what adverse events they are having.
An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: Patty & George Hoag Cancer Center, Newport Beach, California +278 locations
Patty & George Hoag Cancer Center, Newport Beach, California
UC San Diego Health - Moores Cancer Center, San Diego, California
UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology, San Francisco, California
UCLA Health Santa Monica Cancer Care, Santa Monica, California
The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street, Fort Lauderdale, Florida
Memorial Cancer Institute at Miramar, Miramar, Florida
AdventHealth Cancer Institute, Orlando, Florida
Moffitt Cancer Center - Magnolia Campus, Tampa, Florida
Moffitt Cancer Center, Tampa, Florida
Piedmont Cancer Institute - Atlanta, Atlanta, Georgia
John B. Amos Cancer Center, Columbus, Georgia
University of Illinois Hospital - Outpatient Cancer Care Center, Chicago, Illinois
The University of Chicago Medical Center - Hyde Park - Hematology & Oncology, Chicago, Illinois
UM Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
UMass Memorial Medical Center - University Campus - Oncology, Worcester, Massachusetts
Profound Research -OMG - TriAtria Cancer Center, Farmington Hills, Michigan
Profound Research - OMG - Royal Oak Cancer Center, Royal Oak, Michigan
University of Minnesota Medical Center, Minneapolis, Minnesota
R.J. Zuckerberg Cancer Center, New Hyde Park, New York
UC Medical Center - Oncology, Cincinnati, Ohio
Providence Cancer Institute - Franz Clinic, Portland, Oregon
Providence Oncology and Hematology Care Clinic Westside, Portland, Oregon
Allegheny General Hospital, Pittsburgh, Pennsylvania
UT Southwestern, Dallas, Texas
University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston, Texas
Virginia Commonwealth University, Richmond, Virginia
Fundación Cenit para la Investigación en Neurociencias, Caba, Ciudad Auton. De Buenos Aires
Hospital Italiano de Buenos Aires, Buenos Aires, Not set
Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC), Buenos Aires, Not set
Centro Médico Privado CEMAIC, Córdoba, Not set
Instituto Argentino de Diagnostico y Tratamiento (IADT), TBC, Not set
Centro de Investigaciones Clínicas, Clínica Viedma, Viedma, Not set
Blacktown Cancer & Haematology Centre, Blacktown, New South Wales
Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit, Concord, New South Wales
Calvary Mater Hospital Newcastle, Waratah, New South Wales
University of the Sunshine Coast, Buderim, Not set
The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC), Garran, Not set
Austin Hospital - Olivia Newton John Cancer Research Institute, Heidelberg, Not set
Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III, Salzburg, Not set
Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde, Salzburg, Not set
Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie, Wien, Not set
Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik, Wien, Not set
UZ Leuven Gasthuisberg - Pneumology Department, Leuven, Vlaams-Brabant
AZ Delta | Clinical Trial Center - Pneumology, Roeselare, West-Flanders
Antwerp University Hospital | Oncology Department, Antwerpen, Not set
Rede DoR Recife - PE, Recife, Pernambuco
Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica, Natal, Rio Grande Do Norte
Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology, Porto Alegre, Rio Grande Do Sul
Centro de Pesquisa da Clínica de Oncologia Reichow, Blumenau, Santa Catarina
Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos, Sao Paulo
Hospital de Base | Integrated Research Center, São José do Rio Preto, Sao Paulo
NAIC - Instituto do Cancer, Bauru, Not set
Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia, Brasilia, Not set
Pronutrir Fortaleza - CE, Fortaleza, Not set
Hospital Sirio Libanes, Sao Paulo, Not set
A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante, Sao Paulo, Not set
Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima, Sao Paulo, Not set
MHAT Uni Hospital, Panagyurishte, Pazardzhik
MHAT "Heart and brain" Pleven, Pleven, Not set
Complex Oncology Center - Plovdiv EOOD, Plovdiv, Not set
MHAT Park Hospital EOOD, Plovdiv, Not set
Multiprofile Hospital for Active Treatment "Sveta Sofia", Sofia, Not set
MHAT Serdika, Sofia, Not set
Specialized Hospital for Active Treatment of Oncology, Sofia, Not set
University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia, Sofia, Not set
MHAT Sveta Marina EAD, Varna, Not set
BC Cancer - Vancouver Site, Vancouver, British Columbia
Brampton Civic Hospital - Oncology, Brampton, Ontario
Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology, Toronto, Ontario
Jewish General Hospital - Department of Pulmonary Oncology, Montreal, Quebec
Beijing Cancer Hospital - Oncology Department, Beijing, Beijing
Beijing Hospital, Beijing, Beijing
Fujian Cancer Hospital, Fuzhou, Fujian
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang
Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech, Wuhan, Hubei
Hubei Cancer Hospital, Wuhan, Hubei
Hunan Cancer Hospital - Oncology Department, Changsha, Hunan
NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School, Nanjing, Jiangsu
Jilin Cancer Hospital, Changchun, Jilin
Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, Shanghai
West China Hospital Sichuan University, Chengdu, Sichuan
Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department, Hangzhou, Zhejiang
Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, Not set
The People's Liberation Army General Hospital (Beijing 301 Hospital), Beijing, Not set
Beijing chest hospital, Capital Medical University, Beijing, Not set
University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital), Chengdu, Not set
Guangzhou Medical University - The First Affiliated Hospital, Guangzhou, Not set
Shandong University - Shandong Cancer Hospital, Jinan, Not set
LinYi Cancer Hospital (Linyi Tumor Hospital), Linyi, Not set
Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University, Nanjing, Not set
Guangxi Medical University (GXMU) - Affiliated Tumor Hospital, Nanning, Not set
Zhongshan Hospital, Fudan University - Oncology Department, Shanghai, Not set
Xiamen University - The First Affiliated Hospital, Xiamen, Not set
Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie, Zlin, Zlinsky Kraj
Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP), Brno, Not set
Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie, Nový Jicín, Not set
Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy, Olomouc, Not set
Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddelení, Ostrava - Vítkovice, Not set
Aalborg University hospital - oncology department, Aalborg, Not set
Aarhus Universitetshospital, Aarhus N, Not set
Rigshospitalet - Kræftbehandling, Copenhagen OE, Not set
Regionshospitalet Gødstrup - Medicinsk afdeling, Herning, Not set
Odense University Hospital - Oncology Department, Odense C, Not set
Docrates Mehiläinen Syöpäsairaala, Helsinki, Not set
Turun yliopistollinen keskussairaala, Turku, Not set
Institut Bergonie - Unicancer Nouvelle Aquitaine, Bordeaux, Not set
Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie, Brest, Not set
Centre Hospitalier Intercommunal Creteil - Service de pneumologie, Créteil, Not set
Centre Hospitalier Michallon Grenoble - Service pneumologie, La Tronche, Not set
Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire, Lille, Not set
Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique, Limoges, Not set
CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique, Montpellier, Not set
hopital Emile Muller - Service Pneumologie, Mulhouse, Not set
Hopital Nord Laennec - Oncologie medicale thoracique et digestive, Nantes, Not set
Centre Antoine Lacassagne - Departement Oncologie, Nice, Not set
hopital cochin APHP - service de pneumologie, Paris, Not set
Institut Curie - Paris - Oncologie medicale, Paris, Not set
hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique, Pierre Bénite, Not set
CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie, Rouen, Not set
Institut de Cancerologie Ouest - Saint-Herblain, Saint-Herblain, Not set
Hopital Foch - Oncologie digestive et thoracique, Suresnes, Not set
Gustave Roussy - Departement Oncologie-Radiotherapie, Villejuif, Not set
Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie, Giessen, Hessen
Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik, Köln, Nordrhein-Westfalen
Universitaetsklinikum Essen - Innere Klinik (Tumorforschung), Essen, North Rhine-Westphalia
Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Berlin, Not set
Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie, Frankfurt, Not set
Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin, Hemer, Not set
Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde), Nürnberg, Not set
Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin, Stuttgart, Not set
?enry Durant Hospital Center-4th Oncology Department and Clinical Trials Unit, Athens, Not set
University of Athens Medical School-Sotiria General Hospital - 3rd Dept of Medicine & Medical Oncology, Athens, Not set
General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA, Athens, Not set
University General Hospital ATTIKON, Department of Internal Medicine IV, Chaidari, Not set
University General Hospital of Athens "ATTIKON", Chaidari, Not set
University General Hospital of Larissa, Larissa, Not set
Metropolitan Hospital- 4th Oncology Clinic, Piraeus, Not set
Bioclinic Thessaloniki, Thessaloniki, Not set
PAPANIKOLAOU General Hospital of Thessaloniki, Thessaloniki, Not set
Prince of Wales Hospital, Hong Kong, Not set
Queen Mary Hospital, Hong Kong, Not set
Queen Elizabeth Hospital Hong Kong, Hong Kong, Not set
Hong Kong United Oncology Centre, Kowloon, Not set
Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály, Budapest, Not set
Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabanya, Not set
Assuta Ashdod Public Hospital (R.A), Ashdod, Not set
Soroka Medical Center- Legacy Heritage Cancer Center, Be'er Sheva, Not set
Shaare Zedek Medical Center (SZMC), Jerusalem, Not set
Tel-Aviv Sourasky Medical Center, Tel Aviv, Not set
AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica, Avellino, Campania
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica, Bologna, Emilia-Romagna
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica, Meldola, Emilia-Romagna
Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati, Aviano, Friuli-Venezia Giulia
I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2, Roma, Lazio
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare, Roma, Lazio
Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1, Milano, Lombardia
Istituto Europeo di Oncologia s.r.l - Oncologia Toracica, Milano, Lombardia
Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia, Rozzano, Lombardia
Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica, Orbassano, Piemonte
Istituto Oncologico Veneto_Padova - UOC Oncologia 2, Padova, Veneto
Careggi University Hospital - Oncologia Clinica, Firenze, Not set
Careggi University Hospital - Oncologia Clinica, Firenze, Not set
Ospedale Vito Fazzi Lecce - Oncologia, Lecce, Not set
Ospedale San Raffaele s.r.l. - Oncologia Medica, Milano, Not set
Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica, Palermo, Not set
ASST Sette Laghi_Ospedale Macchi - Oncologia, Varese, Not set
Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia, Verona, Not set
National Hospital Organization Nagoya Medical Center, Nagoya, Aichi
National Cancer Center Hospital East, Kashiwa, Chiba
Hokkaido University Hospital, Sapporo, Hokkaido
National Hospital Organization Himeji Medical Center, Himeji, Hyogo
Kobe University Hospital, Kobe, Hyogo
Kitasato University Hospital, Sagamihara, Kanagawa
Sendai Kousei Hospital, Sendai, Miyagi
Kansai Medical University Hospital, Hirakata, Osaka
Kindai University Hospital, Osakasayama, Osaka
Saitama Cancer Center, Kitaadachi-gun, Saitama
Nippon Medical School - Nippon Medical School Hospital - Cancer Center, Bunkyo-ku, Tokyo
Tottori University Hospital, Yonago, Tottori
National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital), Ube, Yamaguchi
National Hospital Organization Kyushu Medical Center, Fukuoka, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka International Cancer Institute, Osaka, Not set
Chungbuk National University Hospital, Cheongju-si, Chungcheongbugdo
Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do
Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo
Severance Hospital, Yonsei University Health System - Oncology Department, Seoul, Seoul Teugbyeolsi
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi
Chonnam National University Hwasun Hospital, Hwasun Gun, Not set
Samsung Medical Center - Oncology Department, Seoul, Not set
Beacon Hospital, Petaling Jaya, Selangor
Columbia Asia Hospital Bukit Rimau, Shah Alam, Selangor
Sunway Medical Centre, Subang Jaya, Selangor
University Hospital Kebangsaan Malaysia, Cheras, Not set
Gleneagles Penang Medical Center, George Town,, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Sunway Medical Centre Penang, Perai, Not set
Instituto Nacional de Cancerología, Mexico, Distrito Federal
Oncare Viaducto Nápoles, Cdmx, Not set
Oncología Integral Satélite, Naucalpan, Not set
Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia, Nuevo León, Not set
Clinica Integral Internacional de Oncologia S. de R.L. de C.V., Puebla, Not set
ONCARE Treatment Center, San Pedro Garza García, Not set
Nederlands Kanker Instituut, Amsterdam, Not set
Radboud University Medical Center | Afdeling Interne Geneeskunde, Nijmegen, Not set
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej, Warsaw, Mazowieckie
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej, Warsaw, Mazowieckie
Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok, Not set
Swietokrzyskie Centrum Onkologii, Kielce, Not set
Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi, Lodz, Not set
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku, Otwock, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii, Poznan, Not set
Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii, Wroclaw, Not set
Hospital Pedro Hispano | Clinical Research Center, Matosinhos, Porto
Unidade Local Saúde Coimbra, E.P.E, Coimbra, Not set
Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica, Lisboa, Not set
CHULN - Hospital Pulido Valente, Lisboa, Not set
IPO Porto, Porto, Not set
Radiotherapy Center Cluj SRL, Flore?ti, Comuna Floresti
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II, Bucuresti, Not set
Spitalul Clinic Coltea, Bucuresti, Not set
CardioMed S.R.L., Cluj-Napoca, Not set
Institutul Oncologic Prof. Dr. Ion Chiricuta, Cluj-Napoca, Not set
Sc Oncolab Srl, Craiova, Not set
Centrul de Oncologie Sfantul Nectarie, Craiova, Not set
S.C Ovidius Clinical Hospital SRL - Oncology Department, Ovidiu, Not set
Oncocenter, Timisoara, Not set
Raffles Cancer Centre, Singapore, Not set
OncoCare Cancer Centre | Gleneagles Medical Centre, Singapore, Not set
Tan Tock Seng Hospital, Singapore, Not set
Curie Oncology | Farrer, Singapore, Not set
POKO Poprad s.r.o., Poprad, Not set
Fakultna nemocnica Trnava, Trnava, Not set
Hospital Universitario Puerta De Hierro De Majadahonda - Oncologia, Majadahonda, Madrid
Complejo Hospitalario Universitario A Coruna (CHUAC), A Coruna, Not set
Institut Catala d'Oncologia (ICO) - Hospital Universitari Germans Trias i Pujol (HUGTP) Location, Badalona, Not set
Hospital Quiron Dexeus - Oncologia, Barcelona, Not set
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona (Hospital Clinic i Provincial), Barcelona, Not set
Hospital General Universitario Gregorio Maranon | Oncologia, Madrid, Not set
Hospital Universitario Ramon Y Cajal - Oncologia, Madrid, Not set
Hospital Universitario Fundacion Jimenez Diaz- Oncology Service, Madrid, Not set
Hospital Universitario De Navarra - Oncologia, Pamplona, Not set
Fundacion Instituto Valenciano de Oncologia (IVO, Valencia, Not set
Hospital Universitario Y Politecnico La Fe - Oncologia, Valencia, Not set
Skåne University Hospital, Lund, Not set
Norrland University Hospital - Cancercentrum, Umeå, Not set
Kantonsspital Baden, Baden, Aargau
HFR Freiburg - Kantonsspital, Fribourg, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Kaohsiung
National Cheng Kung University Hospital, Tainan, TNN
Chung Shan Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi-Mei Medical Center, Liouyine, Tainan, Not set
National Taiwan University Hospital (NTUH) - Cancer Research Center, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Ankara Bilkent Sehir Hastanesi, Bilkent Ankara, Not set
Marmara University Hospital, Istanbul, Not set
Ege Universitesi Tip Fakultesi, Izmir, Not set
Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi, Kadikoy, Not set
I.A.Ü. VM Medical Park Florya Hastanesi, Kucukcekmece, Not set
Sakarya Universitesi Egitim ve Arastirma Hastanesi, Sakarya, Not set
Ankara Etlik Sehir Hastanesi, Yenimahalle, Not set
Adana Sehir Egitim ve Arastirma Hastanesi, Yuregir, Not set
LLC "RDP Ukraine" - Medical Department, Dnipro, Not set
Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center, Kropyvnytskyi, Not set
Kyiv City Clinical Oncology Center - Department of Chemotherapy #1, Kyiv, Not set
Limited Liability Company "MedOffice Group Medical Center", Kyiv, Not set
Medical Center LLC "Verum Expert Clinic", Kyiv, Not set
Volyn Regional Oncology Center, Lutsk, Not set
Municipal Enterprise 'Rivne Regional Antitumor Center" of the Rivne Regional Council", Rivne, Not set
MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department, Uzhhorod, Not set
Torbay Hospital, Torquay, Devon
Belfast City Hospital, Belfast, North Ireland
Royal Surrey County Hospital, Guildford, Surrey
Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit, Cardiff, Not set
Conditions: Advanced Non-small Cell Lung Cancer, HER2 Mutation
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
Active Not Recruiting
This phase III trial studies how well the combination of pembrolizumab, paclitaxel and carboplatin works compared with paclitaxel and carboplatin alone in treating patients with endometrial cancer that is stage III or IV, or has come back after a period of improvement (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Paclitaxel and carboplatin are... Read More
This phase III trial studies how well the combination of pembrolizumab, paclitaxel and carboplatin works compared with paclitaxel and carboplatin alone in treating patients with endometrial cancer that is stage III or IV, or has come back after a period of improvement (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Paclitaxel and carboplatin are chemotherapy drugs used as part of the usual treatment approach for this type of cancer. This study aims to assess if adding immunotherapy to these drugs is better or worse than the usual approach for treatment of this cancer. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/25/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +396 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Alaska Women's Cancer Care, Anchorage, Alaska
CTCA at Western Regional Medical Center, Goodyear, Arizona
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente-Baldwin Park, Baldwin Park, California
Kaiser Permanente-Bellflower, Bellflower, California
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California
Community Cancer Institute, Clovis, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente South Bay, Harbor City, California
Kaiser Permanente-Irvine, Irvine, California
UC San Diego Moores Cancer Center, La Jolla, California
City of Hope Antelope Valley, Lancaster, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View, California
Kaiser Permanente-Oakland, Oakland, California
Saint Joseph Hospital - Orange, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Eisenhower Medical Center, Rancho Mirage, California
Mercy Regional Cancer Center, Redding, California
Mercy Oncology Center, Redding, California
Kaiser Permanente-Riverside, Riverside, California
Kaiser Permanente-Roseville, Roseville, California
Kaiser Permanente Downtown Commons, Sacramento, California
Mercy Cancer Center - Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente-San Diego Zion, San Diego, California
Naval Medical Center -San Diego, San Diego, California
Zuckerberg San Francisco General Hospital, San Francisco, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
Kaiser Permanente-San Francisco, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Kaiser Permanente-San Marcos, San Marcos, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente-South San Francisco, South San Francisco, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
City of Hope Upland, Upland, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
John Muir Medical Center-Walnut Creek, Walnut Creek, California
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
UCHealth Memorial Hospital Central, Colorado Springs, Colorado
Memorial Hospital North, Colorado Springs, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
UCHealth Greeley Hospital, Greeley, Colorado
Medical Center of the Rockies, Loveland, Colorado
Banner McKee Medical Center, Loveland, Colorado
Danbury Hospital, Danbury, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Hartford Hospital, Hartford, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
Yale University, New Haven, Connecticut
Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut
Norwalk Hospital, Norwalk, Connecticut
Stamford Hospital/Bennett Cancer Center, Stamford, Connecticut
Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Helen F Graham Cancer Center, Newark, Delaware
MedStar Washington Hospital Center, Washington, District of Columbia
Sibley Memorial Hospital, Washington, District of Columbia
Florida Cancer Specialists - Bradenton Cancer Center, Bradenton, Florida
Florida Cancer Specialists - Sarasota, Sarasota, Florida
Florida Cancer Specialists - Sarasota Downtown, Sarasota, Florida
Sarasota Memorial Hospital, Sarasota, Florida
Florida Cancer Specialists - Venice Pinebrook, Venice, Florida
Florida Cancer Specialists - Venice Island, Venice, Florida
Grady Health System, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
WellStar Cobb Hospital, Austell, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia
WellStar Health System Inc, Marietta, Georgia
Wellstar Kennestone Hospital, Marietta, Georgia
CTCA at Southeastern Regional Medical Center, Newnan, Georgia
WellStar North Fulton Hospital, Roswell, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
WellStar Vinings Health Park, Smyrna, Georgia
Queen's Medical Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Carle at The Riverfront, Danville, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Crossroads Cancer Center, Effingham, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
University of Chicago Medicine-Orland Park, Orland Park, Illinois
Springfield Clinic, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Midwestern Regional Medical Center, Zion, Illinois
Northwest Cancer Center - Main Campus, Crown Point, Indiana
Northwest Oncology LLC, Dyer, Indiana
Northwest Cancer Center - Hobart, Hobart, Indiana
Saint Mary Medical Center, Hobart, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Community Cancer Center East, Indianapolis, Indiana
Community Cancer Center South, Indianapolis, Indiana
Franciscan Health Indianapolis, Indianapolis, Indiana
Community Cancer Center North, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Saint Catherine Hospital, Indianapolis, Indiana
Franciscan Health Mooresville, Mooresville, Indiana
The Community Hospital, Munster, Indiana
Women's Diagnostic Center - Munster, Munster, Indiana
Northwest Cancer Center - Valparaiso, Valparaiso, Indiana
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kansas Clinical Research Center, Fairway, Kansas
University of Kansas Cancer Center, Kansas City, Kansas
University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
Saint Elizabeth Healthcare Edgewood, Edgewood, Kentucky
LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana
Our Lady of the Lake Physician Group, Baton Rouge, Louisiana
Our Lady of The Lake, Baton Rouge, Louisiana
Our Lady of the Lake Medical Oncology, Baton Rouge, Louisiana
Woman's Hospital, Baton Rouge, Louisiana
East Jefferson General Hospital, Metairie, Louisiana
University Medical Center New Orleans, New Orleans, Louisiana
Ochsner Baptist Medical Center, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Harold Alfond Center for Cancer Care, Augusta, Maine
MaineHealth Waldo Hospital, Belfast, Maine
MaineHealth Maine Medical Center - Biddeford, Biddeford, Maine
Lafayette Family Cancer Center-EMMC, Brewer, Maine
Penobscot Bay Medical Center, Rockport, Maine
MaineHealth Cancer Care and IV Therapy - Sanford, Sanford, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
Luminis Health Anne Arundel Medical Center, Annapolis, Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Saint Agnes Hospital, Baltimore, Maryland
MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
University of Maryland Shore Medical Center at Easton, Easton, Maryland
Lahey Hospital and Medical Center, Burlington, Massachusetts
Lowell General Hospital, Lowell, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester, Massachusetts
UMass Memorial Medical Center - Memorial Division, Worcester, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Cancer Hematology Centers - Flint, Flint, Michigan
Genesee Hematology Oncology PC, Flint, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Munson Medical Center, Traverse City, Michigan
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Essentia Health Cancer Center, Duluth, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Mississippi Baptist Medical Center, Jackson, Mississippi
University of Mississippi Medical Center, Jackson, Mississippi
Saint Luke's Hospital of Kansas City, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Mercy Hospital Springfield, Springfield, Missouri
Community Hospital of Anaconda, Anaconda, Montana
Billings Clinic Cancer Center, Billings, Montana
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska
Nebraska Methodist Hospital, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
Monmouth Medical Center Southern Campus, Lakewood, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
The Valley Hospital - Luckow Pavilion, Paramus, New Jersey
Neurosurgeons of New Jersey-Ridgewood, Ridgewood, New Jersey
Valley Health System Ridgewood Campus, Ridgewood, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Community Medical Center, Toms River, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Valley Medical Group - Wayne Multispecialty Practice, Wayne, New Jersey
Valley Health System-Hematology/Oncology, Westwood, New Jersey
Southwest Gynecologic Oncology Associates Inc, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Northwell Health Imbert Cancer Center, Bay Shore, New York
Island Gynecologic Oncology, Brightwaters, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Commack, Commack, New York
The New York Hospital Medical Center of Queens, Flushing, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
NYU Langone Hospital - Long Island, Mineola, New York
Long Island Jewish Medical Center, New Hyde Park, New York
Mount Sinai Chelsea, New York, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Staten Island University Hospital, Staten Island, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Westchester Medical Center, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina
Margaret R Pardee Memorial Hospital, Hendersonville, North Carolina
Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina
Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Broadway Medical Center, Fargo, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Aultman Health Foundation, Canton, Ohio
Miami Valley Hospital South, Centerville, Ohio
Geauga Hospital, Chardon, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
The Mark H Zangmeister Center, Columbus, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
UH Seidman Cancer Center at Saint John Medical Center, Westlake, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa, Oklahoma
Saint Charles Health System, Bend, Oregon
Saint Alphonsus Cancer Care Center-Ontario, Ontario, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Legacy Meridian Park Hospital, Tualatin, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
WellSpan Medical Oncology and Hematology, Hanover, Pennsylvania
Geisinger Medical Center-Cancer Center Hazleton, Hazleton, Pennsylvania
Jefferson Hospital, Jefferson Hills, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
Lancaster General Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania
Lancaster General Hospital, Lancaster, Pennsylvania
Sechler Family Cancer Center, Lebanon, Pennsylvania
Forbes Hospital, Monroeville, Pennsylvania
UPMC Hillman Cancer Center - Monroeville, Monroeville, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Community Medical Center, Scranton, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Wexford Health and Wellness Pavilion, Wexford, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Asplundh Cancer Pavilion, Willow Grove, Pennsylvania
WellSpan Health-York Cancer Center, York, Pennsylvania
WellSpan Health-York Hospital, York, Pennsylvania
Women and Infants Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Avera Cancer Institute, Sioux Falls, South Dakota
Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Parkland Memorial Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Ben Taub General Hospital, Houston, Texas
Houston Methodist Hospital, Houston, Texas
Methodist Willowbrook Hospital, Houston, Texas
Houston Methodist Sugar Land Hospital, Sugar Land, Texas
Houston Methodist The Woodlands Hospital, The Woodlands, Texas
University of Utah Sugarhouse Health Center, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
University of Vermont Medical Center, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
MultiCare Gig Harbor Medical Park, Gig Harbor, Washington
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
MultiCare Good Samaritan Hospital, Puyallup, Washington
Valley Medical Center, Renton, Washington
Swedish Medical Center-First Hill, Seattle, Washington
MultiCare Tacoma General Hospital, Tacoma, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Monongalia Hospital, Morgantown, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
The Moncton Hospital, Moncton, New Brunswick
Royal Victoria Regional Health Centre, Barrie, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
London Regional Cancer Program, London, Ontario
Lakeridge Health Oshawa, Oshawa, Ontario
Algoma District Cancer Program Sault Area Hospital, Sault Ste Marie, Ontario
Health Sciences North, Sudbury, Ontario
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
Hopital de la Cite-de-la-Sante, Laval, Quebec
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Ehime University Hospital, Toon, Ehime
Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima
Niigata University Medical and Dental Hospital, Niigata City, Niigata
Saitama Medical University International Medical Center, Saitama, Not set
Keimyung University-Dongsan Medical Center, Dalseo-gu, Daegu
Samsung Changwon Hospital, Seoul, Gyeongsangnam-do
Seoul National University Bundang Hospital, Seongnam City, Kyeonggi-do
Kyungpook National University Chilgok Hospital, Daegu, Not set
Asan Medical Center, Seoul, Not set
Gangnam Severance Hospital, Seoul, Not set
Yonsei University Health System-Severance Hospital, Seoul, Not set
Korea Cancer Center Hospital, Seoul, Not set
Centro Comprensivo de Cancer de UPR, San Juan, Not set
Conditions: Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Recurrent Endometrial Adenocarcinoma, Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma, Recurrent Endometrial Dedifferentiated Carcinoma, Recurrent Endometrial Endometrioid Adenocarcinoma, Recurrent Endometrial Mixed Cell Adenocarcinoma, Recurrent Endometrial Serous Adenocarcinoma, Recurrent Endometrial Undifferentiated Carcinoma, Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8, Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
Recruiting
The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physician's choice (TPC) (paclitaxel, nab-paclitaxel, carboplatin plus gemcitabine, and capecitabine) for the treatment of first-line metastatic triple-negative breast cancer (TNBC) or estrogen receptor (ER)-low, human epidermal growth factor receptor 2 (HER2)-negative BC patients who are not candidates... Read More
The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physician's choice (TPC) (paclitaxel, nab-paclitaxel, carboplatin plus gemcitabine, and capecitabine) for the treatment of first-line metastatic triple-negative breast cancer (TNBC) or estrogen receptor (ER)-low, human epidermal growth factor receptor 2 (HER2)-negative BC patients who are not candidates for anti-PD(L)1 therapy and endocrine therapies. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Local Institution - 0303, Hot Springs, Arkansas +241 locations
Local Institution - 0303, Hot Springs, Arkansas
Local Institution - 0307, Cerritos, California
Local Institution - 0308, Cerritos, California
Local Institution - 0309, Cerritos, California
Local Institution - 0311, Long Beach, California
Local Institution - 0290, Los Angeles, California
Local Institution - 0283, Los Angeles, California
Local Institution - 0328, Whittier, California
Local Institution - 0289, Aurora, Colorado
Local Institution - 0304, Newark, Delaware
Local Institution - 0282, Miami, Florida
Local Institution - 0296, Pembroke Pines, Florida
Local Institution - 0294, Atlanta, Georgia
Local Institution - 0278, Chicago, Illinois
Local Institution - 0280, Chicago, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Local Institution - 0324, O'Fallon, Illinois
Local Institution - 0286, Covington, Louisiana
Local Institution - 0288, Boston, Massachusetts
Local Institution - 0287, Boston, Massachusetts
Local Institution - 0313, Minneapolis, Minnesota
Local Institution - 0284, Kansas City, Missouri
Local Institution - 0312, New York, New York
Local Institution - 0279, New York, New York
Clinical Research Alliance, Westbury, New York
Local Institution - 0285, White Plains, New York
Local Institution - 0276, Durham, North Carolina
Local Institution - 0316, Eugene, Oregon
Local Institution - 0310, Philadelphia, Pennsylvania
Local Institution - 0281, Greenville, South Carolina
Local Institution - 0315, Austin, Texas
Local Institution - 0314, Houston, Texas
Local Institution - 0305, Tyler, Texas
Local Institution - 0277, Midlothian, Virginia
Local Institution - 0301, Roanoke, Virginia
Local Institution - 0302, Winchester, Virginia
Local Institution - 0345, Buenas Aires, Buenos Aires
Local Institution - 0011, Ciudad autónoma de Buenos Aires, Buenos Aires
Local Institution - 0214, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0143, Cordoba, Córdoba
Local Institution - 0137, Río Cuarto, Córdoba
Local Institution - 0142, Rosario, Santa Fe
Local Institution - 0317, Buenos Aires, Not set
Local Institution - 0346, Buenos Aires, Not set
Local Institution - 0012, Ciudad Autónoma de Buenos Aires, Not set
Local Institution - 0035, Brisbane, Queensland
Local Institution - 0197, Ballarat Central, Victoria
Local Institution - 0031, Heidelberg, Victoria
Local Institution - 0274, Melbourne, Victoria
Local Institution - 0028, Subiaco, Western Australia
Local Institution - 0292, Graz, Steiermark
Local Institution - 0268, Innsbruck, Tirol
Local Institution - 0267, Salzburg, Not set
Local Institution - 0270, St. Polten, Not set
Local Institution - 0269, Wien, Not set
Local Institution - 0187, Manaus, Amazonas
Local Institution - 0147, Fortaleza, Ceará
Local Institution - 0157, Vitória, Espírito Santo
Local Institution - 0199, Porto Alegre, Rio Grande Do Sul
Local Institution - 0164, São José do Rio Preto, São Paulo
Local Institution - 0153, Rio de Janeiro, Not set
Local Institution - 0144, São Paulo, Not set
Local Institution - 0149, São Paulo, Not set
Local Institution - 0218, Kelowna, British Columbia
Local Institution - 0217, Victoria, British Columbia
Local Institution - 0265, Ottawa, Ontario
Local Institution - 0215, Montréal, Quebec
Local Institution - 0219, Montréal, Quebec
Local Institution - 0350, Saint-Jerome, Quebec
Local Institution - 0216, Sherbrooke, Quebec
Local Institution - 0138, Santiago, Región Metropolitana De Santiago
Local Institution - 0021, Santiago, Región Metropolitana De Santiago
Local Institution - 0017, Santiago, Región Metropolitana De Santiago
Local Institution - 0018, Santiago, Región Metropolitana De Santiago
Local Institution - 0016, Viña del Mar, Valparaíso
Local Institution - 0195, Medellín, Antioquia
Local Institution - 0201, Rionegro, Antioquia
Local Institution - 0194, Barranquilla, Atlántico
Local Institution - 0182, Puerto Colombia, Atlántico
Local Institution - 0181, Montería, COR
Local Institution - 0327, Bogota, Cundinamarca
Local Institution - 0183, Cali, Valle Del Cauca
Local Institution - 0349, Medellin, Not set
Local Institution - 0089, Bordeaux, Aquitaine
Local Institution - 0272, Dijon, Côte-d'Or
Local Institution - 0098, Toulouse, Haute-Garonne
Local Institution - 0095, Montpellier, Hérault
Local Institution - 0099, Rennes, Ille-et-Vilaine
Local Institution - 0092, Saint Herblain, Loire-Atlantique
Local Institution - 0091, Reims, Marne
Local Institution - 0097, Villejuif, Paris
Local Institution - 0093, Marseille, Provence-Alpes-Côte-d'Azur
Local Institution - 0096, Clermont-Ferrand, Puy-de-Dôme
Local Institution - 0090, Lyon, Rhône-Alpes
Local Institution - 0094, Lille, Not set
Local Institution - 0088, Paris, Not set
Local Institution - 0320, Esslingen, Baden-Württemberg
Local Institution - 0256, Augsburg, Bayern
Local Institution - 0271, München, Bayern
Local Institution - 0306, Frankfurt, Hessen
Local Institution - 0333, Langen, Hessen
Local Institution - 0257, Hannover, Niedersachsen
Local Institution - 0293, Düsseldorf, Nordrhein-Westfalen
Local Institution - 0263, Essen, Nordrhein-Westfalen
Local Institution - 0254, Leipzig, Sachsen
Local Institution - 0255, Lübeck, Schleswig-Holstein
Local Institution - 0261, Berlin, Not set
Local Institution - 0260, Berlin, Not set
Local Institution - 0259, Bonn, Not set
Local Institution - 0258, Dresden, Not set
Local Institution - 0262, Heidelberg, Not set
Local Institution - 0291, Ulm, Not set
Local Institution - 0042, Athens, Attikí
Local Institution - 0038, Athens, Attikí
Local Institution - 0086, Heraklion, Irakleío
Local Institution - 0043, Athens, Not set
Local Institution - 0266, New Delhi, Delhi
Local Institution - 0206, New Delhi, Delhi
Local Institution - 0131, Mumbai, Maharashtra
Local Institution - 0134, Nagpur, Maharashtra
Local Institution - 0125, Chennai, Tamil Nadu
Local Institution - 0130, Hyderabad, Telangana
Local Institution - 0133, Varanasi, Uttar Pradesh
Local Institution - 0352, New Delhi, Not set
Local Institution - 0186, Petah Tikva, HaMerkaz
Local Institution - 0044, Ramat Gan, HaMerkaz
Local Institution - 0048, Hadera, HaTsafon
Local Institution - 0123, Haifa, HaTsafon
Local Institution - 0047, Jerusalem, Yerushalayim
Local Institution - 0051, Napoli, Campania
Local Institution - 0049, Bologna, Emilia-Romagna
Local Institution - 0057, Aviano, Friuli-Venezia Giulia
Local Institution - 0054, Genova, Liguria
Local Institution - 0053, Pontedera, Pisa
Local Institution - 0055, Prato, Toscana
Local Institution - 0052, Milano, Not set
Local Institution - 0058, Napoli, Not set
Local Institution - 0061, Novara, Not set
Local Institution - 0056, Padova, Not set
Local Institution - 0062, Roma, Not set
Local Institution - 0236, Nagoya, Aichi
Local Institution - 0230, Chiba-shi, Chiba
Local Institution - 0240, Matsuyama, Ehime
Local Institution - 0226, Otashi, Gunma
Local Institution - 0222, Sapporo, Hokkaido
Local Institution - 0232, Kanazawa, Ishikawa
Local Institution - 0234, Isehara, Kanagawa
Local Institution - 0237, Yokohama, Kanagawa
Local Institution - 0246, Tsu, Mie
Local Institution - 0223, Sendai-shi, Miyagi
Local Institution - 0238, Suita, Osaka
Local Institution - 0227, Hidaka, Saitama
Local Institution - 0224, Ina-machi, Saitama
Local Institution - 0231, Bunkyo-ku, Tokyo
Local Institution - 0229, Chuo-ku, Tokyo
Local Institution - 0228, Koto, Tokyo
Local Institution - 0245, Shinagawa, Tokyo
Local Institution - 0233, Shinjuku-ku, Tokyo
Local Institution - 0242, Fukuoka, Not set
Local Institution - 0225, Fukushima, Not set
Local Institution - 0243, Hiroshima, Not set
Local Institution - 0244, Kagoshima, Not set
Local Institution - 0235, Kyoto, Not set
Local Institution - 0241, Okayama, Not set
Local Institution - 0239, Osaka, Not set
Local Institution - 0066, Goyang-si, Kyǒnggi-do
Local Institution - 0067, Seongnam, Kyǒnggi-do
Local Institution - 0068, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0063, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0071, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0064, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0065, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0069, Daegu, Taegu-Kwangyǒkshi
Local Institution - 0264, Tijuana, Baja California
Local Institution - 0177, Mexico City, DIF
Local Institution - 0329, Mexico City, Distrito Federal
Local Institution - 0178, Guadalajara, Jalisco
Local Institution - 0175, Monterrey, Nuevo León
Local Institution - 0176, Monterrey, Nuevo León
Local Institution - 0173, Oaxaca de Juarez, Oaxaca
Local Institution - 0179, Merida, Yucatán
Local Institution - 0174, Chihuahua, Not set
Local Institution - 0074, Biala Podlaska, Lubelskie
Local Institution - 0072, Warszawa, Mazowieckie
Local Institution - 0220, Warszawa, Mazowieckie
Local Institution - 0076, Opole, Opolskie
Local Institution - 0189, Skórzewo, Wielkopolskie
Local Institution - 0221, Łódź, Łódzkie
Local Institution - 0198, Lisbon, Lisboa
Local Institution - 0106, Lisbon, Lisboa
Local Institution - 0109, Lisbon, Lisboa
Local Institution - 0124, Coimbra, Not set
Local Institution - 0141, Lisboa, Not set
Local Institution - 0111, Porto, Not set
Local Institution - 0253, Porto, Not set
Local Institution - 0212, Bistrita, Bistrița-Năsăud
Local Institution - 0213, Bucharest, București
Local Institution - 0079, Florești, Cluj
Local Institution - 0078, Craiova, Dolj
Local Institution - 0084, Ploiești, Prahova
Local Institution - 0211, Dumbravita, Timiș
Local Institution - 0085, Timișoara, Timiș
Local Institution - 0083, București, Not set
Local Institution - 0077, Cluj, Not set
Local Institution - 0081, Iași, Not set
Local Institution - 0080, Iași, Not set
Local Institution - 0351, East London, Eastern Cape
Local Institution - 0342, Parktown, Gauteng
Local Institution - 0336, Pretoria, Gauteng
Local Institution - 0341, Pretoria, Gauteng
Local Institution - 0340, Soweto, Gauteng
Local Institution - 0105, A Coruña, A Coruña [La Coruña]
Local Institution - 0100, Elche, Alicante
Local Institution - 0102, Barcelona, Barcelona [Barcelona]
Local Institution - 0172, Hospitalet, Barcelona [Barcelona]
Local Institution - 0140, Barcelona, Catalunya [Cataluña]
Local Institution - 0139, San Sebastian, Gipuzkoa
Local Institution - 0104, Madrid, Madrid, Comunidad De
Local Institution - 0108, Madrid, Madrid, Comunidad De
Local Institution - 0101, Malaga, Málaga
Local Institution - 0210, Valencia, Valenciana, Comunitat
Local Institution - 0107, Madrid, Not set
Local Institution - 0103, Sevilla, Not set
Local Institution - 0252, Malmö, Skåne Län [se-12]
Local Institution - 0026, Stockholm, Stockholms Län [se-01]
Local Institution - 0025, Uppsala, Uppsala Län [se-03]
Local Institution - 0024, Örebro, Örebro Län [se-18]
Local Institution - 0247, Linköping, Östergötlands Län [se-05]
Local Institution - 0250, st.Gallen, Sankt Gallen
Local Institution - 0249, Lausanne, Vaud
Local Institution - 0251, Zürich, Not set
Local Institution - 0323, Abu Dhabi, Abū Z̧aby
Local Institution - 0318, Abu Dhabi, Abū Z̧aby
Local Institution - 0322, Al Ain, Abū Z̧aby
Local Institution - 0319, Abu Dhabi, Not set
Local Institution - 0208, Truro, England
Local Institution - 0204, London, London, City Of
Local Institution - 0209, London, London, City Of
Local Institution - 0171, Belfast, Not set
Local Institution - 0004, London, Not set
Local Institution - 0001, Manchester, Not set
Local Institution - 0006, Nottingham, Not set
Conditions: Breast Neoplasms
A Study of MK-1084 in KRAS Mutant Advanced Solid Tumors (MK-1084-001)
Recruiting
This is a study evaluating the safety, pharmacokinetics, and efficacy of MK-1084 alone, and MK-1084 plus other combination therapies in participants with advanced solid tumors with identified kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation.
This is a study evaluating the safety, pharmacokinetics, and efficacy of MK-1084 alone, and MK-1084 plus other combination therapies in participants with advanced solid tumors with identified kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: Moffitt Cancer Center ( Site 0261), Tampa, Florida +70 locations
Moffitt Cancer Center ( Site 0261), Tampa, Florida
START Midwest ( Site 0267), Grand Rapids, Michigan
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0260), Hackensack, New Jersey
Laura and Isaac Perlmutter Cancer Center ( Site 0270), New York, New York
NEXT Virginia ( Site 0271), Fairfax, Virginia
MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0262), Milwaukee, Wisconsin
Chris O'Brien Lifehouse ( Site 0002), Camperdown, New South Wales
Liverpool Hospital-Medical Oncology ( Site 0001), Liverpool, New South Wales
Westmead Hospital ( Site 0006), Westmead, New South Wales
Monash Health-Oncology Research ( Site 0003), Clayton, Victoria
Cross Cancer Institute ( Site 0033), Edmonton, Alberta
The Moncton Hospital ( Site 0037), Moncton, New Brunswick
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0030), Hamilton, Ontario
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0036), Kingston, Ontario
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0032), Toronto, Ontario
James Lind Centro de Investigacion del Cancer ( Site 0043), Temuco, Araucania
Centro de Estudios Clínicos SAGA-CECSAGA ( Site 0041), Santiago., Region M. De Santiago
FALP-UIDO ( Site 0040), Santiago, Region M. De Santiago
Bradfordhill ( Site 0042), Santiago, Region M. De Santiago
Beijing Friendship Hospital Affiliate of Capital University-Oncology ( Site 0417), Beijing, Beijing
Fujian Cancer Hospital ( Site 0419), Fuzhou, Fujian
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 0413), Guangzhou, Guangdong
Sun Yat-sen University Cancer Center-Internal medicine ( Site 0415), Guangzhou, Guangdong
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0418), Wuhan, Hubei
Jilin Cancer Hospital-oncology department ( Site 0412), Changchun, Jilin
Shanghai Chest Hospital-Oncology department ( Site 0410), Shanghai, Shanghai
Shanghai East Hospital ( Site 0416), Shanghai, Shanghai
Zhejiang Cancer Hospital-Thoracic oncology ( Site 0411), Hangzhou, Zhejiang
Odense Universitetshospital-Department of oncology ( Site 0421), Odense, Syddanmark
Rambam Health Care Campus-Oncology ( Site 0090), Haifa, Not set
Shaare Zedek Medical Center-Oncology ( Site 0092), Jerusalem, Not set
Hadassah Medical Center-Oncology ( Site 0094), Jerusalem, Not set
Meir Medical Center. ( Site 0091), Kfar Saba, Not set
Sheba Medical Center-ONCOLOGY ( Site 0093), Ramat Gan, Not set
Humanitas ( Site 0113), Rozzano, Lombardia
ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 0111), Siena, Toscana
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0110), Napoli, Not set
National Cancer Center Hospital East ( Site 0404), Kashiwa, Chiba
Kanagawa Cancer Center ( Site 0402), Yokohama, Kanagawa
Shizuoka Cancer Center ( Site 0401), Nagaizumi, Shizuoka
National Cancer Center Hospital ( Site 0403), Chuo-ku, Tokyo
Cancer Institute Hospital of JFCR ( Site 0400), Koto, Tokyo
Seoul National University Hospital ( Site 0191), Seoul, Not set
Samsung Medical Center-Division of Hematology/Oncology ( Site 0193), Seoul, Not set
Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 0121), Kaunas, Kauno Apskritis
Sarawak General Hospital ( Site 0453), Kuching, Sarawak
New Zealand Clinical Research (Christchurch) ( Site 0004), Christchurch, Canterbury
Centro Oncologico de Panama ( Site 0160), Panama City, Not set
Centro Hemato Oncológico Paitilla ( Site 0163), Panama City, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Oddzial Badan Wczesnych Faz ( Site 0170), Warszawa, Mazowieckie
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0171), Gdansk, Pomorskie
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 0172), Poznan, Wielkopolskie
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0173), Koszalin, Zachodniopomorskie
Clinica Universidad de Navarra ( Site 0213), Madrid, Madrid, Comunidad De
Hospital Universitario Fundación Jiménez Díaz-START Madrid-FJD ( Site 0211), Madrid, Madrid, Comunidad De
Hospital Universitari Vall d'Hebron-Oncology ( Site 0212), Barcelona, Not set
Cantonal Hospital St.Gallen ( Site 0224), St.Gallen, Sankt Gallen
Ospedale Regionale Bellinzona e Valli ( Site 0220), Bellinzona, Ticino
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 0445), Kaohsiung Niao Sung Dist, Kaohsiung
National Cheng Kung University Hospital ( Site 0444), Tainan, Not set
National Taiwan University Hospital-Oncology ( Site 0443), Taipei, Not set
Ege University Medicine of Faculty ( Site 0231), Bornova, Izmir
Erciyes University ( Site 0232), Talas, Kayseri
Hacettepe Universite Hastaneleri-oncology hospital ( Site 0234), Ankara, Not set
Ankara City Hospital-oncology ( Site 0233), Ankara, Not set
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 0254), Cherkasy, Cherkaska Oblast
Communal Non-Commercial Enterprise Prykarpatski Clinical Onc-Chemotherapy department ( Site 0251), Ivano-Frankivsk, Ivano-Frankivska Oblast
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 0255), Kropyvnytskyi, Kirovohradska Oblast
Rivne Regional Clinical Hospital ( Site 0257), Rivne, Rivnenska Oblast
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 0259), Rivne, Rivnenska Oblast
Uzhhorod Multispecialty City Clinical Hospital ( Site 0258), Uzhhorod, Zakarpatska Oblast
Conditions: Advanced Solid Tumors
Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors
Recruiting
This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors
This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
07/23/2025
Locations: Research Site, Duarte, California +58 locations
Research Site, Duarte, California
Research Site, Irvine, California
Research Site, La Jolla, California
Research Site, Aurora, Colorado
Research Site, Louisville, Kentucky
Research Site, Boston, Massachusetts
Research Site, Detroit, Michigan
Research Site, Columbus, Ohio
Research Site, Portland, Oregon
Research Site, Providence, Rhode Island
Research Site, Providence, Rhode Island
Research Site, Houston, Texas
Research Site, Fairfax, Virginia
Research Site, Liverpool, Not set
Research Site, Melbourne, Not set
Research Site, Edmonton, Alberta
Research Site, London, Ontario
Research Site, Toronto, Ontario
Research Site, Montréal, Quebec
Research Site, Montréal, Quebec
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Guangzhou, Not set
Research Site, Jinan, Not set
Research Site, Xi'an, Not set
Research Site, Zhengzhou, Not set
Research Site, Berlin, Not set
Research Site, Essen, Not set
Research Site, Hannover, Not set
Research Site, Leipzig, Not set
Research Site, Mannheim, Not set
Research Site, Regensburg, Not set
Research Site, Haifa, Not set
Research Site, Ramat Gan, Not set
Research Site, Hidaka-shi, Not set
Research Site, Kashiwa, Not set
Research Site, Koto-ku, Not set
Research Site, Sunto-gun, Not set
Research Site, Tokyo, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Taichung, Not set
Research Site, Tainan City, Not set
Research Site, Taipei, Not set
Research Site, Taipei, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Ankara, Not set
Research Site, Istanbul, Not set
Research Site, Cambridge, Not set
Research Site, Glasgow, Scotland, Not set
Research Site, London, Not set
Research Site, London, Not set
Research Site, Sutton, Not set
Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-4830-001)
Active Not Recruiting
This study consists of several parts: dose escalation, dose expansion, dose expansion in Chinese participants residing in China, and coformulation. Dose escalation is to evaluate the safety, tolerability, and preliminary efficacy of MK-4830 monotherapy administration (Arms A and B) and in combination with pembrolizumab (Arm C). Dose expansion is to evaluate the objective response rate (ORR) of MK-4830 in combination with pembrolizumab (Arms A-F); evaluate the safety and tolerability of MK-4830 a... Read More
This study consists of several parts: dose escalation, dose expansion, dose expansion in Chinese participants residing in China, and coformulation. Dose escalation is to evaluate the safety, tolerability, and preliminary efficacy of MK-4830 monotherapy administration (Arms A and B) and in combination with pembrolizumab (Arm C). Dose expansion is to evaluate the objective response rate (ORR) of MK-4830 in combination with pembrolizumab (Arms A-F); evaluate the safety and tolerability of MK-4830 administered in combination with pembrolizumab, carboplatin, and pemetrexed (Arm G) and of MK-4830 administered in combination with pembrolizumab and lenvatinib (Arm H); evaluate the safety, tolerability and ORR of MK-4830 in combination with pembrolizumab plus chemotherapy (Arms I-L); and evaluate the safety and tolerability of MK-4830 in combination with pembrolizumab in Chinese participants from China (Arm M). The coformulation part (Arm N) evaluates the safety and tolerability of MK-4830A (coformulation of MK-4830 800 mg + pembrolizumab 200 mg). There is no formal hypothesis testing in this study. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: University of California at San Francisco ( Site 0004), San Francisco, California +36 locations
University of California at San Francisco ( Site 0004), San Francisco, California
Henry Ford Health System ( Site 0002), Detroit, Michigan
Washington University ( Site 0003), Saint Louis, Missouri
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0005), Hackensack, New Jersey
Laura and Isaac Perlmutter Cancer Center ( Site 0008), New York, New York
Ohio State University Arthur G James Cancer Hospital & Richard J Solove Research Institute ( Site 00, Columbus, Ohio
South Texas Accelerated Research Therapeutics, LLC (START) ( Site 0001), San Antonio, Texas
Utah Cancer Specialists ( Site 0011), Salt Lake City, Utah
Seattle Cancer Care Alliance ( Site 0010), Seattle, Washington
Liverpool Hospital-Medical Oncology ( Site 0250), Liverpool, New South Wales
Princess Alexandra Hospital ( Site 0253), Brisbane, Queensland
Juravinski Cancer Centre ( Site 0034), Hamilton, Ontario
The Ottawa Hospital ( Site 0031), Ottawa, Ontario
Princess Margaret Cancer Centre ( Site 0033), Toronto, Ontario
The First Hospital of Jilin University ( Site 0803), Changchun, Jilin
Shanghai Chest Hospital-Oncology department ( Site 0801), Shanghai, Shanghai
West China Hospital of Sichuan University ( Site 0804), Chengdu, Sichuan
Hôpital Européen Georges Pompidou ( Site 2003), Paris, Ile-de-France
Centre Oscar Lambret ( Site 2002), Lille, Nord
Centre Hospitalier Universitaire de Poitiers ( Site 2000), Poitiers, Vienne
University General Hospital of Heraklion ( Site 0110), Heraklion, Irakleio
Euromedica General Clinic of Thessaloniki-Oncology Unit ( Site 0112), Thessaloniki, Not set
European Interbalkan Medical Center ( Site 0111), Thessaloniki, Not set
Rambam Health Care Campus-Oncology Division ( Site 0042), Haifa, Not set
Rabin Medical Center ( Site 0043), Petah Tikva, Not set
Chaim Sheba Medical Center. ( Site 0044), Ramat Gan, Not set
Sourasky Medical Center ( Site 0041), Tel Aviv, Not set
National Cancer Center Hospital East ( Site 0400), Kashiwa, Chiba
Japanese Foundation for Cancer Research ( Site 0401), Tokyo, Not set
Severance Hospital Yonsei University Health System ( Site 0300), Seoul, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie
Uniwersyteckie Centrum Kliniczne ( Site 0151), Gdansk, Pomorskie
Wits Clinical Research ( Site 0213), Johannesburg, Gauteng
The Oncology Centre ( Site 0212), Durban, Kwazulu-Natal
Cancercare Rondebosch Oncology ( Site 0210), Cape Town, Western Cape
Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0101), Hospitalet de Llobregat, Barcelona
Centro Integral Oncologico Clara Campal START Madrid ( Site 0102), Madrid, Not set
Conditions: Neoplasms
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