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Carboplatin Treatment Options in Canada
A collection of 336 research studies where Carboplatin is the interventional treatment. These studies are located in the Canada . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors
Active Not Recruiting
This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free survival (EFS) and overall survival (OS). The study population will be high-risk patients (non-Wnt and non-Shh sub-groups) with medulloblastoma, and for all patients with central nervous system (CNS) embryonal tumors completing "Head Start 4" Induction. This study will further determine whether the additional... Read More
This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free survival (EFS) and overall survival (OS). The study population will be high-risk patients (non-Wnt and non-Shh sub-groups) with medulloblastoma, and for all patients with central nervous system (CNS) embryonal tumors completing "Head Start 4" Induction. This study will further determine whether the additional labor intensity (duration of hospitalizations and short-term and long-term morbidities) associated with the tandem treatment is justified by the improvement in outcome. It is expected that the tandem (3 cycles) Consolidation regimen will produce a superior outcome compared to the single cycle Consolidation, given the substantially higher dose intensity of the tandem regimen, without significant addition of either short-term or long-term morbidities. Read Less
Gender:
ALL
Ages:
10 years and below
Trial Updated:
08/19/2025
Locations: Children's of Alabama, Birmingham, Alabama +61 locations
Children's of Alabama, Birmingham, Alabama
Phoenix Children's Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Loma Linda University Medical Center, Loma Linda, California
Memorial Care Health Services, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Mattel Children's Hospital (UCLA), Los Angeles, California
UCSF Oakland Benioff, Oakland, California
Children's Hospital Orange County, Orange, California
Children's Hospital Colorado, Aurora, Colorado
Nemours Center for Cancer and Blood Disorders, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Shands Children's Hospital/ University of FL, Gainesville, Florida
Nemours Center for Cancer and Blood Disorders, Jacksonville, Florida
Nicklaus Children's Hospital, Miami, Florida
Orlando Health, Orlando, Florida
John's Hopkins All Children's Hospital, Saint Petersburg, Florida
Children's Healthcare of Atlanta, Atlanta, Georgia
Riley Children's Hospital/University of Indiana, Indianapolis, Indiana
University of Iowa Hospital and Clinics, Iowa City, Iowa
University of Louisville School of Medicine, Louisville, Kentucky
John's Hopkins University School of Medicine, Baltimore, Maryland
Dana Farber Cancer Institute, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Central Michigan University, Detroit, Michigan
Helen DeVos Children's Hospital, Grand Rapids, Michigan
Children's Hospital of Minnesota, Minneapolis, Minnesota
Masonic Children's Hospital/University of Minnesota, Minneapolis, Minnesota
Mayo Clinic, Rochester, Minnesota
Washington University School of Medicine, Saint Louis, Missouri
Children's Specialty Care of Nevada, Las Vegas, Nevada
Joseph Sanzari Children's Hospital/ Hackensack University, Hackensack, New Jersey
Morristown Medical Center, Atlantic Health System, Morristown, New Jersey
New York Medical College, Hawthorne, New York
Northwell Health, Hempstead, New York
NYU Langone Medical Center, New York, New York
Columbia Presbyterian Children's Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Upstate Golisano Children's Hospital/ SUNY Upstate Medical University, Syracuse, New York
Carolina's HealthCare System/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Akron Children's Hospital, Akron, Ohio
Rainbow Babies & Children's Hospital, Cleveland, Ohio
Cleveland Clinic, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
Penn State Hershey Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
MD Anderson Cancer Center, Houston, Texas
Primary Children's Hospital, Salt Lake City, Utah
Virginia Commonwealth University, Richmond, Virginia
American Family Children's Hospital/University of Wisconsin, Madison, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
B.C. Children's Hospital, Vancouver, British Columbia
Alberta Children's Hospital, Calgary, Not set
Stollery Children's Hospital, Edmonton, Not set
Hamilton Health/McMasters Children's Hospital, Hamilton, Canada, Hamilton, Not set
The Hospital of Sick Children, Toronto, Not set
Starship Children's Hospital, Auckland, Not set
Christchurch Children's Hospital, Christchurch, Not set
Conditions: Medulloblastoma, Central Nervous System Embryonal Tumors
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Recruiting
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients... Read More
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT. Read Less
Gender:
ALL
Ages:
Between 3 years and 29 years
Trial Updated:
08/19/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +162 locations
Children's Hospital of Alabama, Birmingham, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
GenesisCare USA - Las Vegas, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Cancer Care Specialists - Reno, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Albany Medical Center, Albany, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Maimonides Medical Center, Brooklyn, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Christchurch Hospital, Christchurch, Not set
Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor, Embryonal Carcinoma, Immature Teratoma, Malignant Teratoma, Mixed Germ Cell Tumor, Pineal Region Germ Cell Tumor, Pineal Region Immature Teratoma, Pineal Region Yolk Sac Tumor, Choriocarcinoma, Suprasellar Germ Cell Tumor
A Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed ES-SCLC Patients in Combination With Carboplatin, Etoposide and Atezolizumab
Recruiting
This study aims to establish a safe and well tolerated dose of \[177Lu\]Lu-DOTA-TATE in combination with carboplatin, etoposide and atezolizumab in this setting and to assess preliminary efficacy of this combination treatment versus the combination of carboplatin, etoposide, and atezolizumab.The study will be essential to assess a new potential therapeutic option in participants with this aggressive cancer type.
This study aims to establish a safe and well tolerated dose of \[177Lu\]Lu-DOTA-TATE in combination with carboplatin, etoposide and atezolizumab in this setting and to assess preliminary efficacy of this combination treatment versus the combination of carboplatin, etoposide, and atezolizumab.The study will be essential to assess a new potential therapeutic option in participants with this aggressive cancer type. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/18/2025
Locations: Georgetown University Lombardi Cancer Center, Washington, District of Columbia +36 locations
Georgetown University Lombardi Cancer Center, Washington, District of Columbia
Advent Health Cancer Institute, Orlando, Florida
University Cancer and Blood Center LLC, Athens, Georgia
University of Kentucky, Lexington, Kentucky
St. Louis University, Saint Louis, Missouri
Hackensack Meridian Health, Edison, New Jersey
University Hospitals Of Cleveland, Cleveland, Ohio
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Novartis Investigative Site, Linz, Oberoesterreich
Novartis Investigative Site, Innsbruck, Tyrol
Novartis Investigative Site, Montreal, Quebec
Novartis Investigative Site, Montreal, Quebec
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Olomouc, Not set
Novartis Investigative Site, Bron, Not set
Novartis Investigative Site, Lille, Not set
Novartis Investigative Site, Marseille, Not set
Novartis Investigative Site, Montpellier, Not set
Novartis Investigative Site, Villejuif, Not set
Novartis Investigative Site, Essen, Not set
Novartis Investigative Site, Koeln, Not set
Novartis Investigative Site, Hong Kong, Not set
Novartis Investigative Site, Haifa, Not set
Novartis Investigative Site, Ramat Gan, Not set
Novartis Investigative Site, Tel Aviv, Not set
Novartis Investigative Site, Milano, MI
Novartis Investigative Site, Napoli, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Singapore, Not set
Novartis Investigative Site, Barcelona, Catalunya
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Malaga, Not set
Novartis Investigative Site, Taichung, Taiwan ROC
Novartis Investigative Site, Taipei, Not set
Novartis Investigative Site, Guildford, Surrey
Conditions: Extensive Stage Small Cell Lung Cancer
A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Active Not Recruiting
The purpose of this study is to assess the efficacy of adding lazertinib to amivantamab, carboplatin, and pemetrexed (LACP/ACP-L dosing strategies) and amivantamab, carboplatin and pemetrexed (ACP) compared with carboplatin and pemetrexed (CP) in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure. The purpose of the extension cohort is to further describe th... Read More
The purpose of this study is to assess the efficacy of adding lazertinib to amivantamab, carboplatin, and pemetrexed (LACP/ACP-L dosing strategies) and amivantamab, carboplatin and pemetrexed (ACP) compared with carboplatin and pemetrexed (CP) in participants with locally advanced or metastatic epidermal growth factor receptor (EGFR) Exon 19del or Exon 21 L858R substitution non-small cell lung cancer (NSCLC) after osimertinib failure. The purpose of the extension cohort is to further describe the safety and efficacy for the ACP-L dosing schedule versus ACP with additional data. After completion of the primary analysis, the study may eventually transition to an open-label extension (OLE) or long-term extension (LTE) phase during which participants will have the option to continue their assigned treatment. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: Southern Cancer Center, PC, Mobile, Alabama +246 locations
Southern Cancer Center, PC, Mobile, Alabama
Arizona Oncology Associates, Tucson, Arizona
City of Hope, Duarte, California
Cedars Sinai Medical Center, Los Angeles, California
University of California Irvine, Orange, California
Rocky Mountain Cancer Centers, Colorado Springs, Colorado
Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, Florida
University Cancer And Blood Center LLC, Athens, Georgia
University of Mississippi Medical Center, Jackson, Mississippi
Nebraska Cancer Specialists, Grand Island, Nebraska
Astera Cancer Care, East Brunswick, New Jersey
TriHealth Network, Cincinnati, Ohio
Providence Portland Medical Center, Portland, Oregon
Kaiser Permanente Northwest, Portland, Oregon
Alliance Cancer Specialists, Horsham, Pennsylvania
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Baptist Cancer Center, Memphis, Tennessee
Texas Oncology-Medical City Dallas, Dallas, Texas
Texas Oncology Baylor Charles A Sammons Cancer Center, Dallas, Texas
Texas Oncology, Grapevine, Texas
Oncology Consultants Texas, Houston, Texas
Texas Oncology - Northeast, Longview, Texas
University of Vermont Medical Center, Burlington, Vermont
University of Virginia, Charlottesville, Virginia
Virginia Cancer Specialists, Fairfax, Virginia
Blue Ridge Cancer Care, Wytheville, Virginia
NorthWest Medical Specialties, PLLC, Puyallup, Washington
Compass Oncology, Vancouver, Washington
CINME Centro de Investigaciones Metabolicas, Caba, Not set
IADT Instituto Argentino de Diagnostico y Tratamiento, Caba, Not set
Centro Medico Fleischer, Caba, Not set
CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Caba, Not set
Hospital Privado Universitario De Cordoba, Cordoba, Not set
Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba, Not set
Hospital Privado de la Comunidad, Mar del Plata, Not set
Clínica Viedma, Viedma, Not set
Grand Hopital De Charleroi Site Les Viviers, Charleroi, Not set
UZA, Edegem, Not set
UZ Gent, Gent, Not set
Jessa Ziekenhuis - Campus Virga Jesse, Hasselt, Not set
UZ Leuven, Leuven, Not set
CHU Sart-Tilman, Liege, Not set
Clinique Saint Pierre, Ottignies, Not set
Cetus Oncologia, Belo Horizonte, Not set
CIONC Centro Integrado de Oncologia de Curitiba, Curitiba, Not set
Ynova Pesquisa Clinica, Florianopolis, Not set
Fundacao Sao Francisco Xavier, Ipatinga, Not set
UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas, Not set
Associacao Hospitalar Moinhos de Vento, Porto Alegre, Not set
Hospital Ernesto Dornelles, Porto Alegre, Not set
Oncoclinicas Rio de Janeiro S A, Rio de Janeiro, Not set
Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro, Not set
Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro, Not set
Nucleo de Oncologia da Bahia, Salvador, Not set
Hospital Sao Rafael, Salvador, Not set
CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia, Santo Andre, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia, Sao Paulo, Not set
Hospital Paulistano, Sao Paulo, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Onco Star SP Oncologia Ltda, Sao Paulo, Not set
IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado, Sorocaba, Not set
Hospital Nove de Julho, São Paulo, Not set
COT - Centro Oncologico do Triangulo S.A, Uberlandia, Not set
Multifunctional Hospital for Active Treatment 'Serdika', Sofia, Not set
Multiprofile Hospital for Active Treatment 'Tokuda Hospital Sofia', Sofia, Not set
Specialized Hospital for Active Treatment in Oncology, Sofia, Not set
UMHAT Sofia Med, Sofia, Not set
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
British Columbia Cancer Agency, Vancouver, British Columbia
McGill University Health Centre, Montreal, Quebec
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, Not set
Peking University People s Hospital, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Chinese PLA General Hospital, Beijing, Not set
Beijing Chest hospital, Capital medical university, Beijing, Not set
Hunan Cancer hospital, Changsha, Not set
Sichuan Cancer Hospital, Chengdu, Not set
West China Hospital Sichuan University, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Southwest Hospital, ChongQing, Not set
The First Affiliated Hospital Sun Yat sen University, Guang Zhou, Not set
Sun Yat-Sen Memorial Hospital Sun Yat-sen University, Guangzhou, Not set
Zhejiang Cancer Hospital, Hang Zhou, Not set
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Not set
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Not set
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Huizhou Municipal Central Hospital, Huizhou, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
Affiliated Hospital of North Sichuan Medical College, Nanchong, Not set
Ruijin Hospital Shanghai Jiao Tong University, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Shanghai East Hospital, Shanghai, Not set
Shenzhen university General Hospital, Shenzhen, Not set
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Weifang People's Hospital, Weifang, Not set
The First Affiliated Hospital of Xian Jiaotong University, XI An, Not set
Yantai Yuhuangding Hospital, Yantai, Not set
Daping Hospital Army Characteristic Medical Center, Yuzhong District, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Fakultni nemocnice Olomouc - I.P.Pavlova 6, Olomouc, Not set
Vitkovicka nemocnice a.s., Ostrava- Vitkovice, Not set
Fakultni nemocnice Plzen, Plzen, Not set
Rigshospitalet, Copenhagen, Not set
Institut Sainte Catherine, Avignon Cedex 9, Not set
Hospices Civils de Lyon HCL, Bron, Not set
CHU de Grenoble Hopital Albert Michallon, La Tronche, Not set
Centre Hospitalier du Mans, le Mans, Not set
CHR Hôpital Calmette, Lille, Not set
Hopital Nord, Marseille Cedex 20, Not set
CHU de Montpellier - Arnaud de Villeneuve, Montpellier Cedex 5, Not set
Institut Curie, Paris, Not set
CHU Bordeaux, Pessac, Not set
CHRU Hopital de Pontchaillou, Rennes, Not set
CHU Nantes, Sain-Herblain, Not set
Nouvel Hopital Civil - CHU Strasbourg, Strasbourg cedex, Not set
CHU Bretonneau, Tours, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Asklepios Klinikum Harburg, Hamburg, Not set
Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, Not set
Onkologische Schwerpunktpraxis, Heilbronn, Not set
POIS Sachsen GmbH iG, Leipzig, Not set
Bethanien Krankenhaus, Moers, Not set
Klinikum der Universitaet Muenchen, München, Not set
Oncologianova GmbH, Recklinghausen, Not set
Universitaetsklinikum Regensburg, Regensburg, Not set
Queen Mary Hospital, Hong Kong, Not set
Health Care Global Enterprises pvt Ltd, Bangalore, Not set
Artemis Hospital, Gurugram, Not set
Tata Medical Center, Kolkata, Not set
Tata Memorial Hospital, Mumbai, Not set
HCG Manavta Cancer Centre, Nasik, Not set
Rajiv Gandhi Cancer Institute and Research Centre, New Delh, Not set
Noble Hospital Pvt Ltd, Pune, Not set
Bhaktivedanta Hospital & Research Institute, Thane, Not set
Soroka University Medical Center, Beersheba, Not set
Rambam Health Corporation, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center, Petah Tikva, Not set
Chaim Sheba Medical Center, Ramat Gan, Not set
Tel Aviv Sourasky Medical Center, Tel-Aviv, Not set
CRO IRCCS Istituto Nazionale Tumori, Aviano, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
Istituto Europeo di Oncologia, Milano, Not set
Azienda Ospedaliero-Universitaria Di Parma, Parma, Not set
Ospedale S. Maria Delle Croci, Ravenna, Not set
Istituto Nazionale Tumori Regina Elena, Roma, Not set
Policlinico G.B.Rossi, Verona, Not set
National Hospital Organization Shibukawa Medical Center, Gunma, Not set
Hyogo Cancer Center, Hyogo, Not set
Kanagawa Cancer Center, Kanagawa, Not set
Kobe City Medical Center General Hospital, Kobe City, Not set
Kurume University Hospital, Kurume, Not set
National Hospital Organization Nagoya Medical Center, Nagoya-shi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Osaka International Cancer Institute, Osaka City, Not set
Shizuoka Cancer Center, Shizuoka, Not set
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Ehime University Hospital, Toon-shi, Not set
Wakayama Medical University Hospital, Wakayama, Not set
National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Not set
National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi, Not set
National Cancer Center, Gyeonggi-do, Not set
CHA Bundang Medical Center, CHA University, Gyeonggi-do, Not set
Seoul National University Bundang Hospital, Gyeonggi-do, Not set
GyeongSang National University Hospital, Gyeongsangnam-do, Not set
Korea University Anam Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Hospital Tengku Ampuan Afzan, Kuantan, Not set
Beacon Hospital Sdn Bhd, Petaling Jaya, Not set
Subang Jaya Medical Centre, Subang Jaya, Not set
Mount Miriam Cancer Hospital, Tanjung Bungah, Not set
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set
CIMOVA, Morals Vargas Centro de Investigación SC, Leon, Not set
Health Pharma Professional Research, Mexico, Not set
Instituto Nacional de Cancerologia, Mexico, Not set
Oncologia Integral Satelite, Naucalpan, Not set
VUMC Amsterdam, Amsterdam, Not set
Ziekenhuis St Jansdal, Harderwijk, Not set
Erasmus MC, Rotterdam, Not set
Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Szpitale Pomorskie Sp z o o, Gdynia, Not set
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn, Not set
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow, Poznan, Not set
Private Specialist Hospitals - MedPolonia, Poznan, Not set
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, Not set
Uls Santa Maria - Hosp. Pulido Valente, Lisboa, Not set
Uls Loures Odivelas - Hosp. Loures, Loures, Not set
Uls Santo Antonio - Hosp. Santo Antonio, Porto, Not set
Instituto Portugues de Oncologia, Porto, Not set
Pan American Center for Oncology Trials LLC, Rio Piedras, Not set
City Clinical Hospital #1, Nalchik, Not set
Llc, Eurocityclinic, Saint Petersburg, Not set
Hosp Univ A Coruna, A Coruña, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp. Univ. Quiron Dexeus, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp Clinic de Barcelona, Barcelona, Not set
Hosp. Univ. Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set
Hosp Univ Fund Jimenez Diaz, Madrid, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Univ. La Paz, Madrid, Not set
Hosp Univ Hm Sanchinarro, Madrid, Not set
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Not set
Hosp Regional Univ de Malaga, Málaga, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Hosp. Virgen Del Rocio, Seville, Not set
Hosp. Gral. Univ. Valencia, Valencia, Not set
Hosp. Univ. I Politecni La Fe, Valencia, Not set
Sahlgrenska Universitetssjukhuset, Goteborg, Not set
Linkoping University Hospital, Linkoping, Not set
Skanes universitetssjukhus, Lund, Not set
Norrlands Universitetssjukhus, Umea, Not set
Akademiska Sjukhuset, Uppsala, Not set
Changhua Christian Hospital, Changhua, Not set
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Not set
Taipei Medical University Shuang Ho Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Taipei, Not set
Adana City Hospital, Adana, Not set
Memorial Ankara Hastanesi, Ankara, Not set
Gazi University Hospital, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Bakirkoy Training and Research Hospital, Istanbul, Not set
Medipol Mega University Hospital, Istanbul, Not set
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul, Not set
Medical Point, Izmir, Not set
Velindre Hospital, Cardiff, Not set
Edinburgh Cancer Centre Western General, Edinburgh, Not set
UCL Cancer Institute, London, Not set
Guys and St Thomas NHS Foundation Trust, London, Not set
The Royal Marsden NHS Trust, London, Not set
The Christie Nhs Foundation Trust, Manchester, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions
Active Not Recruiting
The purpose of this study is to compare the efficacy, as demonstrated by progression-free survival (PFS), in participants treated with amivantamab in combination with chemotherapy, versus chemotherapy alone in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) characterized by EGFR Exon 20ins mutations.
The purpose of this study is to compare the efficacy, as demonstrated by progression-free survival (PFS), in participants treated with amivantamab in combination with chemotherapy, versus chemotherapy alone in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) characterized by EGFR Exon 20ins mutations. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: City of Hope, Duarte, California +228 locations
City of Hope, Duarte, California
University of California Irvine, Orange, California
UCLA, Santa Monica, California
Georgetown University Hospital, Washington, District of Columbia
H. Lee Moffitt Cancer & Research Institute, Tampa, Florida
University Cancer And Blood Center LLC, Athens, Georgia
Henry Ford Hospital, Detroit, Michigan
Washington University Medical Center, Saint Louis, Missouri
Regional Cancer Care Associates LLC, East Brunswick, New Jersey
Langone Health at NYC University, NYU School of Medicine, New York, New York
Columbia University Medical Center, New York, New York
Providence Portland Medical Center, Portland, Oregon
Sanford Health, Sioux Falls, South Dakota
Texas Oncology Pa, Tyler, Texas
Utah Cancer Specialists, Salt Lake City, Utah
Virginia Cancer Specialists, Fairfax, Virginia
Blue Ridge Cancer Care, Salem, Virginia
Chris O'Brien Lifehouse, Camperdown, Not set
St George Hospital, Kogarah, Not set
Cabrini Medical Centre, Malvern, Not set
Sir Charles Gairdner Hospital, Nedlands, Not set
UZ Leuven, Leuven, Not set
Algemeen Ziekenhuis Delta, Roeselare, Not set
CHU UCL Namur - Site Godinne, Yvoir, Not set
Fundacao Pio XII, Barretos, Not set
Cetus Oncologia, Belo Horizonte, Not set
Ynova Pesquisa Clinica, Florianopolis, Not set
Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda, Ijui, Not set
Liga Norte Riograndense Contra O Cancer, Natal, Not set
UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas, Not set
Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Not set
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre, Not set
Ministerio da Saude Instituto Nacional do Cancer, Rio De Janeiro, Not set
Oncoclinicas Rio de Janeiro S A, Rio de Janeiro, Not set
Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro, Not set
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Not set
Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, Not set
Núcleo de Pesquisa São Camilo, Sao Paulo, Not set
IOS - Instituto de Oncologia de Sorocaba Dr. Gilson Delgado, Sorocaba, Not set
Hospital Evangélico de Cachoeiro de Itapemirim, Vitoria, Not set
The Ottawa Hospital Cancer Centre, Ottawa, Ontario
Sunnybrook Health Sciences Centre, Toronto, Ontario
McGill University Health Centre, Montreal, Quebec
Beijing Cancer Hospital, Beijing, Not set
Chinese PLA General Hospital, Beijing, Not set
Beijing Chest hospital, Capital medical university, Beijing, Not set
Peking University International Hospital, Beijing, Not set
Jilin cancer hospital, Changchun, Not set
Hunan Cancer hospital, Changsha, Not set
The First People's Hospital Of Changzhou, Changzhou, Not set
West China Hospital Sichuan University, Chengdu, Not set
Chongqing University Cancer Hospital, Chongqing, Not set
Fujian Medical University Union Hospital, Fuzhou, Not set
The First Affiliated Hospital Sun Yat sen University, Guang Zhou, Not set
Zhejiang Cancer Hospital, Hang Zhou, Not set
The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Not set
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Not set
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Not set
Harbin medical university cancer hospital, Harbin, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
Nanjing Drum Tower Hospital, Nanjing, Not set
Shanghai Chest Hospital, Shanghai, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Shanghai East Hospital, Shanghai, Not set
Shanghai Pulmonary Hospital, Shanghai, Not set
Shengjing Hospital Of China Medical University, Shenyang, Not set
Cancer hospital Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, Not set
Tianjin Medical University General Hospital, Tianjin, Not set
Weifang People's Hospital, Weifang, Not set
TongJi Hospital of TongJi Medical College of Huazhong University of Science & Technology, Wuhan, Not set
Hospital of Jiangnan University, Wuxi, Not set
The First Affiliated Hospital of Xian Jiaotong University, XI An, Not set
Yantai Yuhuangding Hospital, Yantai, Not set
Henan Cancer Hospital, Zhengzhou, Not set
Institut Bergonie, Bordeaux, Not set
Hospices Civils de Lyon HCL, Bron, Not set
Centre Georges Francois Leclerc, Dijon, Not set
Centre Hospitalier Le Mans, le mans Cedex 9, Not set
CHR Hôpital Calmette, Lille CEDEX, Not set
CHU Nantes - Hopital Nord Laënnec, NANTES cedex 1, Not set
Institut Curie, Paris, Not set
CHU Bordeaux, Pessac, Not set
HIA Begin, Saint Mande, Not set
Zentralklinik Bad Berka GmbH, Bad Berka, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Asklepios Klinik Gauting GmbH - Asklepios Fachkliniken Munchen-Gauting, Gauting, Not set
Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, Not set
Onkologische Schwerpunktpraxis, Heilbronn, Not set
Universitaetsklinikum Koeln, Koeln, Not set
Kliniken der Stadt Koeln gGmbH, Koeln, Not set
Bethanien Krankenhaus, Moers, Not set
Pius-Hospital Oldenburg, Oldenburg, Not set
Oncologianova GmbH, Recklinghausen, Not set
Orszagos Koranyi Tbc es Pulmonologiai Intezet, Budapest, Not set
Mátrai Gyógyintézet-Bronchológia, Gyöngyös, Not set
Fejer Varmegyei Szent Gyorgy Egyetemi Oktatokorhaz, Szekesfehervar, Not set
Markusovszky Egyetemi Oktatokorhaz, Szombathely, Not set
Tudogyogyintezet Torokbalint, Torokbalint, Not set
Basavatarakam Indo-American Hospital, Hyderabad, Not set
Tata Medical Center, Kolkata, Not set
Tata Memorial Hospital, Mumbai, Not set
HCG Manavta Cancer Centre, Nasik, Not set
Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, Not set
Noble Hospital Pvt Ltd, Pune, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Hadassah Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center, Petah Tikva, Not set
Tel Aviv Sourasky Medical Center, Tel-Aviv, Not set
A O U Sant Orsola Malpighi, Bologna, Not set
Azienda Ospedaliero Univ. Policlinico Gaspare Rodolico, Catania, Not set
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Not set
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Not set
IRCCS Ospedale San Raffaele, Milano, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set
San Gerardo Hospital, Monza, Not set
Ospedale S. Maria Delle Croci, Ravenna, Not set
Irccs Gemelli, Roma, Not set
Istituto Clinico Humanitas, Rozzano, Not set
Juntendo University Hospital, Bunkyo Ku, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
National Hospital Organization Himeji Medical Center, Himeji, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kanazawa University Hospital, Kanazawa, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Kishiwada City Hospital, Kishiwada, Not set
Kobe City Medical Center General Hospital, Kobe, Not set
Kurashiki Central Hospital, Kurashiki, Not set
Kurume University Hospital, Kurume, Not set
Matsusaka Municipal Hospital, Matsusaka, Not set
Aichi Cancer Center Hospital, Nagoya Shi, Not set
National Hospital Organization Nagoya Medical Center, Nagoya-shi, Not set
Niigata Cancer Center Hospital, Niigata, Not set
Kindai University Hospital, Osaka Sayama shi, Not set
Kitasato University Hospital, Sagamihara, Not set
Hokkaido University Hospital, Sapporo-shi, Not set
Iwate Medical University Hospital, Shiwa-gun, Not set
Shizuoka Cancer Center, Shizuoka, Not set
The Cancer Institute Hospital of JFCR, Tokyo, Not set
Ehime University Hospital, Toon-shi, Not set
Wakayama Medical University Hospital, Wakayama, Not set
National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi, Not set
Inje University Haeundae Paik Hospital, Busan, Not set
National Cancer Center, Gyeonggi-do, Not set
GyeongSang National University Hospital, Gyeongsangnam-do, Not set
Chonnam National University Hwasun Hospital, Jeollanam-do, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set
Hospital Pulau Pinang, George Town, Not set
Hospital Sultan Ismail, Johor Bahru, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre, Kuala Lumpur, Not set
Centro Oncologico de Chihuahua, Chihuahua, Not set
Mexico Centre for Clinical Research, S.A. de C.V., Ciudad de Mexico, Not set
Médica Sur, Ciudad de Mexico, Not set
Instituto Nacional de Cancerologia, Ciudad de Mexico, Not set
Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Not set
Health Pharma Professional Research, Mexico, Not set
i Can Oncology Center, Monterrey, Not set
Oncologia Integral Satelite, Naucalpan, Not set
Centrum Onkologii im Prof F Lukaszczyka, Bydgoszcz, Not set
Uniwersyteckie Centrum Kliniczne, Gdansk, Not set
Szpitale Pomorskie Sp z o o, Gdynia, Not set
Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie, Olsztyn, Not set
Private Specialist Hospitals - MedPolonia, Poznan, Not set
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, Not set
Hosp. Cuf Descobertas, Lisboa, Not set
Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos, Lisboa, Not set
Centro Hospitalar Universitario do Porto, EPE, Porto, Not set
Instituto Portugues de Oncologia, Porto, Not set
Centro Hospitalar de Vila Nova de Gaia Espinho E P E, Vila Nova de Gaia, Not set
Pan American Center for Oncology Trials LLC, Rio Piedras, Not set
Irkutsk Regional Oncology Dispensary, Irkutsk, Not set
Moscow City Oncology Hospital № 62, Krasnogorsk, Not set
Krasnoyarsk Regional Oncology Dispensary, Krasnoyarsk, Not set
Leningrad Regional Oncology Dispensary, Kuzmolovsky, Not set
MCK, Moscow, Not set
City Clinical Hospital #1, Nalchik, Not set
Nizhny Novgorod Regional Oncological Dispensary, Nizhniy Novgorod, Not set
N.N. Petrov Research Institute Of Oncology, Saint Petersburg, Not set
Leningrad Regional Clinical Hospital, Saint-Petersburg, Not set
Oncology Medical Clinics AV Medical group, St-Petersburg, Not set
Tomsk Cancer Research Institute, Tomsk, Not set
Bashkir State Medical University, Ufa, Not set
Yaroslavl Regional Clinical Oncology Hospital, Yaroslavl, Not set
Hosp Univ A Coruna, A Coruna, Not set
Inst. Cat. D'Oncologia-Badalona, Badalona, Not set
Hosp. de La Santa Creu I Sant Pau, Barcelona, Not set
Hosp. Univ. Quiron Dexeus, Barcelona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp. Univ. de Burgos, Burgos, Not set
Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set
Hosp. Univ. Ramon Y Cajal, Madrid, Not set
Hosp. Univ. 12 de Octubre, Madrid, Not set
Hosp. Univ. La Paz, Madrid, Not set
Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda, Not set
Hosp Virgen de La Victoria, Málaga, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Hosp. Virgen Del Rocio, Seville, Not set
Hosp. Clinico Univ. Lozano Blesa, Zaragoza, Not set
Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Not set
Chang Gung Medical Foundation, Kaohsiung, Not set
Taipei Medical University Shuang Ho Hospital, New Taipei, Not set
Chung Shan Medical University Hospital, Taichung, Not set
China Medical University Hospital, Taichung, Not set
National Taiwan University Hospital, Taipei City, Not set
Phramongkutklao Hospital and Medical College, Bangkok, Not set
Siriraj Hospital, Bangkok, Not set
Songklanagarind Hospital, Prince of Songkla University, Songkla, Not set
Adana City Hospital, Adana, Not set
Başkent University Medical Faculty Adana Application and Research Center, Adana, Not set
Gazi University Hospital, Ankara, Not set
Ankara Bilkent City Hospital, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari Anabilim Dali Medikal Onkoloji Bd, Istanbul, Not set
Medipol Mega University Hospital, Istanbul, Not set
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi, Istanbul, Not set
Izmir Medical Park Hospital, Izmir, Not set
Dnipropetrovsk State Medical Academy, Dnipropetrovsk City Multifield Clinical Hospital # 4, Dnipro, Not set
Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies', Kyiv, Not set
National Cancer Institute, Kyiv, Not set
Edinburgh Cancer Centre Western General, Edinburgh, Not set
The Royal Marsden NHS Trust, London, Not set
The Royal Marsden NHS Trust, Sutton, Not set
Conditions: Carcinoma, Non-Small-Cell Lung
Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2
Recruiting
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating th... Read More
This study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating the disease.
Participants in this study will have cancer that has spread through the body (metastatic) or spread near where it started (locally advanced).
In this study, there are 2 different groups. Participants will be assigned to a group randomly. Participants in the disitamab vedotin arm will get the study drug disitamab vedotin once every two weeks and pembrolizumab once every 6 weeks. Participants in the standard of care arm will get gemcitabine once a week for 2 weeks with either cisplatin or carboplatin once every 3 weeks. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Banner Gateway Medical Center, Gilbert, Arizona +328 locations
Banner Gateway Medical Center, Gilbert, Arizona
Banner MD Anderson Cancer Center, Gilbert, Arizona
UCLA Hematology/Oncology - Alhambra, Alhambra, California
Foothill Cardioology, Arcadia, California
Beverly Hills Multi-Specialties Practice, Beverly Hills, California
Providence Saint Joseph Medical Center, Burbank, California
UCLA Burbank Cardiology, Burbank, California
UCLA Hematology/Oncology - Burbank, Burbank, California
UCLA Calabasas Specialty Care, Calabasas, California
UCLA Encino Specialty Care (Radiology), Encino, California
UCLA Hematology/Oncology - Encino, Encino, California
Helios Clinical Research, Glendale, California
Foothill Cardiology Glendora, Glendora, California
Helios Clinical Research, Long Beach, California
UCLA Downtown Los Angeles Primary & Specialty Care, Los Angeles, California
Administrative Address: UCLA Hematology/Oncology, Los Angeles, California
UCLA Cardiovascular Center, Los Angeles, California
UCLA Hematology & Oncology Clinic, Los Angeles, California
UCLA Hematology / Oncology, Los Angeles, California
UCLA Westwood Specialty Care, Los Angeles, California
UCLA Montecito Primary & Specialty Care, Montecito, California
Pacific Cancer Care, Monterey, California
Newport Diagnostics, Newport Beach, California
Foothill Cardiology Pasadena, Pasadena, California
Southern California Heart Specialists, Pasadena, California
UCLA Porter Ranch Primary & Specialty Care, Porter Ranch, California
UCSF Center at China Basin Imaging, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Divisadero, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Post, San Francisco, California
UCSF Cancer Center MZ Phlebotomy, San Francisco, California
UCSF Mount Zion Phlebotomy, San Francisco, California
Helen Diller Family Comprehensive Cancer Center - Imaging Parnassus, San Francisco, California
UCSF Parnassus Phlebotomy, San Francisco, California
UCSF Parnassus-5 Lab, San Francisco, California
Cardiovascular Care and Prevention Center at Mission Bay, San Francisco, California
UCSF Investigational Drugs Pharmacy, San Francisco, California
UCSF Mission Bay Gateway-2 Lab, San Francisco, California
UCSF Mission Bay PCMB-5 Lab, San Francisco, California
UCSF Mission Bay Pediatric Clinical Research Center, San Francisco, California
UCSF Mission Bay Radiology and Nuclear Medicine, San Francisco, California
University of California San Francisco, San Francisco, California
University of California, San Francisco | HDFCCC - Hematopoietic malignancies, San Francisco, California
Diagnostic Medical Group of Southern California, , San Gabriel, CA, San Gabriel, California
Southern California Heart Centers, San Gabriel, California
UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo, California
Sierra Vista Regional Medical Center, San Luis Obispo, California
Helios Clinical Research, Santa Ana, California
UCLA Hematology/Oncology - Santa Barbara, Santa Barbara, California
UCLA Hematology/Oncology - Santa Monica, Santa Monica, California
UCLA Simi Valley Alamo Specialty Care, Simi Valley, California
Twin Cities Community Hospital, Templeton, California
UCLA Thousand Oaks Primary & Specialty Care, Thousand Oaks, California
UCLA Hematology/Oncology - Torrance, Torrance, California
UCLA Torrance Lomita Specialty Care, Torrance, California
UCLA Santa Clarita Primary & Specialty Care, Valencia, California
UCLA Ventura Cardiology, Ventura, California
UCLA Hematology/Oncology - Westlake, Westlake Village, California
Helios Clinical Research, Whittier, California
Greater Baltimore Medical Center, Baltimore, Maryland
M Health Fairview Ridges Cancer Clinic, Burnsville, Minnesota
M Health Fairview Cancer Clinic-Edina, Edina, Minnesota
Minnesota Oncology Hematology Pa, Edina, Minnesota
Minnesota Oncology Hematology, PA, Fridley, Minnesota
M Health Fairview Maple Grove Cancer Center, Maple Grove, Minnesota
Allina Health Cancer Institute-United(VPCI), Minneapolis, Minnesota
Hennepin Country Medical Center, Minneapolis, Minnesota
M Health Fairview University of Minnesota Investigational Drug Services, Minneapolis, Minnesota
Metro Minnesota Community Oncology Research Consortium(MMCORC), Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
M Health Fairview Lakes Medical Center, Wyoming, Minnesota
Nebraska Medicine- Bellevue Medical Center, Bellevue, Nebraska
Nebraska Medicine -Nebraska Medical Center, Omaha, Nebraska
Nebraska Medicine-Cancer Center at Village Pointe Health Center, Omaha, Nebraska
The University of Nebraska Medical Center, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Optum Care Cancer Care at Seven Hills, Las Vegas, Nevada
OptumCare Cancer center, Las Vegas, Nevada
OptumCare Cancer Center Care at Fort Apache, Las Vegas, Nevada
Icahn School of Medicine at Mount Sinai, New York, New York
Ship study drug to: Mount Sinai Hospital- Pharmacy Dept, New York, New York
ECU Health Medical Center, Greenville, North Carolina
AHN Saint Vincent Hospital, Erie, Pennsylvania
AHN Jefferson Hospital, Jefferson Hills, Pennsylvania
AHN Forbes Hospital, Monroeville, Pennsylvania
Allegheny Valley Hospital, Natrona Heights, Pennsylvania
AHN Cancer Institute - Allegheny General Hospital, Pittsburgh, Pennsylvania
AHN Cancer Institute Pharmacy, Pittsburgh, Pennsylvania
AHN West Penn Hospital, Pittsburgh, Pennsylvania
UT Southwestern Medical Center - Redbird, Dallas, Texas
University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas
University of Texas Southwestern Medical Center-Simmons Cancer Center Pharmacy, Dallas, Texas
University of Texas Southwestern Medical Center, Dallas, Texas
UT Southwestern - Simmons Cancer Center - Fort Worth, Fort Worth, Texas
UT Southwestern - Simmons Cancer Center - Richardson/Plano, Richardson, Texas
Inova Schar Cancer Institue Infusion Pharmacy, Fairfax, Virginia
Inova Schar Cancer Institute, Fairfax, Virginia
Harborview Medical Center, Seattle, Washington
Fred Hutchinson Cancer Center., Seattle, Washington
University of Washington Medical Center, Seattle, Washington
Clinica Viedma, Viedma, RIO Negro
Fundación Dr. Ruben Kowalyszyn, Viedma, RÍO Negro
Comisión Provincial de Evaluación de Proyectos de Investigación en Salud Humana (CEEPISH), Viedma, RÍO Negro
Centro de Oncologia e Investigacion de Buenos Aires (COIBA), Berazategui, Not set
Instituto Médico Especializado Alexander Fleming, Buenos Aires, Not set
Centro Medico Austral, Buenos Aire, Not set
Centro Oncologico Korben, Buenos Aire, Not set
Fundacion Cenit, Caba, Not set
Investigaciones Clinicas Moleculares (ICM), Caba, Not set
CEMAIC - Centro Medico Privado, Cordoba, Not set
Hospital Municipal de Morón. O. B. Lavignolle, Morón, Not set
Centro de Investigacion Pergamino SA, Pergamino, Not set
Comité Provincial de Bioética-Rosario, Rosario, Not set
Sanatorio Parque, Rosario, Not set
Consultorio Dr. Miguel Angel Escudero, Salta, Not set
Oncologia Salta, Salta, Not set
Centro para la Atencion Integral del paciente Oncologico, Tucuman, Not set
Concord Repatriation General Hospital, Concord, New South Wales
Saint Vincents Hospital Sydney - Human Research Ethics Committee, Darlinghurst, New South Wales
St Vincent's Clinic, Darlinghurst, New South Wales
Macquarie University Hospital, Macquarie University, New South Wales
Macquarie University, North Ryde, New South Wales
Prince of Wales Hospital, Randwick, New South Wales
North Shore Private Hospital, St Leonards, New South Wales
Mater Misericordiae - Mater Hospital Brisbane, Brisbane, Queensland
Icon Cancer Centre Chermside, Herston, Queensland
Mater Research, South Bribane, Queensland
Peninsula & South Eastern Hematology and Oncology Group (PASO), Frankston, Victoria
Austin Health, Melbourne, Victoria
South Eastern Sydney Local Health District, Caringbah, Not set
Lyell McEwin Hospital, Elizabeth Vale, Not set
Peninsula And South East Oncology, Frankston, Not set
Cabrini., Malvern, Not set
Mid North Coast Local Health District, NSW, Not set
Port Macquarie Base Hospital, Port Macquarie, Not set
Mater Cancer Care Centre, South Brisbane, Not set
Royal North Shore Hospital, St Leonards, Not set
Algemeen Ziekenhuis Maria Middelares, Gent, Not set
AZ St. Lucas, Ghent, Not set
University Hospital Ghent, Ghent, Not set
CHU de Liege Service Oncologie Medicale, Liege, Not set
CHU UCL Namur-Site de Saint Elisabeth, Namur, Not set
GZA Hospital Sint-Augustinus, Wilrijk, Not set
Centro de Oncologia da Bahia, Salvador, BA
Suporte Nutricional e Quimioterapia - PRONUTRIR, Fortaleza, Ceará
Associacao Mario Penna - Hospital Luxemburgo - NEPI Nucleo de Ensino Pesquisa e Inovacao, Belo Horizonte, MG
Hospital Sao Vicente de Paulo, Passo Fundo, RIO Grande DO SUL
Hospital Mae de Deus, Porto Alegre, RIO Grande DO SUL
Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS
Hospital Nossa Senhora da Conceicao / Grupo Hospitalar Conceicao, Porto Alegre, RS
Fundacao Doutor Amaral Carvalho, Jaú, SÃO Paulo
Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos, Not set
Erasto Gaertner Hospital, CuriBba, Not set
Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta
University of Alberta / Cross Cancer Institute, Edmonton, Alberta
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC), Oshawa, Ontario
Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario
Centro de Estudios Clínicos SAGA, Santiago, Not set
Centro de Investigaciones Clinicas Vina del Mar, Vina del mar, Not set
Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové
Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika, Olomouc, Not set
University Hospital of Besancon, Besancon, Not set
Institut Bergonié Centre de Lutte Contre le Cancer (CLCC), Bordeaux Cedex, Not set
Centre de Lutte contre le Cancer - François Baclesse, Caen Cedex 5, Not set
Institut Paoli Calmettes, Marseille, Not set
Institut régional du Cancer de Montpellier - ICM Val d'Aurelle, MONTPELLIER Cedex 5, Not set
Pharmacy ICM Val d'Aurelle - Bat A - Rez-de-Jardin, MONTPELLIER Cedex 5, Not set
Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne, Nice Cedex 2, Not set
Hopital Europeen Georges Pompidou, Paris, Not set
Hospices Civils de Lyon, Pierre Benite, Not set
Unite de Coordination de la Biologie des Essais Cliniques, Strasbourg, Not set
Institut de Cancerologie Strasbourg Europe, Strasbourg, Not set
Institut Gustave Roussy, Villejuif Cedex, Not set
Athens Medical Center, Maroussi, Attikí
Bioclinic Thessalonikis Private Clinic Single Member S.A., Thessaloniki, Kentrikí Makedonía
Metropolitan General Hospital, Cholargos, Not set
Semmelweis Egyetem Urologiai Klinika, Budapest, Not set
Bacs-Kiskun Varmegyei Oktatokorhaz, Kecskemét, Not set
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi
Nirmal Hospital Pvt Ltd, Surat, Gujarat
Cancer Trials Cork, Cork, Not set
Tallaght University Hospital, Tallaght, Not set
Cork University Hospital, Wilton, Not set
Shaare Zedek Medical Center, Jerusalem, Other
Hadassah Medical Center, Jerusalem, Other
Sheba Medical Center., Ramat Gan, Other
Emek Medical Center, Afula, Not set
Soroka Medical Center, Be'er Sheva, Not set
Rambam Health Care Campus, Hafia, Not set
Meir Medical Center, Kefar Sava, Not set
Rabin Medical Center, Petach Tikva, Not set
Kaplan Medical Center, Rehovot, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
IRCCS Istituto Tumori Giovanni Paolo II, Bari, Apulia
Azienda Ospedaliera Cardinale Giovanni Panico, Tricase, Apulia
Oncologia Medica, Ospedale Civile S. Maria delle Croci, Ravenna, Emilia-romagna
Ospedale Policlinico San Martino, Genova, Liguria
Ospedale San Raffaele, Milano, Lombardy
Istituto Clinico Humanitas-Humanitas Cancer Center, Rozzano (Milano), Lombardy
IRCCS Istituto Clinico Humanitas, Rozzano, Milano
IRCCS - Ospedale San Raffaele, Milano, Milan
Azienda Sanitaria Locale Napoli 2 Nord, Giugliano in Campania, Naples
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Other
P.O. "S. Maria Delle Grazie" - Pozzuoli - ASL Napoli Nord 2, Pozzuoli (NA), Other
ASL-AT, Ospedale Cardinal Massaia di Asti, Asti, Piemonte
SOSD Farmacia Ospedaliera, Aviano, Pordenone
Centro di Riferimento Oncologico Di Aviano, Aviano, Pordenone
AUSL Romagna - Presidio Ospedale "Umberto I" di Lugo, Lugo, Ravenna
AUSL della Romagna - Ospedale degli infermi, Faenza, RA
Azienda Ospedaliero Universitaria Careggi, Firenze, Tuscany
Azienda Ospedaliera S. Maria di Terni, Terni, Umbria
ASL Asti - Ospedale Cardinal Massaia - S.C. Farmacia Ospedaliera, Asti, Not set
ASST Cremona Farmacia Ospedaliera, Cremona, Not set
U.O. Farmacia Ospedaliera a Politiche del Farmaco Az. Osp. Universitaria Careggi, Firenze, Not set
Ospedale Policlinico San Martino Farmacia, Genova, Not set
Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale, Napoli, Not set
SC Farmacia Ospedaliera C/O Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale, Napoli, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara, Pisa, Not set
Azienda Ospedaliera Universitaria Pisana, U.O. Farmacia Ospedaliera, Pisa, Not set
Policlinico Universitario Agostino Gemelli, Roma, Not set
Centro Ricerche Cliniche Di Verona Srl, Verona, Not set
Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Not set
Hirosaki University Hospital, Hirosaki, Aomori
Ehime University Hospital, Toon, Ehime
National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka
Gunma Prefectural Cancer Center, Ota-Shi, Gunma
Kobe University Hospital, Kobe-shi, Hyogo
University of Tsukuba Hospital, Tsukuba, Ibaraki
Kagawa University Hospital, Kita-gun, Kagawa
Yokohama City University Medical Center, Yokohama, Kanagawa
Kanagawa Cancer Center, Yokohama, Kanagawa
University of Miyazaki Hospital, Miyazaki City, Miyazaki
Nara Medical University Hospital, Kashihara, Nara
Kindai University Hospital, Osakasayama-Shi, Osaka
Osaka University Hopsital, Suita-city, Osaka
Tokushima University Hospital, Tokushima-Shi, Tokushima
Keio University Hospital, Shinjuku-ku, Tokyo
Wakayama Medical University Hospital, Wakayama-shi, Wakayama
Yamaguchi University Hospital, Ube, Yamaguchi
Chiba Cancer Center, Chiba, Not set
National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set
Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka, Not set
Yamagata University Hospital, Yamagata, Not set
National Cancer Center, Goyang-si, Gyeonggi-do
CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do
The Catholic University of Korea, St. Vincent's Hospital, Suwon-si, Gyeonggi-do
Jeonbuk National University Hospital, Jeonju-si, Jeollabuk-do
Chonnam National University Hwasun Hospital, Hwasun-gun, Jeollanam-do
Wonkwang University Hospital, Iksan-si, Jeonlabuk-do
Inje University Haeundae Paik Hospital, Busan, Not set
Kosin University Gospel Hospital, Busan, Not set
Gachon University Gil Medical Center, Incheon, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Korea University Anam Hospital, Seoul, Not set
Kangbuk Samsung Hospital, Seoul, Not set
Severance Hospital Yonsei University Health System, Seoul, Not set
Asan Medical Center - Oncology, Seoul, Not set
Amphia Ziekenhuis, Breda, Noord-brabant
Haga Ziekenhuis, Den Haag, Zuid-holland
Antoni van Leeuwenhoek Apotheek,I-2, Amsterdam, Not set
Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, Not set
Rijnstate Hospital, Arnhem, Not set
Maastricht Universitair Medisch Centrum+, Maastricht, Not set
Radboud University Medical Center, Nijmegen, Not set
Akershus universitetssykehus HF, Lørenskog, Akershus
Avdeling for blod og kreft sykdommer. Stavanger universitetssykehus, Stavanger, Not set
Hospital Militar Central Coronel Luis Arias Schreiber, Lima, Not set
Hospital Maria Auxiliadora, Lima, Not set
Hospital de Braga, Sao Victor, Braga
Hospital de Braga, Braga, Not set
Centro Clinico Champalimaud, Lisboa, Not set
Hospital de Santa Maria - Centro Hospitalar Universitario Lisboa Norte, Lisboa, Not set
Champalimaud Clinical Center, Lisbon, Not set
Centro Hospitalar Universitário de São João, Porto, Not set
National University Hospital, Singapore, Not set
National University Cancer Institute, Singapore, Not set
National Cancer Centre Singapore, Singapore, Not set
Raffles Hospital, Singapore, Not set
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruna
Farmacia Oncologica - Unidad de Ensayos Clinicos, Santiago de Compostela, A Coruna
Hospital Universitario Badajoz, Badajoz, A Coruña [LA Coruña]
Institut Catala d' Oncologia de Badalona - Hospital Universitari Germans Trias i Pujos, Badalona, Barcelona
Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona
Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), L'Hospitalet de Llobregat, Barcelona
Hospital de Cruzes, Barakaldo, Bizkaia
Hospital Universitario Marques de Valdecilla, Santander, Cantabria
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda, Madrid
Infanta Cristina Hospital, Badajoz, Not set
Hospital Del Mar, Barcelona, Not set
Hospital Universitari Vall D Hebron, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Hospital Clinic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau- Pharmacy, Barcelona, Not set
Hospital de La Santa Creu i Sant Pau, Barcelona, Not set
Unitat d'Assajos Clinics Servei de Farmacia, L'Hospitaler De Llobregat, Not set
Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
Hospital General Universitario Gregorio Maranon, Madrid, Not set
MD Anderson Cancer Center Madrid, Madrid, Not set
Hospital Universitario Ramon y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario La Paz: Servicio de Farmacia, Madrid, Not set
Hospital Universitario La Paz, Madrid, Not set
HM Centro Integral Oncologico Clara Campal, Madrid, Not set
Hospital Universitario HM Sanchinarro, Madrid, Not set
Complejo Hospitalario Universitario de Ourense (CHOU), Ourense, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Consorcio Hospital General Universitario de Valencia (CHGUV), Valencia, Not set
Consorcio Hospital General Universitario de Valencia, Valencia, Not set
Hospital Universitario Miguel Servet, Zaragoza, Not set
Ryhov Hospital, Jonkoping, Not set
Karolinska University Hospital, Stockholm, Not set
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Not set
Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung City, Not set
Kaohsiung Medical University Hospital, Kaohsiung, Not set
China Medical University Hospital - Pharmacy, Taichung, Not set
China Medical University Hospital, Taichung, Not set
Taichung Veterans General Hospital Clinical Trials Pharmacy, Taichung, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Hospital liouying, Tainan City, Not set
Clinical Trial Pharmacy, Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Not set
National Cheng-Kung University Hospital, Tainan, Not set
National Taiwan University Hospital, Investigational Drug Service, Taipei, Not set
National Taiwan University Hospital, Taipei, Not set
NHS Greater Glasgow and Clyde (NHSGGC) - The Beatson West of Scotland Cancer Centre, Glasgow, Other
Barts Health NHS Trust Saint Bartholomews Hospital, London, Not set
Guy's and St Thomas' NHS Foundation Trust, London, Not set
Guy's and St Thomas' NHS Foundation, London, Not set
Conditions: Urothelial Carcinoma
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
Recruiting
Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy.
Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Ironwood Cancer & Research Centers ( Site 0036), Chandler, Arizona +93 locations
Ironwood Cancer & Research Centers ( Site 0036), Chandler, Arizona
Yale New Haven Hospital ( Site 0001), New Haven, Connecticut
AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007), Altamonte Springs, Florida
St. Luke's Cancer Institute: Boise ( Site 0037), Boise, Idaho
MedStar Franklin Square Medical Center ( Site 0031), Baltimore, Maryland
MedStar Good Samaritan Hospital ( Site 0079), Baltimore, Maryland
MedStar Montgomery Medical Center ( Site 0078), Olney, Maryland
Holy Cross Hospital ( Site 0091), Silver Spring, Maryland
Allina Health Cancer Institute ( Site 0069), Minneapolis, Minnesota
Comprehensive Cancer Centers of Nevada ( Site 0015), Las Vegas, Nevada
Renown Regional Medical Center ( Site 0005), Reno, Nevada
New Mexico Oncology Hematology Consultants Ltd. ( Site 0019), Albuquerque, New Mexico
Instituto Alexander Fleming ( Site 2402), Mar De PLata, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2401), Mar del Plata, Buenos Aires
Clinica Viedma ( Site 2403), Viedma, Rio Negro
Fundacion Estudios Clinicos ( Site 2405), Rosario, Santa Fe
Hospital Italiano de Cordoba ( Site 2406), Cordoba, Not set
AZ Maria Middelares ( Site 3103), Gent, Oost-Vlaanderen
ZAS Sint Augustinus ( Site 3102), Antwerpen, Vlaams Gewest
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 2301), São Jose do Rio Preto, Sao Paulo
Jewish General Hospital ( Site 0203), Montreal, Quebec
St. Marys Hospital Center ( Site 0201), Montreal, Quebec
Hopital Du Saint-Sacrement ( Site 0210), Québec, Quebec
Biocenter ( Site 2009), Concepcion, Biobio
IC La Serena Research ( Site 2007), La Serena, Coquimbo
FALP ( Site 2000), Santiago., Region M. De Santiago
Clínica UC San Carlos de Apoquindo ( Site 2008), Santiago, Region M. De Santiago
Bradfordhill ( Site 2001), Santiago, Region M. De Santiago
ONCOCENTRO APYS ( Site 2005), Vina del Mar, Valparaiso
The First Afflilated Hospital of Bengbu Medical College ( Site 5022), Bengbu, Anhui
The First Affiliated Hospital of Chongqing Medical University ( Site 5039), Chongqing, Chongqing
Chongqing University Three Gorges Hospital ( Site 5020), Chongqing, Chongqing
Sun Yat-Sen University Cancer Center ( Site 5014), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital. ( Site 5008), Nanning, Guangxi
Jiangsu Province Hospital ( Site 5009), Nanjing, Jiangsu
Xuzhou Central Hospital ( Site 5036), Xuzhou, Jiangsu
The First Hospital of Jilin University ( Site 5003), Changchun, Jilin
Jinan Central Hospital ( Site 5031), Jinan, Shandong
LinYi Cancer Hospital ( Site 5021), Linyi, Shandong
Sichuan Cancer Hospital. ( Site 5018), Chengdu, Sichuan
Affiliated Tumor Hospital of Xinjiang Medical University ( Site 5006), Urumqi, Xinjiang
Zhejiang Cancer Hospital ( Site 5012), Hangzhou, Zhejiang
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 5024), Hangzhou, Zhejiang
Taizhou Hospital of Zhejiang Province ( Site 5029), Linhai, Zhejiang
Instituto de Cancerología ( Site 2206), Medellin., Antioquia
Centro Cancerologico del Caribe LTD ( Site 2209), Barranquilla, Atlantico
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2203), Bogota., Distrito Capital De Bogota
Rambam Health Care Campus ( Site 3700), Haifa, Not set
Shaare Zedek Medical Center ( Site 3704), Jerusalem, Not set
Rabin Medical Center ( Site 3702), Petah Tikva, Not set
Sheba Medical Center ( Site 3701), Ramat Gan, Not set
Sourasky Medical Center ( Site 3703), Tel Aviv, Not set
Nagoya City University Hospital ( Site 5108), Nagoya, Aichi
Hokkaido University Hospital ( Site 5100), Sapporo, Hokkaido
Tokai University Hospital ( Site 5107), Isehara, Kanagawa
Mie University Hospital ( Site 5109), Tsu, Mie
The University of Osaka Hospital ( Site 5111), Suita, Osaka
Saitama Medical University International Medical Center ( Site 5116), Hidaka, Saitama
Showa Medical University Hospital ( Site 5103), Shinagawa, Tokyo
Fukushima Medical University Hospital ( Site 5101), Fukushima, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 5113), Hiroshima, Not set
Social medical corporation Hakuaikai Sagara Hospital ( Site 5114), Kagoshima, Not set
National Cancer Center ( Site 5202), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 5204), Seongnam, Kyonggi-do
Kyungpook National University Chilgok Hospital ( Site 5205), Daegu, Kyongsangbuk-do
Seoul National University Hospital ( Site 5200), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 5201), Seoul, Not set
Samsung Medical Center ( Site 5203), Seoul, Not set
Harbour Cancer & Wellness ( Site 5600), Newmarket, Auckland
Pratia MCM Krakow ( Site 3812), Krakow, Malopolskie
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3801), Siedlce, Mazowieckie
Mazowiecki Szpital Onkologiczny ( Site 3807), Wieliszew, Mazowieckie
Szpitale Pomorskie Sp. z o. o. ( Site 3805), Gdynia, Pomorskie
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 3800), Koszalin, Zachodniopomorskie
Institutul Oncologic Cluj ( Site 4701), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 4705), Comuna Floresti, Cluj
Centrul de Oncologie "Sfântul Nectarie" ( Site 4702), Craiova, Dolj
Centrul Medical Neolife- Baneasa ( Site 4706), Bucuresti, Not set
Hospital Clinico San Carlos ( Site 4100), Madrid, Madrid, Comunidad De
Hospital General Universitario de Valencia ( Site 4102), Valencia, Valenciana, Comunitat
Parc de Salut Mar - Hospital del Mar ( Site 4106), Barcelona, Not set
Hospital Beata María Ana ( Site 4105), Madrid, Not set
Hospital Universitario Ramon y Cajal ( Site 4103), Madrid, Not set
Taichung Veterans General Hospital ( Site 5303), Taichung, Not set
National Cheng Kung University Hospital ( Site 5304), Tainan, Not set
National Taiwan University Hospital ( Site 5300), Taipei, Not set
Mackay Memorial Hospital ( Site 5301), Taipei, Not set
Chang Gung Memorial Hospital ( Site 5302), Taoyuan, Not set
Faculty of Medicine Siriraj Hospital ( Site 5800), Bangkok, Krung Thep Maha Nakhon
Songklanagarind hospital ( Site 5801), HatYai, Songkhla
Faculty of Medicine - Khon Kaen University ( Site 5802), Khon Kaen, Not set
Royal Cornwall Hospital ( Site 4003), Truro, Cornwall
St Bartholomew's Hospital ( Site 4001), London, London, City Of
Nottingham University Hospital NHS Trust ( Site 4009), Nottingham, Nottinghamshire
Conditions: Triple Negative Breast Neoplasms
Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Recruiting
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pe... Read More
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pemetrexed and carboplatin) in regard to progression-free survival (PFS) and overall survival (OS). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Kaiser Permanente - Oakland ( Site 0054), Oakland, California +152 locations
Kaiser Permanente - Oakland ( Site 0054), Oakland, California
Kaiser Permanente - Roseville ( Site 0055), Roseville, California
Kaiser Permanente - San Francisco ( Site 0056), San Francisco, California
Kaiser Permanente - Santa Clara ( Site 0057), Santa Clara, California
Kaiser Permanente-Kaiser Permanente ( Site 0036), Vallejo, California
Kaiser Permanente - Walnut Creek ( Site 0058), Walnut Creek, California
Mid Florida Hematology and Oncology Center ( Site 0005), Orange City, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0003), Marietta, Georgia
University of Michigan ( Site 0009), Ann Arbor, Michigan
Cox Medical Center North - Cox Medical Center/ Hematology/Medical Oncology ( Site 0051), Springfield, Missouri
Astera Cancer Care ( Site 0032), East Brunswick, New Jersey
Stony Brook University-Cancer Center ( Site 0038), Stony Brook, New York
Sanford Fargo Medical Center ( Site 0028), Fargo, North Dakota
Sanford Cancer Center ( Site 0024), Sioux Falls, South Dakota
Millennium Research & Clinical Development ( Site 0035), Houston, Texas
Clinica Adventista Belgrano-Oncology ( Site 0315), Caba., Buenos Aires
Instituto Alexander Fleming ( Site 0307), Ciudad Autónoma de Buenos Aires, Buenos Aires
Hospital Británico de Buenos Aires-Oncology ( Site 0304), Ciudad autónoma de Buenos Aires, Caba
Centro Privado de RMI Río Cuarto S.A. II ( Site 0310), Río Cuarto, Cordoba
Instituto de Oncología de Rosario ( Site 0301), Rosario, Santa Fe
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0303), La Rioja, Not set
Cross Cancer Institute ( Site 0201), Edmonton, Alberta
Waterloo Regional Health Network (WRHN) ( Site 0207), Kitchener, Ontario
Princess Margaret Cancer Centre ( Site 0203), Toronto, Ontario
McGill University Health Centre ( Site 0204), Montréal, Quebec
Anhui Provincial Cancer Hospital ( Site 3132), Hefei, Anhui
Beijing Cancer hospital ( Site 3100), Beijing, Beijing
Beijing Peking Union Medical College Hospital-pneumology department ( Site 3107), Beijing, Beijing
Chongqing University Cancer Hospital-Medical Oncology ( Site 3128), Chongqing, Chongqing
Fujian Cancer Hospital ( Site 3124), Fuzhou, Fujian
The First Affiliated hospital of Xiamen University ( Site 3125), XiaMen, Fujian
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 3102), Guangzhou, Guangdong
Guangxi Medical University Affiliated Tumor Hospital-Respiratory Oncology ( Site 3103), Nanning, Guangxi
Harbin Medical University Cancer Hospital ( Site 3109), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 3105), Zhengzhou, Henan
Tongji Hospital Tongji Medical,Science & Technology ( Site 3121), Wuhan, Hubei
Hubei Cancer Hospital ( Site 3122), Wuhan, Hubei
The Second Xiangya Hospital of Central South University-Oncology ( Site 3104), Changsha, Hunan
Nanjing Drum Tower Hospital JiangBei International Branch Hospital ( Site 3117), Nanjing, Jiangsu
The First Affiliated Hospital of Soochow University-Respiratory Department ( Site 3118), Suzhou, Jiangsu
The Second Affiliated Hospital of Nanchang University ( Site 3119), Nanchang, Jiangxi
The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 3130), XI An, Shaanxi
Jinan Central Hospital ( Site 3113), Jinan, Shandong
Shandong Cancer Hospital ( Site 3112), Jinan, Shandong
Zhongshan Hospital of Fudan University ( Site 3133), Shanghai, Shanghai
Shanxi Cancer Hospital ( Site 3114), Taiyuan, Shanxi
West China Hospital, Sichuan University ( Site 3126), Cheng Du, Sichuan
Sichuan Cancer hospital. ( Site 3127), Chengdu, Sichuan
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3101), Hangzhou, Zhejiang
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 3106), Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 3120), Wenzhou, Zhejiang
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0601), Valledupar, Cesar
IMAT S.A.S ( Site 0602), Monteria, Cordoba
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0600), Bogota, Distrito Capital De Bogota
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0606), Bogota, Distrito Capital De Bogota
Oncologos del Occidente ( Site 0604), Pereira., Risaralda
Fundacion Valle del Lili- CIC-Oncology CIC ( Site 0605), Cali, Valle Del Cauca
Nouvel Hôpital Civil (NHC) ( Site 1302), Strasbourg, Alsace
Clinique Clairval ( Site 1306), Marseille, Bouches-du-Rhone
Gustave Roussy ( Site 1303), Villejuif, Ile-de-France
Hopitaux Universitaires Paris Centre-Hopital Cochin-Unité d'Oncologie Thoracique ( Site 1304), Paris, Not set
All India Institute of Medical Sciences-Department of medical oncology ( Site 3303), New Delhi, Delhi
Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3301), New Delhi, Delhi
Rajiv Gandhi Cancer Institute And Research Centre ( Site 3300), New Delhi, Delhi
Artemis hospital ( Site 3307), Gurugram, Haryana
Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute-Centre for cancer ( Site 3302), Mumbai, Maharashtra
Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1803), Milano, Lombardia
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1800), Milan, Lombardia
Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1802), Bari, Puglia
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1804), Firenze, Toscana
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1801), Roma, Not set
Fujita Health University Hospital ( Site 3409), Toyoake, Aichi
Ehime University Hospital ( Site 3411), Toon, Ehime
National Hospital Organization Kyushu Cancer Center ( Site 3401), Fukuoka,, Fukuoka
Gunma Prefectural Cancer Center ( Site 3413), Ota, Gunma
Kanazawa University Hospital ( Site 3402), Kanazawa, Ishikawa
St. Marianna University Hospital ( Site 3415), Kawasaki, Kanagawa
Kanagawa Cancer Center ( Site 3416), Yokohama, Kanagawa
Miyagi Cancer Center ( Site 3406), Natori, Miyagi
Kansai Medical University Hospital ( Site 3414), Hirakata, Osaka
Saitama Prefectural Cancer Center ( Site 3417), Kitaadachi-gun, Saitama
Shizuoka Cancer Center ( Site 3405), Sunto-gun, Shizuoka
National Cancer Center Hospital ( Site 3408), Chuo, Tokyo
Toho University Omori Medical Center ( Site 3407), Ota, Tokyo
Kyushu University Hospital ( Site 3400), Fukuoka, Not set
Hiroshima City Hiroshima Citizens Hospital ( Site 3419), Hiroshima, Not set
Niigata Cancer Center Hospital ( Site 3403), Niigata, Not set
Okayama University Hospital ( Site 3404), Okayama, Not set
Osaka International Cancer Institute ( Site 3410), Osaka, Not set
Osaka Metropolitan University Hospital ( Site 3412), Osaka, Not set
Chungbuk National University Hospital ( Site 3804), Cheongju-si, Chungbuk
National Cancer Center ( Site 3803), Goyang-si, Kyonggi-do
Seoul National University Bundang Hospital ( Site 3807), Seongnam, Kyonggi-do
The Catholic University Of Korea St. Vincent's Hospital ( Site 3800), Suwon-si, Kyonggi-do
Ajou University Hospital ( Site 3813), Suwon, Kyonggi-do
Pusan National University Yangsan Hospital ( Site 3802), Pusan, Kyongsangnam-do
Pusan National University Hospital ( Site 3805), Busan, Pusan-Kwangyokshi
Keimyung University Dongsan Hospital CRC room 1 ( Site 3814), Daegu, Taegu-Kwangyokshi
Chungnam national university hospital ( Site 3806), Jung-gu, Taejon-Kwangyokshi
The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3812), Seoul, Not set
Asan Medical Center ( Site 3810), Seoul, Not set
Samsung Medical Center ( Site 3811), Seoul, Not set
Korea University Guro Hospital ( Site 3808), Seoul, Not set
University Malaya Medical Centre ( Site 3507), Lembah Pantai, Kuala Lumpur
National Cancer Institute-Radiotherapy and Oncology ( Site 3504), Putrajaya, Kuala Lumpur
Hospital Tengku Ampuan Afzan ( Site 3506), Kuantan, Pahang
Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 3501), George Town, Pulau Pinang
Sarawak General Hospital-Radiotherapy Unit ( Site 3508), Kuching, Sarawak
Arké SMO S.A. de C.V. ( Site 0706), Mexico, Distrito Federal
CIO - Centro de Inmuno-Oncología de Occidente ( Site 0700), Guadalajara, Jalisco
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0705), Monterrey, Nuevo Leon
Centro de Investigacion Clinica de Oaxaca ( Site 0704), Oaxaca de Juarez, Oaxaca
Oaxaca Site Management Organization S.C. ( Site 0701), Oaxaca, Not set
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003), Bydgoszcz, Kujawsko-pomorskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 2000), Warszawa, Mazowieckie
Bialostockie Centrum Onkologii ( Site 2010), Bialystok, Podlaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach-II Klinika Radioterapi i Chemioterapii ( Site 2002), Gliwice, Slaskie
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2321), LHospitalet de Llobregat, Barcelona
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2322), Santiago de compostela, La Coruna
Hospital Universitario Juan Ramon Jimenez-Oncología Medica ( Site 2323), Huelva, Not set
Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2324), Sevilla, Not set
Karolinska Universitetssjukhuset Solna ( Site 2401), Stockholm, Stockholms Lan
National Cheng Kung University Hospital ( Site 3901), Tainan City, Tainan
Chi Mei Hospital - Liouying Branch ( Site 3909), Tainan City, Tainan
National Taiwan University Cancer Center (NTUCC) ( Site 3907), Taipei City, Taipei
Changhua Christian Hospital ( Site 3904), Changhua, Not set
National Taiwan University Hospital - Hsinchu branch ( Site 3900), Hsinchu, Not set
Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung, Not set
Far Eastern Memorial Hospital ( Site 3912), New Taipei, Not set
Taichung Veterans General Hospital-Chest ( Site 3910), Taichung, Not set
National Taiwan University Hospital-Oncology ( Site 3908), Taipei, Not set
Mackay Memorial Hospital-Chest Medicine ( Site 3902), Taipei, Not set
Taipei Medical University Hospital ( Site 3903), Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 3911), Taoyuan, Not set
Maharaj Nakorn Chiang Mai Hospital ( Site 4005), Muang, Chiang Mai
Faculty of Medicine - Khon Kaen University ( Site 4002), Muang, Khon Kaen
Faculty of Medicine Siriraj Hospital ( Site 4004), Bangkok, Krung Thep Maha Nakhon
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 4006), Dusit, Krung Thep Maha Nakhon
Ramathibodi Hospital ( Site 4001), Ratchathewi, Krung Thep Maha Nakhon
Lampang Cancer Hospital ( Site 4000), Mueang Lampang, Lampang
Songklanagarind hospital ( Site 4003), HatYai, Songkhla
Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2504), Adana, Not set
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2501), Ankara, Not set
Memorial Ankara Hastanesi-Medical Oncology ( Site 2505), Ankara, Not set
Ankara Bilkent Şehir Hastanesi ( Site 2500), Ankara, Not set
I.E.U. Medical Point Hastanesi-Oncology ( Site 2503), Izmir, Not set
Hanoi Oncology Hospital ( Site 4198), Hanoi, Ha Noi
K Hospital - National Cancer Hospital ( Site 4193), Hanoi, Ha Noi
National Lung Hospital-Oncology Department ( Site 4194), Hanoi, Ha Noi
Thong Nhat Hospital ( Site 4192), Tan Binh District, Ho Chi Minh
Cho Ray Hospital ( Site 4190), Ho Chi Minh, Not set
Ho Chi Minh City Oncology Hospital - Tan Phu Ward ( Site 4191), Ho Chi Minh, Not set
Tam Anh Hospital ( Site 4196), Ho Chi Minh, Not set
Conditions: Non-small Cell Lung Cancer (NSCLC)
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
Recruiting
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent.
* EC is a type of cancer that starts in the tissues inside the uterus (womb)
* pMMR indicates that certain normal proteins are present in the cancer cells
* Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery
* Recurrent means the cancer came back after surgery
Sacituzumab tirumo... Read More
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent.
* EC is a type of cancer that starts in the tissues inside the uterus (womb)
* pMMR indicates that certain normal proteins are present in the cancer cells
* Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery
* Recurrent means the cancer came back after surgery
Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines. Sac-TMT is an antibody drug conjugate (ADC). An ADC attaches to specific targets on cancer cells and delivers treatment to destroy those cells.
The goal of this study is to learn if people who receive sac-TMT with pembrolizumab live longer and without the cancer getting worse compared to people who receive pembrolizumab alone. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Mount Sinai Cancer Center ( Site 6031), Miami Beach, Florida +20 locations
Mount Sinai Cancer Center ( Site 6031), Miami Beach, Florida
TRIALS 365 ( Site 6005), Shreveport, Louisiana
Miami Valley Hospital South ( Site 6014), Centerville, Ohio
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6047), Tulsa, Oklahoma
Texas Oncology - DFW ( Site 8004), Fort Worth, Texas
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0108), Mar del Plata, Buenos Aires
Fundación Respirar ( Site 0101), Buenos Aires, Caba
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0605), Montreal, Quebec
ONCOCENTRO APYS ( Site 0704), Vina del Mar, Valparaiso
Rambam Health Care Campus ( Site 2025), Haifa, Not set
Carmel Hospital ( Site 2023), Haifa, Not set
Shaare Zedek Medical Center ( Site 2020), Jerusalem, Not set
Sourasky Medical Center ( Site 2022), Tel Aviv, Not set
Keimyung University Dongsan Hospital ( Site 3105), Daegu, Taegu-Kwangyokshi
Asan Medical Center ( Site 3103), Seoul, Not set
Puerto Rico Cancer Specialists Clinical Trials ( Site 4201), San Juan, Not set
National Cancer Centre Singapore ( Site 3201), Singapore, Central Singapore
Taichung Veterans General Hospital ( Site 3703), Taichung, Not set
National Taiwan University Hospital ( Site 3701), Taipei, Not set
Mackay Memorial Hospital ( Site 3704), Taipei, Not set
Linkou Chang Gung Memorial Hospital ( Site 3705), Taoyuan, Not set
Conditions: Endometrial Cancer
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
Recruiting
This phase III trial studies using risk factors in determining treatment for children with favorable tissue (histology) Wilms tumors (FHWT). Wilms Tumor is the most common type of kidney cancer in children, and FHWT is the most common subtype. Previous large clinical trials have established treatment plans that are likely to cure most children with FHWT, however some children still have their cancer come back (called relapse) and not all survive. Previous research has identified features of FHWT... Read More
This phase III trial studies using risk factors in determining treatment for children with favorable tissue (histology) Wilms tumors (FHWT). Wilms Tumor is the most common type of kidney cancer in children, and FHWT is the most common subtype. Previous large clinical trials have established treatment plans that are likely to cure most children with FHWT, however some children still have their cancer come back (called relapse) and not all survive. Previous research has identified features of FHWT that are associated with higher or lower risks of relapse. The term "risk" refers to the chance of the cancer coming back after treatment. Using results of tumor histology tests, biology tests, and response to therapy may be able to improve treatment for children with FHWT. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
08/14/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +89 locations
Children's Hospital of Alabama, Birmingham, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Loma Linda University Medical Center, Loma Linda, California
Cedars Sinai Medical Center, Los Angeles, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Children's Hospital Colorado, Aurora, Colorado
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Riley Hospital for Children, Indianapolis, Indiana
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Maine Children's Cancer Program, Scarborough, Maine
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Albany Medical Center, Albany, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
East Carolina University, Greenville, North Carolina
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Medical City Dallas Hospital, Dallas, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
IWK Health Centre, Halifax, Nova Scotia
Conditions: Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor, Stage III Mixed Cell Type Kidney Wilms Tumor, Stage IV Mixed Cell Type Kidney Wilms Tumor
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery
Active Not Recruiting
This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them f... Read More
This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving combination chemotherapy may kill more tumor cells than one type of chemotherapy alone. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
08/14/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +204 locations
Children's Hospital of Alabama, Birmingham, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
San Jorge Children's Hospital, San Juan, Not set
University Pediatric Hospital, San Juan, Not set
King Faisal Specialist Hospital and Research Centre, Riyadh, Not set
Conditions: Childhood Hepatocellular Carcinoma, Childhood Malignant Liver Neoplasm, Fibrolamellar Carcinoma, Hepatoblastoma, Hepatocellular Malignant Neoplasm, Not Otherwise Specified
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Not Yet Recruiting
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: Local Institution - 0154, Orange, California +152 locations
Local Institution - 0154, Orange, California
Local Institution - 0139, Edwards, Colorado
Local Institution - 0085, Gainesville, Florida
Local Institution - 0270, Atlanta, Georgia
Local Institution - 0143, Columbus, Georgia
Local Institution - 0153, Chicago, Illinois
Local Institution - 0067, Boston, Massachusetts
Local Institution - 0091, Saint Louis, Missouri
Local Institution - 0269, Mineola, New York
Local Institution - 0090, New York, New York
Local Institution - 0158, New York, New York
Local Institution - 0186, Rochester, New York
Local Institution - 0087, Cleveland, Ohio
Local Institution - 0038, Portland, Oregon
Local Institution - 0205, Philadelphia, Pennsylvania
Local Institution - 0088, Pittsburgh, Pennsylvania
Local Institution - 0268, Chattanooga, Tennessee
Local Institution - 0093, Nashville, Tennessee
Local Institution - 0025, Houston, Texas
Local Institution - 0173, San Antonio, Texas
Local Institution - 0145, Charlottesville, Virginia
Local Institution - 0138, Richmond, Virginia
Local Institution - 0008, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0004, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0094, Cordoba, Córdoba
Local Institution - 0161, Auderghem, Bruxelles-Capitale, Région De
Local Institution - 0022, Yvoir, Namur
Local Institution - 0023, Gent, Oost-Vlaanderen
Local Institution - 0024, Sint-Niklaas, Oost-Vlaanderen
Local Institution - 0190, Calgary, Alberta
Local Institution - 0183, Toronto, Ontario
Local Institution - 0184, Chicoutimi, Quebec
Local Institution - 0185, Montreal, Quebec
Local Institution - 0006, Santiago, Región Metropolitana De Santiago
Local Institution - 0005, Santiago, Región Metropolitana De Santiago
Local Institution - 0007, Santiago, Región Metropolitana De Santiago
Local Institution - 0244, Beijing, Beijing
Local Institution - 0261, Luoyang, Henan
Local Institution - 0243, Wuhan, Hubei
Local Institution - 0257, Shenyang, Liaoning
Local Institution - 0258, Taiyuan, Shanxi
Local Institution - 0229, Valledupar, Cesar
Local Institution - 0228, Bogotá, Cundinamarca
Local Institution - 0227, Montería, Córdoba
Local Institution - 0226, Cali, Valle Del Cauca
Local Institution - 0014, Strasbourg, Alsace
Local Institution - 0017, Toulouse, Haute-Garonne
Local Institution - 0018, La Tronche, Isère
Local Institution - 0170, Saint Herblain, Loire-Atlantique
Local Institution - 0010, Lille, Nord-Pas-de-Calais
Local Institution - 0162, Bron, Rhône
Local Institution - 0019, Villejuif, Val-de-Marne
Local Institution - 0012, Marseille, Not set
Local Institution - 0011, Paris, Not set
Local Institution - 0015, Paris, Not set
Local Institution - 0207, Esslingen, Baden-Württemberg
Local Institution - 0238, Esslingen, Baden-Württemberg
Local Institution - 0212, Stuttgart, Baden-Württemberg
Local Institution - 0236, Donauwörth, Bayern
Local Institution - 0209, Oldenburg, Niedersachsen
Local Institution - 0213, Köln, Nordrhein-Westfalen
Local Institution - 0208, Chemnitz, Sachsen
Local Institution - 0211, Berlin, Not set
Local Institution - 0215, Gauting, Not set
Local Institution - 0210, Heidelberg, Not set
Local Institution - 0054, Athens, Attikí
Local Institution - 0060, Chaidari, Attikí
Local Institution - 0062, Thessaloniki, Thessaloníki
Local Institution - 0070, New Delhi, Delhi
Local Institution - 0083, Ahmedabad, Gujarat
Local Institution - 0072, Gurugram, Haryana
Local Institution - 0069, Bengaluru, Karnataka
Local Institution - 0077, Mumbai, Maharashtra
Local Institution - 0071, Mumbai, Maharashtra
Local Institution - 0078, Howrah, West Bengal
Local Institution - 0028, Ravenna, Emilia-Romagna
Local Institution - 0036, Aviano, Friuli-Venezia Giulia
Local Institution - 0031, Orbassano, Piemonte
Local Institution - 0137, Avellino, Not set
Local Institution - 0032, Milano, Not set
Local Institution - 0034, Napoli, Not set
Local Institution - 0029, Parma, Not set
Local Institution - 0196, Nagoya, Aichi
Local Institution - 0191, Kashiwa, Chiba
Local Institution - 0203, Toon, Ehime
Local Institution - 0201, Kurume, Fukuoka
Local Institution - 0217, Sapporo, Hokkaido
Local Institution - 0199, Nishinomiya, Hyogo
Local Institution - 0193, Yokohama, Kanagawa
Local Institution - 0192, Sendai, Miyagi
Local Institution - 0200, Kurashiki, Okayama
Local Institution - 0198, Hirakata, Osaka
Local Institution - 0204, Osaka-sayama, Osaka
Local Institution - 0194, Ina-machi, Saitama
Local Institution - 0197, Hamamatsu, Shizuoka
Local Institution - 0195, Nagaizumi-cho,Sunto-gun, Shizuoka
Local Institution - 0202, Koto-ku, Tokyo
Local Institution - 0089, Cheongju-si, Chungcheongbuk-do [Chungbuk]
Local Institution - 0043, Goyang-si, Kyǒnggi-do
Local Institution - 0044, Seongnam, Kyǒnggi-do
Local Institution - 0046, Suwon-si, Kyǒnggi-do
Local Institution - 0095, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0045, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0092, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0042, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0225, Mexico City, Distrito Federal
Local Institution - 0224, Oaxaca de Juarez, Oaxaca
Local Institution - 0222, Chihuahua, Not set
Local Institution - 0223, Mexico City, Not set
Local Institution - 0163, Harderwijk, Gelderland
Local Institution - 0216, Amsterdam, Noord-Holland
Local Institution - 0164, Amsterdam, Noord-Holland
Local Institution - 0103, Drammen, Buskerud
Local Institution - 0106, Bergen, Hordaland
Local Institution - 0105, Oslo, Not set
Local Institution - 0220, Lublin, Lubelskie
Local Institution - 0231, Gdynia, Pomorskie
Local Institution - 0219, Bydgoszcz, Not set
Local Institution - 0120, Bucharest, București
Local Institution - 0123, Bucharest, București
Local Institution - 0132, Florești, Cluj
Local Institution - 0130, Craiova, Dolj
Local Institution - 0115, Bucharest, Not set
Local Institution - 0133, Cluj, Not set
Local Institution - 0124, Iași, Not set
Local Institution - 0119, Iași, Not set
Local Institution - 0263, Singapore, Not set
Local Institution - 0262, Singapore, Not set
Local Institution - 0218, Barcelona, Barcelona [Barcelona]
Local Institution - 0177, Barcelona, Catalunya [Cataluña]
Local Institution - 0175, Madrid, Madrid, Comunidad De
Local Institution - 0206, Madrid, Madrid, Comunidad De
Local Institution - 0176, Madrid, Madrid, Comunidad De
Local Institution - 0181, Majadahonda, Madrid, Comunidad De
Local Institution - 0178, Málaga, Not set
Local Institution - 0182, Sevilla, Not set
Local Institution - 0180, València, Not set
Local Institution - 0179, Zaragoza, Not set
Local Institution - 0188, Baden, Aargau
Local Institution - 0187, st.Gallen, Sankt Gallen
Local Institution - 0189, Bellinzona, Not set
Local Institution - 0053, Kaohsiung, Not set
Local Institution - 0050, Taichung, Not set
Local Institution - 0049, Tainan, Not set
Local Institution - 0048, Taipei, Not set
Local Institution - 0047, Taipei, Not set
Local Institution - 0160, Taipei, Not set
Local Institution - 0265, Bangkok, Krung Thep Maha Nakhon
Local Institution - 0264, Bangkok, Not set
Local Institution - 0266, Songkhla, Not set
Local Institution - 0110, Glasgow, Glasgow City
Local Institution - 0061, London, Kensington And Chelsea
Local Institution - 0140, London, London, City Of
Conditions: Non-Small Cell Lung Cancer
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