There are currently 433 active clinical trials seeking participants for Breast Cancer research studies. The states with the highest number of trials for Breast Cancer participants are California, Ohio, Illinois and Michigan.
Safety and Feasibility of Robotic SP Nipple Sparing Mastectomy
NCT05245812
Recruiting
This is a single arm, single-center, prospective clinical trial designed to track the peri, post-operative and oncologic outcomes when utilizing the da-Vinci single port (SP) robotic platform to perform robotic nipple sparing mastectomy (rNSM) and immediate breast reconstruction with tissue expanders/implants and acellular dermal matrix (ADM - Alloderm), for patients with breast cancer as well as those with a high risk for breast cancer. Safety and feasibility measures will be measured as prima... Read More
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
03/26/2025
Locations: UT Southwestern, Dallas, Texas
Conditions: Breast Cancer, High Risk of Breast Cancer
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KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer
NCT05483491
Recruiting
This is a phase I clinical trial to determine the maximum tolerated dose (MTD) of KK-LC-1 TCR-T cells for the treatment of metastatic cancers that express KK-LC-1. Participants will receive a conditioning regimen, KK-LC-1 TCR-T cells, and aldesleukin. The safety profile and clinical response to treatment will be determined.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey +1 locations
Conditions: Gastric Cancer, Breast Cancer, Cervical Cancer, Lung Cancer
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Neoadjuvant Endocrine Therapy in ER-positive, HER2-negative Early Stage Breast Cancer
NCT05150652
Recruiting
The goal of this study is to access whether treatment of early state estrogen-rich breast cancers with neoadjuvant endocrine therapy will result in higher rates of margin negativity on lumpectomy specimen.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
03/25/2025
Locations: University of Kentucky Markey Cancer Center, Lexington, Kentucky
Conditions: Breast Cancer, HER2-negative Breast Cancer, Node-negative Breast Cancer, Breast Carcinoma
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Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors
NCT06340503
Recruiting
The purpose of this research study is to determine whether using the physical activity index screener, exercise coaching, and self-monitoring will increase physical activity and reduce time spent sitting or being inactive in patients who had breast or colon cancer.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/25/2025
Locations: Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina
Conditions: Breast Cancer, Colon Cancer
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Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)
NCT06169371
Recruiting
This is a post-marketing single arm, phase IV trial in which patients with high-risk early-stage HR+HER2- breast cancer will receive adjuvant abemaciclib in combination with endocrine therapy (ET) After study intervention, participants will remain on combination abemaciclib + ET at the discretion of their treating providers
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: University of Illinois, Chicago, Illinois +1 locations
Conditions: Breast Cancer
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MRg-NIRS Imaging System Breast Cancer Trial
NCT06400563
Recruiting
This trial is a study of 20 women with breast cancer to evaluate the addition of MR-guided (MRg) near-infrared spectroscopy (NIRS) with and without contrast, as part of a program to improve clinical management of women receiving breast magnetic resonance imaging (MRI).
Gender:
FEMALE
Ages:
Between 18 years and 83 years
Trial Updated:
03/24/2025
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Breast Cancer
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Longitudinal Sexual and Reproductive Health Study of Women with Breast Cancer and Lymphoma
NCT01788839
Recruiting
The purpose of this study is to see how cancer treatment affects sexual and reproductive function. The patient will also be asked to participate in blood draws to see if and how cancer treatment affects the ovaries and the ability to have children (fertility). These blood draws are optional and the patient can still participate in the questionnaire portion of the study even if they choose not to have their blood drawn.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey +6 locations
Conditions: Breast Cancer, Lymphoma, Hodgkin's Lymphoma
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Repurposing Riluzole for Cancer-Related Cognitive Impairment: a Pilot Trial
NCT06580002
Recruiting
This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels of breast cancer survivors with cancer related cognitive impairment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California
Conditions: Breast Cancer
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Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)
NCT06902311
Recruiting
This study evaluates the rates of radiation-specific toxicity, quality of life, and oncologic outcomes for early-stage breast cancer and ductal carcinoma in situ treated with 5-fraction whole breast irradiation (WBI) with a simultaneous integrated tumor bed boost (SIB). SIB refers to the technique tumor bed boost given at the same time as standard radiation therapy. The FAST-Forward trial previously showed that a 1-week course of radiotherapy had similar effects to the traditional 3-week course... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
03/24/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Breast Cancer, Early-stage Breast Cancer, Ductal Carcinoma in Situ, DCIS
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Cryoablation vs Lumpectomy in T1 Breast Cancers
NCT05505643
Recruiting
This trial studies the efficacy and safety of cryoablation in patients with low risk, early stage breast cancer. Cryoablation is a method of killing a tumor by freezing it. The standard approach for patients with this kind of cancer is a lumpectomy. This study will review the safety of the cryoablation procedure initially, followed by comparing cryoablation to lumpectomy in order to see if the cryoablation results in better disease control, complication rates, and quality of life.
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
03/21/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Breast Cancer, Breast Neoplasm
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Talking to Employers and Medical Staff About Breast Cancer Treatment and Your Job
NCT03572374
Recruiting
The purpose of this study is learn more about how being treated for breast cancer affects patients' employment. Researchers are testing an early version of a mobile app designed to help breast cancer patients keep their jobs during and after treatment. The app provides advice for patients to use when having conversations about breast cancer with their employers and their doctors. The app is called TEAMWork (Talking to Employers And Medical staff about Work). In this study, the investigators are... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Memorial Sloan Kettering Basking Ridge (Consent and Follow-up), Basking Ridge, New Jersey +8 locations
Conditions: Breast Cancer
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Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction
NCT05190978
Recruiting
Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite never being approved by Food and Drug Administration (FDA) for this indication. As surgeons transition to placing breast implants above the chest muscle (pre-pectoral), there has been an increasing reliance on these often expensive mesh products without robust evidence to... Read More
Gender:
FEMALE
Ages:
Between 22 years and 75 years
Trial Updated:
03/20/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Breast Cancer, Breast Implant; Complications, Infection or Inflammation
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