There are currently 98 active clinical trials seeking participants for Head and Neck Cancer research studies. The states with the highest number of trials for Head and Neck Cancer participants are California, Ohio, Pennsylvania and New York.
A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
NCT05812027
Recruiting
TScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous participant-derived T cells are engineered to express a T cell receptor that recognizes cancer-associated antigens presented on specific Human Leukocyte Antigen (HLA) molecules. The purpose of this screening study is to collect samples to conduct HLA genotyping, HLA Loss of Heterozygosity (LOH) and expression of Tumor-associated Antigens (TAA) testing. These results will be used to determine if p... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2025
Locations: HonorHealth Research and Innovation Institute, Scottsdale, Arizona +17 locations
Conditions: Head and Neck Cancer, Cervical Cancer, Non Small Cell Lung Cancer, Melanoma, Ovarian Cancer, HPV16 Related Cancers
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Mental Health App for Cancer Survivors Study
NCT06472726
Recruiting
The goal of this clinical trial is to adapt a mental health digital app to treat depression among head and neck cancer patients and survivors. Participants will download and use the digital mental health app for a 6-week period, and will complete related surveys.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/28/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Head and Neck Cancer, Head and Neck Cancers, Depression
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Tumescence in HNC Skin Graft Reconstruction
NCT04967391
Recruiting
Our primary objective is to determine if the use of tumescence has a meaningful effect on STSG uptake at the recipient site. This is an important outcome because poor graft uptake results in the need for prolonged local wound care, additional clinic visits for patients and increased risk of infection. A prospective, randomized comparison of the tumescence to our current standard of care will allow us to definitively evaluate any benefits to this technique. Tumescence is commonly used in the tre... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2025
Locations: UC Davis Health, Sacramento, California
Conditions: Head and Neck Cancer, Surgery--Complications, Graft Failure
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COPD Care Pathway Among Patients With Cancer
NCT05984680
Recruiting
This study gathers information for the development of a COPD care pathway for patients with cancer that reduces the treatment burden of patients, implements critical components of COPD care, and overcomes common barriers to COPD care in the community oncology clinic.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina
Conditions: Chronic Obstructive Pulmonary Disease, Lung Cancer, Head and Neck Cancer
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Pilot Trial of Adaptive Radiotherapy Boost for HNSCC
NCT06137274
Recruiting
The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Squamous Cell Carcinoma, Head and Neck Cancer
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Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology
NCT02507141
Recruiting
The purpose of this study is to get images (pictures) of oral lesions, which occur inside the mouth, before the patient's surgery using a special camera. These pictures will be used in our research to evaluate a new technology that uses a laser and takes pictures of the microscopic structure of tissue. The technology is called "reflectance confocal microscopy." We would like to compare what the camera sees to biopsies (pathology) of the same area. We will evaluate the pictures obtained from the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Memorial Sloan Kettering Basking Ridge (consent only), Basking Ridge, New Jersey +4 locations
Conditions: Head and Neck Cancer, Squamous Cell Carcinoma (SCC) of the Oral Cavity
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Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions
NCT05327270
Recruiting
To characterize the safety and tolerability of nivolumab injected intralesionally in patients with high-risk oral premalignant lesions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Head and Neck Cancer
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ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy
NCT05318027
Recruiting
Evaluate the feasibility of using a chatbot combined with continuous activity monitoring to proactively identify, appropriately triage and help manage patients' symptoms during cancer treatment Determine whether such an early outpatient clinic-based intervention can decrease rates of excess triage visits Correlate changes in activity and early symptom management to emergency department visits, unplanned inpatient hospitalizations and treatment breaks
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Lung Cancer, Gastrointestinal Cancer, Head and Neck Cancer
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Using an End-of-life Conversation Game to Engage Patients with Cancer in Advance Care Planning: Phase 2
NCT06384417
Recruiting
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with various solid cancer types (including: breast, gastro-intestinal, lung, melanoma, head and neck, and/or genito-urinary cancers) treated at Penn State Health clinics and their loved ones perform advance care planning (ACP). The main questions it aims to answer are: What modifications and/or adaptations are necessary to Hello for u... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/03/2025
Locations: Penn State Cancer Institute, Hershey, Pennsylvania
Conditions: Breast Cancer, Lung Cancer, Genito-Urinary Cancer, Colorectal Cancer, Gastric Cancer, Pancreatic Cancer, Liver Cancer, Head and Neck Cancer, Melanoma
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Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)
NCT05538533
Recruiting
This is a phase 1 study to determine the safety of a condensed preoperative radiation regimen (10, 7, or 5 fractions) for the management of head and neck squamous cell carcinoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Head and Neck Cancer
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New MRI Biomarkers in Head and Neck Cancers
NCT03483337
Recruiting
Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt. This makes specific organs, blood vessels, or tumors easier to see. Diffusion MRI lets us measure the motion of water in the tumor. The purpose of this study is to see if new MRI methods can give us more information about the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Memorial Sloan Kettering Cancer Center, New York, New York
Conditions: Head and Neck Cancer, Thyroid Cancer
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"QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer
NCT04373642
Recruiting
The purpose of this study is to test the safety of palliative "QUAD SHOT" radiotherapy combined with pembrolizumab and evaluate the effects of the combination treatment patients with recurrent cancer of head and neck.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Stephenson Cancer Center, Oklahoma City, Oklahoma
Conditions: Head and Neck Cancer
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