There are currently 96 active clinical trials seeking participants for Head and Neck Cancer research studies. The states with the highest number of trials for Head and Neck Cancer participants are California, Ohio, Pennsylvania and New York.
Intraoral Hypothermia Device for Preserving Taste During Radiation
NCT06579248
Recruiting
Radiation therapy to the head and neck region is known to cause taste dysfunction. Preliminary studies showed that cooling normal structures may lower damage caused by radiation. The purpose of this research study is to see if it is feasible to use an intraoral cooling device during radiation treatments to preserve or lower the decline of taste function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Head and Neck Cancer, Taste Dysfunction, Radiation Therapy
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Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT
NCT05442957
Recruiting
In this multi-center randomized clinical trial, head and neck cancer (HNC) survivors with clinically significant body image distress (BID) (N=180) will be randomized to BRIGHT (a brief video tele-cognitive behavioral therapy intervention) or Attention Control (AC, a manualized tele-supportive care intervention that controls for professional attention, dose, delivery method, and common factors). HNC survivors will complete IMAGE-HN (a validated patient-reported outcome measure \[PROM\] of HNC-rel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: Henry Ford Hospital, Detroit, Michigan +3 locations
Conditions: Head and Neck Cancer, Body Image Disturbance, Body Image, Survivorship, Psychosocial Impairment, Mental Health Issue
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Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
NCT05156060
Recruiting
This is a study to establish a safe and feasible dose for prophylactic use of a combination of gabapentin and ketamine in head and neck cancer patients undergoing chemoradiation.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/17/2024
Locations: Vanderbilt-Ingram Cancer Center, Nashville, Tennessee
Conditions: Head and Neck Cancer, Locally Advanced Head and Neck Carcinoma
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A Motion Exergaming Approach for Symptom Management: HNC
NCT04632654
Recruiting
This overall objective of the RCT is to test an intervention to overcome the PA barriers for head and neck cancer (HNC) patients during the first 6 months after their treatment. PAfitME stands for a personalized Physical Activity intervention with fitness graded Motion Exergames. PAfitME is delivered via a tested mix of FaceTime calls and home visits, uses commercially available exergaming platforms (Nintendo Switch). We propose the following specific aims: (1) When compared to an attention cont... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/10/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Head and Neck Cancer
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Improving Care for Rural Patients With Solid Tumors
NCT04916990
Recruiting
This study will assess if the CARES (Cancer Advocacy, Resources, Education and Support) intervention improves time to start of treatment after diagnosis and time to treatment completion for solid tumors (ex: lung, head, neck, thyroid, cervical, breast, bladder, colon, and rectal cancers) in rural patients.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
09/13/2024
Locations: University of Colorado Hospital, Aurora, Colorado +11 locations
Conditions: Lung Cancer, Head and Neck Cancer, Thyroid Cancer, Cervical Cancer, Breast Cancer, Bladder Cancer, Colon Cancer, Rectum Cancer
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A Phase 2 Open Label Study of BA3021 in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
NCT05271604
Recruiting
This is a multi-center, open-label Phase 2 study designed to evaluate the efficacy and safety of BA3021 as monotherapy and combination therapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: USC Norris Comprehensive Cancer Center, Los Angeles, California +7 locations
Conditions: Head and Neck Cancer, Squamous Cell Carcinoma of Head and Neck, Recurrent Squamous Cell Carcinoma of the Head and Neck, Metastatic Cancer, Metastatic Squamous Cell Carcinoma of the Head and Neck
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TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
NCT05108870
Recruiting
Doctors leading this study hope to learn about the safety and effectiveness of combining medications HB-201 and HB-202 (also known as TheraT® vectors) with chemotherapy using carboplatin and paclitaxel in the beginning of the study (induction) and if combining these medications can increase tumor shrinkage after therapy and reduce the amount of radiotherapy and chemotherapy that will later be needed. In addition, the study is looking at ways to reduce side effects overall using robotic surgery,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: University of Chicago, Chicago, Illinois
Conditions: Human Papilloma Virus, HPV, HPV Positive Oropharyngeal Squamous Cell Carcinoma, Head and Neck Cancer
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Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery
NCT05954676
Recruiting
This phase of the project will evaluate the utility and efficacy of a personalized online patient education platform developed from efforts in Phase 1 in 1) increasing patients' and caregivers' pre- and post-operative preparedness and satisfaction, and 2) reducing readmission, ED/Urgent care/unplanned clinic visits and telephone calls to clinic staff.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Head and Neck Cancer, Head and Neck Neoplasms
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Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
NCT00900419
Recruiting
RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer.
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
08/28/2024
Locations: University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado
Conditions: Esophageal Cancer, Head and Neck Cancer, Lung Cancer, Precancerous Condition
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Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
NCT05995821
Recruiting
This research is being done to collect and store biological specimens (biospecimens) from people with cancer, regardless of tumor type, who are receiving treatments known or thought to have an effect on the immune system. The goal of this discovery and exploratory study is to: * Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work. * Identify risk factors for those who go o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Head and Neck Cancer, Lung Cancer, Gastrointestinal Cancer
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Safety and Efficacy of APG-157 in Head and Neck Cancer
NCT05312710
Recruiting
The purpose of this clinical research study is to study safety and efficacy of orally administered APG-157 as the neoadjuvant/induction therapy in newly diagnosed, locally advanced patients with Head \& Neck Cancer of oral cavity and/or oropharynx. The study hypothesis is that neoadjuvant use of APG-157 will reduce the tumor burden prior to any definitive therapy to improve the outcomes over current standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2024
Locations: VAGLAHS, West Los Angeles, Los Angeles, California +1 locations
Conditions: Head and Neck Cancer, Squamous Cell Carcinoma of Oral Cavity, Squamous Cell Carcinoma of the Oropharynx
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Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment
NCT06108089
Recruiting
Tumor hypoxia is one of the physiological factors for treatment resistance and likely contributes to poor overall survival among patients with head and neck cancer (HNC). Identifying hypoxic features of HNC may allow the personalizing treatment plan. The investigators propose multiparametric Hypoxia MR (HMR) imaging using diffusion, perfusion, and oxygenation as non-invasive, in-vivo imaging components of a hypoxia phenotype. Assessing the hypoxia phenotypes' expression will be critically import... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/09/2024
Locations: University of Utah, Salt Lake City, Utah
Conditions: Head and Neck Cancer, Hypoxia, Magnetic Resonance Imaging, Cancer Neck
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