There are currently 324 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and New York.
The Weight of Cardiovascular Disease
NCT06053645
Recruiting
The purpose of this study is to evaluate the impact of a cardiometabolic clinic on percent body weight loss, body mass index (BMI), and visceral adiposity distribution in obese adults with cardiovascular disease (CVD) at 12 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cardiovascular Diseases, Obesity
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Tirzepatide for Obesity and Meth Use Disorder
NCT06745128
Recruiting
This is an open-label pilot study to evaluate the feasibility and preliminary efficacy of using tirzepatide when prescribed for its United States (US) Food and Drug Administration (FDA)-approved weight-related indication in individuals with comorbid methamphetamine use disorder.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/24/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Obesity, Methamphetamine Use Disorder
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Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
NCT06284681
Recruiting
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight loss) and weight-neutral (i.e., weight loss is not an explicit goal) adaptive biobehavioral interventions for improving cardiometabolic health in Black adults with overweight or obesity (BMI ≥27 kg/m2) plus at least one weight-related cardiometabolic condition (high blood... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Obesity, Prehypertension, Hypertension, PreDiabetes, Type 2 Diabetes, Dyslipidemia
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A Weight Maintenance Program Promoting Fat Loss in Pregnancy in Women With Obesity
NCT04731688
Recruiting
The aims of this randomized controlled trial are to determine the effects of a lifestyle program that supports weight maintenance and fat mass loss during pregnancy in women with obesity on changes in 1) maternal weight, fat mass, and cardiometabolic risk factors; 2) safety measures, including fetal and neonatal growth; 3) the mediators and moderators of the fat mass loss intervention and 4) the effects gestational fat mass loss has on reducing incidence of adverse obstetrical outcomes, includin... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/23/2025
Locations: California Polytechnic State University, San Luis Obispo, California +1 locations
Conditions: Gestational Weight Gain, Obesity
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Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer Survivors
NCT06171945
Recruiting
The purpose of this study is to conduct a 6-month pilot randomized trial to determine the feasibility and acceptability of theory-based mobile weight loss interventions for survivors of adolescent and young adult cancer (AYAs). The interventions use a mobile smartphone application, previously developed for individuals at risk for type 2 diabetes and adapted for AYAs, that integrates weight and physical activity from digital devices with simplified dietary monitoring in a behavioral weight loss p... Read More
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
04/23/2025
Locations: Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
Conditions: Cancer, Physical Activity, Cancer Survivorship, Mental Health, Obesity
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The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
NCT05545306
Recruiting
Background: Diet-induced thermogenesis (DIT) is the amount of energy one s body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet can affect DIT. Objective: To learn how different diets can change a person s DIT. Eligibility: Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6 months. De... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/23/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Normal Physiology, Healthy Volunteers
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Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
NCT05723679
Recruiting
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
04/23/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Heart Failure With Preserved Ejection Fraction, Obesity
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A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT06075667
Recruiting
The main purpose of this study is to evaluate the safety and efficacy of tirzepatide in adolescents that have obesity or overweight with at least one weight-related comorbidity. The study will last approximately 90 weeks and may include up to 25 visits.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/22/2025
Locations: CenExel iResearch, LLC, Decatur, Georgia +37 locations
Conditions: Obesity, Overweight
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Early Tracking of Childhood Health Determinants (ETCHED) Study
NCT03481829
Recruiting
Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term effects on the child s health. Children who become overweight or obese during childhood tend to remain so as adults. Researchers want to study many risk factors during and after pregnancy, and how these affect a child s development. They will also follow the mother s he... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
04/22/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Fatty Liver, Diabetes Mellitus
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Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity
NCT06771115
Recruiting
This is a study to understand if taking VTX3232 alone or in combination with semaglutide is safe in participants diagnosed with Obesity. Approximately 160 patients will take VTX3232 Dose A, Placebo, VTX3232 Dose A in combination with semaglutide, or Placebo in combination with semaglutide. This study consists of a 30-day Screening Period (to see if a participant qualifies for a study), a 12-week double-blind treatment period (a participant receives VTX3232 Dose A, Placebo, VTX3232 Dose A in com... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/21/2025
Locations: 840005, Birmingham, Alabama +13 locations
Conditions: Obesity
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Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)
NCT06098079
Recruiting
A randomized, double-blinded, placebo controlled study intended to capture cardiovascular outcomes during real-world use of naltrexone/bupropion (NB).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: Accel Research Sites Network, Birmingham, Alabama +123 locations
Conditions: Obesity
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PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
NCT04971720
Recruiting
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death. Natriuretic Peptides (NPs) are hormones produced by the heart which directly regulate BP by causing dilation of blood vessels and by removing sodium and water from the body. NPs have a 24-hour day-night rhythm and this controls the day-night rhythm of BP as well. The NP-BP rhythm relationship is b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Obesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood Pressure, Natriuretic Peptides, Renin-Angiotensin-Aldosterone System
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