There are currently 325 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and New York.
The Effects of Metabolic & Bariatric Surgery on Lipid Metabolism, Myeloid-Derived Suppressor Cells, and Cancer Cell Biology
Recruiting
This study aims to determine the relationship between lipid kinetics changes and blood immunosuppressive cells by metabolic surgery in two patient cohorts.
Gender:
FEMALE
Ages:
Between 35 years and 60 years
Trial Updated:
02/13/2025
Locations: Pennington Biomedical Resarch Center, Baton Rouge, Louisiana
Conditions: Obesity
Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools
Recruiting
The purpose of this protocol is to test the effects on weight of an evidence-based behavioral weight loss program enhanced with culturally targeted stress management strategies compared to the evidence-based weight loss program alone among adult black females with obesity and elevated stress levels. Participants will be randomized to receive either a behavioral weight loss intervention with a focus on stress management or the weight loss intervention alone for 26 sessions.
Gender:
FEMALE
Ages:
Between 21 years and 75 years
Trial Updated:
02/12/2025
Locations: Moffitt Cancer Center, Tampa, Florida
Conditions: Obesity
A Study of LY3532226 in Participants With Obesity
Recruiting
The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY3532226 in participants with obesity. Blood tests will be performed to check how much LY3532226 gets into the bloodstream and how long it takes the body to eliminate it following weekly or monthly administration. Part A of the study will last approximately 16 weeks, excluding screening period. Part B of the study will last approximately 20 weeks, excluding the screening period.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/11/2025
Locations: Fortrea Clinical Research Unit, Daytona Beach, Florida +3 locations
Conditions: Obesity
The Retrain Your Brain for Healthy Eating Study
Recruiting
The aim of this mixed methods, single-group, single-center study will be to examine the feasibility of a food response training (FRT). This study will be conducted in patients with obesity recruited from NYU Langone Health. Measurements will occur at screening, baseline, and 3 months, for a subgroup of participants for we will collect saliva samples for genetic analysis at baseline assessment (ancillary study).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/11/2025
Locations: NYU Clinical & Translational Science Institute Clinical Research Center (CTSI CRC), New York, New York +1 locations
Conditions: Obesity
Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity
Recruiting
Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations occurring in the post-weight loss setting, including neuroendocrine-mediated changes in appetite/satiety and reduction of energy expenditure. Following weight loss, peripheral and central mechanisms respond in a way similar to starvation by conveying a sense that energy reserves have dwindled, activating a strong counter-response to increase caloric intake. Moreover, metaboli... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/07/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Obesity
Fit for Duty: mHealth Intervention for Weight Gain Prevention
Recruiting
Weight gain is disproportionately high among young adults compared to other age groups and of particular concern in the military, which is comprised largely of young adults, as obesity has emerged as a threat to national security. Despite the critical need to address weight gain in young military personnel who can face discharge for failing to meet weight standards, there is currently no evidence-based programs available to them. This study aims to adapt an evidence-based weight gain prevention... Read More
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
02/07/2025
Locations: Joint Base San Antonio-Lackland, San Antonio, Texas
Conditions: Obesity
Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)
Recruiting
A randomized, double-blinded, placebo controlled study intended to capture cardiovascular outcomes during real-world use of naltrexone/bupropion (NB).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Accel Research Sites Network, Birmingham, Alabama +111 locations
Conditions: Obesity
Metabolic Effects of Angiotensin-(1-7)
Recruiting
The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity. Pharmacologic approaches to increase angiotensin-(1-7) levels or its actions are currently in development for treatment of metabolic-related diseases such as obesity and type II diabetes, based on findings from animal studies. It is unclear if this peptide contributes to the regulation of metabolism in humans. The investigators will test if a... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/06/2025
Locations: Vanderbilt University School of Medicine, Nashville, Tennessee
Conditions: Obesity, Insulin Resistance, Hypertension, Metabolic Cardiovascular Syndrome
A Study of Adipose Tissue in Adaptive Responses to Exercise
Recruiting
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/06/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Healthy, Obesity
Stepped Care for Weight Loss Maintenance
Recruiting
This study is a 3-group, parallel design, randomized controlled trial (RCT) in approximately 258 adults with obesity that will investigate whether a 16-week behavioral weight loss treatment and a 52-week stepped-care digital health intervention can improve the maintenance of a ≥ 5% weight loss. 16-week run-in (Phase 1). To qualify for randomization, participants must lose ≥ 5% of initial weight in the 16-week run-in. This loss will be achieved with the provision of weekly-group lifestyle counse... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/06/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Obesity
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
Recruiting
The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, which have traditionally had less accurate results in this population. The main questions it aims to answer are: * Determine accuracy of EUS-SWE for liver fibrosis screening compared to other non-inva... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis, Obesity
Tirzepatide for Obesity and Meth Use Disorder
Recruiting
This is an open-label pilot study to evaluate the feasibility and preliminary efficacy of using tirzepatide when prescribed for its United States (US) Food and Drug Administration (FDA)-approved weight-related indication in individuals with comorbid methamphetamine use disorder.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/04/2025
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Obesity, Methamphetamine Use Disorder