There are currently 43 active clinical trials seeking participants for Obsessive-Compulsive Disorder research studies. The states with the highest number of trials for Obsessive-Compulsive Disorder participants are Florida, California, New York and Massachusetts.
CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD
NCT05609916
Recruiting
The purpose of this study is to examine whether youth with OCD who benefit from CBT augmentation to SRI can discontinue their medication without relapse over 24 weeks.
Gender:
All
Ages:
Between 7 years and 17 years
Trial Updated:
06/20/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Cognitive Behavioral Therapy, Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder in Children, Obsessive-Compulsive Disorder in Adolescence
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Neurostimulation Versus Therapy for Problems With Emotions
NCT05712057
Recruiting
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
06/13/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders, OCD, Impulse Control Disorder, Eating Disorders, Emotional Dysfunction, Emotional Instability, Emotional Distress, Emotional Maladjustment, Emotional Impulsivity, Obsessive-Compulsive Disorder, Emotion Dysregulation, Borderline Personality Disorder
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Theta Burst Stimulation Plus Habit Override Training for Compulsive Behaviors
NCT04580043
Recruiting
This project seeks to identify causal neural mechanisms underlying unwanted, repetitive behaviors (compulsions). Using non-invasive brain stimulation coupled with practice in a computer task, we will modulate activity in a target brain region and measure effects on compulsive behaviors and related measures. This work could ultimately lead to the ability to treat compulsions more effectively by targeting the regions of the brain that can help or hinder attempts to overcome compulsions.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
06/04/2024
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Compulsive Behavior, Obsessive-Compulsive Disorder
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SEEG-Guided DBS for OCD
NCT05623306
Recruiting
This is a multi-site, double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of DBS surgery and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment.
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
05/31/2024
Locations: Stanford University, Stanford, California +1 locations
Conditions: Obsessive-Compulsive Disorder
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Effects of Psilocybin in Obsessive Compulsive Disorder
NCT05546658
Recruiting
This study will test the feasibility, safety, and evidence for efficacy of psilocybin administration in participants with obsessive compulsive disorder (OCD). This will serve as a preliminary proof of concept study for future larger studies aimed to investigate the utility, cognitive mechanisms, and neural correlates of this intervention.
Gender:
All
Ages:
Between 21 years and 70 years
Trial Updated:
05/28/2024
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Obsessive-Compulsive Disorder
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CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
NCT05467683
Recruiting
Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?"
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/06/2024
Locations: Boston University, Boston, Massachusetts +1 locations
Conditions: Obsessive-Compulsive Disorder, Post Traumatic Stress Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
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Using Personalized Assessments in the Treatment of Childhood OCD
NCT06407648
Recruiting
The primary purpose of this study is to learn whether personalized assessment of obsessive-compulsive disorder (OCD) symptoms in childhood OCD using mobile health technology are feasible and acceptable for youth and parents. The investigators will also examine whether personalized cognitive-behavioral therapy (CBT) that is informed by personalized OCD assessments yields better clinical outcomes when compared to standard CBT for youth with OCD
Gender:
All
Ages:
Between 8 years and 17 years
Trial Updated:
05/06/2024
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Obsessive-Compulsive Disorder
Register for Updates
Personalized DBS for OCD Guided by Stereoencephalography Mapping
NCT06347978
Recruiting
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of 4-lead DBS surgery with bilateral IPGs and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label trea... Read More
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
05/01/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Obsessive-Compulsive Disorder, OCD
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Study of Dextromethorphan in OCD and Related Disorders
NCT04899687
Recruiting
The purpose of the study is to assess the tolerability and efficacy of dextromethorphan in combination with fluoxetine for symptom relief in OCD and related disorders.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/24/2024
Locations: Stanford University, Stanford, California
Conditions: Obsessive-Compulsive Disorder, Illness Anxiety Disorder, Body Dysmorphic Disorders, Somatic Symptom Disorder
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Efficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder
NCT04641143
Recruiting
The study's purpose is to evaluate the efficacy and safety of troriluzole as adjunctive therapy compared to placebo in subjects with Obsessive Compulsive Disorder (OCD)
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2024
Locations: Metropolitan Neuro Behavioral Institute, Chandler, Arizona +84 locations
Conditions: Obsessive-Compulsive Disorder
Register for Updates
Efficacy and Safety Study of Adjunctive Troriluzule in Obsessive Compulsive Disorder
NCT04693351
Recruiting
The study's purpose its to evaluate the efficacy and safety of troriluzole as adjunctive therapy compared to placebo in subjects with Obsessive Compulsive Disorder (OCD)
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2024
Locations: Alea Research, Phoenix, Arizona +110 locations
Conditions: Obsessive-Compulsive Disorder
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Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
NCT04131829
Recruiting
The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/10/2024
Locations: Yale OCD Research Clinic - CMHC/CNRU, 34 Park ST, New Haven, Connecticut
Conditions: Obsessive-Compulsive Disorder
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