There are currently 34 active clinical trials seeking participants for Obsessive-Compulsive Disorder research studies. The states with the highest number of trials for Obsessive-Compulsive Disorder participants are California, Florida, New York and Massachusetts.
Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD
NCT05521074
Recruiting
The investigators want to learn more about how human beings learn not to fear and the impact of changing the fear network in the brain using transcranial Direct Current Stimulation (tDCS) in individuals with obsessive compulsive disorder (OCD). The investigators hope this study will help us understand how future treatments can help patients with OCD better control unwanted fear.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/10/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Obsessive-Compulsive Disorder
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Theta Burst Stimulation Plus Habit Override Training for Compulsive Behaviors
NCT04580043
Recruiting
This project seeks to identify causal neural mechanisms underlying unwanted, repetitive behaviors (compulsions). Using non-invasive brain stimulation coupled with practice in a computer task, we will modulate activity in a target brain region and measure effects on compulsive behaviors and related measures. This work could ultimately lead to the ability to treat compulsions more effectively by targeting the regions of the brain that can help or hinder attempts to overcome compulsions.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/09/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Compulsive Behavior, Obsessive-Compulsive Disorder
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A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
NCT05624528
Recruiting
The primary aim of the present study is to examine the efficacy and safety of tolcapone in adults with moderate to severe OCD.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/02/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Obsessive-Compulsive Disorder, OCD
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Using Personalized Assessments in the Treatment of Childhood OCD
NCT06407648
Recruiting
The primary purpose of this study is to learn whether personalized assessment of obsessive-compulsive disorder (OCD) symptoms in childhood OCD using mobile health technology are feasible and acceptable for youth and parents. The investigators will also examine whether personalized cognitive-behavioral therapy (CBT) that is informed by personalized OCD assessments yields better clinical outcomes when compared to standard CBT for youth with OCD
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
05/14/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Obsessive-Compulsive Disorder
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Effects of Psilocybin in Obsessive Compulsive Disorder
NCT05546658
Recruiting
This study will test the feasibility, safety, and evidence for efficacy of psilocybin administration in participants with obsessive compulsive disorder (OCD). This will serve as a preliminary proof of concept study for future larger studies aimed to investigate the utility, cognitive mechanisms, and neural correlates of this intervention.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
05/12/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Obsessive-Compulsive Disorder
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Interpretation Bias as a Mechanism of Treatment Response in OCD
NCT05224414
Recruiting
This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes ass... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Obsessive-Compulsive Disorder
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Personalized DBS for OCD Guided by Stereoencephalography Mapping
NCT06347978
Recruiting
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of 4-lead DBS surgery with bilateral IPGs and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label trea... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
04/18/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Obsessive-Compulsive Disorder, OCD
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Retrospective Analyses of TrakStar Database
NCT06917339
Recruiting
In this study, real-world data will be used to better understand the effects patient characteristics, symptoms and TMS protocol parameters have on clinical outcomes with NeuroStar TMS.
Gender:
ALL
Ages:
Between 5 years and 120 years
Trial Updated:
03/31/2025
Locations: Neuronetics, Malvern, Pennsylvania
Conditions: Depression, Obsessive-Compulsive Disorder, Anxiety Depression
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Cortical Stimulation to Treat Obsessive Compulsive Disorder
NCT04958096
Recruiting
The purpose of this study is to identify abnormal brain signals associated with Obsessive Compulsive Disorder (OCD) and psychiatric symptoms and to investigate novel therapeutic stimulation sites. While treating OCD with standard deep brain stimulation (DBS) therapy, the investigators will also monitor the activity of the anterior cingulate and prefrontal cortex, a region known be involved with OCD, decision making, and emotion regulation, and the investigators will identify abnormal activity co... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/24/2025
Locations: UCSF Nancy Friend Pritzker Psychiatry Building, San Francisco, California
Conditions: Obsessive-Compulsive Disorder
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Neurostimulation Versus Therapy for Problems With Emotions
NCT05712057
Recruiting
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/18/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders, OCD, Impulse Control Disorder, Eating Disorders, Emotional Dysfunction, Emotional Instability, Emotional Distress, Emotional Maladjustment, Emotional Impulsivity, Obsessive-Compulsive Disorder, Emotion Dysregulation, Borderline Personality Disorder
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SEEG-Guided DBS for OCD
NCT05623306
Recruiting
This is a multi-site, double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of DBS surgery and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment.
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/13/2025
Locations: Stanford University, Stanford, California +1 locations
Conditions: Obsessive-Compulsive Disorder
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Efficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder
NCT04641143
Recruiting
The study's purpose is to evaluate the efficacy and safety of troriluzole as adjunctive therapy compared to placebo in subjects with Obsessive Compulsive Disorder (OCD)
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/07/2025
Locations: Metropolitan Neuro Behavioral Institute, Chandler, Arizona +95 locations
Conditions: Obsessive-Compulsive Disorder
Register for Updates