There are currently 39 active clinical trials seeking participants for Obsessive-Compulsive Disorder research studies. The states with the highest number of trials for Obsessive-Compulsive Disorder participants are California, Florida, New York and Massachusetts.
Cortical Stimulation to Treat Obsessive Compulsive Disorder
NCT04958096
Recruiting
The purpose of this study is to identify abnormal brain signals associated with Obsessive Compulsive Disorder (OCD) and psychiatric symptoms and to investigate novel therapeutic stimulation sites. While treating OCD with standard deep brain stimulation (DBS) therapy, the investigators will also monitor the activity of the anterior cingulate and prefrontal cortex, a region known be involved with OCD, decision making, and emotion regulation, and the investigators will identify abnormal activity co... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/24/2025
Locations: UCSF Nancy Friend Pritzker Psychiatry Building, San Francisco, California
Conditions: Obsessive-Compulsive Disorder
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Neurostimulation Versus Therapy for Problems With Emotions
NCT05712057
Recruiting
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/18/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders, OCD, Impulse Control Disorder, Eating Disorders, Emotional Dysfunction, Emotional Instability, Emotional Distress, Emotional Maladjustment, Emotional Impulsivity, Obsessive-Compulsive Disorder, Emotion Dysregulation, Borderline Personality Disorder
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SEEG-Guided DBS for OCD
NCT05623306
Recruiting
This is a multi-site, double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of DBS surgery and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment.
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/13/2025
Locations: Stanford University, Stanford, California +1 locations
Conditions: Obsessive-Compulsive Disorder
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Efficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder
NCT04641143
Recruiting
The study's purpose is to evaluate the efficacy and safety of troriluzole as adjunctive therapy compared to placebo in subjects with Obsessive Compulsive Disorder (OCD)
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/07/2025
Locations: Metropolitan Neuro Behavioral Institute, Chandler, Arizona +95 locations
Conditions: Obsessive-Compulsive Disorder
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University of Iowa Interventional Psychiatry Service Patient Registry
NCT04480918
Recruiting
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/25/2025
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Obsessive-Compulsive Disorder
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Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
NCT06376734
Recruiting
Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/30/2025
Locations: Acacia Clinics, Sunnyvale, California +1 locations
Conditions: Major Depressive Disorder, Obsessive-Compulsive Disorder, Schizophrenia, Generalized Anxiety Disorder, Mood Disorders, Psychiatric Disorder, Mental Disorder, Depression, Anxiety
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Effects of Repeated Psilocybin Dosing in OCD
NCT05370911
Recruiting
This study aims to investigate the effects of repeated dosing of oral psilocybin on obsessive-compulsive disorder (OCD) symptomatology in a randomized, waitlist-controlled design with blinded independent ratings, and assess psychological mechanisms that may mediate psilocybin's therapeutic effects on OCD.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/28/2025
Locations: Yale OCD Research Clinic (40 Temple St, 4th Floor), New Haven, Connecticut
Conditions: Obsessive-Compulsive Disorder
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Epidiolex in Obsessive Compulsive Disorder and Related Disorders
NCT04978428
Recruiting
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs). Subjects will be treated in an open-label fashion with Epidiolex for two weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/06/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
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A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
NCT05624528
Recruiting
The primary aim of the present study is to examine the efficacy and safety of tolcapone in adults with moderate to severe OCD.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/06/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Obsessive-Compulsive Disorder, OCD
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ERP Plus Improv Group Therapy for OCD (IMPROVE Study)
NCT06265233
Recruiting
The goal of this study is to pilot test a novel group therapy intervention for adults with OCD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/18/2024
Locations: 401 Quarry, Stanford, California
Conditions: Obsessive-Compulsive Disorder
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Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
NCT05940324
Recruiting
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/17/2024
Locations: Department of Psychiatry & Behavioral Sciences, Stanford, California
Conditions: Obsessive-Compulsive Disorder
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Efficacy of Nitrous Oxide in OCD: Pilot Study
NCT03826693
Recruiting
This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/26/2024
Locations: Stanford University, Stanford, California
Conditions: Obsessive-Compulsive Disorder
Register for Updates