Delaware is currently home to 287 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Newark, Wilmington, Lewes and Rehoboth Beach. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Identifying the Optimal Dynamic Ankle-Foot Orthosis Bending Stiffness for Individuals Post-Stroke
NCT06304519
Recruiting
Ankle braces are commonly prescribed to individuals who have suffered a stroke to help their ankle joints work properly, which allows these individuals to walk better. Currently, there are no standardized guidelines to follow when choosing which brace is best for an individual. Prior work has shown that customizing the level of assistance that these braces provide based on each individual's level of ankle impairment improves the individuals' walking function more than their current brace. The ne... Read More
Gender:
All
Ages:
Between 21 years and 85 years
Trial Updated:
03/04/2024
Locations: University of Delaware STAR Campus, Newark, Delaware
Conditions: Stroke
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Precise Infliximab Exposure and Pharmacodynamic Control
NCT05660746
Recruiting
Approximately 3 million people in the United States are living with inflammatory bowel disease, which includes Crohn's Disease (CD). There are limited treatment options approved for use in children and adults with Crohn's disease. Physicians need better ways to inform decisions on treatment. The main reason for this research study is to determine if a computer program that calculates an individualized dose based on a patient's blood testing results (precision dosing) can better achieve the best... Read More
Gender:
All
Ages:
Between 6 years and 22 years
Trial Updated:
03/01/2024
Locations: Nemours Children's Health System-Wilmington, Wilmington, Delaware
Conditions: Crohn Disease
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Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
NCT03500328
Recruiting
FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other complications associated with higher-efficacy treatments highlight the need to quantify their effectiveness in preventing disability. The TRaditional versus Ear... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/28/2024
Locations: Christiana Care Health Services, Inc., Newark, Delaware
Conditions: Multiple Sclerosis, Relapsing-Remitting
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Sirolimus in Combination With Metronomic Chemotherapy in Children With Recurrent and/or Refractory Solid and CNS Tumors
NCT02574728
Recruiting
This study aims to determine the efficacy of daily sirolimus and celecoxib, with low dose etoposide alternating with cyclophosphamide for pediatric participants with relapsed or refractory tumors.
Gender:
All
Ages:
Between 12 months and 30 years
Trial Updated:
02/21/2024
Locations: Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Cancer
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Dietary Approaches for Cardiovascular Health Study
NCT05180435
Recruiting
The primary purpose of this study is to examine the efficacy of family meal frequency as an intervention target in addressing the primary prevention of CVD.
Gender:
All
Ages:
Between 6 years and 12 years
Trial Updated:
02/15/2024
Locations: University of Delaware, Energy Balance and Nutrition Laboratory, Newark, Delaware
Conditions: Cardiovascular Diseases
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Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study
NCT05633602
Recruiting
This phase III trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may in... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Beebe South Coastal Health Campus, Frankford, Delaware
Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
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Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
NCT04076813
Recruiting
The purpose of this registry is to address optimal platelet inhibition during the early management of MI patients prior to coronary angiography or CABG.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Christiana Care Health Services, Inc., Newark, Delaware
Conditions: Myocardial Infarction
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Mindfulness and Romantic Relationship Quality
NCT04177836
Recruiting
The overarching aim of this proposal is to experimentally test whether a mindfulness intervention improves relationship quality. Romantic couples from the community will be randomly assigned to one of two arms: mindfulness vs. active control. Both interventions will be completed on a smart-phone for 14 days using identical intervention activities as our existing published research. After the 14-day period, couples will attend a lab visit and provide relationship quality data.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/02/2024
Locations: University of Delaware, Newark, Delaware
Conditions: The Focus of the Study is Romantic Relationship Quality
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L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients
NCT03982160
Recruiting
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. A potential signal driving sympathetic nerve activity (SNA) involves accumulation of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). ADMA is elevated in CKD and is a strong, independent predictor of future ca... Read More
Gender:
All
Ages:
Between 35 years and 75 years
Trial Updated:
01/14/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Chronic Kidney Disease
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Chronic Postsurgical Pain
NCT05764681
Recruiting
The study purpose is to document the typical trajectory of perioperative pain experience in Cerebral Palsy (CP) and to identify important predictive factors for the development of chronic postsurgical pain. The main aims of the investigators are to: Quantify the trajectory of pain and opioid use in the context of orthopedic surgery in children with CP. Identify predictors for CPSP in children with CP and develop an applicable risk index. Examine relationships between perioperative pain severity... Read More
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
01/12/2024
Locations: Nemour's Children's Hospital, Wilmington, Delaware
Conditions: Cerebral Palsy, Chronic Post Surgical Pain
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Central Sodium Sensing: Implications for Blood Pressure Regulation
NCT05480722
Recruiting
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pre... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
12/07/2023
Locations: William B Farquhar, Newark, Delaware
Conditions: Salt Sensitivity of Blood Pressure
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Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
NCT04233957
Recruiting
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.
Gender:
All
Ages:
Between 21 years and 45 years
Trial Updated:
11/28/2023
Locations: Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware
Conditions: Sodium Excess
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