Delaware is currently home to 278 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Newark, Wilmington, Lewes and Rehoboth Beach. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer
NCT03418961
Recruiting
This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2024
Locations: Bayhealth Hospital Kent Campus, Dover, Delaware
Conditions: Cardiotoxicity, HER2/Neu Positive, Metastatic Malignant Neoplasm in the Brain, Recurrent Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7
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Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
NCT00736749
Recruiting
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
Gender:
ALL
Ages:
All
Trial Updated:
04/10/2024
Locations: Alfred I duPont Hospital for Children, Wilmington, Delaware
Conditions: Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
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Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
NCT06094816
Recruiting
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role... Read More
Gender:
ALL
Ages:
Between 40 years and 60 years
Trial Updated:
03/13/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Salt-Sensitivity of Blood Pressure
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Testing Tactile Aids With Blind Subjects
NCT06237829
Recruiting
The objective of this project is to create richer tactile aids by using materials chemistry to create tactile sensations in tactile aids, as an alternative to traditional physical bumps, lines, or textures. These materials are commonly used in household products, but have not yet been used to enrich tactile aids. Successful outcomes are primarily the accuracy with which low vision or blind subjects identify objects made from tactile coatings versus traditional tactile aids. Other outcomes includ... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
03/11/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Vision, Low, Blindness
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LOWER: Lomitapide Observational Worldwide Evaluation Registry
NCT02135705
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: Alfieri Cardiology, Newark, Delaware
Conditions: Homozygous Familial Hypercholesterolemia
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Identifying the Optimal Dynamic Ankle-Foot Orthosis Bending Stiffness for Individuals Post-Stroke
NCT06304519
Recruiting
Ankle braces are commonly prescribed to individuals who have suffered a stroke to help their ankle joints work properly, which allows these individuals to walk better. Currently, there are no standardized guidelines to follow when choosing which brace is best for an individual. Prior work has shown that customizing the level of assistance that these braces provide based on each individual's level of ankle impairment improves the individuals' walking function more than their current brace. The ne... Read More
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
03/04/2024
Locations: University of Delaware STAR Campus, Newark, Delaware
Conditions: Stroke
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Mindfulness and Romantic Relationship Quality
NCT04177836
Recruiting
The overarching aim of this proposal is to experimentally test whether a mindfulness intervention improves relationship quality. Romantic couples from the community will be randomly assigned to one of two arms: mindfulness vs. active control. Both interventions will be completed on a smart-phone for 14 days using identical intervention activities as our existing published research. After the 14-day period, couples will attend a lab visit and provide relationship quality data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2024
Locations: University of Delaware, Newark, Delaware
Conditions: The Focus of the Study is Romantic Relationship Quality
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Chronic Postsurgical Pain
NCT05764681
Recruiting
The study purpose is to document the typical trajectory of perioperative pain experience in Cerebral Palsy (CP) and to identify important predictive factors for the development of chronic postsurgical pain. The main aims of the investigators are to: 1. Quantify the trajectory of pain and opioid use in the context of orthopedic surgery in children with CP. 2. Identify predictors for CPSP in children with CP and develop an applicable risk index. 3. Examine relationships between perioperative pain... Read More
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
01/12/2024
Locations: Nemour's Children's Hospital, Wilmington, Delaware
Conditions: Cerebral Palsy, Chronic Post Surgical Pain
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Central Sodium Sensing: Implications for Blood Pressure Regulation
NCT05480722
Recruiting
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pre... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
12/07/2023
Locations: William B Farquhar, Newark, Delaware
Conditions: Salt Sensitivity of Blood Pressure
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Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
NCT04233957
Recruiting
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who regularly exercise are protected from these effects.
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
11/28/2023
Locations: Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware
Conditions: Sodium Excess
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Determinants of Changes in Arterial Load Following Exercise
NCT05820243
Recruiting
The goal of this study is to learn about how blood vessel dilation after exercise effects pulse wave reflection and influences the function of the heart in healthy young adults. The main question it aims to answer is: Are post-exercise decreases in reflected pulse waves due to a decrease in the stiffness of large arteries in the leg or an increase in leg blood flow? Participants will exercise on a stationary bicycle at a moderate intensity for 1 hour during two laboratory visits. Participants wi... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
11/27/2023
Locations: Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware
Conditions: Post-Exercise Hypotension
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Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
NCT00680264
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: A.I. Dupont Hospital for Children, Wilmington, Delaware
Conditions: Cerebral Palsy, Scoliosis
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