District Of Columbia is currently home to 920 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Washington, Washington, D.C., Washington DC and Washington, Dc. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
NCT05610787
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: Children's National, Washington, District of Columbia
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
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The DC Mother-Infant Behavioral Wellness Program
NCT05345834
Recruiting
This randomized controlled study will examine the effectiveness of patient navigation with culturally adapted cognitive-behavioral interventions and peer support groups for low-income Black/of African Descent pregnant women who are experiencing stress, anxiety, and/or depression.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
02/06/2023
Locations: Unity Healthcare - Brentwood, Washington, District of Columbia
Conditions: Perinatal Depression, Perinatal Anxiety, Prenatal Stress
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Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool
NCT05311046
Recruiting
The overall objective of this proposed research is the derivation of a biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) (software) that can be used in combination with the hospital's electronic health record (EHR) system to monitor and assess real-time emergency department (ED) electronic health record (EHR) data towards the enhancement of early pediatric sepsis recognition and the initiation of timely, aggressive personalized sepsis therapy known to i... Read More
Gender:
All
Ages:
Between 3 months and 17 years
Trial Updated:
02/06/2023
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Sepsis
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Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
NCT04833465
Recruiting
The overarching goal of this study is the development of a physiologic endpoint of pain and treatment effect in three distinct rheumatology populations. This would enable objective assessment of pain and treatment in these populations and enable a much more precise approach to treatment. Such an endpoint stands to significantly improve outcomes in these patients by eliminating the need for a trial-and-error approach to treatment. This is a single site observational study that aims to collect ini... Read More
Gender:
All
Ages:
Between 5 years and 21 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Fibromyalgia
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Physiologic Measure of VIPN
NCT04786977
Recruiting
The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents. The ability to more easily detect and monitor VIPN, even before it is clinically evident, would facilitate optimizing the dosing of vincristine for maximal disease response while minimizing the risk of lifelong functional deficits affecting quality of life. This approach would also enable th... Read More
Gender:
All
Ages:
Between 6 years and 18 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Chemotherapy-induced Peripheral Neuropathy
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ACT NOW Longitudinal Study: Outcomes of Babies With Opioid Exposure Study
NCT04149509
Recruiting
The objective of this longitudinal cohort study is to quantify the effects of antenatal opioid exposure on the trajectory of brain development over the first 2 years of life, examine associations with developmental and neurobehavioral outcomes, and explore how specific factors (differing antenatal and postnatal exposures, severity of neonatal opioid withdrawal, maternal stress/depression/parenting) modify these effects
Gender:
All
Ages:
1 month and below
Trial Updated:
01/31/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Neonatal Opioid Withdrawal Syndrome
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Measuring Analgesic Interventions
NCT03794362
Recruiting
It is generally recognized that pain assessment and management especially in newborns, children and other nonverbal populations is an unmet need. According to the American Medical Association, "the pediatric population is at risk of inadequate pain management, with age-related factors affecting pain management in children. Children are often given minimal or no analgesia for procedures that would routinely be treated aggressively in adults. Although much is now known about pain management in chi... Read More
Gender:
All
Ages:
Between 7 years and 21 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Pain
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Developing a Method to Objectively Measure Opioid Analgesia
NCT03605966
Recruiting
Inappropriate prescribing is the fundamental upstream driver of the opioid epidemic. Objective measures to determine the appropriateness of an opioid intervention, provide monitoring of the therapy for adequacy of dose and detection of tolerance or hyperalgesia would eliminate the subjective nature of opioid mediated pain management and obviate iatrogenic facilitation of opioid abuse. The present study is designed to objectively determine whether our device can pain type and determine analgesic... Read More
Gender:
All
Ages:
Between 7 years and 21 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Analgesics, Antipyretics and Anti-Inflammatory Drugs Causing Adverse Effects in Therapeutic Use
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Ultrasound for Scoliosis Diagnostic Evaluation
NCT03222739
Recruiting
Scoliosis is a complex 3-dimensional deformity of the spine. It may occur at any time throughout growth and development and is typically detected through x-ray imaging. Although effective at visualizing a curve, x-ray imaging is costly and may expose children to potentially harmful ionizing radiation. This is a 30 patient study to evaluate the reliability of ultrasound, an imaging technique without radiation, to effectively measure scoliosis deformities compared to the gold-standard of x-ray.
Gender:
All
Ages:
Between 7 years and 17 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Scoliosis Idiopathic, Scoliosis; Juvenile
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Digital Dysmorphology Project
NCT02651493
Recruiting
In this study, the investigators propose a novel method to detect Down syndrome using photography for facial dysmorphology, a tool called computer-aided diagnosis (CAD). After validating the method, this technology will be expanded to perform similar functions to assist in the detection of other dysmorphic syndromes. By using photography and image analysis this automated assessment tool would have the potential to improve the diagnosis rate and allow for remote, non-invasive diagnostic evaluati... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
01/31/2023
Locations: Children's National, Washington, District of Columbia
Conditions: Down Syndrome
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Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811
Recruiting
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in both confirmed cases of BE/EAC and in controls (subjects without a prior diagnosis but undergoing screening for BE/EAC)
Gender:
Male
Ages:
50 years and above
Trial Updated:
01/23/2023
Locations: Lucid Investigative Site, Washington, District of Columbia
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
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