District Of Columbia is currently home to 918 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Washington, Washington, D.C., Washington DC and Washington, Dc. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Acetaminophen Dosing in Obese Adolescents
NCT03192566
Recruiting
Although there are numerous studies investigating the pharmacokinetic properties of intravenous acetaminophen in infants and children with normal weight, there are none in the obese pediatric patient . This study will investigate the pharmacokinetics and pharmacodynamics of acetaminophen (total Cl and Vd) in obese children and adolescents
Gender:
All
Ages:
Between 10 years and 18 years
Trial Updated:
02/10/2023
Locations: Childrens National Health System, Washington, District of Columbia
Conditions: Obesity, Childhood
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Study of NGM707 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
NCT04913337
Recruiting
Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2023
Locations: Georgetown University Medical Center, Washington, District of Columbia
Conditions: Mesothelioma, Glioblastoma, Renal Cell Carcinoma, Non Small Cell Lung Cancer, Melanoma, Pancreatic Ductal Adenocarcinoma, Gastric Cancer, Squamous Cell Carcinoma of Head and Neck, Cholangiocarcinoma, Breast Cancer, Ovarian Cancer, Cervical Cancer, Endocervical Cancer, Colorectal Cancer, Esophageal Cancer
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Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
NCT01106794
Recruiting
The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma, either during therapy or at autopsy, in order to characterize the molecular abnormalities of this tumor.
Gender:
All
Ages:
21 years and below
Trial Updated:
02/08/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Diffuse Intrinsic Pontine Glioma, Brainstem Glioma
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GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
NCT05266001
Recruiting
The GRACE-2 study is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with mild to moderate inflammation.
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
NCT05610787
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: Children's National, Washington, District of Columbia
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
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The DC Mother-Infant Behavioral Wellness Program
NCT05345834
Recruiting
This randomized controlled study will examine the effectiveness of patient navigation with culturally adapted cognitive-behavioral interventions and peer support groups for low-income Black/of African Descent pregnant women who are experiencing stress, anxiety, and/or depression.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
02/06/2023
Locations: Unity Healthcare - Brentwood, Washington, District of Columbia
Conditions: Perinatal Depression, Perinatal Anxiety, Prenatal Stress
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Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool
NCT05311046
Recruiting
The overall objective of this proposed research is the derivation of a biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) (software) that can be used in combination with the hospital's electronic health record (EHR) system to monitor and assess real-time emergency department (ED) electronic health record (EHR) data towards the enhancement of early pediatric sepsis recognition and the initiation of timely, aggressive personalized sepsis therapy known to i... Read More
Gender:
All
Ages:
Between 3 months and 17 years
Trial Updated:
02/06/2023
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Sepsis
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Interventions to Promote Well-being of Nightshift Nursing Team Members
NCT05722249
Recruiting
Background: Nightshift health care employees can experience greater likelihood of health threats such as weight gain, hypertension, and sleep disturbances. Evidence indicates a willingness of nightshift health care professionals to engage in wellness activities initiated at the work setting and during the assigned nightshift. In this single site study at a freestanding pediatric tertiary care hospital, inpatient units will be randomized to one of two nightshift interventions during an 8-week st... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Professional Quality of Life
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Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
NCT04833465
Recruiting
The overarching goal of this study is the development of a physiologic endpoint of pain and treatment effect in three distinct rheumatology populations. This would enable objective assessment of pain and treatment in these populations and enable a much more precise approach to treatment. Such an endpoint stands to significantly improve outcomes in these patients by eliminating the need for a trial-and-error approach to treatment. This is a single site observational study that aims to collect ini... Read More
Gender:
All
Ages:
Between 5 years and 21 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Fibromyalgia
Register for Updates
Physiologic Measure of VIPN
NCT04786977
Recruiting
The purpose of this study is the development of a physiologic endpoint using a novel technology that would provide an objective, easy to use and more sensitive assessment of VIPN in children and adolescents. The ability to more easily detect and monitor VIPN, even before it is clinically evident, would facilitate optimizing the dosing of vincristine for maximal disease response while minimizing the risk of lifelong functional deficits affecting quality of life. This approach would also enable th... Read More
Gender:
All
Ages:
Between 6 years and 18 years
Trial Updated:
01/31/2023
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Chemotherapy-induced Peripheral Neuropathy
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ACT NOW Longitudinal Study: Outcomes of Babies With Opioid Exposure Study
NCT04149509
Recruiting
The objective of this longitudinal cohort study is to quantify the effects of antenatal opioid exposure on the trajectory of brain development over the first 2 years of life, examine associations with developmental and neurobehavioral outcomes, and explore how specific factors (differing antenatal and postnatal exposures, severity of neonatal opioid withdrawal, maternal stress/depression/parenting) modify these effects
Gender:
All
Ages:
1 month and below
Trial Updated:
01/31/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Neonatal Opioid Withdrawal Syndrome
Register for Updates