Tallahassee, FL Clinical Trials

A listing of Tallahassee, FL clinical trials actively recruiting patient volunteers.

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120 trials found

Development and Evaluation of a Tonic Immobility Focused Psychoeducational Intervention

NCT05113277

A randomized controlled trial is planned to evaluate a brief, web-based intervention intended to educate about tonic immobility (TI) within a sample of those who experienced TI in the context of a traumatic event.

Conditions: Posttraumatic Stress Disorder, Tonic Immobility Response
Phase: Not Applicable

A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 in Participants With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy (NPDR)

NCT05066230

This Phase 3 Study will evaluate the efficacy and safety of KSI-301 in participants with moderately severe to severe non-proliferative diabetic retinopathy (NPDR).

Conditions: Non-proliferative Diabetic Retinopathy

Neuromodulation for Dysphoria

NCT05061745

This is an open label prospective pilot study of two neuromodulation interventions for patients suffering from dysphoria. Dysphoria is a transdiagnostic symptom of unease or dissatisfaction experienced across a range of diagnoses, including mood disorders and pain. There is a significant gap of treatment options across conditions with dysphoria, particularly non-medicated and self-care alternatives. Many neuromodulation therapies require extensive medical resources or time to deliver. Thus, the ...

Conditions: Dysphoria
Phase: Not Applicable

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

NCT04965493

The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm B) in patients with CLL/SLL who have been previously treated with at least one prior line of therapy. Participation could last up to five years.

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

MEOI and HRQoL in CLL Patients Treated With BTKis

NCT04938141

This is a multi-site observational study of medical events of interest (MEOI) and health-related quality of life (HRQoL) in chronic lymphocytic leukemia (CLL) patients initiating treatment with the Bruton's tyrosine kinase inhibitors (BTKi) acalabrutinib or ibrutinib in the United States (US).

Conditions: Chronic Lymphocytic Leukemia

Feasibility of Mobile and Technology Assisted Aftercare Services for Crisis Stabilization Units

NCT04899934

In this study investigators are examining the feasibility and acceptability of an expanded and technology-assisted aftercare program with persons released from a crisis stabilization unit (CSU) who were brought to the CSU by choice of law enforcement. Investigators are assessing the critical elements of CSUs, examining the feasibility and acceptability of pairing mobile and technology-assisted aftercare to improve treatment access and retention; and developing a study protocol to be used in a fu ...

Conditions: Substance Abuse, Criminal Behavior, Mental Disorder
Phase: Not Applicable

Perceptual Training to Improve Listeners' Ability to Understand Speech Produced by Individuals With Dysarthria

NCT04897711

There exist very few effective treatments that ease the intelligibility burden of dysarthria. Perceptual training offers a promising avenue for improving intelligibility of dysarthric speech by offsetting the communicative burden from the speaker with dysarthria on to their primary communication partners-family, friends, and caregivers. This project, utilizing advanced explanatory models, will permit identification of speaker and listener parameters, and their interactions, that allow perceptual ...

Conditions: Dysarthria, Intelligibility, Speech
Phase: Not Applicable

Digestible Energy Determination in Normal Weight and Overweight Females

NCT04877262

This 2-period, prospective study will investigate intra- and interindividual differences in digestible and metabolizable energy during a 9-day energy balanced, controlled-feeding diet in non-Hispanic black (NHB) and non-Hispanic white (NHW) females who are either normal-weight (BMI:18.5-24.9kg/m^2) or overweight (BMI: 25-29.9kg/m^2) but have similar energy requirements. This study will also examine factors that may predict intestinal absorption efficiency (i.e., digestibility) including microbia ...

Conditions: Overweight
Phase: Not Applicable

Online Mindfulness-based Intervention to Prevent Chronic Pain

NCT04848428

Cardiac surgeries are frequent procedures. However, pain after cardiac surgery may become chronic (lasting >3 months) in adults. Once discharged from the hospital, patients are at risk for chronic post-surgical pain (CPSP) and prolonged opioid use, as they become isolated with high levels of pain. Psychological risk and protective factors such as pain-related catastrophic thoughts and pain acceptance will determine their ability to cope and their opioid use, which makes a support for pain self-m ...

Conditions: Pain, Postoperative, Chronic Pain, Heart Diseases, Pain Catastrophizing, Pain, Acute
Phase: Not Applicable

A Study to Test if TEV-53275 is Effective in Relieving Asthma

NCT04847674

The primary objective of the study is to evaluate the efficacy of TEV-53275 administered subcutaneously (sc) in adult participants with persistent asthma and an eosinophilic phenotype compared to placebo. A secondary objective is to evaluate the efficacy of TEV-53275 compared to placebo assessed by lung function, asthma symptoms, rescue medication use, and quality of life measures. Another secondary objective is to evaluate the safety and tolerability of TEV-53275 administered sc in adult partic ...

Conditions: Asthma

Mindfulness-Based Art Therapy and Generation Z

NCT04834765

A randomized controlled trial will be conducted to determine the unique role of the arts as a proactive mental health strategy for college students in Generation Z. Arts-only, mindfulness-only, and arts-based mindfulness interventions as they compare to a non-intervention control group. These interventions will be delivered using a minimal contact, web-based approach. Psychological and physiological outcomes will be measured to determine if arts-related interventions activate unique and distingu ...

Conditions: Anxiety Depression
Phase: Not Applicable

MI-CBT Adherence Program for Lifestyle Interventions in Older Adults

NCT04817176

Objective 1: Assess feasibility and acceptability of all protocol components of a pilot pragmatic trial testing a 6-week telehealth ketogenic nutrition adherence (KNA) program using motivational interviewing and cognitive behavioral strategies (MI-CBT) compared to a KN information only group for older adults with mild cognitive impairment (MCI) in a community senior health clinic to prepare for a full-scale trial. Specifically, the investigators will examine the feasibility of the recruitment, ...

Conditions: Mild Cognitive Impairment, Adherence, Patient, Ketosis
Phase: Not Applicable