There are currently 2029 clinical trials in Chicago, Illinois looking for participants to engage in research studies. Trials are conducted at various facilities, including Northwestern University, Rush University Medical Center, University of Chicago and University of Chicago Comprehensive Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
NCT05135091
Recruiting
This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/03/2025
Locations: Rush University Medical Center, Chicago, Illinois +1 locations
Conditions: Mesial Temporal Lobe Epilepsy
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Nomad P-KAFO Study
NCT05644522
Recruiting
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The main questions it aims to answer are to quantify the effectiveness of the Nomad in improving mobility, balance, frequency of falls, and quality of life in individuals with lower-extremity impairments compared to their own brace, over three months of daily home and community use. Participants will:... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
04/03/2025
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Cerebrovascular Accident, Post-polio Syndrome, Spinal Cord Injuries, Multiple Sclerosis, Muscular Dystrophy, Paralysis
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GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
NCT05818150
Recruiting
This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using Embosphere Microspheres or steroid injection over a period of 24 months.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/03/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Knee Osteoarthritis
Register for Updates
A Phase 1, Study of BMF-500 in Adults With Acute Leukemia
NCT05918692
Recruiting
A Phase 1 first-in-human dose-escalation and dose-expansion study of BMF-500, an oral FLT3 inhibitor, in adult patients with acute leukemia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois +1 locations
Conditions: Acute Myeloid Leukemia
Register for Updates
EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA
NCT05480228
Recruiting
The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 13 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Northwestern Department of Neurology, Chicago, Illinois
Conditions: Painful Diabetic Neuropathy
Register for Updates
Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)
NCT05942469
Recruiting
FOREST is a positive emotion skills program designed to target mental health and coping needs for frontline violence prevention workers at UCAN. Ten skills are taught over a period of nine months during existing meetings and wellness activities, as well as in online modules in UCAN's Learning Management System (LMS). Through infusing the FOREST skills throughout UCAN, we hope to inspire organizational culture change that will emphasize the importance of wellbeing and enhance resilience, therefor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Northwestern University Feinberg School of Medicine, Chicago, Illinois
Conditions: Burnout, Burnout, Professional, Positive Affect, Depression, Anxiety, Compassion Fatigue, Job Stress
Register for Updates
Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence
NCT06480227
Recruiting
This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after conservative care. The Primary Aim is to determine the comparative effectiveness (as defined by "much" or "very much" better on PGI-I) of transurethral bulking agent (TBA) \[for 1 or 2 injections in 12 months\] vs. single-incision sling (SIS) 12 months after treatment interventio... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/02/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Stress Urinary Incontinence, Urinary Incontinence, Mixed Urinary Incontinence
Register for Updates
Study in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT06560762
Recruiting
A Phase 1, Open label, Multiple Ascending Dose Study to Assess Safety and Tolerability of STM-01 in Participants with Heart Failure with Preserved Ejection Fraction (HFpEF)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Northwestern Medicine, Chicago, Illinois
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF)
Register for Updates
Technology-Enhanced Asthma Care in Children at Clinic and Home Study
NCT06820593
Recruiting
A randomized controlled trial with parent-child pairs of children with persistent or uncontrolled asthma. An intervention group (n=40 parent-child pairs) will receive the mobile health (mHealth) app and digital sensors with enhanced support from a population health manager role, hereinafter referred to as an asthma coordinator, to provide remote patient monitoring (RPM). A comparison group (n=40 parent-child pairs) will receive the mHealth app and sensors without RPM support to silently collect... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
04/02/2025
Locations: Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Asthma in Children, Chronic Diseases in Children
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Shockwave in Postoperative Breast Reconstruction Fibrosis
NCT06919042
Recruiting
This study evaluates the potential for extracorporeal shockwave therapy to reduce post-operative soft tissue fibrosis.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/02/2025
Locations: Lavin Pavilion Suite 2060, Chicago, Illinois
Conditions: Fibrosis Breast
Register for Updates
A Multicenter Multinational Observational Study of Children With Hypochondroplasia
NCT06212947
Recruiting
This study will assess growth over time and the clinical course of HCH in children by collecting growth measurements and other variables of interest.
Gender:
ALL
Ages:
15 years and below
Trial Updated:
04/01/2025
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Hypochondroplasia
Register for Updates
WATER IV Prostate Cancer
NCT06651632
Recruiting
This is a multicenter, prospective, randomized clinical trial that aims to assess the safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to high-risk localized prostate cancer who are candidates for, or have opted for, prostatectomy. Participants will be randomized to either Aquablation Therapy or radical prostatectomy and followed up to 10 years.
Gender:
MALE
Ages:
45 years and above
Trial Updated:
04/01/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Localized Prostate Cancer
Register for Updates