There are currently 2006 clinical trials in Chicago, Illinois looking for participants to engage in research studies. Trials are conducted at various facilities, including Northwestern University, Rush University Medical Center, University of Chicago and University of Chicago Comprehensive Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
NCT06247787
Recruiting
This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile myelomonocytic leukemia (JMML) that has not responded to previous treatment (refractory) or that has come back after a period of improvement (recurrent). Imetelstat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs... Read More
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
02/11/2025
Locations: Lurie Children's Hospital-Chicago, Chicago, Illinois
Conditions: Recurrent Juvenile Myelomonocytic Leukemia, Refractory Juvenile Myelomonocytic Leukemia, Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome, Refractory Childhood Acute Myeloid Leukemia, Refractory Childhood Myelodysplastic Syndrome
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Families Filming Infants Learning Movement
NCT06278961
Recruiting
The study objective is to improve accuracy in the early detection of neurodevelopmental impairment, especially CP, by evaluating the timepoint (in weeks post term age) that the Prechtl GMA is most useful for prediction of neurodevelopmental impairment at two years of age in children with and without medical complexity. The study team plans to recruit 100 healthy, term-born infants and 250 infants at risk of developing CP for a total of 350 enrolled infants.
Gender:
ALL
Ages:
Between 10 weeks and 20 weeks
Trial Updated:
02/11/2025
Locations: Feinberg School of Physical Therapy and Human Movement Sciences, Chicago, Illinois
Conditions: Infant Development, Cerebral Palsy, Motor Disorders, Neurological Disorder
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Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation
NCT06317701
Recruiting
The purpose of this study is to determine if the treatment of Obstructive sleep apnea (OSA) by hypoglossal nerve stimulation (HGNS) will alter glucose metabolism. The study team will also determine if the treatment of Obstructive sleep apnea (OSA) by (hypoglossal nerve stimulation) HGNS will alter predictors of cardiovascular outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2025
Locations: The University of Chicago, Chicago, Illinois
Conditions: Obstructive Sleep Apnea
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Dysbiosis & Long COVID
NCT06825819
Recruiting
The SARS-CoV-2 virus causes COVID-19, which ranges from mild initial symptoms to severe multi-organ dysfunction. While some patients recover to their baseline states, others develop a long COVID, or post-acute sequelae of SARS-CoV-2 (PASC) consisting of symptoms persisting \>2-6 months post-infection. PASC symptoms include post-exertional malaise, fatigue, and heart palpitations as well as incident GI disorders, cognitive dysfunction, and arthritis. Based on prevalence/incidence studies, it is e... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/11/2025
Locations: The University of Chicago, Chicago, Illinois
Conditions: COVID-19
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Surgical or Medical Treatment
NCT04128995
Recruiting
This study will test the hypothesis that metabolic bariatric surgery will be more effective at providing durable glycemic control and reduce co-morbidities than intensive medical therapy in youth with type 2 diabetes.
Gender:
ALL
Ages:
Between 13 years and 19 years
Trial Updated:
02/10/2025
Locations: Lurie Children's Hospital, Chicago, Illinois
Conditions: Diabetes Mellitus, Type 2, Pediatric Obesity, Bariatric Surgery Candidate
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A Clinical Trial in Healthy Volunteers and Volunteers with Recurrent Genital Herpes to Study the Safety, Tolerability, and Immune Responses After Vaccination with an Investigational Vaccine Designed to Prevent Genital Herpes Lesions
NCT05432583
Recruiting
This exploratory trial will have three parts. Part A is a dose escalation part, Part B is an expanded safety and dose evaluation part, and Part C is a safety and immunogenicity evaluation part in individuals with recurrent HSV-2 genital herpes. Part A will focus on the safety evaluations, and in addition, vaccine-induced immune responses (specifically neutralizing antibodies) will also be analyzed to assess if there is a dose-response. Part B of the trial will expand the safety characterizatio... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
02/10/2025
Locations: Great Lakes Clinical Trials - Flourish Research, Chicago, Illinois
Conditions: Genital Herpes Simplex Type 2
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Point-of-Care Echocardiography in Patients with Known or Suspected Aortic Stenosis
NCT06717373
Recruiting
This is a prospective clinical trial intended to capture echocardiographic images in patients clinically indicated for an echocardiographic examination using an additional Point of Care Ultrasound device . The images collected will be used to test and possibly validation an AI base Aortic Valve Stenosis algorithm
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Patients with an Indication for an Echocardiographic Examination with Suspicion of Valcular Heart Disease
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Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children
NCT05026749
Recruiting
The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway.
Gender:
ALL
Ages:
Between 3 days and 2 years
Trial Updated:
02/07/2025
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Respiratory Syncytial Virus Infections
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Study of JK07 in Patients With Chronic Heart Failure
NCT06369298
Recruiting
This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to assess the safety, tolerability, and efficacy of JK07 in participants aged 18-85 with heart failure. There will be 2 cohorts in this study: Cohort 1: Heart failure (HF) participants with left ventricular ejection fraction (LVEF) of ≤ 40%. Cohort 2: Heart failure (HF) participants with left ventricular ejection fraction (LVEF) \> 40% and ≤ 65%.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/07/2025
Locations: Site 160, Chicago, Illinois
Conditions: Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
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Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics
NCT06401577
Recruiting
The DREAM-ON study will investigate whether continuous glucose monitoring (CGM) is useful to predict risk for developing diabetes mellitus (DM) and pre-diabetes mellitus (PDM), the need for insulin therapy among those who develop DM, and to determine whether CGM can provide insight into the pathophysiology and DM subtype among participants who have experienced an episode of acute pancreatitis (AP). Thus, the results of the DREAM-ON study could inform future clinical practice guidelines for the m... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2025
Locations: Northwestern University, Chicago, Illinois +1 locations
Conditions: Acute Pancreatitis
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GYNecologic Cancer-Related COGnitive Impairment
NCT06662435
Recruiting
The goal of this study is to test a home-based and patient-tailored cognitive training intervention among gynecologic cancer patients who have completed chemotherapy and who have experienced cancer-related cognitive impairment.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Ovarian Cancer, Endometrial Cancer, Cervical Cancers, Vulvar Cancers, Uterine Cancer, Cervix Cancer, Ovary Cancer
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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
NCT06122077
Recruiting
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine, standard-of-care screening Low-Dose Computed Tomography (LDCT).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/06/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Lung Cancer Diagnosis
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