There are currently 834 clinical trials in Indianapolis, Indiana looking for participants to engage in research studies. Trials are conducted at various facilities, including Indiana University, Indiana University Melvin and Bren Simon Cancer Center, Riley Hospital for Children and Indiana University Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Testing Experimental Anti-cancer Drug SLC-391 with an Approved Immunotherapy Drug, Pembrolizumab, for Advanced Lung Cancers
NCT05860296
Recruiting
SLC-391 is a novel, potent and specific small molecule inhibitor of receptor tyrosine kinase AXL with desirable potency and pharmaceutical properties. The study is being done to evaluate the safety and pharmacokinetic (PK) profile of SLC-391 in combination with pembrolizumab in participants with non-small cell lung cancer (NSCLC). Each treatment cycle lasts 21 days. Participants will swallow SLC-391 pills two times every day. Participants will get pembrolizumab intravenously (IV) from the stud... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2024
Locations: Community Health Network, Indianapolis, Indiana
Conditions: Lung Cancer, Nonsmall Cell, Lung Cancer Stage IV, Lung Cancer Metastatic
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The Happy Families Project: Testing the Effectiveness of a Conflict Resolution Program for Families
NCT04980794
Recruiting
This study is designed to test the effectiveness of a psychoeducation-based program to address communication and conflict resolution in families, thereby supporting mental health in children and their caregivers.
Gender:
ALL
Ages:
4 years and above
Trial Updated:
11/13/2024
Locations: Indianapolis Virtual Site, Indianapolis, Indiana
Conditions: Mental Health, Conflict
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SAMe Trial for Patients with Alcoholic Cirrhosis
NCT04250259
Recruiting
The proposed of this randomized, double blinded, placebo-controlled study is to assess the effect of SAMe compared to placebo in patients with alcoholic cirrhosis Child Class A and B. The primary objective of the study is to test relationship between SAMe (S-adenosylmethionine) supplement on liver function. The hypothesis is that SAMe supplement will improve liver function in patients with alcoholic liver disease. The improvement in liver function will lead to the reduction in all-cause mortalit... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/12/2024
Locations: Indiana University Hospital, Indianapolis, Indiana
Conditions: Alcoholic Cirrhosis
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Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.
NCT06593665
Recruiting
This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. Investigators plan to compare their analgesic effectiveness at different postoperative time intervals.
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
11/11/2024
Locations: Indiana Univeristy, Indianapolis, Indiana +1 locations
Conditions: Testicular Cancer
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Predict Tooth Wear
NCT06681844
Recruiting
Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stages. Monitoring alterations in tooth shape via intraoral scanners aids early detection, but restoration remains challenging. Prevention through early detection is vital, as patients may not fully compre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/07/2024
Locations: Indiana University Hospital, Indianapolis, Indiana
Conditions: Prediction of Tooth Wear
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Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder
NCT06538558
Recruiting
This study is examining the use of Tezampanel (TZP) for treatment of Opioid Withdrawal Syndrome (OWS) in participants with Opioid Use Disorder (OUD). Participants will receive TZP or placebo (PBO) daily on Days 2 - 7 during a 7-day inpatient stay at the research center to determine safety, pharmacokinetic (PK) assessment, and efficacy of TZP for OWS.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/04/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Opioid Use Disorder
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Study of Individuals Affected With Hypoplasminogenemia
NCT03797495
Recruiting
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities
Gender:
ALL
Ages:
All
Trial Updated:
10/30/2024
Locations: Indiana Hemophila @Thrombosis Center, Indianapolis, Indiana
Conditions: Plasminogen Deficiency
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Utilizing Palliative Leaders In Facilities to Transform Care for Alzheimer's Disease
NCT04520698
Recruiting
The purpose of this study is to evaluate a comprehensive model for integrating both primary and specialty Palliative Care for older adults with dementia into nursing facilities. Palliative Care is a supportive care approach that aims to improve the quality of life of patients and their families facing serious or life-threatening illnesses, through the prevention and relief of suffering through the treatment of pain and other problems, using physical, psychosocial and spiritual approaches. Pallia... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: American Senior Communities, Indianapolis, Indiana
Conditions: Alzheimer Disease
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Post-Market Clinical Investigation of the IotaSOFT Insertion System
NCT06664697
Recruiting
The purpose of the proposed study is to evaluate the continued safety of the iotaSOFT Insertion System when used by a surgeon to assist with inserting a CI electrode array in one ear per subject
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/29/2024
Locations: Indiana University, Indianapolis, Indiana
Conditions: Hearing Loss, Cochlear, Cochlear Implantation, Hearing Loss, Sensorineural
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Clinical Decision Support Tool in PARDS Pilot Study
NCT04068012
Recruiting
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation. This study seeks to scale an established Clinical Decision Support (CDS) tool to facilitate dissemination and implementation of evidence-based research in mechanical ventilation of infants and children with pediatric ARDS (PARDS). This will be accomplished by using CDS t... Read More
Gender:
ALL
Ages:
Between 1 month and 18 years
Trial Updated:
10/28/2024
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
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Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
NCT02901184
Recruiting
Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT) that will test the hypothesis that spironolactone plus standard of care compared to standard of care alone reduc... Read More
Gender:
ALL
Ages:
Between 50 years and 99 years
Trial Updated:
10/21/2024
Locations: St. Vincent Medical Group, Indianapolis, Indiana
Conditions: Heart Failure With Preserved Ejection Fraction
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Nivolumab With Ruxolitinib in Relapsed or Refractory Classical Hodgkin Lymphoma
NCT03681561
Recruiting
This is a Phase I/II, multicenter, open-label, dose escalation/dose-expansion study to evaluate the tolerability, safety, and the maximum tolerated dose (MTD) of ruxolitinib when given with fixed dose nivolumab in patients with relapsed or refractory classical Hodgkin lymphoma (cHL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Indiana Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana
Conditions: Hodgkin Lymphoma
Register for Updates