There are currently 797 clinical trials in Indianapolis, Indiana looking for participants to engage in research studies. Trials are conducted at various facilities, including Indiana University, Indiana University Melvin and Bren Simon Cancer Center, Riley Hospital for Children and Indiana University Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Hemlibra in Mild Hemophilia A
NCT04567511
Recruiting
This is a single arm, phase 4, prospective, open-label, United States single-center study to determine the hemostatic characteristics of Hemlibra (emicizumab) as measured by coagulation laboratory parameters in the mild hemophilia A male patient population with endogenous altered FVIII (baseline FVIII activity of \>5% to 30%). The safety and hemostatic efficacy of Hemlibra (emicizumab) in this patient population will be investigated. Secondary outcomes will assess changes in joint health and qua... Read More
Gender:
MALE
Ages:
Between 5 years and 45 years
Trial Updated:
03/13/2024
Locations: Indiana Hemophila @Thrombosis Center, Indianapolis, Indiana
Conditions: Factor VIII Deficiency, Congenital
Register for Updates
LOWER: Lomitapide Observational Worldwide Evaluation Registry
NCT02135705
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
ALL
Ages:
All
Trial Updated:
03/11/2024
Locations: Community Health Network, Indianapolis, Indiana +1 locations
Conditions: Homozygous Familial Hypercholesterolemia
Register for Updates
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
NCT03440697
Recruiting
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity.
Gender:
ALL
Ages:
All
Trial Updated:
03/06/2024
Locations: IU School of Medicine, Indianapolis, Indiana
Conditions: Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease, Thoracic Aortic Dissection, Thoracic Aortic Rupture, Ascending Aortic Disease, Descending Aortic Disease, Ascending Aortic Aneurysm, Descending Aortic Aneurysm, Marfan Syndrome, Loeys-Dietz Syndrome, Shprintzen-Goldberg Syndrome, Turner Syndrome, PHACE Syndrome, Autosomal Recessive Cutis Laxa, Congenital Contractural Arachnodactyly, Arterial Tortuosity Syndrome, Vascular Ehlers-Danlos Syndrome, Bicuspid Aortic Valve-Associated Aortopathy, Bicuspid Aortic Valve, Familial Thoracic Aortic Aneurysm and Aortic Dissection
Register for Updates
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543
Recruiting
MANTRA is a prospective, multiple-arm, multi-center, global, post-market clinical follow-up study. The main objective is to monitor ongoing safety and performance of the CORCYM devices and accessories used for aortic, mitral and tricuspid valvular diseases in a real-world setting. Corcym S.r.l., is a medical device manufacturer with a broad product portfolio for cardiac surgeons, offering solutions for the treatment of aortic, mitral and tricuspid valve disease. The MANTRA Master Plan (Master... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/05/2024
Locations: St. Vincent Heart Center of Indiana, Indianapolis, Indiana
Conditions: Cardiac Valve Disease
Register for Updates
Biomarker of Diabetic Retinopathy
NCT05079399
Recruiting
Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional. This can lead to an improper supply of oxygen and nutrients to the retinal tissue, or it may trigger the formation of new blood vessels in response to the oxygen/nutrient deficiency. Ultimately affecting the normal vision. There is no known marker that will provide information on the health status of retinal blood vessels. Using highly specialized cell... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Eskenazi Eye Clinic, Indianapolis, Indiana +1 locations
Conditions: Diabetic Retinopathy
Register for Updates
Molecular Mechanisms Associated With Breast Implant Complications
NCT05736354
Recruiting
Bacterial biofilms cause implant failures, chronic inflammation, and immune polarization. The study investigates the possible role of bacterial biofilm as a factor in the etiology of Breast Implant Illness. Three patient cohorts will be studied (A) Subjects with breast implant with BII manifestations (B) Subjects with breast implants without BII manifestations (C) Subjects without breast implants who underwent breast surgery procedure. Blood, surgically discarded tissue, implants, and associated... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: IU Health Methodist Hospital, Indianapolis, Indiana
Conditions: Breast Implant; Complications, Infection or Inflammation
Register for Updates
ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies
NCT05653271
Recruiting
ACE1831 is an off-the-shelf, allogeneic gamma delta T (gdT) cell therapy derived from healthy donors, that is under investigation for the treatment of CD20-expressing B-cell malignancies. The ACE1831-001 study is an open-label, Phase I, first-in-human (FIH) study that aims to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and efficacy of ACE1831 in patients with CD20-expressing Non-Hodgkin lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Indiana University Simon Comprehensive Cancer Center, Indianapolis, Indiana
Conditions: B-cell Lymphoma, Non Hodgkin Lymphoma, DLBCL, Primary Mediastinal Large B Cell Lymphoma, Marginal Zone Lymphoma, Follicular Lymphoma
Register for Updates
Dissemination and Implementation of Improving Pediatric Obesity Practice Using Prompts
NCT05627011
Recruiting
The purpose of this study is to evaluate the dissemination and implementation of electronic health record-based clinical decision support tools for the management of pediatric overweight and obesity in primary care.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
02/27/2024
Locations: Eskenazi Health, Indianapolis, Indiana
Conditions: Obesity, Childhood
Register for Updates
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Indiana University, Indianapolis, Indiana
Conditions: Huntington's Disease
Register for Updates
Mediterranean Diet Versus Western Diet on Fatigue in Autoimmune Hepatitis Patients
NCT06250309
Recruiting
This is a single-center, proof-of-concept pilot study which uses a cross-over design to compare two dietary interventions/treatments: Western Diet (WD) vs Mediterranean (MD) and impact on quality-of-life parameters in AIH. Participants will receive both treatments through two phases and will be divided into two groups.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/19/2024
Locations: IU Health University Hosptial, Indianapolis, Indiana
Conditions: Autoimmune Hepatitis
Register for Updates
Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
NCT02432079
Recruiting
The goal of this study is to obtain specimens and data from individuals and their families with heterotaxy and related congenital heart defects in order to clarify the molecular genetics of this disorder. The knowledge gained from the analysis of this information will provide the basis for future genetic counseling as well as contribute to knowledge about the biology of normal and abnormal development of left-right anatomic asymmetry.
Gender:
ALL
Ages:
All
Trial Updated:
02/05/2024
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Heterotaxy Syndrome, Congenital Heart Defects
Register for Updates
Pediatric Cardiomyopathy Mutation Analysis
NCT02432092
Recruiting
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder. This will provide the basis for future genetic counseling as well as contribute to elucidating the biology of normal and abnormal cardiac function.
Gender:
ALL
Ages:
All
Trial Updated:
02/05/2024
Locations: IU School of Medicine, Indianapolis, Indiana
Conditions: Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Left Ventricular Non-compaction Cardiomyopathy
Register for Updates