There are currently 874 clinical trials in Indianapolis, Indiana looking for participants to engage in research studies. Trials are conducted at various facilities, including Indiana University, Indiana University Melvin and Bren Simon Cancer Center, Riley Hospital for Children and Indiana University Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Improving Post-discharge Antimicrobial Use
NCT05471726
Recruiting
One in five hospitalized patients is prescribed an antimicrobial at the time of discharge, and a large proportion of these post-discharge antimicrobials are unnecessary. The investigators will evaluate a novel method for reviewing post-discharge antimicrobial prescriptions in real-time with the goal of improving antimicrobial selection and duration.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Richard Roudebush VA Medical Center, Indianapolis, Indiana
Conditions: Infections
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Gastric Per-Oral Endoscopic Myotomy (G-POEM) for the Treatment of Gastroparesis
NCT04434781
Recruiting
Gastric Per-Oral Endoscopic Myotomy (G-POEM) is a procedure for the Treatment of Gastroparesis.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2023
Locations: Indiana University Hospital, Indianapolis, Indiana
Conditions: Gastroparesis
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Physical Therapy for Men Undergoing Prostatectomy
NCT02558946
Recruiting
The purpose of this study is to determine if pelvic floor muscle training with a physical therapist before and after surgery will improve health-related quality of life following robot-assisted radical prostatectomy.
Gender:
Male
Ages:
18 years and above
Trial Updated:
05/19/2023
Locations: IU Health Methodist Hospital and IU Health University Hospital, Indianapolis, Indiana
Conditions: Prostate Cancer, Urinary Incontinence, Pelvic Floor Physical Therapy
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Factors Predicting Persistence of Oncogenic HPV and Cervical Dysplasia in HIV Infected Kenyan Women
NCT04045652
Recruiting
This study will utilize a longitudinal study design to better understand the natural history of oncogenic Human Papillomavirus (HPV) infections in Human Immunodeficiency Virus (HIV)-infected and HIV-uninfected Kenyan women, including the potentially modifiable (and non-modifiable) factors that are associated with progression of oncogenic HPV infection to clinical disease, including cervical cancer.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
05/17/2023
Locations: Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana
Conditions: HIV/AIDS, Cervical Dysplasia, HIV Infections
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PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
NCT04129931
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Asthma
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JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors
NCT04720976
Recruiting
To evaluate the safety and tolerability of JAB-3312 administered in investigational regimens in adult participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: Research Site, Indianapolis, Indiana
Conditions: Solid Tumor, NSCLC
Register for Updates
Academic-Community EPINET (AC-EPINET)
NCT04497857
Recruiting
The investigators propose to examine the effects of CSC services delivered via TH (CSC-TH) versus the standard clinic-based CSC model (CSC-SD) on engagement and outcomes in a 12-month, randomized trial.
Gender:
All
Ages:
Between 16 years and 35 years
Trial Updated:
05/16/2023
Locations: Prevention and Recovery Center for Early Psychosis, Indianapolis, Indiana
Conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Major Depression With Psychotic Features, Bipolar Disorder With Psychotic Features
Register for Updates
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study
NCT03312686
Recruiting
This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/13/2023
Locations: Indiana University, Indianapolis, Indiana
Conditions: Eosinophilic Esophagitis
Register for Updates
Canine-Assisted Anxiety Reduction In Emergency Care
NCT03784573
Recruiting
Compare the effect of a single exposure to a therapy dog and handler within the pediatric emergency department patient with anxiety by measuring the change in patient perception of anxiety before and after dog exposure using the FACES scale. We will also measure galvanic skin response (resistance to electrical current).
Gender:
All
Ages:
Between 4 years and 17 years
Trial Updated:
05/08/2023
Locations: IU Health Riley Children's Hospital, Indianapolis, Indiana
Conditions: Anxiety, Opioid Use, Children, Therapy Dog
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Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children
NCT04509050
Recruiting
This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children with cystic fibrosis (CF).
Gender:
All
Ages:
5 years and below
Trial Updated:
05/04/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Cystic Fibrosis
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Leg Heat Therapy in Peripheral Artery Disease
NCT05465070
Recruiting
The goal of this randomized, double-blind, sham-controlled clinical trial is to evaluate the benefits of home-based, leg heat therapy (HT) on lower-extremity functioning and quality of life in patients who suffer from lower-extremity peripheral artery disease (PAD). We will randomize 106 patients to one of two groups that either receive leg HT or a sham intervention. The primary study outcome is the change in 6-minute walk distance between baseline and the 12-week follow up. Secondary outcomes i... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
04/29/2023
Locations: Indiana University Health Methodist Hospital, Indianapolis, Indiana
Conditions: Peripheral Artery Disease
Register for Updates
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Indiana University Health University Hospital (IUHUH), Indianapolis, Indiana
Conditions: Spinal Muscular Atrophy (SMA)
Register for Updates