There are currently 632 clinical trials in Louisville, Kentucky looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Louisville, Jewish Hospital, Norton Cancer Institute and Saints Mary and Elizabeth Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS
NCT03905707
Recruiting
The primary objective of the trial is to evaluate the long-term safety of glepaglutide treatment in patients with short bowel syndrome (SBS). Glepaglutide is the International Nonproprietary Name and USAN for ZP1848.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
11/23/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Short Bowel Syndrome
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Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)
NCT04564339
Recruiting
The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and demonstrate proof-of-concept of the efficacy of terminal complement inhibition in participants with LN (LN Cohort) or IgAN (IgAN Cohort).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/22/2023
Locations: Clinical Study Site, Louisville, Kentucky
Conditions: Lupus Nephritis, Immunoglobulin A Nephropathy
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MElanoma Research Lymph Node Prediction Implementation National_001
NCT04759781
Recruiting
MERLIN_001 is a prospective registry study of a primary melanoma gene-signature to predict sentinel node (SN) status and to determine its prognostic value for more accurate staging of SN-negative melanoma patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/21/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Melanoma
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Immunotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
NCT03080974
Recruiting
Compare the efficacy and tolerability of irreversible electroporation in combination with Nivolumab in patients with locally advanced pancreatic cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Pancreatic Adenocarcinoma
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American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry
NCT02674100
Recruiting
The purpose of this study is to create a registry to provide insight into treatment selection and treatment outcome of pancreatic IRE in order to develop an evidence base such that physicians can provide the best possible care to patients with pancreatic cancer requiring surgical interventions. The investigators seek a better understanding of the uses of ablation in the treatment of unresectable soft tissue pancreatic tumors and the limitations, concerns and complications that earlier users hav... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Pancreatic Cancer
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Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
NCT03484299
Recruiting
Compare the efficacy and tolerability of IRE in combination with either FOLFIRINOX or gemcitabine in patients with locally advanced pancreatic cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Pancreas Cancer
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Administration of Allogeneic-MSC in Patients With Non-Ischemic Dilated Cardiomyopathy
NCT04476901
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called human allogeneic mesenchymal stem cell therapy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
11/15/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Non-ischemic Dilated Cardiomyopathy
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A Study of RGX-104 in Patients With Advanced Lung & Endometrial Cancer
NCT02922764
Recruiting
Study RGX-104-001 is a Phase 1, first-in-human, dose escalation and expansion study of RGX-104, an oral small molecule targeting the liver X receptor (LXR), as a single agent and in combination with nivolumab, ipilimumab, docetaxel, or pembrolizumab plus carboplatin/pemetrexed.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/10/2023
Locations: James Graham Brown Cancer Center, Louisville, Kentucky
Conditions: Endometrial Cancer, Endometrial Cancer Recurrent, Lung Cancer Recurrent, Lung Cancer, Non-small Cell Lung Cancer Metastatic, Non-small Cell Carcinoma
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Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED
NCT05727878
Recruiting
The primary objective of the study is to investigate the safety and efficacy of KPI-012 compared to vehicle in participants who have a documented clinical diagnosis of PCED.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/06/2023
Locations: Principal Investigator, Louisville, Kentucky
Conditions: Persistent Corneal Epithelial Defect
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FT819 in Subjects With B-cell Malignancies
NCT04629729
Recruiting
This is a Phase I dose-finding study of FT819 as monotherapy and in combination with IL-2 in subjects with relapsed/refractory B-cell Lymphoma, Chronic Lymphocytic Leukemia and Precursor B-cell Acute Lymphoblastic Leukemia. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Norton Cancer Institute, St. Matthews Campus, Louisville, Kentucky
Conditions: Lymphoma, B-Cell, Chronic Lymphocytic Leukemia, Precursor B-Cell Acute Lymphoblastic Leukemia
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The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery
NCT04554693
Recruiting
The purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
10/25/2023
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Endometriosis, Endometriosis-related Pain
Register for Updates
Improving Bowel Function and Quality of Life After Spinal Cord Injury
NCT03949660
Recruiting
Bowel dysfunction is consistently rated as one of the most common complications affecting daily life for individuals with spinal cord injury. The overall objective of this study is to investigate whether the use of specific spinal cord epidural stimulation will affect bowel function. This study will also examine how alterations in bowel function influence quality of life outcomes. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries tha... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/25/2023
Locations: Frazier Rehab Institute, Louisville, Kentucky +1 locations
Conditions: Neurogenic Bowel
Register for Updates