There are currently 584 clinical trials in Louisville, Kentucky looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Louisville, Jewish Hospital, Norton Cancer Institute and Norton Children's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of DF9001 in Patients With Advanced Solid Tumors
NCT05597839
Recruiting
DF9001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express epidermal growth factor receptor (EGFR). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Solid Tumor, Adult
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Resistance Training in Type 1 Diabetes Mellitus
NCT05315037
Recruiting
The purpose of this study is to learn how different resistance training programs affects blood sugar in young athletes with T1DM.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
05/09/2024
Locations: Norton Healthcare, Louisville, Kentucky +1 locations
Conditions: Type 1 Diabetes
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Neoadjuvant Combination Immunotherapy for Stage III Melanoma
NCT03842943
Recruiting
Determine safety and efficacy of pre-operative combination immunotherapy with Talimogene Laherparepvec (T-VEC)/Pembrolizumab given prior to complete lymph node dissection in resectable stage 3 cutaneous melanoma with clinically apparent lymph node metastases.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Cutaneous Melanoma
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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
NCT01656603
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: James Graham Brown Cancer Center, Louisville, Kentucky
Conditions: Infusion Reactions
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Alveolar Ridge Preservation With Putty Allograft vs. Putty Alloplast Graft
NCT05484492
Recruiting
The primary aims of this study are to compare, after 4 months, the clinical and histologic results of a combination demineralized/mineralized putty allograft vs. synthetic calcium phosphosilicate (CPS) putty alloplast graft utilization in socket preservation procedures. A regenerative tissue matrix membrane will be used to cover each graft lying below the flap.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Alveolar Bone Resorption
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Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative
NCT05565079
Recruiting
24 patients will be treated with a coronally positioned tunnel with AlloDerm RTM with or without the addition of Enamel Matrix Derivative to compare the baseline and 6-month changes in recession defect coverage, clinical attachment levels, amount of keratinized tissue width, and soft tissue thickness.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Recession, Gingival
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Guided Bone Regeneration With and Without the Use of Intra-marrow Penetrations
NCT06353399
Recruiting
The primary aims of this study are to compare, after 6 months, the clinical and histologic results of intra-marrow penetrations vs no intra-marrow penetrations when performing guided bone regeneration procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2024
Locations: University of Louisville, Louisville, Kentucky +1 locations
Conditions: Ridge Augmentation
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PDA Occlusion Using NIRS
NCT06359522
Recruiting
Our study will be a prospective observational study of all patients in the Norton Children's Hospital NICU (Neonatal Intensive Care Unit) who undergo a transcatheter PDA occlusion or medical closure of PDA to compare the two populations regarding changes in organ perfusion determined by using NIRS monitoring to follow the regional saturation of oxygen (rSO2) of the cerebral and renal regions. We suspect that medical treatment will have no significant change in rSO2 as described in previous liter... Read More
Gender:
ALL
Ages:
Between 0 months and 3 months
Trial Updated:
04/05/2024
Locations: Norton Children's Hospital, Louisville, Kentucky
Conditions: Organ Perfusion Determined by Using NIRS Post Transcatheter PDA Occlusion or Medical Closure of PDA
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Esophageal and Gastric Registry and Biorepository
NCT05180253
Recruiting
The evaluation of the foregut, the esophagus and stomach, has come a long way over the past two decades, and continues to experience exciting discoveries in the clinical evaluation of foregut physiology. Assessing esophageal peristalsis has relied for the past several decades on High Resolution Manometry (HRM), however it has recently become known that even though HRM is an extremely effective tool, that there are certain subsets of patients in which additional information is required. Additiona... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/02/2024
Locations: Norton Healthcare, Louisville, Kentucky
Conditions: Gastro Esophageal Reflux
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A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium
NCT05456425
Recruiting
The objective is to evaluate the safety and efficacy of low dose and high dose CBT-001 eye drop dosed twice daily for 24 months compared to vehicle in reducing conjunctival hyperemia and preventing pterygium progression in eyes with pterygia.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/29/2024
Locations: The Eye Care Institute, Louisville, Kentucky
Conditions: Pterygium
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Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening
NCT04968548
Recruiting
This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
03/28/2024
Locations: Norton Cancer Institute, Louisville, Kentucky
Conditions: Lung Cancer
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Normative QEEG/ERP Data for Healthy Volunteers
NCT05869032
Recruiting
Many scientific papers have reported that ERP and QEEG biomarkers can be useful in the evaluation of neurological and psychiatric disorders. A study previously conducted with the COGNISION® system has shown how data collected with the system could help detect cognitive deficits in elderly individuals with probable early Alzheimer's disease (Cecchi et al., 2015). Furthermore, normative ranges for ERP and QEEG parameters are sensitive to subject age (see for example van Dinteren et al., 2014). Thi... Read More
Gender:
ALL
Ages:
Between 20 years and 59 years
Trial Updated:
03/27/2024
Locations: Cognision, Louisville, Kentucky
Conditions: Healthy
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