There are currently 585 clinical trials in Louisville, Kentucky looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Louisville, Jewish Hospital, Norton Cancer Institute and Norton Children's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Register for Updates
Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma
NCT04513028
Recruiting
The purpose of this study is to determine how beta-glucan affects the immune system in subjects with melanoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Melanoma Stage III, Melanoma Stage IV
Register for Updates
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
NCT03891888
Recruiting
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia. Both groups will undergo primary fixation via reamed intramedulary nailing (IMN), a common treatment for tibia shaft fractures in adults. The study group will have a bone graft applied to the open cortex of the fracture. The bone graft will be composed of the intramedullary reamings, whic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: University of Louisville Hospital, Louisville, Kentucky +1 locations
Conditions: Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
Register for Updates
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
NCT04474223
Recruiting
Fetal complete (i.e., third degree, 3°) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies and results in death in a fifth of cases. To date treatment of 3° AVB has been ineffective in restoring normal rhythm (NR) which may be because current surveillance is limited to once- weekly fetal echocardiograms. It is hypothesized that there may be a vital transition p... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/17/2024
Locations: University of Louisville / Norton Children's Hospital, Louisville, Kentucky
Conditions: AVB - Atrioventricular Block, Fetal AVB
Register for Updates
Study of DF9001 in Patients With Advanced Solid Tumors
NCT05597839
Recruiting
DF9001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express epidermal growth factor receptor (EGFR). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Solid Tumor, Adult
Register for Updates
Resistance Training in Type 1 Diabetes Mellitus
NCT05315037
Recruiting
The purpose of this study is to learn how different resistance training programs affects blood sugar in young athletes with T1DM.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
05/09/2024
Locations: Norton Healthcare, Louisville, Kentucky +1 locations
Conditions: Type 1 Diabetes
Register for Updates
Neoadjuvant Combination Immunotherapy for Stage III Melanoma
NCT03842943
Recruiting
Determine safety and efficacy of pre-operative combination immunotherapy with Talimogene Laherparepvec (T-VEC)/Pembrolizumab given prior to complete lymph node dissection in resectable stage 3 cutaneous melanoma with clinically apparent lymph node metastases.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Cutaneous Melanoma
Register for Updates
Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
NCT01656603
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: James Graham Brown Cancer Center, Louisville, Kentucky
Conditions: Infusion Reactions
Register for Updates
Alveolar Ridge Preservation With Putty Allograft vs. Putty Alloplast Graft
NCT05484492
Recruiting
The primary aims of this study are to compare, after 4 months, the clinical and histologic results of a combination demineralized/mineralized putty allograft vs. synthetic calcium phosphosilicate (CPS) putty alloplast graft utilization in socket preservation procedures. A regenerative tissue matrix membrane will be used to cover each graft lying below the flap.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Alveolar Bone Resorption
Register for Updates
Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative
NCT05565079
Recruiting
24 patients will be treated with a coronally positioned tunnel with AlloDerm RTM with or without the addition of Enamel Matrix Derivative to compare the baseline and 6-month changes in recession defect coverage, clinical attachment levels, amount of keratinized tissue width, and soft tissue thickness.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Recession, Gingival
Register for Updates
Guided Bone Regeneration With and Without the Use of Intra-marrow Penetrations
NCT06353399
Recruiting
The primary aims of this study are to compare, after 6 months, the clinical and histologic results of intra-marrow penetrations vs no intra-marrow penetrations when performing guided bone regeneration procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2024
Locations: University of Louisville, Louisville, Kentucky +1 locations
Conditions: Ridge Augmentation
Register for Updates
PDA Occlusion Using NIRS
NCT06359522
Recruiting
Our study will be a prospective observational study of all patients in the Norton Children's Hospital NICU (Neonatal Intensive Care Unit) who undergo a transcatheter PDA occlusion or medical closure of PDA to compare the two populations regarding changes in organ perfusion determined by using NIRS monitoring to follow the regional saturation of oxygen (rSO2) of the cerebral and renal regions. We suspect that medical treatment will have no significant change in rSO2 as described in previous liter... Read More
Gender:
ALL
Ages:
Between 0 months and 3 months
Trial Updated:
04/05/2024
Locations: Norton Children's Hospital, Louisville, Kentucky
Conditions: Organ Perfusion Determined by Using NIRS Post Transcatheter PDA Occlusion or Medical Closure of PDA
Register for Updates