There are currently 1574 clinical trials in Baltimore, Maryland looking for participants to engage in research studies. Trials are conducted at various facilities, including Johns Hopkins University, Johns Hopkins Hospital, University of Maryland and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
NCT05912881
Recruiting
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/05/2024
Locations: Johns Hopkins Medicine, Baltimore, Maryland
Conditions: Anosmia, Skull Base Neoplasms
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DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Fibrolamellar Hepatocellular Carcinoma
NCT04248569
Recruiting
The primary objective of the trial is the safety and tolerability of administering a vaccine targeting the DNAJB1-PRKACA fusion kinase, in combination with nivolumab and ipilimumab in patients with unresectable or metastatic FLC and with non-FLC solid tumors and to assess the T-cell response.
Gender:
All
Ages:
12 years and above
Trial Updated:
06/05/2024
Locations: Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Fibrolamellar Hepatocellular Carcinoma (FLC)
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Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
NCT02682511
Recruiting
The purpose of this phase 2 multicenter, randomized, double-blind, placebo-controlled, study is to assess the safety and efficacy of ifetroban in patients with diffuse cutaneous systemic SSc (dcSSc) or SSc-associated pulmonary arterial hypertension (SSc-PAH).
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
06/05/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Scleroderma, Diffuse, Scleroderma, Systemic, Scleroderma, Limited, Sclerosis, Progressive Systemic, Skin Diseases, Connective Tissue Diseases, Pathologic Processes, Autoimmune Diseases
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Biliary Atresia Study in Infants and Children
NCT00345553
Recruiting
Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To identify polymorphisms that may be important in disease progression such as HLA polymorphisms; To characterize the natural history of the older, non-... Read More
Gender:
All
Ages:
Between 6 months and 20 years
Trial Updated:
06/04/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Biliary Atresia
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A Prospective Database of Infants With Cholestasis
NCT00061828
Recruiting
Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Childhood Liver Disease Research Network (ChiLDReN) is to establish a database of clinical information and plasma, serum, and tissue samples from cholestatic children to facilitate research and to perform clinical, epidemiological and therapeutic trials in these important pediat... Read More
Gender:
All
Ages:
6 months and below
Trial Updated:
06/04/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Biliary Atresia, Neonatal Cholestasis
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Autologous Volar Fibroblast Injection Into the Stump Site of Amputees
NCT03947450
Recruiting
This study is a clinical trial testing the safety and efficacy of volar fibroblast (skin cells from the palm or sole) injections for thickening the epidermal (skin) layer at the stump site in people with below the knee amputations. The study will enroll adults seen at Johns Hopkins.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
06/04/2024
Locations: Department of Dermatology at Johns Hopkins University, Baltimore, Maryland
Conditions: Amputation, Skin Wound, Stem Cell
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T CELL THERAPY OPPOSING NOVEL COVID-19 INFECTION IN IMMUNOCOMPROMISED PATIENTS
NCT05141058
Recruiting
This is an open label, phase I dose-escalation study to evaluate the safety of coronavirus-specific T cell (CST) therapy for prevention of SARS-CoV-2 infection in immunocompromised patients following hematopoietic stem cell transplantation (HSCT). Participants will receive donor-derived CSTs for prevention of SARS-CoV-2 infection after HSCT (≥28 days and <4 months after HSCT). In this dose escalation trial, three doses (1x107/m2, 2x107/m2, and 4x107/m2) will be tested for safety, with study ar... Read More
Gender:
All
Ages:
Between 12 years and 80 years
Trial Updated:
06/04/2024
Locations: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
Conditions: SARS-CoV-2 Infection
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Feasibility Study for Fibroblast Autologous Skin Grafts
NCT01964859
Recruiting
This research is being done to determine if investigators can change skin from one type to another. Specifically, investigators are interested in making normal skin into the thicker skin found on our palms and soles.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
06/04/2024
Locations: Johns Hopkins School of Medicine, Dermatology Department, Baltimore, Maryland
Conditions: Wounds and Injuries
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Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
NCT06170970
Recruiting
Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness. Previous research indicates that these agents may be beneficial specifically for MS patients with concomitant excessive daytime sleepiness. This study uses a randomized, double-blind, placebo-controlled crossover design. Participants will undergo a 10-day lead-in with he medicati... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
06/04/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Multiple Sclerosis, Multiple Sclerosis Fatigue
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Combination Radiotherapy and Radiopharmaceutical Therapy Treatment Planning for Thyroid Cancer
NCT04892303
Recruiting
The goal of this study is to evaluate combined radioactive iodine (RAI, 131-I) and external beam radiotherapy (XRT) to optimize the radiation dose delivered to treat well differentiated thyroid cancers (DTC) with iodine-avid metastases. The investigators hypothesize that precise dosimetric planning will permit this combined RAI-XRT radiotherapeutic approach to be safe and permit higher tumor radiation doses than could otherwise be delivered. Patients with metastatic well-differentiated DTC) that... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
06/03/2024
Locations: The Johns Hopkins SKCCC, Baltimore, Maryland
Conditions: Recurrent Thyroid Cancer
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Systemic Hypothermia in Acute Cervical Spinal Cord Injury
NCT02991690
Recruiting
This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
06/03/2024
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Spinal Cord Injury, Acute
Register for Updates
Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy
NCT06383091
Recruiting
In this clinical trial, the investigators are seeking to learn if a course of voice therapy, including neck massage, stretches and pain science education in addition to voice exercise and scar massage will effectively treatment patient complaints of swallowing or voice changes after total thyroidectomy as compared to voice exercise and scar massage alone. The main questions it aims to answer are: Will neck massage, stretches and pain science education reduce patient complaints of swallowing ch... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Total Thyroidectomy
Register for Updates