There are currently 2703 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Ulcerative Colitis
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MR Antagonist and LSD1
NCT04840342
Recruiting
Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury in Blacks who carry the risk allele for LSD1 (rs587168). The findings of these investigations may lead to a new approach in treating a subset (\~30%) of the essenti... Read More
Gender:
ALL
Ages:
17 years and above
Trial Updated:
08/06/2024
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Hypertension, Mineralocorticoid Excess
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Neuromodulation for a Novel OCD Biomarker and Treatment
NCT05994053
Recruiting
Although multiple treatments for OCD exist, slow symptom decrease, high remission, and significant side effects for some OCD patients limit their efficacy. More research into the precise neural mechanisms and linked cognitive functions in OCD is also necessary. To address both concerns, this study by Dr. Reinhart and his team will test a new, non-invasive, and well-tolerated neuromodulation method for reducing OCD symptoms, based on reward-related rhythms of the orbitofrontal cortex (OFC; a brai... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: Boston University Center for Anxiety and Related Disorders (BU-CARD), Boston, Massachusetts
Conditions: OCD
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Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
NCT01177618
Recruiting
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.
Gender:
ALL
Ages:
All
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Chronic Obstructive Pulmonary Disease
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Feasibility of the AveCure Microwave Ablation Technology for the Bronchoscopic Treatment of Malignant Central Airway Obstructions
NCT06105606
Recruiting
This research is being done to evaluate the feasibility of the AveCure Flexible Microwave destruction of tissue (Ablation) Probe for the treatment of malignant central airway obstruction using a thin, tube-like instrument with a light and a lens for viewing and removing tissue (bronchoscopic). The name of the intervention being used in this research study is: AveCure Flexible Microwave Ablation Probe (handheld, surgical device that delivers microwave energy via flexible probe tip)
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Airway Obstruction, Central Airway Obstruction
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Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
NCT06538376
Recruiting
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second. It is coupled with an analytical software that allows it to provide more advanced measures of lung motion, ventilation, and perfusion compared to traditional chest radiography. While implementation of DDR fixed machines are beginning elsewhere in the US, this trial involves the first applications of an FDA-approved portable DDR machine, for use at the b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion, Acute Rejection of Lung Transplant (Disorder), Airway Obstruction, Rib Fractures, Acute Copd Exacerbation, Asthma COPD, Pulmonary Embolism, Hemothorax, Pneumothorax, Mesothelioma, Diaphragmatic Paralysis
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The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease
NCT06483126
Recruiting
This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease. For the purpose of this survey, "natural environment" refers to places that primarily consist of natural elements, such as vegetation, water bodies, and landscapes. This includes greenspaces (such as parks, gardens, neighborhood streets lined with trees, forests, or nature reserves) bluespaces (such as next to beaches, lakes, rivers, ponds, or waterfronts), and desert... Read More
Gender:
ALL
Ages:
Between 40 years and 100 years
Trial Updated:
08/05/2024
Locations: Vision and Cognition Laboratory, Boston University, Boston, Massachusetts
Conditions: Parkinson Disease, Mood, Cognition
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Statins In Intracerbral Hemorrhage
NCT03936361
Recruiting
The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins should be influenced by an individual's Apolipoprotein-E (APOE) genotype. An MRI ancillary study (SATURN MRI), in a subset of SATURN participants , will evaluate the effects of continuation vs. discontinuation of statin drugs on hemorrhagic and ischemic MRI markers of cere... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Intracerebral Hemorrhage
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Cerebellar Modulation of Cognition in Psychosis
NCT06107764
Recruiting
The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain acti... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder I, Psychosis
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AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention
NCT06235112
Recruiting
AI INFORM is a multicenter randomized trial that will test the hypothesis that providing clinicians information on the presence and amount of coronary artery calcifications (CAC), will result in initiation or intensification of preventive therapies. The study will use a cloud-based artificial intelligence (AI) platform (Nanox.AI) that can analyze non contrast chest CT and estimate the amount of CAC.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease
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Perception in Parkinson's Disease
NCT05483036
Recruiting
The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to pa... Read More
Gender:
ALL
Ages:
Between 40 years and 110 years
Trial Updated:
08/05/2024
Locations: Vision and Cognition Laboratory, Boston University, Boston, Massachusetts
Conditions: Parkinson's Disease, Visual Hallucination, Perception
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Dietary Intervention to Mitigate Adverse Consequences of Night Work
NCT04868526
Recruiting
The goal of this clinical trial is to test whether our dietary intervention can prevent or lessen the negative health effects of night shift work in healthy participants. Participants will: * complete 2 inpatient stays * be provided with identical meals * have frequent blood draws * provide urine, saliva, stool and rectal swab samples
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Dietary Habits
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