There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Post-stroke Motor Rehabilitation Using Functional Near-infrared Spectroscopy-based Brain-computer-interface
Recruiting
Chronic stroke survivors suffering from weaknesses or movement difficulties in their hand/arm are provided a system to aid in at-home rehabilitation for 6 weeks. This rehabilitation system includes a headband that measures and provides feedback from the brain during rehabilitation, together with tablet-based software. Throughout the 6 week rehabilitation period (as well as in a follow-up session 1 month afterwards) several assessments are taken to understand the effect of this rehabilitation on... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/20/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hemiparesis
Kidney Precision Medicine Project
Recruiting
Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and CKD has been hampered by: Non-predictive animal models The inability to identify and prioritize human targets The limited availability of human kidney biopsy tissue A poor understanding of AKI and CK... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/18/2022
Locations: Brigham & Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury, Acute Renal Insufficiency, Kidney Failure, Acute, Kidney Insufficiency, Acute, Renal Failure, Acute, Renal Insufficiency, Acute, Chronic Kidney Diseases, Chronic Kidney Insufficiency, Chronic Renal Diseases, Chronic Renal Insufficiency, Kidney Insufficiency, Chronic
Comparative Effectiveness of Bariatric Surgery With PROMs
Recruiting
This long-term, nationwide observational data collection repository will obtain patient-reported outcomes from metabolic and bariatric surgery patients. The data will be used in conjunction with clinical outcomes to determine quality, safety, and comparative effectiveness of various metabolic and bariatric procedures.
Gender:
All
Ages:
0 years and above
Trial Updated:
05/17/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Bariatric Surgery, Metabolic Surgery, Weight Reduction
Struvite Stones Antibiotic Study
Recruiting
The aim of this research is to determine an effective antibiotic regimen following definitive surgical therapy of kidney stones caused by bacterial infection (struvite stones).
Gender:
All
Ages:
19 years and above
Trial Updated:
05/16/2022
Locations: Harvard University - Massachusetts General Hospital, Boston, Massachusetts
Conditions: Kidney Stones
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
Recruiting
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Mitral Regurgitation
Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus
Recruiting
The hypothesis for this study is that women with different physiologic subtypes of gestational diabetes (GDM) (insulin secretion deficit vs. insulin sensitivity deficit) will differ in their glycemic responses to meals with different portions of dietary macronutrients. Investigators will determine GDM subtype based on glucose and insulin levels taken at multiple time points during an oral glucose tolerance test. Participants will consume two meals with different macronutrient content while weari... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
05/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Gestational Diabetes
Enhancing Analgesia in Chronic Pain Through Exercise
Recruiting
Background: Current pain management strategies for pediatric patients are not integrating the analgesic potential of movement-based therapies. To date, experiencing a painful stimulus has been known to disrupt motor activity in an attempt to minimize injury. However, physical activity, even when it increases ongoing pain initially, has been shown to significantly reduce pain symptoms eventually through neuromodulation. In both acute and chronic pain cohorts, exercise protocols and neuromodulatio... Read More
Gender:
All
Ages:
Between 10 years and 24 years
Trial Updated:
05/06/2022
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pain, Chronic Widespread Pain, Fibromyalgia
The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
Recruiting
The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeons. Patients will be treated following one of three study arms: 1) a craniotomy where the resection boundaries for motor or language functions will be identified by the "awake" mapping technique (awake craniotomy, AC); 2) a craniotomy where the resection boundaries for motor functions will be identif... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/05/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Glioblastoma
Trauma Informed Guilt Reduction Therapy
Recruiting
The goal of this project is to determine if a 6-session psychotherapy intervention will help Veterans feel less deployment-related guilt and less distress related to their guilt. Half of the participants will receive the guilt focused intervention and half will receive a supportive intervention. A supplemental pilot study added in FY2021 will examine the intervention for pandemic-related guilt events.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2022
Locations: National Center for PTSD, Boston, Massachusetts
Conditions: Guilt, Shame, Post-traumatic Stress Disorders
Developing a Test for the Detection of Ovarian Cancer
Recruiting
The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples of the wash and the blood will be taken before surgery. After surgery, doctors will determine whether the participant had ovarian cancer or a benign disease of the ovaries. The tests of the washings and the blood will be examined to see how much the participants with ovarian cancer can be separated... Read More
Gender:
Female
Ages:
30 years and above
Trial Updated:
04/29/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Ovarian Neoplasms, Ovarian Epithelial Carcinoma, Fallopian Tube Neoplasms, High Grade Ovarian Serous Adenocarcinoma, Stage I Ovarian Cancer, Stage II Ovarian Cancer, Stage III Ovarian Cancer AJCC v8, Stage IIIA Ovarian Cancer AJCC v8, Stage IIIA1 Ovarian Cancer AJCC v8, Stage IIIA2 Ovarian Cancer AJCC v8, Stage IIIB Ovarian Cancer AJCC v8, Stage IIIC Ovarian Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IVA Ovarian Cancer AJCC v8, Stage IVB Ovarian Cancer AJCC v8
The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
Recruiting
Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient popula... Read More
Gender:
All
Ages:
All
Trial Updated:
04/29/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sudden Cardiac Death
Bronchial NIR Image-guided Resection
Recruiting
This is a clinical trial to evaluate the use of peritumoral injection of near-infrared dye indocyanine green to identify lung lesions and sentinel lymph nodes. The primary purpose is to determine if the use of ICG injected via navigational bronchoscopy, CT-guided or transthoracic allows us to identify the first lymph node that drains from the tumor, and thus would be the most likely site for metastatic disease, and remove it for analysis to improve the ability to detect tumor in this node and to... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Sentinel Lymph Node