There are currently 2703 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Granzyme B PET Imaging Drug as a Predictor of Immunotherapy Response to Checkpoint Inhibitors
NCT04169321
Recruiting
First in Human Safety of \[68Ga\]-NOTA-hGZP PET Imaging in subjects with cancer undergoing treatment with a checkpoint inhibitor either as a monotherapy of in combination I-O therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/17/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Solid Tumor, Unspecified, Adult, Lymphoma
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Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid
NCT04291599
Recruiting
This will be a phase 2, single-center, unblinded randomized controlled pilot trial of two arms comparing opioid-sparing analgesia to the current Boston Children's Hospital institutional practice which has been reported to predominantly include administration of opioids as a first-line analgesic to pediatric patients who present to the emergency department with a diagnosis of acute pancreatitis (AP). This is a pilot trial for which many outcomes have not previously been studied in the pediatric A... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
02/13/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Acute Pancreatitis
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MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)
NCT04428372
Recruiting
This proposal will measure the effects of mannitol administration versus placebo in hypotensive-prone, adult, maintenance hemodialysis patients with respect to changes in patient symptoms and blood pressure stability.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Hemodialysis Complication, Hemodynamic Instability
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Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation
NCT05498181
Recruiting
This randomized placebo-controlled clinical trial will evaluate the effect of sacubitril/valsartan (compared with placebo) on echocardiographic measures of hypervolemia, preservation of residual renal function, and key safety parameters in incident hemodialysis patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Hemodialysis
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Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma
NCT06073353
Recruiting
This clinical trial aims to evaluate whether a psychosocial mobile application (THRIVE-M), is efficacious for improving quality of life, psychological distress, and fatigue in patients living with multiple myeloma compared to usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Multiple Myeloma
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's Hospital Boston (UCDC New England Center), Boston, Massachusetts
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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MOLAR: Mapping Oral Health and Local Area Resources
NCT05688982
Recruiting
The goal of this clinical trial is to test the impact of a screening and linkage intervention for adverse social determinants of health (aSDoH) on oral health linkage to care for emergency department patients. Researchers will compare three groups: Patients in Arm A will receive paper handouts with general oral health and aSDoH resources. Patients in Arm B will receive paper handouts with geographically-proximate oral health and aSDoH resources. Patients in Arm C will receive geographically-prox... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
02/09/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Dental Diseases
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fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
NCT04439552
Recruiting
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Gender:
ALL
Ages:
Between 8 years and 35 years
Trial Updated:
02/07/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
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Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation
NCT05995899
Recruiting
The aim of this study is to better understand how tenapanor affects the metagenomics and metabolomics of patients with irritable bowel syndrome with constipation (IBS-C). Tenapanor is the newest FDA-approved agent for IBS-C. It is a small molecule that inhibits the NHE3 receptor, leading to impaired sodium and water absorption in the intestine. Previous clinical trials comparing tenapanor to placebo showed that a 50 mg dose of tenapanor led to increased bowel movements and decreased abdominal pa... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: IBS, IBS - Irritable Bowel Syndrome
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Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas
NCT06132165
Recruiting
This study will evaluate the effectiveness of skin cooling in increasing tolerability of four treatments in Neurofibromatosis Type 1 Cutaneous Neurofibromas. These treatments are: a 980nm laser, a 755nm laser, radio-frequency injection, and a Kybella injection. Each patient will have a treatment and a control site..
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/07/2024
Locations: Wellman Center for Photomedicine, Boston, Massachusetts
Conditions: Neurofibromatosis 1
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Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
NCT04215809
Recruiting
Assess the safety and tolerability, identify dose-limiting toxicities (DLT) and determine the maximum tolerated dose (MTD) / recommended phase 2 dose (RP2D) of APG-2575.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/06/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: CLL/SLL
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Interstage Monitoring Using an Implantable Loop Recorder: A Pilot Study
NCT05744934
Recruiting
The primary objective of this investigation is to evaluate the feasibility and safety of implantable loop recorder implantation (using the LUX-DX™) in newborns undergoing stage 1 palliation. The secondary objective of the investigation is to evaluate the feasibility of continuous measurement of heart rate and arrhythmia using an implantable loop recorder (LUX-Dx™) during the interstage period. An implantable loop recorder will be placed at the time of chest closure following stage 1 palliation... Read More
Gender:
ALL
Ages:
30 days and below
Trial Updated:
02/06/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Univentricular Heart
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