There are currently 2781 clinical trials in Boston, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center and Brigham and Women's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging
NCT03265535
Recruiting
We propose a single-scan two-injection myocardial perfusion imaging protocol using ammonia. Subjects will undergo single-scan two-injection imaging as well as regular stress single-scan single-injection protocol and the myocardial blood flow of both techniques will be compared.
Gender:
All
Ages:
Between 30 years and 75 years
Trial Updated:
04/11/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease, Myocardial Ischemia
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Impact of Diet on the Gut-Muscle Axis in Older Adults
NCT05549622
Recruiting
Muscle health declines during aging. One factor that may impact muscle health is the community of bacteria that live in our intestines, but studies aimed at improving muscle health by targeting the gut in older adults are sparse. The primary goal of this study is to use a diet that is enriched in soluble fiber, which is exclusively utilized by gut bacteria to make substances that can impact muscle health, to improve muscle-related measures in older adults.
Gender:
All
Ages:
65 years and above
Trial Updated:
04/10/2023
Locations: Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
Conditions: Sarcopenia, Dietary Exposure, Microbial Colonization
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Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
NCT04773457
Recruiting
Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.
Gender:
All
Ages:
Between 12 months and 19 years
Trial Updated:
04/10/2023
Locations: Boston Children's Hopsital, Boston, Massachusetts
Conditions: Surgical Site Infection
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Identifying Genetic Causes of IC/BPS
NCT00389142
Recruiting
Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS), or chronic pelvic pain syndrome(CPPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, we are collecting genetic material and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS/CPPS. We are enrolling families... Read More
Gender:
All
Ages:
Between 1 week and 100 years
Trial Updated:
04/09/2023
Locations: Boston Children's Hospital (BCH), Boston, Massachusetts
Conditions: Interstitial Cystitis, Chronic Pelvic Pain Syndrome, Bladder Pain Syndrome
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Estrogen Administration for the Treatment of NASH in Postmenopausal Women
NCT04833140
Recruiting
Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited. Preclinical and preliminary clinical data suggest that estrogen deficiency plays an important role in the pathology of steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Post-menopausal women are a growing population with particularly high risk of NASH due to their lack of estrogen. This study will exam... Read More
Gender:
Female
Ages:
Between 45 years and 70 years
Trial Updated:
04/07/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: NASH - Nonalcoholic Steatohepatitis
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Remote Monitoring in Progressive Supranuclear Palsy (PSP)
NCT04753320
Recruiting
This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year. Participants will perform supervised remote assessments monthly and in-person assessments approximately every 6 months.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
04/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Progressive Supranuclear Palsy
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Intervention to Improve HIV Self-care Among People Who Inject Drugs
NCT05819411
Recruiting
This study will implement a pilot randomized controlled trial (RCT, N=70) to refine and assess the feasibility and acceptability of an emotion regulation and communication skills intervention designed to improve engagement in HIV-care among substance using HIV+ PWID sub-optimally engaged in HIV care.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: Fenway Community Health, Boston, Massachusetts
Conditions: Hiv, Substance Use Disorders
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Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension
NCT04500574
Recruiting
In this research study, we will assess the safety, tolerability, comfort, and feasibility of lowering intraocular pressure using a novel Contact Lens Drug Delivery System with latanoprost. Latanoprost is a well-studied medication and has been used to treat glaucoma for decades. Currently, latanoprost is FDA-approved to be administered to patients as eye drops, but using eye drops has challenges (having to remember to take the drop, getting the drop in the eye). This clinical trial is being done... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/04/2023
Locations: Massachusetts Eye and Ear, Boston, Massachusetts
Conditions: Glaucoma, Ocular Hypertension
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The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
NCT04943172
Recruiting
A prospective, non blinded, single arm, multicenter study designed to assess the safety and effectiveness of the bioprosthetic, VenoValve, which is surgically implanted into the deep venous system for treatment of patients with deep venous valvular insufficiency ( C4b-C6 patients).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Deep Venous Insufficiency (Diagnosis)
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MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
NCT05730816
Recruiting
In this research study, investigators will test whether prophylactic high-dose IV Mg administration attenuates the risk of AKI in patients with malignant mesothelioma receiving intraoperative chemotherapy (HIOC) with cisplatin compared to placebo .
Gender:
All
Ages:
18 years and above
Trial Updated:
04/03/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Mesothelioma
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Auditory Neural Function in Implanted Patients With Usher Syndrome
NCT04906135
Recruiting
Usher syndrome (USH) causes extensive degeneration in the cochlear nerve (CN), especially in CN fibers innervating the base of the cochlea. As the first step toward developing evidence-based practice for managing implant patients with USH, this study evaluates local neural health, as well as the neural encoding of temporal and spectral cues at the CN in implanted patients with USH. Aim 1 will determine local CN health in patients with USH by assessing the sensitivity of the electrically evoked c... Read More
Gender:
All
Ages:
Between 1 year and 85 years
Trial Updated:
04/03/2023
Locations: Boston children's Hospital, Boston, Massachusetts
Conditions: Usher Syndrome, Cochlear Implantation
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Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia
NCT05248295
Recruiting
Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a pers... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/03/2023
Locations: MGH IHP, Boston, Massachusetts
Conditions: Aphasia, Apraxia of Speech
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