There are currently 50 clinical trials in Cambridge, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Harvard University, Cambridge Health Alliance and Massachusetts Institute of Technology. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Prevention and Early Identification for High Risk Youth in School-based Clinics
NCT04935710
Recruiting
The proposed research project provides a novel approach to screening, early assessment, and preventive interventions for high-risk youth in racial/ethnic/linguistically (REL)-diverse communities. The investigators assess a health promotion intervention as a way of reducing treatment disparities in REL-minority youth. This population is underrepresented in child psychiatry research. It is often excluded from clinical trials of medication or therapy because of challenges with transportation, lite... Read More
Gender:
All
Ages:
Between 12 years and 24 years
Trial Updated:
01/30/2024
Locations: CHA-Teen Health Center at Cambridge Rindge and Latin School, Cambridge, Massachusetts +2 locations
Conditions: Community Mental Health Services, Adolescent Well Being, Resilience, Psychological, Health Equity, Screening
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Phase 2 Tolerability and Effects of ALK-001 on Stargardt Disease
NCT02402660
Recruiting
The purpose of this study is to determine the long term safety and tolerability of ALK-001 (C20-D3-retinyl acetate), and to explore the effects of ALK-001 on the progression of Stargardt disease in patients between the ages of 8 and 70 years old. Funding Source - FDA OOPD
Gender:
All
Ages:
Between 8 years and 70 years
Trial Updated:
01/25/2024
Locations: Alkeus Coordinating Center, Cambridge, Massachusetts
Conditions: Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)
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REEV SENSE for Gait Analysis in Post-stroke Gait Impairment (SENS-AG)
NCT06234878
Recruiting
The purpose of this study is to evaluate the clinical performance of the investigational REEV SENSE gait tracker to measure gait features in subjects with post-stroke gait impairment. REEV SENSE is intended to be used by trained healthcare professionals as a simple procedure adapted to clinical routine. The reference method for performance comparison will be motion capture.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: MIT Center for Clinical and Translational Research, Cambridge, Massachusetts
Conditions: Stroke, Gait Disorders, Neurologic
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Optimized tDCS for Fibromyalgia: Targeting the Endogenous Pain Control System
NCT03371225
Recruiting
This trial aims at understanding the mechanisms of optimized transcranial direct current stimulation (tDCS) (16 tDCS sessions combined with exercise)] on pain control. Optimized tDCS can lead to stronger engagement of the endogenous pain regulatory system that will ultimately lead to increased pain relief in patients with fibromyalgia (FM). Therefore, the investigators designed a 2x2 factorial mechanistic trial [tDCS (active and sham) and aerobic exercise (AE) (active and control)] to evaluate t... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/15/2024
Locations: Spaulding Rehabilitation Hospital for Continuing Care, Cambridge, Massachusetts
Conditions: Fibromyalgia
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A Study of Spinraza (Nusinersen) Exposure in Pregnant Women With Spinal Muscular Atrophy (SMA) Within Existing SMA Registries
NCT05789758
Recruiting
The primary objectives of the study are to prospectively evaluate pregnancy complications and outcomes in participants with SMA, birth outcomes and adverse effects in infants born to participants with SMA, who were exposed to nusinersen up to 14 months prior to the first day of their last menstrual period (LMP) before conception, 14.5 months before the date of conception, and/or at any time during their pregnancy. The secondary objective of the study is to evaluate pregnancy outcomes in particip... Read More
Gender:
Female
Ages:
Between 18 years and 54 years
Trial Updated:
01/15/2024
Locations: Research Site, Cambridge, Massachusetts
Conditions: Muscular Atrophy, Spinal
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A Mindful Community for People With ALS and Their Primary Caregivers
NCT05595850
Recruiting
The psychological impact of ALS on patients and caregivers is high, significantly affecting their quality of life (QOL). Despite this impact, there is not much research about psychological interventions that could reduce psychological distress and improve QOL. The efficacy of mindfulness-based treatments for the improvement of QOL was previously demonstrated by the investigator's group. Despite preliminary positive results, treatment efficacy tends to weaken over time. The investigators believe... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/13/2024
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Amyotrophic Lateral Sclerosis, Caregiver Burden
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Combination Therapy to Improve SCI Recovery.
NCT05563103
Recruiting
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
12/18/2023
Locations: Spaulding Rehabilitation Hospital, Cambridge, Massachusetts
Conditions: Spinal Cord Injuries
Register for Updates
Understanding the Effects of Transauricular Vagus Nerve Stimulationon on Neural Networks and Autonomic Nervous System
NCT05801809
Recruiting
This trial aims to perform an exploratory, mechanistic, randomized double-blind sham-control trial in healthy participants to assess the physiologic effects of a single 60 minutes session of bilateral taVNS, on neural networks and autonomic function.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
12/15/2023
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Healthy Volunteers
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Mechanisms of Open and Hidden Placebo in Stroke Recovery
NCT05832567
Recruiting
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Stroke, Hemiparesis
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AMI Construction in Lower Extremity Residual Limbs
NCT04063592
Recruiting
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: Massachusetts Institute of Technology, Cambridge, Massachusetts
Conditions: Amputation
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Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity
NCT04742257
Recruiting
This is a multi-center, randomized, double-blind (patient and evaluator), sham-controlled study to be conducted in stroke patients with upper-extremity spasticity. The main objectives of this study are to evaluate the performance and safety of the MyoRegulator® device in active- versus sham-treated patients after 5 consecutive days of treatment. The MyoRegulator® device is a non-significant risk (NSR) investigational non-invasive neuromodulation device that uses multi-site direct current (multi-... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/28/2023
Locations: Spaulding Rehabilitation Hospital, Cambridge, Massachusetts
Conditions: Muscle Spasticity, Stroke
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Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
NCT02323945
Recruiting
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/27/2023
Locations: Spaulding Rehabilitation Hospital, Cambridge, Massachusetts
Conditions: Spinal Cord Injuries
Register for Updates