There are currently 40 clinical trials in Cambridge, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Harvard University, Cambridge Health Alliance and Massachusetts Institute of Technology. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Pre-exposure Prophylaxis (PrEP) for Health
NCT04430257
Recruiting
This randomized controlled trial will test the efficacy of "PrEP for Health," a behavioral intervention to improve the use of antiretroviral pre-exposure prophylaxis (PrEP) among at-risk people who inject drugs (PWID) in two syringe service program (SSP) settings in Lawrence and Boston/Cambridge, Massachusetts. The investigators will equally randomize 200 PWID to receive either (a) the "PrEP for Health" intervention condition involving theory-informed HIV and PrEP education, motivational intervi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2025
Locations: AIDS Action, Cambridge, Massachusetts
Conditions: Substance Dependence, HIV (Human Immunodeficiency Virus)
Register for Updates
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
NCT03072927
Recruiting
This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure. This study will start with patients treated with a study procedure having an index date on or after January 1, 2017, and enrollment will continue until stopped by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2025
Locations: New England Ambulatory SurgiCenter, Cambridge, Massachusetts
Conditions: Lumbar Spinal Stenosis
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Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy
NCT04586166
Recruiting
SASS (Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy) will be a multicenter, prospective, randomized, single-blind non-inferiority trial.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/24/2025
Locations: Boston Urogynecology Associates, Cambridge, Massachusetts
Conditions: Stress Urinary Incontinence, Pelvic Floor Disorders
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The Mycophenolate Pregnancy Registry
NCT01733082
Recruiting
The Mycophenolate Pregnancy Registry is designed as a prospective, observational registry collecting data regarding mycophenolate exposure during pregnancy, and pregnancy outcomes, fetal and infant outcomes after exposure. Early and later term pregnancy outcomes will be solicited at selected gestational time points. Structural and functional birth defects identified in the perinatal period through one year of life will be collected and classified. This is a non-proprietary registry and is a com... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
04/18/2025
Locations: Quintiles Outcome, Cambridge, Massachusetts
Conditions: Heart Transplantation, Kidney Transplantation, Liver Transplantation, Autoimmune Diseases
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Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy
NCT06686680
Recruiting
This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA). We are doing the research to investigate the effects of extracorporeal shockwave therapy (ESWT) on pain, function, biomechanics, knee range of motion and strength, inflammation, and joint structure and integrity of the knee.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/01/2025
Locations: Spaulding Cambridge Hospital, Cambridge, Massachusetts
Conditions: Knee Osteoarthristis, ACL Injuries, Post-Traumatic
Register for Updates
BE WELL With Migraine: Brain Education and WELLness With Migraine
NCT05987592
Recruiting
The goal of this randomized clinical trial is to evaluate two different non-drug, virtual treatment options designed to improve the lives of patients with migraine. Both interventions involve 8 weekly sessions and an online platform with additional content and learning. Participants can stay on all their medications during this study. Information from this study may help determine how to better treat migraine.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2025
Locations: Cambridge Health Alliance - Center for Mindfulness and Compassion, Cambridge, Massachusetts
Conditions: Migraine
Register for Updates
Treatment for Individuals Interacting with the Criminal Justice System
NCT06564948
Recruiting
The proposed Center will leverage burgeoning real-time data linkage capabilities among health systems, Medicaid payors, and criminal legal (e.g., jail booking data, jail release data) systems, to identify individuals coming in and out of jail for suicide assessment and prevention, and to better coordinate care across these disparate systems. This Center will advance the fields of suicide prevention and criminal legal system-based mental health by solving a well-known, central problem in both fie... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/12/2025
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Suicide Risk, Psychiatric Disorders
Register for Updates
A Study of Spinraza (Nusinersen) Exposure in Pregnant Women With Spinal Muscular Atrophy (SMA) Within Existing SMA Registries
NCT05789758
Recruiting
The primary objectives of the study are to prospectively evaluate pregnancy complications and outcomes in participants with SMA, birth outcomes and adverse effects in infants born to participants with SMA, who were exposed to nusinersen up to 14 months prior to the first day of their last menstrual period (LMP) before conception, 14.5 months before the date of conception, and/or at any time during their pregnancy. The secondary objective of the study is to evaluate pregnancy outcomes in particip... Read More
Gender:
FEMALE
Ages:
Between 18 years and 54 years
Trial Updated:
02/24/2025
Locations: Research Site, Cambridge, Massachusetts
Conditions: Muscular Atrophy, Spinal
Register for Updates
Enhanced Coordinated Specialty Care for Early Psychosis
NCT06071858
Recruiting
The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is: • Does the addition of certain elements of care increase the number of visits in treatment for first-episode psychosis? Participants will either: * Receive care as usual (CSC) or * Receive care as usual (CSC) plus five additional care elements (CSC 2.0): 1. Individual peer support... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/20/2025
Locations: Cambridge Health Alliance RISE Clinic, Cambridge, Massachusetts
Conditions: Psychosis, Schizophrenia, Schizoaffective Disorder, Psychosis Nos/Other, Bipolar Disorder
Register for Updates
Pragmatic Trial of Remote TDCS and Somatosensory Training for Phantom Limb Pain with Machine Learning to Predict Treatment Response
NCT05188183
Recruiting
The investigators have designed a pragmatic trial of home-based transcranial direct current stimulation (tDCS) for phantom limb pain (PLP), the PLP-EVEREST trial (PLP-EffectiVEness pRagmatic Stimulation Trial) to test a portable device that would reach underrepresented populations and would validate this therapy in a more pragmatic setting. Subjects will be randomized to home-based tDCS of the primary motor cortex (M1) with somatosensory training or usual care only (including their current pharm... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2025
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Phantom Limb Pain
Register for Updates
Follow-up Visit of High Risk Infants
NCT00009633
Recruiting
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which surviving extremely low birth-weight infants born in participating network centers receive neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were seen at 18-22 months corrected age). Data regarding pregnancy and neonatal outcome are collected prospectively. The goal is to identify potential maternal and neonatal risk factors that may... Read More
Gender:
ALL
Ages:
Between 18 months and 26 months
Trial Updated:
02/11/2025
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Register for Updates
Generic Database of Very Low Birth Weight Infants
NCT00063063
Recruiting
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is "generic"). Data are analyzed to find associations and trends between baseline information, treatments, and infant outcome, and to develop future NRN trials.
Gender:
ALL
Ages:
14 days and below
Trial Updated:
02/11/2025
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Register for Updates