There are currently 48 clinical trials in Cambridge, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Harvard University, Cambridge Health Alliance and Massachusetts Institute of Technology. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Phase 2 Tolerability and Effects of ALK-001 on Stargardt Disease
NCT02402660
Recruiting
The purpose of this study is to determine the long term safety and tolerability of ALK-001 (C20-D3-retinyl acetate), and to explore the effects of ALK-001 on the progression of Stargardt disease in patients between the ages of 8 and 70 years old. Funding Source - FDA OOPD
Gender:
All
Ages:
Between 8 years and 70 years
Trial Updated:
06/18/2024
Locations: Alkeus Coordinating Center, Cambridge, Massachusetts
Conditions: Stargardt Disease, Stargardt Macular Degeneration, Stargardt Macular Dystrophy, Autosomal Recessive Stargardt Disease 1 (ABCA4-related)
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Understanding the Effects of Transauricular Vagus Nerve Stimulationon on Neural Networks and Autonomic Nervous System
NCT05801809
Recruiting
This trial aims to perform an exploratory, mechanistic, randomized double-blind sham-control trial in healthy participants to assess the physiologic effects of a single 60 minutes session of bilateral taVNS, on neural networks and autonomic function.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
06/14/2024
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Healthy Volunteers
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The Ukrainian Student Problem Solving Project
NCT06064578
Recruiting
The purpose of this study is to test the effectiveness of a universal, digital, single-session intervention for youth mental health, functioning, and well-being. The investigators will be providing access to a brief online program (Project SOLVE) for students as part of the school curriculum. Ukrainian students living in Poland will be randomly assigned to receive Project SOLVE either immediately or after 3 months. The program is designed to help students manage stress and reach their academic a... Read More
Gender:
All
Ages:
Between 10 years and 18 years
Trial Updated:
06/14/2024
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Trauma, Anxiety, Depression, Child Behavior
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The Mycophenolate Pregnancy Registry
NCT01733082
Recruiting
The Mycophenolate Pregnancy Registry is designed as a prospective, observational registry collecting data regarding mycophenolate exposure during pregnancy, and pregnancy outcomes, fetal and infant outcomes after exposure. Early and later term pregnancy outcomes will be solicited at selected gestational time points. Structural and functional birth defects identified in the perinatal period through one year of life will be collected and classified. This is a non-proprietary registry and is a com... Read More
Gender:
Female
Ages:
All
Trial Updated:
06/04/2024
Locations: Quintiles Outcome, Cambridge, Massachusetts
Conditions: Heart Transplantation, Kidney Transplantation, Liver Transplantation, Autoimmune Diseases
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Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy
NCT05655195
Recruiting
Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. The investigator's lab found that boosting gamma waves in AD mouse models using light and sound stimulation at 40Hz not only reduced amyloid and tau in the brain, but also improved memory. The investigators developed a light and sound device for humans that stimulates the brain at 40Hz that can be used safely at home. For the... Read More
Gender:
All
Ages:
Between 65 years and 100 years
Trial Updated:
05/30/2024
Locations: Massachusetts Institute of Technology, Cambridge, Massachusetts
Conditions: Alzheimer Disease, Alzheimer Disease, Early Onset, Alzheimer Disease, Late Onset, Alzheimer's Disease (Incl Subtypes), Alzheimer's, Alzheimer's Disease
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Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy
NCT04586166
Recruiting
SASS (Single-incision Versus Retropubic Mid-Urethral Sling (Solyx) for SUI During Minimally Invasive Sacrocolpopexy) will be a multicenter, prospective, randomized, single-blind non-inferiority trial.
Gender:
Female
Ages:
21 years and above
Trial Updated:
05/28/2024
Locations: Boston Urogynecology Associates, Cambridge, Massachusetts
Conditions: Stress Urinary Incontinence, Pelvic Floor Disorders
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TCF-001 TRACK (Target Rare Cancer Knowledge) Study
NCT04504604
Recruiting
This open label, non-randomized, multi-center, pragmatic study aims to establish whether patients with rare tumors can benefit from matched molecular therapy as dictated by their next-generation sequencing (NGS) results.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: TargetCancer Foundation, Cambridge, Massachusetts
Conditions: Rare Cancers, Cholangiocarcinoma, Cancer of Unknown Primary Site
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Prevention and Early Identification for High Risk Youth in School-based Clinics
NCT04935710
Recruiting
The proposed research project provides a novel approach to screening, early assessment, and preventive interventions for high-risk youth in racial/ethnic/linguistically (REL)-diverse communities. The investigators assess a health promotion intervention as a way of reducing treatment disparities in REL-minority youth. This population is underrepresented in child psychiatry research. It is often excluded from clinical trials of medication or therapy because of challenges with transportation, lite... Read More
Gender:
All
Ages:
Between 12 years and 24 years
Trial Updated:
05/13/2024
Locations: CHA-Teen Health Center at Cambridge Rindge and Latin School, Cambridge, Massachusetts +2 locations
Conditions: Community Mental Health Services, Adolescent Well Being, Resilience, Psychological, Health Equity, Screening
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Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain
NCT04827992
Recruiting
This study will use a randomized controlled design to test whether medical marijuana use by adults on high-dose chronic opioid therapy (COT) for chronic non-cancer pain is associated with reduced opioid dose and improved pain intensity and interference when added to a 24-week behavioral intervention (POTS).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/07/2024
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Opioid Use, Pain, Marijuana Use
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MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
NCT03072927
Recruiting
This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure. This study will start with patients treated with a study procedure having an index date on or after January 1, 2017, and enrollment will continue until stopped by... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: New England Ambulatory SurgiCenter, Cambridge, Massachusetts
Conditions: Lumbar Spinal Stenosis
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A Study to Assess New Participant's Perspectives Beyond Clinical Efficacy of Monoclonal Antibody-Based Relapsing Remitting Multiple Sclerosis (RRMS) Treatments
NCT06127095
Recruiting
The primary objective of the study is to understand what the added value of natalizumab (Tysabri®) treatment is from a participant's perspective at a given time, based on a one-shot survey. The secondary objectives of the study also aim to characterize the participant's decision-making process to get the treatment; the burden of treatment, characterization of the study population, assessment of the quality of life (QoL), and fatigue dimension.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2024
Locations: Biogen, Cambridge, Massachusetts
Conditions: Multiple Sclerosis, Relapsing-Remitting
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Patients' Attitudes Toward and Experiences With Buprenorphine Treatment
NCT05121428
Recruiting
This study will disseminate five surveys collecting individual's attitudes and experiences during buprenorphine treatment for Opioid Use Disorder during the COVID-19 pandemic.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2024
Locations: CHA Center for Mindfulness and Compassion, Cambridge, Massachusetts
Conditions: Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
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