There are currently 41 clinical trials in Cambridge, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including Massachusetts General Hospital, Harvard University, Cambridge Health Alliance and Massachusetts Institute of Technology. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
High Frequency Light, Sound, and Tactile Stimulation to Improve Motor and Cognitive Deficits in Parkinson's Disease
NCT05268887
Recruiting
Parkinson's disease (PD) impacts different types of neural oscillations in the brain, including beta (13-30Hz) and gamma oscillations (30-80Hz), which contributes to PD's cardinal symptoms of resting tremor, rigidity, bradykinesia (slowness of movement), and gait instability. The investigators' lab has developed a non-invasive method of increasing gamma power in the brain using Gamma Entrainment Using Sensory Stimulation (GENUS) through light, sound, and tactile stimulation devices. For this stu... Read More
Gender:
ALL
Ages:
Between 45 years and 90 years
Trial Updated:
12/13/2024
Locations: Massachusetts Institute of Technology, Cambridge, Massachusetts
Conditions: Parkinson Disease
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Skilled Nursing Facility Care At Home
NCT06416670
Recruiting
We will perform a parallel-group multicenter patient-level randomized controlled evaluation of skilled nursing facility care at home. Patients typically referred to a skilled nursing facility following hospitalization will be eligible for enrollment. Instead of admission to a skilled nursing facility, participants will receive care from a technology-enabled team in their own homes or will be allocated to receive care in a traditional skilled nursing facility setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Skilled Nursing Facility, Rehabilitation
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Phase 2 Study of KH001 in Long-term Relief from Dentin Hypersensitivity
NCT06464939
Recruiting
The purpose of this study is to evaluate the efficacy and safety of KH001 in subjects with dentin hypersensitivity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: ADA Forsyth, Cambridge, Massachusetts +1 locations
Conditions: Dentin Hypersensitivity
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Testing FIRST in Youth Outpatient Psychotherapy
NCT04725721
Recruiting
The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions.
Gender:
ALL
Ages:
Between 7 years and 15 years
Trial Updated:
10/08/2024
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Anxiety, Depression, Trauma, Behavior Problem
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Gamma Frequency Stimulation in Individuals With Down Syndrome
NCT05196984
Recruiting
Down Syndrome (DS) is characterized by an additional copy of chromosome 21, which also increases risk of Alzheimer's Disease (AD). The investigators' lab found a non-invasive way to remove toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators then translated this non-invasive method, which uses light and sound to stimulate the brain, to be used in mild Alzheimer's patients and cognitively normal adults. The i... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
09/27/2024
Locations: Massachusetts Institute of Technology, Cambridge, Massachusetts
Conditions: Down Syndrome
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Modulating Exercise Dosage to Improve Concussion Recovery
NCT05434130
Recruiting
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity l... Read More
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
09/24/2024
Locations: Spaulding Rehabilitation Hospital, Cambridge, Massachusetts
Conditions: Concussion, Brain, Treatment, Aerobic Exercise, Inflammation, Depression, Anxiety
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TCF-001 TRACK (Target Rare Cancer Knowledge) Study
NCT04504604
Recruiting
This open label, non-randomized, multi-center, pragmatic study aims to establish whether patients with rare tumors can benefit from matched molecular therapy as dictated by their next-generation sequencing (NGS) results.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2024
Locations: TargetCancer Foundation, Cambridge, Massachusetts
Conditions: Rare Cancers, Cholangiocarcinoma, Cancer of Unknown Primary Site
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High Intensity Focused Electromagnetic Field Device for Urinary Incontinence
NCT04031014
Recruiting
High intensity focused electromagnetic (HIFEM) technology induces deep pelvic floor muscle contractions designed to deliver the equivalent of 11,200 Kegel exercise over 28 minutes, with the intention of increasing neuromuscular tone of the pelvic floor. This study will have looking at treatment of the two of the most common pelvic floor disorders: stress or stress predominant urinary incontinence and urge or urge predominant urinary incontinence.
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
08/07/2024
Locations: Boston Urogynecology Associates, Cambridge, Massachusetts
Conditions: Stress Urinary Incontinence, Urge Incontinence, Urge and Stress, Overactive Bladder
Register for Updates
Mechanisms of Open and Hidden Placebo in Stroke Recovery
NCT05832567
Recruiting
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Stroke, Hemiparesis
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Understanding the Effects of Transauricular Vagus Nerve Stimulationon on Neural Networks and Autonomic Nervous System
NCT05801809
Recruiting
This trial aims to perform an exploratory, mechanistic, randomized double-blind sham-control trial in healthy participants to assess the physiologic effects of a single 60 minutes session of bilateral taVNS, on neural networks and autonomic function.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/14/2024
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Healthy Volunteers
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A Mindful Community for People With ALS and Their Primary Caregivers
NCT05595850
Recruiting
The psychological impact of ALS on patients and caregivers is high, significantly affecting their quality of life (QOL). Despite this impact, there is not much research about psychological interventions that could reduce psychological distress and improve QOL. The efficacy of mindfulness-based treatments for the improvement of QOL was previously demonstrated by the investigator's group. Despite preliminary positive results, treatment efficacy tends to weaken over time. The investigators believe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2024
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Amyotrophic Lateral Sclerosis, Caregiver Burden
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Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
NCT02323945
Recruiting
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/27/2023
Locations: Spaulding Rehabilitation Hospital, Cambridge, Massachusetts
Conditions: Spinal Cord Injuries
Register for Updates