There are currently 1094 clinical trials in Rochester, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic - Rochester and Mayo Clinic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases
NCT06788886
Recruiting
This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relationship between respiration, cardiovascular effects in the brain, mental health, and neurophysiological mechanisms are significant for patient populations facing complex health challenges, such as those with cancer and neurodegenerative disease, and their caregivers. By measuring oxygen delivery to brai... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
07/14/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Malignant Brain Neoplasm, Malignant Solid Neoplasm, Multiple Sclerosis, Neuroendocrine Tumor, Prostate Carcinoma
Register for Updates
Study of Aspirin in Patients With Vestibular Schwannoma
NCT03079999
Recruiting
This is a phase II prospective, randomized, double-blind, longitudinal study evaluating whether the administration of aspirin can delay or slow tumor growth and maintain or improve hearing in VS patients.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/11/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Vestibular Schwannoma, Acoustic Neuroma, Neurofibromatosis 2
Register for Updates
Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia
NCT03418038
Recruiting
This phase II trial studies the effect of ascorbic acid and combination chemotherapy in treating patients with lymphoma that has come back (recurrent) or does not respond to therapy (refractory), clonal cytopenia of undetermined significance and chronic myelomonocytic leukemia (CMML). Ascorbic acid may make cancer cells more sensitive to chemotherapy. Drugs used in chemotherapy, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Hodgkin Lymphoma, Recurrent Lymphoma, Refractory Diffuse Large B-Cell Lymphoma, Refractory Lymphoma, Clonal Cytopenia of Undetermined Significance, Chronic Myelomonocytic Leukemia
Register for Updates
Longitudinal Early-onset Alzheimer's Disease Study Protocol
NCT03507257
Recruiting
The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EOnonAD) participants, and (3) cognitively normal (CN) control participants.
Gender:
ALL
Ages:
Between 40 years and 64 years
Trial Updated:
07/11/2025
Locations: Mayo Clinic, Rochester, Rochester, Minnesota
Conditions: Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment
Register for Updates
Concomitant Renal and Urinary Bladder Allograft Transplantation
NCT04626167
Recruiting
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
Gender:
ALL
Ages:
Between 1 year and 60 years
Trial Updated:
07/11/2025
Locations: Mayo Clinic, Rochester, Minnesota +1 locations
Conditions: Chronic Kidney Diseases, Bladder Dysfunction, Bladder Absence, Posterior Urethral Valve, Neurogenic Bladder, Bladder Exstrophy, Bladder Outlet Obstruction, Failure, Kidney, Transplant
Register for Updates
Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial
NCT05497804
Recruiting
This phase II trial test whether combination chemotherapy works to improve blood test results in patients with high-risk multiple myeloma. Chemotherapy drugs, such as carfilzomib, daratumumab, lenalidomide, and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may help determine if patients who have a small amount of cancer left after the initial treatment, called m... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/11/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: ISS Stage III Plasma Cell Myeloma, Multiple Myeloma
Register for Updates
Melatonin Effects on Cardiovascular Disease Mechanisms in the Menopause Transition: A Randomized Clinical Trial
NCT06826755
Recruiting
The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.
Gender:
FEMALE
Ages:
Between 40 years and 55 years
Trial Updated:
07/11/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Perimenopause, Hypertension
Register for Updates
A Study of Pyridostigmine in Postural Tachycardia Syndrome
NCT00409435
Recruiting
This is a 3-day study comparing pyridostigmine versus placebo in the treatment of postural tachycardia syndrome (POTS). The researchers expect pyridostigmine to improve tachycardia and stabilize blood pressure.
Gender:
ALL
Ages:
Between 15 years and 55 years
Trial Updated:
07/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Postural Tachycardia Syndrome
Register for Updates
Intracardiac Flow Assessment in Cardiac Amyloidosis
NCT05379101
Recruiting
The primary objective of this study is to define the intracardiac flow imaging biomarkers in cardiac amyloidosis.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Amyloidosis Cardiac, Healthy Adults
Register for Updates
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
NCT05836259
Recruiting
This is a first-in-human, non-randomized, open-label study designed to evaluate the safety, tolerability, and pharmacodynamics (PD) of TN-201 in adult patients with symptomatic hypertrophic cardiomyopathy (HCM) caused by mutations in the MYBPC3 gene.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hypertrophic Cardiomyopathy
Register for Updates
MMRC Horizon One Adaptive Platform Trial Evaluating Therapies in RRMM
NCT06171685
Recruiting
This trial is an adaptive platform trial. The structure of the protocol allows the trial to evolve over time. Multiple investigational arms will be included within the trial under a Master Protocol (MP). These investigational arms may be added as appendices at different times depending on whether they are trial-ready and whether accrual in the trial will support another arm. Accrual to an arm will terminate in accord with the arm's appendix to the Master Protocol. The purpose of this proposed s... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/10/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Relapse Multiple Myeloma, Refractory Multiple Myeloma
Register for Updates
Improving Outcomes in PICS With Home-Based Program of Rehabilitation and Health Coaching
NCT06184308
Recruiting
The purpose of this study is to gather information on the effectiveness of a home-based rehabilitation program that also includes health coaching in patients who may suffer from post-intensive care syndrome (PICS). Many patients who are admitted to a hospital ICU suffer from new or worsening symptoms related to their medical condition and ICU care. These new or worsening symptoms may persist for some time and are collectively called post-intensive care syndrome (PICS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Post-Intensive Care Syndrome
Register for Updates