There are currently 217 clinical trials in Columbia, Missouri looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Missouri, Ellis Fischel Cancer Center - Columbia, Ellis Fischel Cancer Center at University of Missouri - Columbia and University of Missouri - Ellis Fischel. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC
Recruiting
The purpose of ARTEMIDE-Lung03 is to evaluate the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line treatment of patients with non-squamous mNSCLC whose tumors express PD-L1.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2025
Locations: Research Site, Columbia, Missouri
Conditions: Non-squamous Non-small Cell Lung Cancer
Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation
Recruiting
The primary purpose of this registry is to obtain real-world clinical experience of Paroxysmal (PAF) and Persistent (PsAF) Atrial Fibrillation ablation radiofrequency (RF) technologies. Data from the registry will be used to assess clinical outcomes, including procedural efficiency, safety, and long-term, effectiveness of catheter ablation with novel RF technologies in PAF and PsAF patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Randomized Trial Comparing Immediate Vs. Deferred Surgery for Symptomatic ERM
Recruiting
Vitrectomy to remove an epiretinal membrane (ERM) is one of the most common procedures performed by retinal surgeons. Patients who present with significant macular changes on optical coherence tomography (OCT) but relatively good vision are often advised to defer surgery until vision declines to 20/40 or worse. However, it is unknown if delaying surgery, which allows the foveal architecture to remain compromised and potentially to deteriorate, results in worse visual acuity outcomes than if surg... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/18/2025
Locations: The Curators of the University of Missouri, Columbia, Missouri
Conditions: Epiretinal Membrane
The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation
Recruiting
This registry will study the use of the Aurora® Surgiscope to provide surgical access and visualization in minimally invasive removal of hematoma in the brain. Many methods of hematoma removal are available and will be based on surgeon preference. The impact of patient selection and time to surgery from last known well time will be explored.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/17/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Supratentorial Hemorrhage
Periprosthetic Fracture Registry (PPFx)
Recruiting
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2025
Locations: University of Missouri Health Care, Columbia, Missouri
Conditions: Periprosthetic Fractures, Periprosthetic Fracture Around Prosthetic Joint Implant
Registry of Pediatric Orthopedic Trauma and Health Outcomes in Skeletally Immature Children
Recruiting
International registry to collect prospective treatment and outcomes data on specific, key non-pathological fractures in children with open physes. Data will be collected during follow-up visits according to standard of care at 3 to 8 weeks, 3, 6, 12 and 24 months
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/13/2025
Locations: University of Missouri Health Care, Columbia, Missouri
Conditions: Long Bone Fractures
Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects with Myasthenia Gravis
Recruiting
Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-106.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/12/2025
Locations: University of Missouri, NextGen Precision Health, Columbia, Missouri
Conditions: Myasthenia Gravis, Generalized Myasthenia, AChR Myasthenia Gravis, MuSK MG
A Study of ECHELON 3000 (Next Generation Powered Stapler) in General Abdominal and Thoracic Lung Resection Procedures
Recruiting
The purpose of this study is to assess the safety and performance of the ECHELON 3000 Stapler (next generation powered stapler) and reload system in participants undergoing laparoscopic sleeve gastrectomy or lung resection procedures (Video-Assisted Thoracoscopic \[ATS\] or open approach).
Gender:
ALL
Ages:
All
Trial Updated:
02/07/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Laparoscopic Sleeve Gastrectomy (LSG), Thoracic Lung Resection Procedure
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
Recruiting
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and clinical outcomes. Given that bromocriptine prevents breastfeeding, an additional 50 women with peripartum cardiomyopathy excluded from the trial due to a desire to continue breastfeeding but meeting all other entry criteria will be followed in an observational cohort.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Karen L Florio, MD, Columbia, Missouri
Conditions: Peripartum Cardiomyopathy, Postpartum
Improving Participation After Stroke Self-Management-Rehabilitation
Recruiting
The overall goal of this proposed study is to evaluate the efficacy of a small-group, stroke-specific, self-management program delivered via telehealth to improve self-efficacy, activity performance, and quality of life in individuals with sub-acute stroke.
Gender:
ALL
Ages:
Between 45 years and 85 years
Trial Updated:
02/03/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Stroke
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. The purpose of this registry is to assess the long term outcomes of patients with SMA in the c... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: University of Missouri Health System, Columbia, Missouri
Conditions: Spinal Muscular Atrophy (SMA)
International Multicentric Observational Study to Characterize Subpopulations of Patients with Autism Spectrum Disorder
Recruiting
To determine sufficient number of biological and clinical markers to identify subgroups of potential best responders to a specific medication
Gender:
ALL
Ages:
Between 12 years and 65 years
Trial Updated:
01/29/2025
Locations: University of Missouri, Thompson Center for Autism & Neurodevelopmental Disorders, Columbia, Missouri
Conditions: Autism Spectrum Disorder