New Hampshire is currently home to 312 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Lebanon, Manchester, Nashua and Portsmouth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study
NCT04653064
Recruiting
This functional magnetic-resonance imaging study of the brain will feature a within-subject crossover design to investigate the effects of a placebo cream on painful thermal stimulation rendered upon eight body sites. The investigators aim to 1.) improve the understanding of how the brain represents thermal pain responses somatotopically (i.e., across different body-sites) 2.) to test these brain representations with and without the presence of a pain-targeted placebo intervention, and 3.) to ex... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: Dartmouth College, Hanover, New Hampshire
Conditions: Pain
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Immune Profiling for Cancer Immunotherapy Response
NCT06116032
Recruiting
In patients clinically treated with FDA-approved immunotherapy the investigators will assess the predictive value of pre- and on-treatment 1) immune-methylation profiling across cancer types, and 2) immune-methylation profiling and cytokine profiling within cancer types.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Cancer, Tumor, Solid, Hematologic Malignancy, Blood Cancer
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ATEMPT 2.0: Adjuvant T-DM1 Vs TH
NCT04893109
Recruiting
This research study is studying how well newly diagnosed breast cancer that has tested positive for a protein called HER2 responds using one of two different combination of HER2-directed therapies as a treatment after surgery. The name of the study drugs involved are: * Trastuzumab-emtansine (T-DM1, Kadcyla) * Trastuzumab SC (Herceptin Hylecta) * Paclitaxel
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2024
Locations: NH Oncology-Hematology, PA - Payson Center for Cancer Care, Concord, New Hampshire
Conditions: Breast Cancer, HER2-positive Breast Cancer
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A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
NCT05287126
Recruiting
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years up to \< 18 years of age). Participants who will complete the total 52-week treatment period will have the opportunity to continue in a Long-Term Extension (LTE) Period of up to 4 years (5 years after study enrollment), or until marketing authorization is obtained in the participant's country, which... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
11/07/2024
Locations: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Ulcerative Colitis
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CAncer TReatment INformed by the Molecular Tumor Board At Dartmouth
NCT05405413
Recruiting
This is a single-arm Phase II study to measure the impact of Molecular Tumor Board treatment recommendations on treatment decision-making in clinical practice at the Dartmouth Cancer Center. Following tumor genetic profiling, subjects will be screened for eligibility. Eligible subjects' cases will be evaluated by the Dartmouth Cancer Center Molecular Tumor Board, and treatment recommendations will be entered into the medical record as per standard procedure. The primary endpoint is a survey res... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Cancer
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Protocol for Genomically Profiling, Collecting, Archiving and Distributing Blood and Bone Marrow Specimens from Children and Young Adults with Hematologic Malignancy
NCT04968834
Recruiting
This research study is a genomic profiling and repository study for children and young adults who have leukemia, myelodysplastic syndrome (MDS) or myeloproliferative syndrome (MPS). Genes are the part of cells that contain the instructions which tell cells how to make the right proteins to grow and work. Genes are composed of DNA letters that spell out these instructions. Genomic profiling helps investigators understand why the disease develops and the instructions that led to its development. U... Read More
Gender:
ALL
Ages:
30 years and below
Trial Updated:
11/04/2024
Locations: Dartmouth-Hitchcock, Lebanon, New Hampshire
Conditions: Leukemia, Myelodysplastic Syndromes, Myeloproliferative Syndrome
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Comparison of Compounded Topical Anesthetics
NCT06569537
Recruiting
The primary objective for this pilot study is to evaluate the efficacy of the compounded topical anesthetic Benzocaine 20%/ Lidocaine 8%/Tetracaine 4% (BLT) compared to 4% Lidocaine topical in providing relief of pain during IPL, PDL, and microneedling procedures.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/01/2024
Locations: Dartmouth Hitchcock Dermatology Clinic, Lebanon, New Hampshire
Conditions: Procedural Pain
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Phase II Study of Neoadjuvant ArOMatase Inhibitor Therapy for ER+ Breast Cancer (NAOMI)
NCT04568616
Recruiting
This is a single-arm, open-label study testing the effects of neoadjuvant therapy with the aromatase inhibitor letrozole in post-menopausal women with Stage I-III ER+, HER2- breast cancer. Eligible subjects will be treated with letrozole therapy for 4 to 24 weeks prior to surgical resection of the tumor. Tumor specimens obtained at baseline (diagnostic biopsy) and at surgery (surgical specimen) will be compared using molecular analyses. A subset of subjects will be asked to provide an optional r... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Breast Cancer, ER Positive Breast Cancer
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Utility of CC7 Transfer in Stroke Subtypes
NCT06001736
Recruiting
The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/20/2024
Locations: Dartmouth-Health, Lebanon, New Hampshire
Conditions: Stroke, Ischemic, Stroke Hemorrhagic, Spastic Hemiparesis
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CORE: CO Monitoring for Reach and Efficacy in Tobacco Treatment for Cancer Patients
NCT04675515
Recruiting
The purpose of this study is to assess the cessation success rates of an intensive tobacco treatment program in a patients undergoing cancer treatment at 30 days, 3 months and 6 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Tobacco Use, Cancer
Register for Updates
Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection
NCT04600973
Recruiting
Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus trans... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: Trustees of Dartmouth College, Hanover, New Hampshire
Conditions: Infection
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Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)
NCT06438640
Recruiting
The objective of this study is to assess the implementation process for and the effectiveness of a quality improvement (QI) strategy to increase shared decision-making around anesthesia options for hip fracture surgery at 6 US hospitals. The QI strategy is to be facilitated by a clinician-administered 1-page bedside conversation aid designed to improve the quality of physician-patient communication, paired with brief clinician training. The evaluation will occur via a stepped wedge, cluster rand... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
10/01/2024
Locations: Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Hip Fractures, Femoral Neck Fractures, Intertrochanteric Fractures, Subtrochanteric Fractures
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