There are currently 237 active clinical trials seeking participants for Stroke research studies. The states with the highest number of trials for Stroke participants are California, Florida, New York and Ontario.
Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke
NCT06615973
Recruiting
Background: Stroke is the fifth leading cause of death in the United States. It is also a leading cause of disability. More than 70% of people who survive strokes have mental impairment or dementia. Medical factors, such as the severity of the stroke, affect whether a person will have mental impairment afterward. But social factors, such as education and ethnicity, seem to play a role as well. Researchers want to learn more about how social and lifestyle factors affect a person s chances of mai... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/08/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Stroke, Brain Disease, Vascular Diseases, Cerebrovascular Disorder
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tVNS Responsiveness Testing With Pupil Size
NCT06335199
Recruiting
The goal of this study is to learn about the acute pupil response to transcutaneous vagus nerve stimulation (tVNS) in stroke survivors and healthy adults. The main question it aims to answer is whether pupil size response is greater with bilateral tVNS compared to unilateral tVNS. Participants will receive tVNS and sham at the outer ear unilaterally and bilaterally in resting condition. The pupil size of the participants will be recorded during tVNS.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
05/08/2025
Locations: Human Neuromuscular Physiology Lab, Atlanta, Georgia
Conditions: Stroke
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A Pivotal Investigational Device Exemption Study on Laminar Left Atrial Appendage Elimination
NCT06168942
Recruiting
The purpose of this study is to compare the safety and effectiveness of Laminar Left Atrial Appendage Closure (LAAC) device as compared to the commercially available LAAC devices in participants with non-valvular atrial fibrillation (NVAF) to reduce the risk of stroke (blocked blood vessel or bleeding in brain) and systemic embolism (blockage in a blood vessel harming vital organs).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: Grandview Medical Center, Birmingham, Alabama +63 locations
Conditions: Non-valvular Atrial Fibrillation, Stroke, Systemic Embolism
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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
NCT05047172
Recruiting
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of ischemic stroke, intracerebral hemorrhage, or vascular death.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
05/07/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +124 locations
Conditions: Intracranial Arteriosclerosis, Stroke
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Reflex Excitability in Post-stroke Stiff-Knee Gait
NCT04947865
Recruiting
The purpose of this study is to examine the reflex excitability of the rectus femoris in individuals with and without post-stroke Stiff-Knee gait. We use electrical stimulation of the peripheral nerve innervating the rectus femoris for a well-controlled reflex stimulus. We are investigating whether reflex excitability of the rectus femoris correlates with gait kinematics.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Stroke, Chronic Stroke, Gait, Hemiplegic, Gait, Spastic, Gait Disorder, Sensorimotor, Gait Disorders, Neurologic, Walking, Difficulty
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Effectiveness of Immersive Virtual Reality Combined With Task-Specific Training on Hemiplegic Arm Function Following Stroke
NCT05728866
Recruiting
The purpose of this research study is to understand the efficacy of using an immersive Virtual Reality (VR) environment, with task-specific training, to encourage arm movement following stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Stroke
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Neurologic Stem Cell Treatment Study
NCT02795052
Recruiting
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain neurologic conditions. http://mdstemcells.com/nest/
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: MD Stem Cells, Westport, Connecticut +3 locations
Conditions: Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders, Stroke, Traumatic Brain Injury, Cadasil, Chronic Traumatic Encephalopathy, Cerebral Infarction, Cerebral Ischemia, Cerebral Stroke, Cerebral Hemorrhage, Parkinson, Multi-System Degeneration, MSA - Multiple System Atrophy, Progressive Supranuclear Palsy, ALS, Amyotrophic Lateral Sclerosis, Neuropathy, Diabetic Neuropathies, Alzheimer Disease, Dementia, Frontotemporal Dementia, Lewy Body Disease, Cognitive Impairment, Lewy Body Variant of Alzheimer Disease
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Non-invasive VNS in Stroke Recovery
NCT06761404
Recruiting
To evaluate feasibility and effectiveness of non-invasive VNS to enhance stroke recovery
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/03/2025
Locations: Houston Methodist Research Institute, Houston, Texas
Conditions: Stroke
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Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke
NCT06681207
Recruiting
This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
05/01/2025
Locations: Physical Therapy, University of Texas Medical Branch, Galveston, Texas
Conditions: Stroke
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Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke
NCT06303869
Recruiting
The goal of this study is to verify whether the use of deep brain stimulation can improve motor function of the hand and arm and speech abilities for people following a stroke. Participants will undergo a surgical procedure to implant deep brain stimulation electrode leads. The electrodes will be connected to external stimulators and a series of experiments will be performed to identify the types of movements that the hand and arm can make and how speech abilities are affected by the stimulation... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/30/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Stroke, Brain Disease, Central Nervous System Diseases, Nervous System Diseases, Cardiovascular Diseases
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Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.
NCT04432883
Recruiting
62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-u... Read More
Gender:
ALL
Ages:
Between 25 years and 85 years
Trial Updated:
04/30/2025
Locations: University of New Mexico Center for Brain Recovery and Repair, Albuquerque, New Mexico
Conditions: Stroke, Aphasia
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EMG Controlled Device in Acute Rehabilitation After Acute Stroke
NCT04599036
Recruiting
Stroke is a medically relevant problem for the aging population. Individuals with stroke experience a high amount of arm functional deficits despite receiving rehabilitation. Functional deficits can be improved by combining rehabilitation with innovative rehabilitative tools that target the brain mechanisms that guide the recovery early after stroke. This study aims to explore the feasibility of implementing an EMG controlled device in the acute rehabilitation for stroke survivors with severe ar... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/29/2025
Locations: Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
Conditions: Stroke
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