The state of North Carolina currently has 62 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Durham, Charlotte, Winston-Salem and Chapel Hill.
COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children
Recruiting
Evaluate the content validity and comprehensibility of a caregiver observer-reported outcome assessment and clinician-reported assessments for acute pain in children aged 0 to <2 years. The primary objective of the Qualitative Protocol in the UH3 phase study is to establish or create reliable Clinical Outcome Assessments (COAs) and endpoints that can assess acute pain during clinical trials of pain therapeutics specifically designed for infants and young children (0 - <2 years).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/18/2024
Locations: Duke Clinical Research Institute, Durham, North Carolina
Conditions: Acute Pain
Anesthetics and Analgesics in Children
Recruiting
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
Gender:
All
Ages:
Between 0 years and 17 years
Trial Updated:
01/17/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Anesthesia, Pain
Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery
Recruiting
The goal of this clinical trial is to evaluate the efficacy and safety of OCS-01 in treating inflammation and pain in subjects following cataract surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Oculis Investigative Site, Elizabeth City, North Carolina
Conditions: Inflammation Eye, Pain, Postoperative, Cataract
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/08/2024
Locations: Premier Pain Solutions, Asheville, North Carolina
Conditions: Chronic Pain
Healthy Lifestyles After Cancer for Adolescents and Young Adults: A Program to Reduce Cardiovascular Risk Factors
Recruiting
There are close to 700,000 survivors of adolescent and young adult (AYA) cancer (aged 15 to 39 at diagnosis) in the US. Survivorship for AYAs is often complicated by long-term and late-effects. Cardiovascular disease (CVD), in particular, is a leading cause of death for cancer survivors and is a growing public health concern for survivors diagnosed as AYAs. Risk of CVD may be associated with treatment exposures and may be potentiated by weight gain and poor health behaviors. Healthy eating and p... Read More
Gender:
All
Ages:
Between 18 years and 39 years
Trial Updated:
01/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Cancer, Cardiovascular Diseases, Weight Management, Pain, Fatigue, Distress, Emotional, Physical Inactivity
A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain
Recruiting
This is a multicenter randomized, double-blind, placebo-controlled phase 2 study to evaluate efficacy, safety, tolerability, pharmacokinetics, and target engagement of GSK3858279 in adult participants with chronic Diabetic Peripheral Neuropathic Pain (DPNP). The primary objective of the study is to assess the efficacy of GSK3858279 in participants with DPNP who have been unable to sufficiently manage their pain.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
12/05/2023
Locations: GSK Investigational Site, Huntersville, North Carolina
Conditions: Pain
Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery
Recruiting
This is an interventional, Phase III, double-blind, randomized, controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated topical application of Qutenza (capsaicin 8% topical system) versus low-dose capsaicin control (capsaicin 0.04% topical system) in subjects with moderate to severe postsurgical neuropathic pain (PSNP).
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Accellacare, Wilmington, North Carolina +1 locations
Conditions: Post Surgical Neuropathic Pain
Reliability of Pupil Response to Acute Pain
Recruiting
The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
12/01/2023
Locations: Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Pain, Osteoarthritis
The Pain Intervention Via Video Optimization Trial
Recruiting
This project tests a brief evidence-based video to help educate patients regarding effective and safe pharmacologic and non-pharmacologic therapies for acute musculoskeletal pain (MSP). Subjects will be randomly placed into one of two study arms: intervention (educational video) and usual care. Patients will be contacted at baseline and at 1 and 3 months after the date of an emergency department (ED) or urgent care encounter for follow-up. The aim of this study is to evaluate the success of the... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
11/30/2023
Locations: University of North Carolina Hospitals, Chapel Hill, North Carolina
Conditions: Acute Musculoskeletal Pain, Chronic Pain
Supervised Exercise as a Therapeutic Strategy for Interstitial Cystitis/Bladder Pain Syndrome
Recruiting
In this study, the efficacy of exercise to improve interstitial cystitis/bladder pain syndrome symptoms and quality of life will be investigated.
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
11/29/2023
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Interstitial Cystitis, Bladder Pain Syndrome
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Recruiting
The investigators will conduct a 12,500-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Gender:
All
Ages:
18 years and above
Trial Updated:
11/22/2023
Locations: Wake Forest, Winston-Salem, North Carolina
Conditions: Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm
Investigation of PEMF Therapy for Female Patients With IC/BPS
Recruiting
The purpose of this study is to gather information about the safety and effectiveness of the non-pharmacological (non-drug), non-invasive treatment known as low-frequency pulsed electromagnetic field (PEMF) therapy. The study team will distribute the PEMF device to female adults with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) to measure its ability to decrease bladder and pelvic pain as well as other urinary symptoms associated with IC/BPS. There are two sequential Aims in this study a... Read More
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Interstitial Cystitis, Chronic Interstitial Cystitis, Bladder Pain Syndrome