Pain Trials in North Carolina

A listing of Pain Trials in North Carolina actively recruiting patient volunteers.

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29 trials found

Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn

NCT05619289

The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question[s] it aims to answer are: Is the clinical trial protocol feasible? Is Vitamin D administration following burn injury safe? How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be asked t ...

Conditions: Burn Injury, Chronic Pain

Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy

NCT05472740

The purpose of this study is to see whether transcutaneous electrical nerve stimulation (or TENS) reduces pain during an endometrial biopsy. A TENS unit is an over-the-counter, FDA approved device that sends low-level electrical impulses through the skin to reduce the amount of discomfort experienced during procedures. A TENS unit is very low-risk and used in a lot of ways, including for chronic pain, after surgery, and during labor. Since there is no standard way of managing discomfort during a ...

Conditions: Endometrial Diseases, Pain, Postoperative
Phase: Not Applicable

True Functional Restoration and Analgesia in Non-Radicular Low Back Pain

NCT05419297

To study the response of objective and quasi-objective 'True' functional outcomes, analgesia and safety in chronic non-radicular back pain to buprenorphine buccal film (BBF) using a small 'n' phase IV design. To assess associations between traditional pain relevant subjective outcomes and objective or quasi-objective functional outcomes; In a small 'n' construct, to assess more powerful, 'new' statistical methods (e.g. hierarchical linear models, joint trajectory analysis) compared to traditiona ...

Conditions: Back Pain Lower Back Chronic, Chronic Pain

Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures

NCT05415384

To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation

Conditions: Pain, Postoperative, Rib Fracture Multiple
Phase: Not Applicable

Radiofrequency Hyperthermia Safety Study

NCT05399771

This study will include 20 healthy subjects with intact skin on their lower legs that meet inclusion criteria. Participants will serve as their own control, by heating one leg and not the other. The radiofrequency device consists of a 4 by 6 inch heating pad connected to a temperature controller. Subjects will receive weekly treatments for 4 weeks, and will be re-evaluated 4 weeks after the last treatment to assess any tissue changes that continue after the treatments have concluded.

Conditions: Chronic Pain, Soft Tissue Injuries, Wound Heal, Blood Flow
Phase: Not Applicable

Meaning-Centered Pain Coping Skills Training for Cancer Pain

NCT05385965

This study is a randomized controlled trial of a psychosocial pain management intervention called, Meaning-Centered Pain Coping Skills Training (MCPC). Patients with advanced solid tumor cancer and pain interference (N=210) will be randomized to MCPC or a standard care control condition. Patient-reported outcomes will be assessed at baseline and 8- and 12-week follow-ups. The risk and safety issues in this trial are low and limited to those common to a psychosocial intervention (e.g., loss of co ...

Conditions: Advanced Solid Tumor, Pain
Phase: Not Applicable

RCT for Innovating Stress-related eHealth

NCT05305235

The Randomized Control Trial for Innovating Stress-related eHealth (RISE) Study tests the hypotheses that a highly promising digital therapeutic (RISE Guide) targeting anxiety sensitivity (AS) will be acceptable to women sexual assault survivors; reduce survivors' anxiety sensitivity, and, in turn, posttraumatic stress. If successful, RISE Guide could be provided at no cost to all women who present to US emergency departments for emergency care after sexual assault.

Conditions: Posttraumatic Stress Disorder, Sexual Assault, Pain
Phase: Not Applicable

PENG Block Versus LP Block for THA Postop Pain

NCT05261009

The purpose of this randomized, double blinded, prospective study is to compare the postoperative analgesia provided by the PENG block to that provided by the LPB for patients undergoing primary anterior approach THA.

Conditions: Pain, Postoperative, Hip Pain Chronic

Safety of Pediatric COVID-19 Vaccination

NCT05157191

This is a prospective, observational study. During the study, children and adolescents (ages ≥ 5 to < 16) will be followed post administration of mRNA COVID-19 vaccines. Injection site (local), systemic reaction, and unsolicited adverse event data will be assessed on vaccination day and during the 7 days following each vaccination using either identical web-based or paper diaries, depending on study participant preference. At Duke University, Cincinnati's Children Hospital, and Kaiser Permanen ...

Conditions: Pain, Injection Site Reaction, Adverse Drug Event

Low Nicotine Cigarettes, Smoking, and Chronic Pain

NCT05032755

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on experiences with craving, withdrawal, and pain among individuals with chronic back pain who smoke cigarettes daily.

Conditions: Chronic Pain, Smoking, Cigarette
Phase: Not Applicable

Using Mobile Devices for Neurofeedback to Reduce Opioid Use in Chronic Pain

NCT04838925

The purpose of this study is to develop and test the feasibility of a commercially-ready mobile neurofeedback app for individuals with chronic pain. Thirty (30) participants who are prescribed opioids for chronic pain will use the new mobile neurofeedback app and an EEG headset for 10 minutes at a time, 4 times a week for 12 weeks and provide feedback about using the app.

Conditions: Chronic Pain, Opioid Use
Phase: Not Applicable

Differential Target Multiplexed Spinal Cord Stimulation (DTM-SCS®) Real World Outcomes

NCT04725838

The UPGRADE registry will capture long-term, real-world outcomes to understand the effect of Differential Target Multiplexed (DTM®) programming in the Spinal Cord Stimulation (SCS) implanted population on the management of chronic pain, primarily on its use for trunk and/or limb pain. The clinical study is sponsored by Celéri Health and is funded through a financial grant from Medtronic's External Research Program. The registry study will be conducted across approximately 25 centers in the Unite ...

Conditions: Chronic Pain