Patient Retrospective Outcomes (PRO)
NCT01550575
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
All
Ages:
18 years and above
Locations: Vidant Roanoke - Chowan Hospital Pain Center, Ahoskie, North Carolina +117 locations
Conditions: Chronic Pain
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RELIEF - A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
NCT01719055
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use - and - To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
All
Ages:
18 years and above
Locations: Carolinas Research Institute, PLLC, Huntersville, North Carolina +110 locations
Conditions: Pain
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Anesthetics and Analgesics in Children
NCT03427736
Recruiting
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
Gender:
All
Ages:
Between 0 years and 17 years
Locations: Duke University Medical Center, Durham, North Carolina +10 locations
Conditions: Anesthesia, Pain
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Neuroimaging of Opioid Phase
NCT05905419
Recruiting
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
Gender:
Female
Ages:
18 years and above
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chronic Pain, Opioid Use
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Paresthesia-Free Fast-Acting Subperception (FAST) Study
NCT04618471
Recruiting
Study to evaluate the effectiveness of FAST-SCS (fast-acting paresthesia-free therapy) and additional SCS therapy options in patients with chronic pain using Boston Scientific WaveWriter SCS Systems.
Gender:
All
Ages:
22 years and above
Locations: The Center for Clinical Research, Winston-Salem, North Carolina +11 locations
Conditions: Chronic Pain
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Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
NCT03876054
Recruiting
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's neurostimulation systems.
Gender:
All
Ages:
18 years and above
Locations: Premier Pain Solutions, Asheville, North Carolina +54 locations
Conditions: Chronic Pain
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Radiofrequency Hyperthermia Safety Study
NCT05399771
Recruiting
This study will include 20 healthy subjects with intact skin on their lower legs that meet inclusion criteria. Participants will serve as their own control, by heating one leg and not the other. The radiofrequency device consists of a 4 by 6 inch heating pad connected to a temperature controller. Subjects will receive weekly treatments for 4 weeks, and will be re-evaluated 4 weeks after the last treatment to assess any tissue changes that continue after the treatments have concluded.
Gender:
All
Ages:
Between 18 years and 99 years
Locations: Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina
Conditions: Chronic Pain, Soft Tissue Injuries, Wound Heal, Blood Flow
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Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
NCT05415384
Recruiting
To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation
Gender:
All
Ages:
Between 18 years and 80 years
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Pain, Postoperative, Rib Fracture Multiple
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Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
NCT04427709
Recruiting
The purpose of this research is to evaluate the effects of oxytocin (naturally occurring hormone) given by an intramuscular (IM; into the muscle) injection, has on your parasympathetic nervous system. The parasympathetic nervous system is the part of the involuntary nervous system that is sometimes called the "rest and digest" system; the parasympathetic system conserves energy as it slightly slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gast... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Chronic Pain, Osteoarthritis, Knee
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Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
NCT05619289
Recruiting
The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question[s] it aims to answer are: Is the clinical trial protocol feasible? Is Vitamin D administration following burn injury safe? How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be asked t... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Locations: University Of North Carolina, Chapel Hill, North Carolina
Conditions: Burn Injury, Chronic Pain
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Pain Response Evaluation of a Combined Intervention to Cope Effectively
NCT04395001
Recruiting
The purpose of this research is is to determine if the combination of non-opioid medication (duloxetine) and web-based pain-coping skills training (PCST) is beneficial for individuals with chronic musculoskeletal pain (CMP).
Gender:
All
Ages:
Between 18 years and 65 years
Locations: Wake Forest Baptist Health Department of Rheumatology, Winston-Salem, North Carolina
Conditions: Chronic Pain
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Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System
NCT04341948
Recruiting
The purpose of this study is to gather information about how knee pain changes when small amounts of electricity are delivered to the nerves in the leg. This study will involve the use of a Peripheral Nerve Stimulation (PNS) System that is made by SPR Therapeutics (the sponsor of the study). The SPRINT PNS System was cleared by the FDA for up to 60 days of use in the back and/or extremities for the management of acute and chronic pain.
Gender:
All
Ages:
21 years and above
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina +10 locations
Conditions: Postoperative Pain, Total Knee Replacement, Total Knee Arthroplasty, Partial Knee Replacement
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