The state of North Carolina currently has 64 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Durham, Winston-Salem, Charlotte and Chapel Hill.
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Recruiting
The investigators will conduct a 12,500-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Gender:
All
Ages:
18 years and above
Trial Updated:
11/22/2023
Locations: Wake Forest, Winston-Salem, North Carolina
Conditions: Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm
Investigation of PEMF Therapy for Female Patients With IC/BPS
Recruiting
The purpose of this study is to gather information about the safety and effectiveness of the non-pharmacological (non-drug), non-invasive treatment known as low-frequency pulsed electromagnetic field (PEMF) therapy. The study team will distribute the PEMF device to female adults with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) to measure its ability to decrease bladder and pelvic pain as well as other urinary symptoms associated with IC/BPS. There are two sequential Aims in this study a... Read More
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
10/24/2023
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Interstitial Cystitis, Chronic Interstitial Cystitis, Bladder Pain Syndrome
Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
Recruiting
The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question[s] it aims to answer are: Is the clinical trial protocol feasible? Is Vitamin D administration following burn injury safe? How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be asked t... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
10/18/2023
Locations: University Of North Carolina, Chapel Hill, North Carolina
Conditions: Burn Injury, Chronic Pain
A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis Pain
Recruiting
This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis (OA) pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe dose(s) of GSK3858279.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
10/11/2023
Locations: GSK Investigational Site, Greensboro, North Carolina
Conditions: Pain
Mobile Neurofeedback for Low Back Pain
Recruiting
The purpose of this study is to learn more about improving the quality of treatments for people who have chronic low back pain. Participants will complete interviews with Duke researchers at four different time points: the beginning of the study, at 3 months, at 6 months, and at 9 months. Participants will be asked to use a mobile app and a headset that are designed to train the brain to be more relaxed. Participants will use the mobile app for 10 minutes at a time, four times a week for three m... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
10/10/2023
Locations: Duke University Medical Center, Department of Psychiatry, Durham, North Carolina
Conditions: Chronic Low Back Pain
Well-Being After Breast Cancer Surgery
Recruiting
The purpose of this study is to compare the benefits of skills training and health education interventions designed specifically to increase the well-being of people with persistent pain after breast surgery for lobular carcinoma in situ (LCIS), ductal carcinoma in situ (DCIS), or invasive breast cancer, and to examine the roles of psychological and physiological variables as modifiable contributors to the continuing burden of persistent pain.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: General Health Education, Coping Skills Training for Persistent Post-Surgical Pain
Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin
Recruiting
The goal of this clinical trial is to learn about oxytocin ( a naturally occurring hormone made in the brain that transmits messages) and the effects it may have on thermal heat pain after intravenous administration. The main question it aims to define is the time course of change in pain score after a 5 minute heating of the skin administered at intervals during and following infusion of intravenous oxytocin in order to create a Pharmacokinetic and a Pharmacodynamic model for oxytocin-induced a... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/23/2023
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Acute Pain, Chronic Pain, Healthy Volunteer
TENS and Perioperative Fracture Patients
Recruiting
This is a pilot study designed to evaluate the effectiveness of TENS as part of post-operative pain management. Subjects receiving a TENS unit as part of clinical practice will be approached for consent and followed for 12 months.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: Carolinas Medical Center, Department of Orthopaedic Surgery, Charlotte, North Carolina
Conditions: Musculoskeletal Pain
Low Nicotine Cigarettes, Smoking, and Chronic Pain
Recruiting
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on experiences with craving, withdrawal, and pain among individuals with chronic back pain who smoke cigarettes daily.
Gender:
All
Ages:
Between 21 years and 65 years
Trial Updated:
07/07/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chronic Pain, Smoking, Cigarette
Safety and Effectiveness of Magnetic Peripheral Nerve Stimulation for the Treatment of Chemotherapy Induced Neuropathy
Recruiting
Assess the safety and effectiveness of Axon Therapy in the treatment of chemotherapy-induced neuropathy
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
07/05/2023
Locations: Carolinas Pain Institute and Center for Clinical Research, Winston-Salem, North Carolina
Conditions: Neuralgia, Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Recruiting
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving wellbeing after surgery.
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/14/2023
Locations: Atrium Health - Levine Cancer Institute, Charlotte, North Carolina +1 locations
Conditions: Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance, Malignant Female Reproductive System Neoplasm
Pain and Neurological Function Improvements With 10 kHz Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy
Recruiting
The purpose of this post-market study is to evaluate changes in pain and neurological function with high frequency, 10 kHz spinal cord stimulation (SCS) therapy in patients with chronic, intractable lower limb pain associated with diabetic peripheral neuropathy, a condition known as painful diabetic neuropathy (PDN). This is a multi-center, prospective, randomized controlled study to evaluate improvement in pain and neurological function in PDN patients, with neurological function assessed via o... Read More
Gender:
All
Ages:
22 years and above
Trial Updated:
05/09/2023
Locations: Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina
Conditions: Painful Diabetic Neuropathy